| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Tian, Shijie Jin, Vanessa Promes, Xuemei Liu, Yunling Zhan. Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 5. 2021-11-22. PMID:33219470. |
proteins including glt1 and gfap, from sod1 g93a tg (transgenic) astrocyte lysate were determined by western blot. |
2021-11-22 |
2023-08-13 |
Not clear |
| Kala N Nwachukwu, William A Evans, Tori R Sides, Christopher P Trevisani, Ambryia Davis, S Alex Marshal. Chemogenetic manipulation of astrocytic signaling in the basolateral amygdala reduces binge-like alcohol consumption in male mice. Journal of neuroscience research. vol 99. issue 8. 2021-11-18. PMID:33844860. |
results indicate that non-dependent consumption increased glial fibrillary acidic protein (gfap) density but not the number of gfap+ cells, suggesting that non-dependent ethanol is sufficient to elicit astrocyte activation. |
2021-11-18 |
2023-08-13 |
mouse |
| Vassilia Michailidis, Navdeep K Lidhar, Chulmin Cho, Loren J Marti. Characterizing Sex Differences in Depressive-Like Behavior and Glial Brain Cell Changes Following Peripheral Nerve Injury in Mice. Frontiers in behavioral neuroscience. vol 15. 2021-11-17. PMID:34776894. |
analysis of astrocyte density did not reveal any significant changes in glial fibrillary acidic protein (gfap) staining in the acc or nucleus accumbens. |
2021-11-17 |
2023-08-13 |
mouse |
| Jiang-Zhou Yu, Jennifer Wang, Steven D Sheridan, Roy H Perlis, Mark M Rasenic. N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32504049. |
during astrocyte differentiation, we found that n-3 pufas increased gfap expression and gfap positive cell formation. |
2021-11-15 |
2023-08-13 |
Not clear |
| Katharina Timper, Almudena Del Río-Martín, Anna Lena Cremer, Stephan Bremser, Jens Alber, Patrick Giavalisco, Luis Varela, Christian Heilinger, Hendrik Nolte, Aleksandra Trifunovic, Tamas L Horvath, Peter Kloppenburg, Heiko Backes, Jens C Brünin. GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell metabolism. vol 31. issue 6. 2021-11-09. PMID:32433922. |
conversely, postnatal glp-1 receptor (glp-1r) deletion in glial fibrillary acidic protein (gfap)-expressing astrocytes impairs astrocyte mitochondrial integrity and activates an integrated stress response with enhanced fibroblast growth factor (fgf)21 production and increased brain glucose uptake. |
2021-11-09 |
2023-08-13 |
mouse |
| Heather Bondi, Valeria Bortolotto, Pier Luigi Canonico, Mariagrazia Grill. Complex and regional-specific changes in the morphological complexity of GFAP Neurobiology of aging. vol 100. 2021-11-08. PMID:33493951. |
complex and regional-specific changes in the morphological complexity of gfap during aging, alterations in astrocyte phenotype occur in areas associated with age-related cognitive decline, including hippocampus. |
2021-11-08 |
2023-08-13 |
Not clear |
| Kaiwen Luo, Yadong Xing, Mengdie Wan. Identifying the effectual-combination ingredients of Zhi-zi-Hou-po decoction based on metabolic difference-oriented network regulation strategy. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1184. 2021-11-08. PMID:34653845. |
then the bioactivity was evaluated by cell viability and expression of glial fibrillary acid protein (gfap), tumor necrosis factor α (tnfα) and interleukin 1β (il-1β) of a lipopolysaccharide-induced astrocyte depression model. |
2021-11-08 |
2023-08-13 |
rat |
| Michelle M Boyd, Suzanne J Litscher, Laura L Seitz, Albee Messing, Tracy L Hagemann, Lara S Collie. Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes. Journal of neuroinflammation. vol 18. issue 1. 2021-11-02. PMID:33685480. |
in axd, mutant gfap in combination with increased gfap expression result in astrocyte dysfunction and the accumulation of rosenthal fibers. |
2021-11-02 |
2023-08-13 |
mouse |
| Dehong Mao, Zhongmei He, Wei Xuan, Jiao Deng, Weichun Li, Xiaoying Fang, Linglong Li, Feng Zhan. Effect and Mechanism of BDNF/TrkB Signaling on Vestibular Compensation. Bioengineered. 2021-11-01. PMID:34719333. |
glial fibrillary acidic protein (gfap) (astrocyte marker)-positive cells were identified and gaba type a receptor (gaba |
2021-11-01 |
2023-08-13 |
rat |
| Yudan Zheng, Wenjie Ding, Tao Zhang, Zixuan Zhao, Rui Wang, Zhijie Li, Shali Yu, Jinlong Li, Xinyuan Zhao, Qiyun W. Antimony-induced astrocyte activation via mitogen-activated protein kinase activation-dependent CREB phosphorylation. Toxicology letters. vol 352. 2021-10-29. PMID:34571074. |
in this study, we found that sb exposure promoted astrocyte proliferation and increased the expression of inducible nitric oxide synthase (inos) and glial fibrillary acidic protein (gfap), two key protein markers of reactive astrogliosis, at both the gene and protein level, suggesting that sb induced astrocyte activation. |
2021-10-29 |
2023-08-13 |
Not clear |
| Claudia Sticozzi, Giuseppe Belmonte, Maria Frosini, Federica Pessin. Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-α-Induced Expression of Glial Fibrillary Acid Protein. Journal of molecular neuroscience : MN. vol 71. issue 4. 2021-10-27. PMID:32964397. |
astrocyte activation is characterized by hypertrophy with increased glial fibrillary acidic protein (gfap), whose expression may involve pro-inflammatory cytokines. |
2021-10-27 |
2023-08-13 |
Not clear |
| Michele Siqueira, Ana Paula Bérgamo Araujo, Flávia Carvalho Alcantara Gomes, Joice Stipursk. Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33387302. |
treatment of cortical astrocytes with conditioned medium (cm) from ethanol exposed ecs, upregulated astrocyte's expression of gfap, cx43, and lipocalin-2 genes, as well as the pro-inflammatory genes, il-1beta, il-6, and tnf-alpha, which was accompanied by nf-kappa b protein nuclear accumulation. |
2021-10-27 |
2023-08-13 |
mouse |
| Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-E Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kon. GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 13. 2021-10-26. PMID:33753498. |
interestingly, it was found that palmitoylated gfap promotes astrocyte proliferation in vitro. |
2021-10-26 |
2023-08-13 |
mouse |
| Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-E Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kon. GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 13. 2021-10-26. PMID:33753498. |
furthermore, we showed that ppt1 depalmitoylates gfap, and the level of palmitoylated gfap is overwhelmingly up-regulated in ppt1-knockin mice, which lead us to speculate that the elevated level of palmitoylated gfap might accelerate astrocyte proliferation in vivo and ultimately led to astrogliosis in incl. |
2021-10-26 |
2023-08-13 |
mouse |
| Kayla Farrell, Madeline Musaus, Shaghayegh Navabpour, Kiley Martin, W Keith Ray, Richard F Helm, Timothy J Jarom. Proteomic Analysis Reveals Sex-Specific Protein Degradation Targets in the Amygdala During Fear Memory Formation. Frontiers in molecular neuroscience. vol 14. 2021-10-22. PMID:34658783. |
interestingly, gfap, a critical component of astrocyte structure, was a target of k48 polyubiquitination in both males and females, indicating that protein degradation is likely occurring in astrocytes following fear conditioning. |
2021-10-22 |
2023-08-13 |
rat |
| Cathryn R Formichella, Simone K Abella, Stephanie M Sims, Heather M Cathcart, Rebecca M Sappingto. Astrocyte Reactivity: A Biomarker for Retinal Ganglion Cell Health in Retinal Neurodegeneration. Journal of clinical & cellular immunology. vol 5. issue 1. 2021-10-21. PMID:25133067. |
in a murine model, we examined the spatial characteristics of astrocyte reactivity (migration/proliferation, hypertrophy and gfap expression) in healthy retina, retina with two glaucoma-related risk factors (aging and genetic predisposition) and glaucomatous retina and established relationships between these reactivity indices and the spatial organization of astrocytes as well as rgc health. |
2021-10-21 |
2023-08-13 |
Not clear |
| T C Melzer, H J Cranston, L M Weiss, S K Halone. Host Cell Preference of Toxoplasma gondii Cysts in Murine Brain: A Confocal Study. Journal of neuroparasitology. vol 1. 2021-10-20. PMID:21625284. |
no cysts were identified in astrocytes, using the astrocyte marker, gfap. |
2021-10-20 |
2023-08-12 |
mouse |
| Jin Wang, Yushu Hou, Lixia Zhang, Min Liu, Jianshuai Zhao, Zhen Zhang, Yulong Ma, Wugang Ho. Estrogen Attenuates Traumatic Brain Injury by Inhibiting the Activation of Microglia and Astrocyte-Mediated Neuroinflammatory Responses. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33085047. |
we found that e2 treatment significantly alleviated tbi-induced neurological deficits, neuronal injuries, and brain edema and significantly inhibited iba1 and gfap expression, which are markers of microglia and astrocyte activation, respectively. |
2021-10-13 |
2023-08-13 |
mouse |
| Rachel Waller, Ruth Narramore, Julie E Simpson, Paul R Heath, Nikita Verma, Megan Tinsley, Jordan R Barnes, Hanna T Haris, Frances E Henderson, Fiona E Matthews, Connor D Richardson, Carol Brayne, Paul G Ince, Raj N Kalaria, Stephen B Wharto. Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies. Brain pathology (Zurich, Switzerland). vol 31. issue 3. 2021-10-13. PMID:33336479. |
the current study tested the hypothesis that different patterns of neuroinflammation are associated with svd compared to ad neuropathology by assessing the immunoreactive profile of the microglial (cd68, iba1 and mhc-ii) and astrocyte (gfap) markers in ageing parietal white matter (parwm) obtained from the cognitive function and ageing study (cfas), an ageing population-representative neuropathology cohort. |
2021-10-13 |
2023-08-13 |
Not clear |
| Zengyu Yao, Zhinan Zhang, Jiping Zhang, Xiaowen Cai, Zheng Zhong, Yong Huang, Shanshan Q. Electroacupuncture alleviated the depression-like behavior by regulating FGF2 and astrocytes in the hippocampus of rats with chronic unpredictable mild stress. Brain research bulletin. vol 169. 2021-10-07. PMID:33434624. |
behavioral test, immunohistochemistry (ihc), western blot (wb) and quantitative real-time pcr (qpcr) were conducted to evaluate the intervene effect and the changes of fgf2 and astrocyte marker (glial fibrillary acidic protein, gfap). |
2021-10-07 |
2023-08-13 |
rat |