| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
andrographolide treatment during cch suppressed astrocyte activation as evidenced by reduced gfap expression, enhanced expression of bdnf and trkb, improved impaired spatial learning and memory, and reversed upregulated tnf-α, il-1β, and caspase-3 expression. |
2020-08-31 |
2023-08-13 |
rat |
| Kyria M Webster, Mujun Sun, Peter J Crack, Terence J O'Brien, Sandy R Shultz, Bridgette D Sempl. Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice. The Journal of comparative neurology. vol 527. issue 6. 2020-08-17. PMID:30499129. |
cortical tissue was collected for western blot detection of astrocyte and microglial activation (gfap and cd68) and hmgb1 at 2 hr, 6 hr, 24 hr, 3 days, and 7 days postinjury, and serum was collected for enzyme-linked immunoassays to quantify peripheral hmgb1. |
2020-08-17 |
2023-08-13 |
mouse |
| Su Jing Chan, Wanting Niu, Kazuhide Hayakawa, Gen Hamanaka, Xiaoying Wang, Pike See Cheah, Shuzhen Guo, Zhangyang Yu, Ken Arai, Magdy H Selim, Motoichi Kurisawa, Myron Spector, Eng H L. Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels. Stem cells translational medicine. vol 8. issue 12. 2020-07-13. PMID:31483567. |
both egf alone and egf-hydrogel equally promoted astrocyte proliferation, but egf-hydrogels further enhanced astrocyte activation, as evidenced by a significantly elevated glial fibrillary acidic protein (gfap) gene expression. |
2020-07-13 |
2023-08-13 |
Not clear |
| M Baloğlu, E Gökalp Özkorkma. Neuroprotective effects of allopurinol on spinal cord injury in rats: a biochemical and immunohistochemical study. Folia morphologica. vol 78. issue 4. 2020-07-07. PMID:30949995. |
glial fibrillary acidic protein (gfap) takes part in astrocyte and neuronal interconnection and synaptic transmission. |
2020-07-07 |
2023-08-13 |
rat |
| Yu Zhong, Jialin Chen, Jing Chen, Yanhua Chen, Li Li, Yubo Xi. Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury. Journal of neurochemistry. vol 151. issue 2. 2020-06-11. PMID:31314915. |
here, we quantified pain behaviour after cci; detected the localization of p35, cdk5, phosphorylated erk1/2 (perk1/2), phosphorylated peroxisome proliferator-activated receptor γ (ppparγ), neuronal nuclei (a neuronal marker), glial fibrillary acidic protein (gfap, an activated astrocyte marker) and ionized calcium binding adaptor molecule 1 (a microglial marker) in the dorsal horn using immunofluorescence; measured the protein levels of cdk5, p35, perk1/2, ppparγ and gfap using western blot analysis; and gauged the enzyme activity of cdk5/p35 kinase using a cdk5/p35 kinase activity assay kit. |
2020-06-11 |
2023-08-13 |
rat |
| Tomoyuki Kurose, Shinya Takahashi, Takashi Otsuka, Kei Nakagawa, Takeshi Imura, Taijiro Sueda, Louis Yug. Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats. Stem cell research. vol 41. 2020-06-02. PMID:31731179. |
glial fibrillary acidic protein (gfap)-positive (reactive) astrocyte numbers were increased in all three groups, and brain-derived neurotrophic factor (bdnf) was colocalized with gfap-positive cells in spinal ventral horn. |
2020-06-02 |
2023-08-13 |
rat |
| Motaz M Fadul, Claire J Garwood, Rachel Waller, Navonna Garrett, Paul R Heath, Fiona E Matthews, Carol Brayne, Stephen B Wharton, Julie E Simpso. NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain. International journal of molecular sciences. vol 21. issue 1. 2020-06-02. PMID:31947996. |
expression of ndrg2 did not correlate with other astrocyte markers, including glial fibrillary acidic protein (gfap), excitatory amino acid transporter 2 (eaat2) and glutamine synthetase (gs). |
2020-06-02 |
2023-08-13 |
Not clear |
| Alexandre Umpierrez Amaral, Bianca Seminotti, Janaína Camacho da Silva, Francine Hehn de Oliveira, Rafael Teixeira Ribeiro, Guilhian Leipnitz, Diogo Onofre Souza, Moacir Wajne. Acute lysine overload provokes marked striatum injury involving oxidative stress signaling pathways in glutaryl-CoA dehydrogenase deficient mice. Neurochemistry international. vol 129. 2020-06-01. PMID:31121257. |
lys also provoked a reduction of neun and synaptophysin, as well as an increase of astrocytic gfap, in the striatum of gcdh-/- mice, indicating neuronal loss and astrocyte reactivity. |
2020-06-01 |
2023-08-13 |
mouse |
| Minati Singh, Janelle E Garrison, Kai Wang, Val C Sheffiel. Absence of BBSome function leads to astrocyte reactivity in the brain. Molecular brain. vol 12. issue 1. 2020-05-26. PMID:31072410. |
increased gfap expression is a hallmark of astrocyte reactivity that is associated with microglia activation and neuro-inflammation. |
2020-05-26 |
2023-08-13 |
mouse |
| Frankie H F Lee, Terence K Y Lai, Ping Su, Fang Li. Altered cortical Cytoarchitecture in the Fmr1 knockout mouse. Molecular brain. vol 12. issue 1. 2020-05-26. PMID:31200759. |
using primary astrocytes derived from ko mice, we further demonstrated the presence of astrogliosis characterized by an increase in gfap expression and astrocyte hypertrophy. |
2020-05-26 |
2023-08-13 |
mouse |
| Yun Wang, Hua-Feng Jiang, Jing Ni, Lin Gu. Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 7. 2020-05-20. PMID:30798370. |
in the present study, we took advantage of primary astrocyte culture and a highly selective agonist of sigma-1 receptor, (+)skf-10047 to determine the effect of sigma-1 receptor on brdu (bromodeoxyuridine) labeling positive cells, migration as well as gfap (glial fibrillary acidic protein) expression of astrocyte. |
2020-05-20 |
2023-08-13 |
Not clear |
| Hannah C Bowers, Matthew L Fiori, Janki B Khadela, Paul A Janmey, Peter A Gali. Cell-matrix tension contributes to hypoxia in astrocyte-seeded viscoelastic hydrogels composed of collagen and hyaluronan. Experimental cell research. vol 376. issue 1. 2020-05-18. PMID:30658092. |
our results indicate that incorporation of the cns matrix component hyaluronan into a collagen hydrogel increases expression of the intermediate filament protein gfap and results in a higher shear storage modulus of the cell/matrix composite, establishing the correlation between astrocyte activation and increased cell contractility. |
2020-05-18 |
2023-08-13 |
Not clear |
| Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. |
astrocyte gfap expression was increased in close vicinity to the tau clusters in cisplatin-treated mice. |
2020-05-13 |
2023-08-13 |
mouse |
| Rita Machaalani, Melisande Thawley, Jessica Huang, Hui Che. Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem. Neurotoxicology. vol 74. 2020-05-12. PMID:31121239. |
using a mouse model of pre- into post- natal cigarette smoke exposure (se), we aimed to determine the effects on brain derived neurotrophic factor (bdnf) and its receptor trkb, neuropeptide pituitary adenylate cyclase activating polypeptide (pacap) and its receptor pac1, and astrocyte (gfap) and microglia (iba-1) immunohistochemical expression, in seven nuclei of the medulla and the facial (fac) nucleus of the pons. |
2020-05-12 |
2023-08-13 |
mouse |
| Alex J Smith, Tianjiao Duan, Alan S Verkma. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31068220. |
aqp4 deficient 5xfad mice also showed a significant reduction in the density of gfap labeled peri-plaque astrocyte processes. |
2020-04-21 |
2023-08-13 |
mouse |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
the effects of hmgb1 inhibition on the early spinal cord edema, astrocyte activation (glial fibrillary acidic protein [gfap] expression), and aqp4 expression after sci (12 h-3 days) were analyzed. |
2020-04-10 |
2023-08-13 |
rat |
| Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun H. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29929431. |
these results implicate that hmgb1 inhibition improved locomotor function and reduced early spinal cord edema, which was associated with a downregulation of astrocyte activation (gfap expression) and aqp4 expression in sci rats. |
2020-04-10 |
2023-08-13 |
rat |
| Eduardo Fernandes Bondan, Carolina Vieira Cardoso, Maria de Fátima Monteiro Martins, Rosemari Otto. Memory impairments and increased GFAP expression in hippocampal astrocytes following hypercaloric diet in rats. Arquivos de neuro-psiquiatria. vol 77. issue 9. 2020-04-08. PMID:31553389. |
as the hippocampus plays important roles in the consolidation of information, this investigation aimed to observe the memory function and the astrocyte expression of gfap in the hippocampus of rats that received either a hypercaloric or a normocaloric diet. |
2020-04-08 |
2023-08-13 |
rat |
| Ke-Yu Xie, Qiang Wang, De-Jun Cao, Jia Liu, Xian-Feng Xi. Spinal astrocytic FGFR3 activation leads to mechanical hypersensitivity by increased TNF-α in spared nerve injury. International journal of clinical and experimental pathology. vol 12. issue 8. 2020-03-25. PMID:31934126. |
increased gfap expression in dorsal horn of the spinal cord indicated the participation of astrocyte in npp. |
2020-03-25 |
2023-08-13 |
Not clear |
| Daniela Lecca, Miaad Bader, David Tweedie, Alexander F Hoffman, Yoo Jin Jung, Shin-Chang Hsueh, Barry J Hoffer, Robert E Becker, Chaim G Pick, Carl R Lupica, Nigel H Grei. (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice. Neurobiology of disease. vol 130. 2020-03-24. PMID:31295555. |
actions on astrocyte activation by mtbi were followed by evaluating gfap, and were similarly mitigated by phen. |
2020-03-24 |
2023-08-13 |
mouse |