| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zengyu Yao, Zhinan Zhang, Jiping Zhang, Xiaowen Cai, Zheng Zhong, Yong Huang, Shanshan Q. Electroacupuncture alleviated the depression-like behavior by regulating FGF2 and astrocytes in the hippocampus of rats with chronic unpredictable mild stress. Brain research bulletin. vol 169. 2021-10-07. PMID:33434624. |
the results showed that ea and paroxetine could improve depression-like behavior in cums rats, and up-regulated the expression level of fgf2 in the hippocampus, increased gfap protein expression and the mean optical density of gfap-immunoreactive astrocyte (gfap-ir astrocyte). |
2021-10-07 |
2023-08-13 |
rat |
| Fatemeh Jafari Jahed, Reza Rahbarghazi, Hajar Shafaei, Aysa Rezabakhsh, Mohammad Karimipou. Application of neurotrophic factor-secreting cells (astrocyte - Like cells) in the in-vitro Alzheimer's disease-like pathology on the human neuroblastoma cells. Brain research bulletin. vol 172. 2021-10-07. PMID:33895268. |
mesenchymal stem cells (mscs) - to-ntf-scs (astrocyte -like cells) trans-differentiation was confirmed using immunofluorescence staining of gfap. |
2021-10-07 |
2023-08-13 |
human |
| Oiva Arvola, Brian Griffiths, Anand Rao, Lijun Xu, Iason-Alexander Pastroudis, Creed M Star. Expression of miR-200c corresponds with increased reactive oxygen species and hypoxia markers after transient focal ischemia in mice. Neurochemistry international. vol 149. 2021-10-06. PMID:34343653. |
in the present study we demonstrate that the fluorescent hypoxia indicator pimonidazole hydrochloride, the reactive-oxygen-species marker 8-hydroxy-deoxyguanosine, neuronal marker map2 and neun, and the reactive astrocyte marker gfap can be effectively complexed to determine regional differences in ischemic injury as early as 30 min post-reperfusion after experimental stroke, and can be effectively used to distinguish ischemic core from surrounding penumbral and unaffected regions for targeted therapy. |
2021-10-06 |
2023-08-13 |
mouse |
| Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazem. Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation. Biological trace element research. vol 199. issue 11. 2021-09-27. PMID:33400154. |
at postnatal day 60, the density of both microglia and astrocyte cells and the expression levels of il-6, il-1β, inos, tnf-α, nf-κb, and gfap were evaluated in the pfc of male pups. |
2021-09-27 |
2023-08-13 |
rat |
| MiaoJun Lv, GuoFang Xue, HuiFeng Cheng, PengFei Meng, Xia Lian, Christian Hölscher, DongFang L. The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinson's disease more effectively than the GLP-1 single-receptor agonist NLY01. Brain and behavior. vol 11. issue 8. 2021-09-22. PMID:34125470. |
when measuring the levels of the inflammation markers toll-like receptor 4 (tlr4), specific markers of microglia activation (iba-1), the marker of astrocyte activation glial fibrillary acidic protein (gfap), nuclear factor-κb (nf-κb), tumor necrosis factor (tnf-α), and transforming growth factor β1 (tgf-β1), da5-ch was very effective in reducing the chronic inflammation response, while nly01 did not show significant effects. |
2021-09-22 |
2023-08-13 |
mouse |
| Andrea Lewen, Thuy-Truc Ta, Tiziana Cesetti, Jan-Oliver Hollnagel, Ismini E Papageorgiou, Bruno Chausse, Oliver Kan. Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32638411. |
chronic exposure of slice cultures to liposome-encapsulated clodronate reduced the microglial cell population by about 96%, whereas neuronal structures, astrocyte gfap expression, and basal levels of cytokines and no were unchanged. |
2021-09-17 |
2023-08-13 |
rat |
| Serpil Ünver Saraydin, Berna Özdenoglu Kutlu, Dursun Saraydı. Effects of diabetes on apoptosis and mitosis in rat hippocampus. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 6. 2021-09-17. PMID:32938250. |
we investigated caspase-3, caspase-7 and ki 67 levels immunohistochemically for mitotic activity, the tunel method for apoptosis and gfap for astrocyte cell density in the hippocampal ca1 region. |
2021-09-17 |
2023-08-13 |
rat |
| b' Macarena L Herrera, Romina Deza-Ponzio, Marisa S Ghersi, Emilce A de la Villarmois, Miriam B Virgolini, Mariela F P\\xc3\\xa9rez, Victor A Molina, Mar\\xc3\\xada J Bellini, Claudia B Here\\xc3\\xb1\\xc3\\xb. Early Cognitive Impairment Behind Nigrostriatal Circuit Neurotoxicity: Are Astrocytes Involved? ASN neuro. vol 12. 2021-09-15. PMID:32466659.' |
we evaluated tyrosine hydroxylase (th) as a dopamine marker, aldehyde dehydrogenase 2 (aldh2), a mitochondria detoxification enzyme and astrocyte glial fibrillar acid protein (gfap) an immunoreactivity marker involved in different areas: cpu, substantia nigra, prefrontal cortex, and hippocampus. |
2021-09-15 |
2023-08-13 |
Not clear |
| Dongyang Li, Tong Li, Jiawei Yu, Xiaoyu Liu, Shuwei Jia, Xiaoran Wang, Ping Wang, Yu-Feng Wan. Astrocytic Modulation of Supraoptic Oxytocin Neuronal Activity in Rat Dams with Pup-Deprivation at Different Stages of Lactation. Neurochemical research. vol 46. issue 10. 2021-09-14. PMID:32930948. |
they also significantly increased the expression of glial fibrillary acidic protein (gfap) in western blots while increased gfap filaments and the colocalization of gfap filaments with aquaporin 4 (aqp4) puncta in astrocyte processes surrounding oxytocin neuronal somata in immunohistochemistry in the supraoptic nucleus. |
2021-09-14 |
2023-08-13 |
rat |
| Chengya Dong, Shaohong Wen, Shunying Zhao, Si Sun, Shangfeng Zhao, Wen Dong, Pingxin Han, Qingfang Chen, Ting Gong, Wentao Chen, Wenqian Liu, Xiangrong Li. Salidroside Inhibits Reactive Astrogliosis and Glial Scar Formation in Late Cerebral Ischemia via the Akt/GSK-3β Pathway. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33389472. |
it also reduced brain glial scar volume and decreased expression of the glial scar marker, glial fibrillary acidic protein (gfap) and inhibited astrocyte proliferation. |
2021-09-14 |
2023-08-13 |
mouse |
| Juliana Esma Bajic, Gordon Stanley Howarth, Suzanne Mashtoub, Alexandra Louise Whittaker, Larisa Bobrovskaya, Mark Rowland Hutchinso. Neuroimmunological complications arising from chemotherapy-induced gut toxicity and opioid exposure in female dark agouti rats. Journal of neuroscience research. 2021-09-12. PMID:34510524. |
utilizing a 5-fluorouracil-induced gt (5igt) rat model and analgesic intervention (carprofen (car), buprenorphine (bup), and tramadol (tram)), spinal and brain neuroimmune modulation was examined via microglial, astrocyte, and proinflammatory (cluster of differentiation molecule 11b; cd11b, glial fibrillary associated protein; gfap, and interleukin-1 beta; il1β) reactivity marker expression changes by western blot analysis. |
2021-09-12 |
2023-08-13 |
rat |
| Israa M Abd El-Fatah, Heba M A Abdelrazek, Sherehan M Ibrahim, Dalaal M Abdallah, Hanan S El-Abha. Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories. Neurochemistry international. vol 148. 2021-09-08. PMID:34052296. |
these behavioral upturns were associated with increased intact neurons (nissl stain) and a reduction in ovx/d-gal-mediated hippocampal ca1 neurodegeneration and astrocyte activation assessed as gfap immunoreactivity. |
2021-09-08 |
2023-08-13 |
rat |
| Minori Koga, Hiroyuki Toda, Manabu Kinoshita, Fumiho Asai, Masanori Nagamine, Kunio Shimizu, Yasushi Kobayashi, Yuji Morimoto, Aihide Yoshin. Investigation of the impact of preconditioning with lipopolysaccharide on inflammation-induced gene expression in the brain and depression-like behavior in male mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32464240. |
notably, lps preconditioning attenuated an increase in expression of the astrocyte marker gfap caused by systemic inflammation, suggesting that astrocytes have a key role in endotoxin tolerance in the brain induced by lps preconditioning. |
2021-08-27 |
2023-08-13 |
mouse |
| Atefeh Vafaei, Reza Rahbarghazi, Mahshid Kharaziha, Negar Abbasi Avval, Aysa Rezabakhsh, Mohammad Karimipou. Polycaprolactone fumarate acts as an artificial neural network to promote the biological behavior of neural stem cells. Journal of biomedical materials research. Part B, Applied biomaterials. vol 109. issue 2. 2021-08-27. PMID:32798302. |
the protein levels of map-2 and gfap were detected by using immunofluorescence staining to show neural and astrocyte differentiation capacity. |
2021-08-27 |
2023-08-13 |
mouse |
| Abdeslam Mouihate, Samah Kalak. Maternal Interleukin-6 Hampers Hippocampal Neurogenesis in Adult Rat Offspring in a Sex-Dependent Manner. Developmental neuroscience. vol 43. issue 2. 2021-08-25. PMID:34023825. |
blunting the naturally occurring il-6 during pregnancy did not have a significant long-lasting impact on astrocyte cell density (gfap), or on anxiety-like behavior as assessed with elevated plus maze and open field tests. |
2021-08-25 |
2023-08-13 |
rat |
| Alastair J MacDonald, Fiona E Holmes, Craig Beall, Anthony E Pickering, Kate L J Ellacot. Regulation of food intake by astrocytes in the brainstem dorsal vagal complex. Glia. vol 68. issue 6. 2021-08-19. PMID:31880353. |
mice fed high-fat chow for 12 hr during the dark phase showed nts astrocyte activation, reflected in an increase in the number (65%) and morphological complexity of glial-fibrillary acidic protein (gfap)-immunoreactive cells adjacent to the area postrema (ap), compared to control chow fed mice. |
2021-08-19 |
2023-08-13 |
mouse |
| Lucía Viejo, Ayush Noori, Emily Merrill, Sudeshna Das, Bradley T Hyman, Alberto Serrano-Poz. Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease. Neuropathology and applied neurobiology. 2021-08-18. PMID:34297416. |
reactive astrocytes in alzheimer's disease (ad) have traditionally been demonstrated by increased glial fibrillary acidic protein (gfap) immunoreactivity; however, astrocyte reaction is a complex and heterogeneous phenomenon involving multiple astrocyte functions beyond cytoskeletal remodelling. |
2021-08-18 |
2023-08-13 |
human |
| Awatef Esshili, Marie-Pierre Manitz, Nadja Freund, Georg Jucke. Induction of inducible nitric oxide synthase expression in activated microglia and astrocytes following pre- and postnatal immune challenge in an animal model of schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 35. 2021-08-10. PMID:32439226. |
at postnatal day 30 (pnd0), the animals were sacrificed and the hippocampus, corpus callosum, striatum, cortex, fimbria and ventricle were immunostained for iba-1, a microglial marker, glial fibrillary acidic protein (gfap), an astrocyte marker, and inos, an activation marker for no. |
2021-08-10 |
2023-08-13 |
mouse |
| Allison S Liang, Joanna E Pagano, Christopher A Chrzan, Randall D McKinno. Suicide transport blockade of motor neuron survival generates a focal graded injury and functional deficit. Neural regeneration research. vol 16. issue 7. 2021-08-04. PMID:33318406. |
wortmannin also generated a transient and significant increase in astrocyte gfap transcripts after 14 days with a return to control levels at 90 days. |
2021-08-04 |
2023-08-13 |
mouse |
| Céline Cansell, Katharina Stobbe, Clara Sanchez, Ophélia Le Thuc, Coralie-Anne Mosser, Selma Ben-Fradj, Joris Leredde, Cynthia Lebeaupin, Delphine Debayle, Lucile Fleuriot, Frédéric Brau, Nadège Devaux, Alexandre Benani, Etienne Audinat, Nicolas Blondeau, Jean-Louis Nahon, Carole Rovèr. Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice. Glia. vol 69. issue 1. 2021-07-28. PMID:32659044. |
hfd exposure increased gene expression of astrocyte and microglial markers (glial fibrillary acidic protein [gfap] and iba1, respectively) compared to sd-treated mice and induced morphological modifications of microglial cells in ht. |
2021-07-28 |
2023-08-13 |
mouse |