| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander A Sosunov, Eileen Guilfoyle, Xiaoping Wu, Guy M McKhann, James E Goldma. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616550. |
to study the effects of gfap mutations on astrocyte morphology and physiology, we have examined hippocampal astrocytes in three mouse models of axd, a transgenic line (gfap(tg)) in which the normal human gfap is expressed in several copies, a knock-in line (gfap(+/r236h)) in which one of the gfap genes bears an r236h mutation, and a mouse derived from the mating of these two lines (gfap(tg); gfap(+/r236h)). |
2013-06-25 |
2023-08-12 |
mouse |
| Alexander A Sosunov, Eileen Guilfoyle, Xiaoping Wu, Guy M McKhann, James E Goldma. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616550. |
we report changes in astrocyte phenotype in all lines, with the most severe in the gfap(tg);gfap(+/r236h), resulting in the conversion of protoplasmic astrocytes to cells that have lost their bushy-like morphology because of a reduction of distal fine processes, and become multinucleated and hypertrophic. |
2013-06-25 |
2023-08-12 |
mouse |
| Seul Ki Min, Sung Hoon Kim, Cho Rong Kim, Sang-Min Paik, Sang-Myung Jung, Hwa Sung Shi. Effect of topography of an electrospun nanofiber on modulation of activity of primary rat astrocytes. Neuroscience letters. vol 534. 2013-06-18. PMID:23178191. |
in this study, an electrospun nanofibrous scaffold of polycaprolactone (pcl) was investigated with respect to its topographic effects on astrocyte behavior and expression of gfap. |
2013-06-18 |
2023-08-12 |
rat |
| Takayuki Suzuki, Honami Sakata, Chiaki Kato, John A Connor, Mitsuhiro Morit. Astrocyte activation and wound healing in intact-skull mouse after focal brain injury. The European journal of neuroscience. vol 36. issue 12. 2013-06-11. PMID:23013365. |
two distinct types of perilesional reactive astrocyte, identified by gfap upregulation and hypertrophy, were found. |
2013-06-11 |
2023-08-12 |
mouse |
| Chunling Fan, Yiyan Zheng, Xiaoxin Cheng, Xiangbei Qi, Ping Bu, Xuegang Luo, Dong H Kim, Qilin Ca. Transplantation of D15A-expressing glial-restricted-precursor-derived astrocytes improves anatomical and locomotor recovery after spinal cord injury. International journal of biological sciences. vol 9. issue 1. 2013-06-07. PMID:23289019. |
grafted gdas expressed gfap, suggesting they remained astrocyte lineage in the injured spinal cord. |
2013-06-07 |
2023-08-12 |
Not clear |
| William M McKillop, Magdalena Dragan, Andreas Schedl, Arthur Brow. Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury. Glia. vol 61. issue 2. 2013-05-30. PMID:23027386. |
one week after injury, sox9 conditional knock-out mice expressed reduced levels of cspg biosynthetic enzymes (xt-1 and c4st), cspg core proteins (brevican, neurocan, and aggrecan), collagens 2a1 and 4a1, and gfap, a marker of astrocyte activation, in the injured spinal cord compared with controls. |
2013-05-30 |
2023-08-12 |
mouse |
| Norah Hibbits, Jun Yoshino, Tuan Q Le, Regina C Armstron. Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination. ASN neuro. vol 4. issue 6. 2013-05-23. PMID:23025787. |
this astrocyte reaction is characterized by (a) early proliferation, (b) increased expression of gfap (glial fibrillary acidic protein), vim (vimentin), fn1 (fibronectin) and cspgs (chondroitin sulphate proteoglycans) and (c) elaboration of a dense network of processes. |
2013-05-23 |
2023-08-12 |
Not clear |
| Barbara Ahlemeyer, Kristine Kehr, Elke Richter, Manuela Hirz, Eveline Baumgart-Vogt, Christiane Herde. Phenotype, differentiation, and function differ in rat and mouse neocortical astrocytes cultured under the same conditions. Journal of neuroscience methods. vol 212. issue 1. 2013-05-17. PMID:23026192. |
we obtained highly enriched rat and mouse astrocyte cultures, where most cells were positively stained for the astrocyte markers gfap, vimentin, and s100β, whereas neuronal and oligodendrocyte markers were undetectable. |
2013-05-17 |
2023-08-12 |
mouse |
| H Imbe, A Kimura, T Donishi, Y Kaneok. Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter. Neuroscience. vol 223. 2013-05-01. PMID:22890077. |
postmortem studies of stress-related psychiatric disorders have demonstrated a decrease in the number of astrocytes and the level of glial fibrillary acidic protein (gfap), a marker for astrocyte, in the cerebral cortex. |
2013-05-01 |
2023-08-12 |
rat |
| Susan M Sullivan, Robert K P Sullivan, Stephanie M Miller, Zoe Ireland, S Tracey Björkman, David V Pow, Paul B Coldit. Phosphorylation of GFAP is associated with injury in the neonatal pig hypoxic-ischemic brain. Neurochemical research. vol 37. issue 11. 2013-04-23. PMID:22528834. |
glial fibrillary acidic protein (gfap) is an intermediate filament protein expressed in the astrocyte cytoskeleton that plays an important role in the structure and function of the cell. |
2013-04-23 |
2023-08-12 |
Not clear |
| Susan M Sullivan, Robert K P Sullivan, Stephanie M Miller, Zoe Ireland, S Tracey Björkman, David V Pow, Paul B Coldit. Phosphorylation of GFAP is associated with injury in the neonatal pig hypoxic-ischemic brain. Neurochemical research. vol 37. issue 11. 2013-04-23. PMID:22528834. |
phosphorylation of gfap may play an important role in astrocyte remodelling during development and disease and could potentially contribute to the plasticity of the central nervous system. |
2013-04-23 |
2023-08-12 |
Not clear |
| Hao Yang, Guo-Dong Feng, Cathy Olivera, Xi-Ying Jiao, Angela Vitale, Ju Gong, Si-Wei Yo. Sonic hedgehog released from scratch-injured astrocytes is a key signal necessary but not sufficient for the astrocyte de-differentiation. Stem cell research. vol 9. issue 2. 2013-04-02. PMID:22771389. |
here, we found that sonic hedgehog (shh) production in astrocytes following mechanical injury was significantly elevated, and that incubation of astrocyes with the injured astrocyte conditioned medium (acm) causes astrocytes to gradually lose their immunophenotypical profiles, and acquire nspc characteristics, as demonstrated by down-regulation of typical astrocytic markers (gfap and s100) and up-regulation of markers that are generally expressed in nscs, (nestin, sox2, and cd133). |
2013-04-02 |
2023-08-12 |
Not clear |
| Qi-Liang Mao-Ying, Xiao-Wei Wang, Chang-Jiang Yang, Xiu Li, Wen-Li Mi, Gen-Cheng Wu, Yan-Qing Wan. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats. Molecular brain. vol 5. 2013-03-11. PMID:22607655. |
this neuroinflammation was characterized by enhanced immunostaining of both glial fibrillary acidic protein (gfap, astrocyte marker) and ox-42 (microglia marker), and an elevated level of il-1β, il-6 and tnf-α mrna. |
2013-03-11 |
2023-08-12 |
rat |
| Andrew W Kraft, Xiaoyan Hu, Hyejin Yoon, Ping Yan, Qingli Xiao, Yan Wang, So Chon Gil, Jennifer Brown, Ulrika Wilhelmsson, Jessica L Restivo, John R Cirrito, David M Holtzman, Jungsu Kim, Milos Pekny, Jin-Moo Le. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 1. 2013-03-07. PMID:23038755. |
we deleted the genes encoding two intermediate filament proteins required for astrocyte activation-glial fibrillary acid protein (gfap) and vimentin (vim)-in transgenic mice expressing mutant human amyloid precursor protein and presenilin-1 (app/ps1). |
2013-03-07 |
2023-08-12 |
mouse |
| Andrew W Kraft, Xiaoyan Hu, Hyejin Yoon, Ping Yan, Qingli Xiao, Yan Wang, So Chon Gil, Jennifer Brown, Ulrika Wilhelmsson, Jessica L Restivo, John R Cirrito, David M Holtzman, Jungsu Kim, Milos Pekny, Jin-Moo Le. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 1. 2013-03-07. PMID:23038755. |
astrocyte morphology was markedly altered by the deletions: wild-type astrocytes had hypertrophied processes that surrounded and infiltrated plaques, whereas gfap(-/-)vim(-/-) astrocytes had little process hypertrophy and lacked contact with adjacent plaques. |
2013-03-07 |
2023-08-12 |
mouse |
| Yucui Dong, Qinglian Han, Yan Zou, Zhenling Deng, Xinliang Lu, Xiaohua Wang, Weihua Zhang, Hua Jin, Jun Su, Tao Jiang, Huan Re. Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells. Molecular and cellular biochemistry. vol 370. issue 1-2. 2013-03-05. PMID:22829019. |
increased expression of gfap (astrocyte marker) and class iii β-tubulin isotype (tuj1, neuron marker) were detected with morphology like neurons or astrocytes in rg-im cells. |
2013-03-05 |
2023-08-12 |
Not clear |
| Hyunjin Cho, Young-Kwon Seo, Hee-Hoon Yoon, Soo-Chan Kim, Sung-Min Kim, Kye-Yong Song, Jung-Keug Par. Neural stimulation on human bone marrow-derived mesenchymal stem cells by extremely low frequency electromagnetic fields. Biotechnology progress. vol 28. issue 5. 2013-03-01. PMID:22848041. |
and also both oligodendrocyte and astrocyte related proteins like o4 and gfap were expressed by elf-emfs. |
2013-03-01 |
2023-08-12 |
human |
| N Collongues, J B Chanson, F Blanc, J Steibel, C D Lam, A Shabbir, E Trifilieff, J Honnorat, D Pham-Dinh, M S Ghandour, J de Sez. The Brown Norway opticospinal model of demyelination: does it mimic multiple sclerosis or neuromyelitis optica? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22634288. |
increasing attention has recently focused on astrocyte markers, aquaporin-4 (aqp4) and glial fibrillary acidic protein (gfap) in these diseases. |
2013-02-05 |
2023-08-12 |
rat |
| Min Gong, Shu-qing Li, Fan L. [Primary culture and purification of cerebral astrocyte of tree shrew]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 1. 2013-01-31. PMID:21340440. |
astrocyte layer, was taken out and cultured, and the third passage was identified by immunocytochemical staining and immunofluorescence with anti-glial fibrillary acidic protein (gfap) antibody. |
2013-01-31 |
2023-08-12 |
Not clear |
| Donald E Kimbler, Jessica Shields, Nathan Yanasak, John R Vender, Krishnan M Dhandapan. Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815977. |
notably, p2x7 localized within astrocytic end feet and administration of bbg decreased the expression of glial fibrillary acidic protein (gfap), a reactive astrocyte marker, and attenuated the expression of aquaporin-4 (aqp4), an astrocytic water channel that promotes cellular edema. |
2013-01-16 |
2023-08-12 |
mouse |