| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pampa Saha, Subhalakshmi Guha, Subhas Chandra Biswa. P38K and JNK pathways are induced by amyloid-β in astrocyte: Implication of MAPK pathways in astrogliosis in Alzheimer's disease. Molecular and cellular neurosciences. vol 108. 2021-07-28. PMID:32896578. |
next, to investigate the downstream consequences of these two mapks (jnk and p38k) in aβ-induced astrocyte activation, we individually blocked these pathways by specific inhibitors in presence and absence of aβ and checked aβ-induced cellular proliferation, morphological changes and glial fibrillary acidic protein (gfap) upregulation. |
2021-07-28 |
2023-08-13 |
rat |
| Pampa Saha, Subhalakshmi Guha, Subhas Chandra Biswa. P38K and JNK pathways are induced by amyloid-β in astrocyte: Implication of MAPK pathways in astrogliosis in Alzheimer's disease. Molecular and cellular neurosciences. vol 108. 2021-07-28. PMID:32896578. |
we found that activation of both jnk and p38k signalling cascades are involved in astrocyte proliferation evoked by aβ, whereas only p38k pathway is implicated in morphological changes and gfap upregulation in astrocytes exposed to aβ. |
2021-07-28 |
2023-08-13 |
rat |
| Martin Marsala, Kota Kamizato, Takahiro Tadokoro, Michael Navarro, Stefan Juhas, Jana Juhasova, Silvia Marsala, Hana Studenovska, Vladimir Proks, Tom Hazel, Karl Johe, Manabu Kakinohana, Shawn Driscoll, Thomas Glenn, Samuel Pfaff, Joseph Ciacc. Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats. Stem cells translational medicine. vol 9. issue 2. 2021-07-21. PMID:31800978. |
immunofluorescence staining and mrna sequencing analysis demonstrated a near-complete occupation of the spinal cord by injected cells, in which transplanted human nscs (hnscs) preferentially acquired glial phenotypes, expressing oligodendrocyte (olig2, apc) or astrocyte (gfap) markers. |
2021-07-21 |
2023-08-13 |
human |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
elevated gfap isoform expression promotes protein aggregation and compromises astrocyte function. |
2021-07-19 |
2023-08-13 |
mouse |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
alexander disease (axd) caused by mutations in the coding region of gfap is a neurodegenerative disease characterized by astrocyte dysfunction, gfap aggregation, and rosenthal fiber accumulation. |
2021-07-19 |
2023-08-13 |
mouse |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
our recent studies demonstrated that intronic gfap mutations cause disease by altering gfap splicing, suggesting that an increase in gfap isoform expression could lead to protein aggregation and astrocyte dysfunction that typify axd. |
2021-07-19 |
2023-08-13 |
mouse |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
here we test this hypothesis by establishing primary astrocyte cultures from transgenic mice overexpressing human gfap. |
2021-07-19 |
2023-08-13 |
mouse |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
in conclusion, our findings provide evidence that links elevated gfap isoform expression with gfap aggregation and impaired glutamate transport, and suggest a potential non-cell-autonomous mechanism underlying neurodegeneration through astrocyte dysfunction. |
2021-07-19 |
2023-08-13 |
mouse |
| Muh-Shi Lin, I-Hsiang Chiu, Chai-Ching Li. Ultrarapid Inflammation of the Olfactory Bulb After Spinal Cord Injury: Protective Effects of the Granulocyte Colony-Stimulating Factor on Early Neurodegeneration in the Brain. Frontiers in aging neuroscience. vol 13. 2021-07-13. PMID:34248610. |
in particular, the sci group had upregulated mrna and protein expression levels of glial fibrillary acidic protein (gfap; a marker of astrocyte reactivation) and pro-inflammatory mediators [il-1β, il-6, and nestin (marker of nscs)] in the olfactory bulb compared to levels in the sham control group. |
2021-07-13 |
2023-08-13 |
mouse |
| Liam Anuj O'Leary, Naguib Mechawa. Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans. Glia. vol 69. issue 9. 2021-07-09. PMID:33734498. |
when comparing astrocyte density and morphometry studies, astrocytes are more abundant and smaller in human subcortical than cortical brain regions, and immunohistochemical labeling for the astrocyte markers glial fibrillary acidic protein (gfap) and vimentin (vim) reveals fewer than 15% of all astrocytes that are present in cortical and subcortical regions, as revealed using other staining techniques. |
2021-07-09 |
2023-08-13 |
human |
| Chia-Li Chung, Chieh-Hsin Wu, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwa. Blocking Hepatoma-Derived Growth Factor Attenuates Vasospasm and Neuron Cell Apoptosis in Rats Subjected to Subarachnoid Hemorrhage. Translational stroke research. 2021-07-06. PMID:34227049. |
immunofluorescence staining for iba-1, gfap, tunel, and neun was detected proliferation of microglia and astrocyte and apoptosis of neuron cells. |
2021-07-06 |
2023-08-13 |
rat |
| Fei He, Hao Wu, Liqiang Zhou, Quan Lin, Yin Cheng, Yi E Su. Tet2-mediated epigenetic drive for astrocyte differentiation from embryonic neural stem cells. Cell death discovery. vol 6. 2021-06-25. PMID:32377393. |
in this study, we discovered that a ten-eleven translocation (tet) protein, tet2, which was critically involved in active dna demethylation through oxidation of 5-methylcytosine (5mc), drove astrocyte differentiation from nscs by demethylation of astroglial lineage genes including gfap. |
2021-06-25 |
2023-08-13 |
Not clear |
| Linda Melzer, Thomas M Freiman, Amin Derouich. Rab6A as a Pan-Astrocytic Marker in Mouse and Human Brain, and Comparison with Other Glial Markers (GFAP, GS, Aldh1L1, SOX9). Cells. vol 10. issue 1. 2021-06-23. PMID:33466322. |
in mouse brain, rab6a immunostaining is found to be unexpectedly massive, diffuse in all regions, and is detected preferentially and abundantly in the peripheral astrocyte processes, which is hardly evident without glial fibrillary acid protein (gfap) co-staining. |
2021-06-23 |
2023-08-13 |
mouse |
| Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Dallas Boodhoo, Armugam Mekala, Cornelia Cudrici, Tudor C Badea, Dafin F Muresanu, Violeta Rus, Horea Ru. RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis. Frontiers in immunology. vol 11. 2021-06-23. PMID:33569054. |
in control mice, gfap expression and astrocyte density were also significantly higher in the wt group, whereas the number of vimentin and fabp7-positive radial glia was significantly higher in the rgc-32 ko group. |
2021-06-23 |
2023-08-13 |
mouse |
| Giedre Milinkeviciute, Sima M Chokr, Karina S Crame. Auditory Brainstem Deficits from Early Treatment with a CSF1R Inhibitor Largely Recover with Microglial Repopulation. eNeuro. vol 8. issue 2. 2021-06-18. PMID:33558268. |
defective pruning of calyces of held and significant reduction of the mature astrocyte marker glial fibrillary acidic protein (gfap) were observed after hearing onset. |
2021-06-18 |
2023-08-13 |
mouse |
| Amira A H Ali, Beryl Schwarz-Herzke, Astrid Rollenhagen, Max Anstötz, Martin Holub, Joachim Lübke, Christine R Rose, Hans-Joachim Schnittler, Charlotte von Gal. Bmal1-deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes. Glia. vol 68. issue 5. 2021-06-10. PMID:31743496. |
in summary, our data demonstrate that bmal1-deficiency affects morphology of the fine astrocyte processes prior to strong upregulation of gfap, presumably because of impaired cttn expression and reduced rho-gtp activation. |
2021-06-10 |
2023-08-13 |
mouse |
| Antonio Garrido, Mariano De La Serna, Mónica De La Fuente, Eva María Marco, Meritxell López-Gallard. Neuronal and glial region dependent changes in female mice from a model of premature aging. Experimental gerontology. vol 146. 2021-06-02. PMID:33388380. |
through the application of immunohistochemical techniques we evaluated changes in the expression of neun (a neuronal marker), iba-1 (a microglia marker) and gfap (an astrocyte marker) in brain areas related to the behavioral alterations previously detected in both pam and chronologically old mice. |
2021-06-02 |
2023-08-13 |
mouse |
| Karen Bohmwald, Jorge A Soto, Catalina Andrade-Parra, Ayleen Fernández-Fierro, Janyra A Espinoza, Mariana Ríos, Eliseo A Eugenin, Pablo A González, María Cecilia Opazo, Claudia A Riedel, Alexis M Kalergi. Lung pathology due to hRSV infection impairs blood-brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32979471. |
we identified the presence of hrsv in the brain cortex where it colocalizes with vwf, map-2, iba-1, and gfap, which are considered markers for endothelial cells, neurons, microglia, and astrocyte, respectively. |
2021-05-27 |
2023-08-13 |
mouse |
| Forough Ebrahim-Tabar, Atena Nazari, Mahdi Pouramir, Manuchehr Ashrafpour, Fereshteh Pourabdolhossei. Arbutin Improves Functional Recovery and Attenuates Glial Activation in Lysolecethin-Induced Demyelination Model in Rat Optic Chiasm. Molecular neurobiology. vol 57. issue 7. 2021-05-19. PMID:32506379. |
the myelin-specific staining was performed to assess demyelination and gfap staining as an astrocyte marker. |
2021-05-19 |
2023-08-13 |
rat |
| Forough Ebrahim-Tabar, Atena Nazari, Mahdi Pouramir, Manuchehr Ashrafpour, Fereshteh Pourabdolhossei. Arbutin Improves Functional Recovery and Attenuates Glial Activation in Lysolecethin-Induced Demyelination Model in Rat Optic Chiasm. Molecular neurobiology. vol 57. issue 7. 2021-05-19. PMID:32506379. |
finally, arbutin attenuated gfap as an astrocyte marker. |
2021-05-19 |
2023-08-13 |
rat |