| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronald B Pringle, Edward C Meek, Howard W Chambers, Janice E Chamber. Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 166. issue 2. 2019-11-13. PMID:30496567. |
the histochemical astrocyte marker glial fibrillary acidic protein (gfap) was investigated as an indication of neuropathology in two brain regions, the piriform cortex and the dentate gyrus of the hippocampus, which are regions known to be damaged by nerve agent toxicity. |
2019-11-13 |
2023-08-13 |
rat |
| Xiaoxu Chen, Xiaoke Nie, Jiamin Mao, Yan Zhang, Kaizhi Yin, Pingping Sun, Jiashan Luo, Yiming Liu, Shengyang Jiang, Lingli Su. Perfluorooctane sulfonate mediates secretion of IL-1β through PI3K/AKT NF-кB pathway in astrocytes. Neurotoxicology and teratology. vol 67. 2019-10-25. PMID:29577981. |
the low-doses of pfos increased the cell number and the expression of glial fibrillary acidic protein (gfap), a well-known hallmark of reactive astrocytes, in c6 astrocyte cells. |
2019-10-25 |
2023-08-13 |
Not clear |
| Naohiro Sunamura, Shinzo Iwashita, Kei Enomoto, Taisuke Kadoshima, Fujio Ison. Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30072797. |
transcriptome analysis of the npcs derived from fmr1-knockout human induced pluripotent stem cells (ipscs) showed altered expression of neural differentiation markers, particularly a marked induction of the astrocyte marker glial fibrillary acidic protein (gfap). |
2019-10-21 |
2023-08-13 |
mouse |
| Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen L. Presymptomatic change in microRNAs modulates Tau pathology. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29915328. |
similar to what was observed in tau brains, overexpressing mir142 in wildtype cortical neurons augments mrna levels of glial fibrillary acidic protein (gfap) and colony stimulating factor 1 (csf1), accompanied by a significant increase in microglia and reactive astrocyte numbers. |
2019-10-09 |
2023-08-13 |
mouse |
| Alinny Rosendo Isaac, Emerson Alexandre Neves da Silva, Rhowena Jane Barbosa de Matos, Ricielle Lopes Augusto, Giselle Machado Magalhães Moreno, Ingrid Prata Mendonça, Raphael Fabrício de Souza, Paulo Euzébio Cabral-Filho, Cláudio Gabriel Rodrigues, Catarina Gonçalves-Pimentel, Marcelo Cairrão Araujo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Low omega-6/omega-3 ratio in a maternal protein-deficient diet promotes histone-3 changes in progeny neural cells and favors leukemia inhibitory factor genetranscription. The Journal of nutritional biochemistry. vol 55. 2019-09-17. PMID:29573696. |
in astrocyte cultures and cortical tissue, the gfap protein levels were assessed. |
2019-09-17 |
2023-08-13 |
rat |
| Gang Luo, Yinuo Huang, Dapeng Mo, Ning Ma, Feng Gao, Ligang Song, Xuan Sun, Xiaotong Xu, Lian Liu, Xiaochuan Huo, Bo Wang, Xiaoqing Li, Baixue Jia, Yiming Deng, Xuelei Zhang, Alejandro Fernandez-Escobar, Guangge Peng, Zhongrong Mia. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation. Neurochemistry international. vol 121. 2019-09-13. PMID:30291953. |
the reduction of cytokines from astrocyte might be due to its inhibition of astrocyte activation and regulation of stat3 signaling pathway since tyrosol attenuated the expression level of gfap (glial fibrillary acidic protein) and the phosphorylation of stat3. |
2019-09-13 |
2023-08-13 |
Not clear |
| Hang-Soo Park, Hyosung Kwon, Jewon Yu, Yeonju Bae, Jae-Yong Park, Kyung-Ah Choi, Yeonho Choi, Sunghoi Hon. Precise nanoinjection delivery of plasmid DNA into a single fibroblast for direct conversion of astrocyte. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup1. 2019-08-20. PMID:29506416. |
consequently, 2500 dna molecules, no more or less, were found to be the optimal amount that dramatically increased the expression levels of the astrocyte-specific markers gfap and s100b and the demethylation gene tet1, the expression of which was sustained to maintain astrocyte functionality. |
2019-08-20 |
2023-08-13 |
mouse |
| Soheila Madadi, Parichehr Pasbakhsh, Fatemeh Tahmasebi, Keywan Mortezaee, Maryam Khanehzad, Fatemeh Beigi Boroujeni, Golaleh Noorzehi, Iraj Ragerdi Kashan. Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30652255. |
astrocyte ablation reduced protein expressions for gfap (an astrocyte marker) and iba-1 (a microglial marker), but increased expression of olig2 (an oligodendrocyte marker) assessed by immunofluorescence. |
2019-08-13 |
2023-08-13 |
mouse |
| Markley Silva Oliveira-Junior, Erica Patricia Pereira, Vanessa Cristina Meira de Amorim, Luã Tainã Costa Reis, Ravena Pereira do Nascimento, Victor Diogenes Amaral da Silva, Silvia Lima Cost. Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors. International immunopharmacology. vol 70. 2019-08-13. PMID:30852286. |
on the other hand, through icq for gfap, it was possible to observe that lupeol modulated the astrocyte morphology for bergmann glia-like phenotype and, especially for velate astrocyte-like phenotype, both phenotypes associated with the neuroprotective profile. |
2019-08-13 |
2023-08-13 |
rat |
| Michael V Sofronie. Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP. Cell stem cell. vol 23. issue 5. 2019-07-24. PMID:30388417. |
gain-of-function mutations in the canonical astrocyte protein, gfap, cause a fatal neurodevelopmental disorder with myelination abnormalities, seizures, and psychomotor disturbances. |
2019-07-24 |
2023-08-13 |
Not clear |
| Michael V Sofronie. Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP. Cell stem cell. vol 23. issue 5. 2019-07-24. PMID:30388417. |
(2018) (in cell reports) have shown that patient ipsc-derived astrocytes with mutant gfap have disrupted astrocyte functions, revealing disease mechanisms and potential roles of gfap. |
2019-07-24 |
2023-08-13 |
Not clear |
| Christopher D Johnson, Anthony R D'Amato, Devan L Puhl, Douglas M Wich, Amanda Vesperman, Ryan J Gilber. Electrospun fiber surface nanotopography influences astrocyte-mediated neurite outgrowth. Biomedical materials (Bristol, England). vol 13. issue 5. 2019-07-15. PMID:29762127. |
western blot results show that the differences in morphology were not associated with significant changes in glial fibrillary acidicprotein (gfap) or vinculin in either astrocyte population, suggesting that surface pits and divots do not induce a reactive phenotype in either cortical or spinal cord astrocytes. |
2019-07-15 |
2023-08-13 |
rat |
| Louis Nerurkar, Alison McColl, Gerard Graham, Jonathan Cavanag. The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29185473. |
indeed, the association of imiquimod with the brain correlated with increased iba1 and gfap staining, indicative of microglia and astrocyte reactivity. |
2019-07-03 |
2023-08-13 |
mouse |
| Álvaro Viedma-Poyatos, Yolanda de Pablo, Milos Pekny, Dolores Pérez-Sal. The cysteine residue of glial fibrillary acidic protein is a critical target for lipoxidation and required for efficient network organization. Free radical biology & medicine. vol 120. 2019-06-25. PMID:29635011. |
conversely, alterations in gfap assembly or degradation cause intracellular aggregates linked to astrocyte dysfunction and neurological disease. |
2019-06-25 |
2023-08-13 |
Not clear |
| Wenqin Xu, Zhicha Hu, Yang Lv, Guorui Dou, Zifeng Zhang, Haiyan Wang, Yusheng Wan. Microglial density determines the appearance of pathological neovascular tufts in oxygen-induced retinopathy. Cell and tissue research. vol 374. issue 1. 2019-06-17. PMID:29767277. |
after checking the expression of iba1, a microglial marker and gfap, an astrocyte and müller cell marker, we found that minocycline and clodronate could inhibit the activation of microglia or decrease the density of microglia, while they had no significant effect on astrocytes and müller cells. |
2019-06-17 |
2023-08-13 |
mouse |
| Jiayin Zhou, Yuanyuan Deng, Fei Li, Caixia Yin, Jingshan Shi, Qihai Gon. Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30590319. |
as expected, lps injection exhibited neuronal morphological damage, and ionized calcium binding adapter molecule 1 (iba-1) of microglia and glial fibrillary acidic protein (gfap) of astrocyte were activated. |
2019-06-13 |
2023-08-13 |
rat |
| Brandon Stopnicki, Manon Blain, Qiao-Ling Cui, Timothy E Kennedy, Jack P Antel, Luke M Healy, Peter J Darlingto. Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII-independent manner. Glia. vol 67. issue 4. 2019-06-11. PMID:30444064. |
glial fibrillary acidic protein (gfap) is an intermediate filament protein that is part of the astrocyte cytoskeleton that can become fragmented in neuroinflammatory conditions. |
2019-06-11 |
2023-08-13 |
human |
| Wenqian Yang, Qulian Guo, Zhigang Cheng, Yunjiao Wang, Nianyue Bai, Zhenghua H. [mTOR signaling pathway of spinal cord is involved in peripheral nerve injury-induced hyperalgesia in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 4. 2019-05-30. PMID:31113912. |
the gfap immunohistochemistry positive area and absorbance value in the dorsal horn of the lumbar spinal cord in the cci rats were decreased in the cci+early rapa group compared with the cci+early dmso group (p<0.05 or p<0.01), and which were also decreased in the cci+later rapa group compared with the cci+later dmso group (p<0.05 or p<0.01).
conclusion: mtor signaling pathway may be involved in hyperalgesia induced by peripheral nerve injury via spinal astrocyte activation in the dorsal horn of the spinal cord. |
2019-05-30 |
2023-08-13 |
rat |
| Ahsia M Clayton, Qingmei Shao, Nina D Paauw, Ashtin B Giambrone, Joey P Granger, Junie P Warringto. Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy. Brain, behavior, and immunity. vol 70. 2019-05-21. PMID:29588233. |
western blot analysis showed no changes in astrocyte marker, glial fibrillary acidic protein (gfap); however, the microglia marker, ionized calcium binding adaptor molecule (iba1) tended to increase in hippocampus of rupp-exposed rats. |
2019-05-21 |
2023-08-13 |
rat |
| Rachel N Hardy, Zinar D Simsek, Brandon Curry, Sheri L Core, Terry Beltz, Baojian Xue, Alan K Johnson, Robert L Thunhorst, Kathleen S Curti. Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. Physiology & behavior. vol 192. 2019-04-22. PMID:29518407. |
to determine whether this age-related decrease in water intake was accompanied by changes in central nervous system areas associated with fluid balance, we assessed astrocyte density and neuronal activation in the sfo, ovlt, son, ap and nts of these rats using immunohistochemical labeling for gfap and c-fos, respectively. |
2019-04-22 |
2023-08-13 |
rat |