All Relations between microtubule-associated protein tau and neuroglial cell

Reference Sentence Publish Date Extraction Date Species
Connor M Wander, Jui-Heng Tseng, Sheng Song, Heba A Al Housseiny, Dalton S Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B Meeker, David J Irwin, Todd J Cohe. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience vol 23 issue 7 2021 32585593 the accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging. 2021-05-11 2022-01-13 Not clear
M Catarina Silva, Stephen J Haggart. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International journal of molecular sciences vol 21 issue 23 2021 33255694 tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (mapt) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. 2021-03-05 2022-01-13 Not clear
Justyna Zareba-Paslawska, Kalicharan Patra, Luca Kluzer, Tamas Revesz, Per Svenningsso. Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice. Frontiers in neurology vol 11 issue 2021 33519674 the aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies. 2021-02-02 2022-01-13 Not clear
Elisabetta Lauretti, Ozlem Dincer, Domenico Pratic\\xc3\\xb. Regional and temporal miRNAs expression profile in a transgenic mouse model of tauopathy: implication for its pathogenesis. Molecular psychiatry vol issue 2021 31988432 studies have shown that the expression level of different micrornas (mirnas) is altered in neurodegenerative disorders including tauopathies, a group of diseases pathologically defined by accumulation of tau protein in neurons and glia cells. 2021-01-26 2022-01-13 Not clear
Hui Mai, Weihao Fan, Yan Wang, Yujie Cai, Xiaohui Li, Feng Chen, Xiongjin Chen, Jingqi Yang, Pei Tang, Huiyi Chen, Ting Zou, Tingting Hong, Conghua Wan, Bin Zhao, Lili Cu. Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model. Molecular therapy. Nucleic acids vol 18 issue 2021 31707205 in this study, using a noninvasive nasal administration, we discovered that a mir-146a agomir (m146ag) rescued cognitive impairment in the app/ps1 transgenic mouse and alleviated the overall pathological process in the ad mouse model, including neuroinflammation, glia activation, a\xce\xb2 deposit, and tau phosphorylation in hippocampi. 2021-01-10 2022-01-14 Not clear
Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Gani. Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration. Cellular and molecular neurobiology vol 40 issue 3 2020 31584139 we explicate the role of key neuroproteomic drug targets notably a\xce\xb2, tau, alpha synuclein, prions, secretases, acetylcholinesterase (ache), lrrk2, molecular chaperones, a2a receptors, muscarinic acetylcholine receptors (machr), n-methyl-d-aspartate receptor (nmdar), glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) and mitochondrial/oxidative stress-related proteins for combating neurodegeneration and associated cognitive and motor impairment. 2020-12-07 2022-01-13 Not clear
Lu Wang, Lin Yu Wei, Ran Ding, Yanyan Feng, Dongliang Li, Chaokun Li, Philippa Malko, Sharifah A Syed Mortadza, Weidong Wu, Yaling Yin, Lin-Hua Jian. Predisposition to Alzheimer's and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel. Frontiers in physiology vol 11 issue 2020 32174842 studies have also documented that pm2.5 exposure causes ad-linked molecular and cellular alterations, such as mitochondrial dysfunction, synaptic deficits, impaired neurite growth, neuronal cell death, glial cell activation, neuroinflammation, and neurovascular dysfunction, in addition to elevated levels of amyloid \xce\xb2 (a\xce\xb2) and tau phosphorylation. 2020-09-28 2022-01-13 Not clear
Hamza Ayayd\\xc4\\xb1n, Adnan Kirmit, Hakim \\xc3\\x87elik, \\xc4\\xb0smail Akaltun, \\xc4\\xb0smail Koyuncu, \\xc5\\x9eermin Bilgen Ulga. High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol 18 issue 2 2020 32329316 the purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (neuron-specific enolase [nse], tau, serum 100 beta protein [s100b], respectively) and apoptosis markers (active caspase 3, m30, m65) and whether these parameters can be used as diagnostic biomarkers in autism spectrum disorders (asd). 2020-09-28 2022-01-13 Not clear
David W Hampton, Sandra Amor, David Story, Megan Torvell, Malika Bsibsi, Johannes M van Noort, Siddarthan Chandra. HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy. Frontiers in neuroscience vol 14 issue 2020 32595446 counteracting such pathogenic effects of tau by simultaneously inhibiting protein aggregation as well as pro-inflammatory glial cell responses would be of significant therapeutic interest. 2020-09-28 2022-01-13 Not clear
Sneha Narasimhan, Lakshmi Changolkar, Dawn M Riddle, Alexandra Kats, Anna Stieber, Sarah A Weitzman, Bin Zhang, Zhiyong Li, Erik D Roberson, John Q Trojanowski, Virginia M Y Le. Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. The Journal of experimental medicine vol 217 issue 2 2020 31826239 tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. 2020-09-09 2022-01-13 Not clear
Lary C Walke. Glial tauopathy: Neurons optional? The Journal of experimental medicine vol 217 issue 2 2020 31830204 testing the hypothesis that the aggregated tau in glia derives from neurons, narasimhan et al. 2020-08-26 2022-01-13 Not clear
Nobutaka Sakae, Keith A Josephs, Irene Litvan, Melissa E Murray, Ranjan Duara, Ryan J Uitti, Zbigniew K Wszolek, Neil R Graff-Radford, Dennis W Dickso. Neuropathologic basis of frontotemporal dementia in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society vol 34 issue 11 2020 31433871 progressive supranuclear palsy (psp) is a neurodegenerative disorder characterized by neuronal loss in the extrapyramidal system with pathologic accumulation of tau in neurons and glia. 2020-07-08 2022-01-13 Not clear
Joonki Kim, Sharmelee Selvaraji, Sung Wook Kang, Wei Thye Lee, Christopher Li-Hsian Chen, Hyungwon Choi, Edward H Koo, Dong-Gyu Jo, Kah Leong Lim, Yun-An Lim, Thiruma V Arumuga. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain, behavior, and immunity vol 80 issue 2020 30980950 aggregation of the microtubule-associated protein, tau, can lead to neurofibrillary tangle formation in neurons and glia which is the hallmark of tauopathy. 2020-05-21 2022-01-13 Not clear
Kee Chan Ahn, Cameron R Learman, Glen B Baker, Charles L Weaver, Phil Sang Chung, Hyung Gun Kim, Mee Sook Son. Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease? Journal of Korean medical science vol 34 issue 46 2020 31779058 in this article, we will discuss the well-known pathologies of ad, including a\xce\xb2 plaques and tau tangles, as well as other mechanisms shared in ad and diabetes including reactive glia and the breakdown of blood brain barrier in order to evaluate the presence of any potential, indirect or direct links of pre-diabetic conditions to ad pathology. 2020-05-14 2022-01-13 Not clear
Momoko Ebashi, Yoshinori Ito, Miho Uematsu, Ayako Nakamura, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihar. How to demix Alzheimer-type and PSP-type tau lesions out of their mixture -hybrid approach to dissect comorbidity. Acta neuropathologica communications vol 7 issue 1 2020 31060611 tau-positive lesions were sorted based on their cell type (neuron versus glia), and tau isoforms: three-repeat (3r) versus four-repeat (4r) tau. 2020-04-21 2022-01-13 Not clear
Dah-Eun Chloe Chung, Yari Carlomagno, Casey N Cook, Karen Jansen-West, Lillian Daughrity, Laura J Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W Dickson, Leonard Petrucell. Tau exhibits unique seeding properties in globular glial tauopathy. Acta neuropathologica communications vol 7 issue 1 2020 30845985 tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. 2020-03-30 2022-01-13 Not clear
J\\xc3\\xbcrgen G\\xc3\\xb6tz, Glenda Halliday, Rebecca M Nisbe. Molecular Pathogenesis of the Tauopathies. Annual review of pathology vol 14 issue 2020 30355155 the tauopathies constitute a group of diseases that have tau inclusions in neurons or glia as their common denominator. 2020-03-04 2022-01-13 Not clear
Radu Constantinescu, Kaj Blennow, Lars Rosengren, Barbro Eriksson, Thordis Gudmundsdottir, Yvonne Jansson, Bo Johnels, Annika Renck, Filip Bergquis. Cerebrospinal fluid protein markers in PD patients after DBS-STN surgery-A retrospective analysis of patients that underwent surgery between 1993 and 2001. Clinical neurology and neurosurgery vol 174 issue 2019 30248592 cerebrospinal fluid (csf) markers of neurodegeneration [neurofilament light chain (nfl), total tau (t-tau)], tau pathology [phosphorylated tau (p-tau)], glial cell damage or activation [glial fibrillary acidic protein (gfap)], and brain amyloidosis [\xce\xb2-amyloid 1-42 (a\xce\xb242)] are useful for diagnosis and prognosis in several neurodegenerative disorders. 2019-11-25 2022-01-13 Not clear
Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J James, Pyry Koivula, John Q Trojanowski, Amos B Smith, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular neurodegeneration vol 13 issue 1 2019 30404654 alzheimer's disease (ad) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. 2019-04-12 2022-01-13 Not clear
Juan Ram\\xc3\\xb3n Perea, Jes\\xc3\\xbas \\xc3\\x81vila, Marta Bol\\xc3\\xb3. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology vol 310 issue 2019 30138606 in these diseases, intracellular tau is secreted to the extracellular space, where it interacts with other cells, such as neurons and glia, promoting inflammation. 2019-03-21 2022-01-13 Not clear
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