| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Connor Langworth-Green, Saisha Patel, Zane Jaunmuktane, Edwin Jabbari, Huw Morris, Maria Thom, Andrew Lees, John Hardy, Michael Zandi, Karen Duf. Chronic effects of inflammation on tauopathies. The Lancet. Neurology. vol 22. issue 5. 2023-04-14. PMID:37059510. |
tauopathies are a heterogeneous group of neurodegenerative disorders that are characterised by the aggregation of the microtubule-associated protein tau into filamentous inclusions within neurons and glia. |
2023-04-14 |
2023-08-14 |
Not clear |
| Kurt A Jellinge. Pathomechanisms of cognitive impairment in progressive supranuclear palsy. Journal of neural transmission (Vienna, Austria : 1996). 2023-03-02. PMID:36862189. |
this four-repeat tauopathy is morphologically featured by accumulation of tau protein in neurons and glia causing neuronal loss and gliosis in the extrapyramidal system associated with cortical atrophy and white matter lesions. |
2023-03-02 |
2023-08-14 |
Not clear |
| Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters. 2023-01-19. PMID:36657633. |
bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. |
2023-01-19 |
2023-08-14 |
Not clear |
| Melissa K Edler, Emily L Munger, Hannah Maycon, William D Hopkins, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain. Journal of neuroscience research. 2023-01-17. PMID:36647571. |
vascular amyloid correlated with decreased astrocyte and microglia densities, while tau lesions were associated with morphological changes in microglia and greater total glia density and glia: neuron ratio. |
2023-01-17 |
2023-08-14 |
human |
| George Anderso. Why Do Anti-Amyloid Beta Antibodies not work? Time to reconceptualize Dementia Pathophysiology by incorporating astrocyte melatonergic pathway desynchronization from amyloid-beta production. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2022-12-26. PMID:36571832. |
emphasis is placed on the importance of released glia melatonin and autocrine effects in limiting the duration of amyloid-β production and paracrine melatonin's anti-inflammatory effects in neurons, including the suppression of hyperphosphorylated tau. |
2022-12-26 |
2023-08-14 |
Not clear |
| Qi Zhang, Bishuang Chen, Ping Yang, Jipan Wu, Xinping Pang, Chaoyang Pan. Bioinformatics-based study reveals that AP2M1 is regulated by the circRNA-miRNA-mRNA interaction network and affects Alzheimer's disease. Frontiers in genetics. vol 13. 2022-12-05. PMID:36468008. |
the hallmark illnesses include extracellular senile plaques caused by β-amyloid protein deposition, neurofibrillary tangles caused by tau protein hyperphosphorylation, and neuronal loss accompanying glial cell hyperplasia. |
2022-12-05 |
2023-08-14 |
Not clear |
| Stella M K Glasauer, Susan K Goderie, Jennifer N Rauch, Elmer Guzman, Morgane Audouard, Taylor Bertucci, Shona Joy, Emma Rommelfanger, Gabriel Luna, Erica Keane-Rivera, Steven Lotz, Susan Borden, Aaron M Armando, Oswald Quehenberger, Sally Temple, Kenneth S Kosi. Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem cell reports. 2022-08-19. PMID:35985329. |
mutations in the mapt gene that encodes tau lead to frontotemporal dementia (ftd) with pathology evident in both cerebral neurons and glia. |
2022-08-19 |
2023-08-14 |
human |
| Stella M K Glasauer, Susan K Goderie, Jennifer N Rauch, Elmer Guzman, Morgane Audouard, Taylor Bertucci, Shona Joy, Emma Rommelfanger, Gabriel Luna, Erica Keane-Rivera, Steven Lotz, Susan Borden, Aaron M Armando, Oswald Quehenberger, Sally Temple, Kenneth S Kosi. Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem cell reports. 2022-08-19. PMID:35985329. |
human cerebral organoids (hcos) from individuals harboring pathogenic tau mutations can reveal the earliest downstream effects on molecular pathways within a developmental context, generating interacting neurons and glia. |
2022-08-19 |
2023-08-14 |
human |
| Shanshan Ma, Xinkui Zhou, Yaping Wang, Zhe Li, Yingying Wang, Jijing Shi, Fangxia Gua. MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway. Redox biology. vol 53. 2022-05-07. PMID:35525026. |
furthermore, mg53 combined with young huc-mscs transplantation alleviated cognitive deficit and depression-like behavior in ad mice, reduced aβ deposition and tau phosphorylation, promoted neurogenesis, and inhibited glia cells activation and oxidative stress by activating the nrf2 signaling. |
2022-05-07 |
2023-08-13 |
mouse |
| Chao Zhou, Wanyan Ni, Taiyang Zhu, Shuyu Dong, Ping Sun, Fang Hu. Cellular Reprogramming and Its Potential Application in Alzheimer's Disease. Frontiers in neuroscience. vol 16. 2022-04-25. PMID:35464309. |
extracellular amyloid-beta deposition, intracellular tau hyperphosphorylation, neuronal death, glial cell activation, white matter damage, blood-brain barrier disruption, and other mechanisms all take part in this complicated disease, making it difficult to find an effective therapy. |
2022-04-25 |
2023-08-13 |
Not clear |
| Marta Caamaño-Moreno, Ricardo Gargin. Tauopathies: the role of tau in cellular crosstalk and synaptic dysfunctions. Neuroscience. 2022-03-10. PMID:35272005. |
all of them are characterized by aberrant aggregation of tau protein in neurons and glia that are distributed in different brain regions according to their susceptibility. |
2022-03-10 |
2023-08-13 |
Not clear |
| Marta Caamaño-Moreno, Ricardo Gargin. Tauopathies: the role of tau in cellular crosstalk and synaptic dysfunctions. Neuroscience. 2022-03-10. PMID:35272005. |
in this way, this review shows how tau inclusions in glia influence the synaptic dysfunctions that result in the cognitive symptoms characteristic of tauopathies. |
2022-03-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. |
although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as alzheimer's disease has been associated with its ability to phosphorylate tau in neurons. |
2022-02-09 |
2023-08-13 |
mouse |
| Chijioke Akunwafo, Jeiran Choupan, Farshid Sepehrban. Premortem perivascular space morphology is a predictor of postmortem glia tau pathology in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109135. |
premortem perivascular space morphology is a predictor of postmortem glia tau pathology in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ashlyn G Johnson, James A Webster, Chadwick M Hale. Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration. Neurobiology of aging. vol 112. 2022-01-20. PMID:35051675. |
to understand how glia may be altered in frontotemporal degeneration with tau pathology (ftd-tau), we used a nanostring glial profiling panel to measure 770 transcripts related to glial biology in human control (n = 8), alzheimer's disease (ad) (n = 8), and ftd-tau (n = 8) dorsolateral prefrontal cortex. |
2022-01-20 |
2023-08-13 |
human |
| Mennatallah O Zaki, Doaa A Elsherbiny, Mohamed Salama, Samar S Aza. Potential role of Drug Repositioning Strategy (DRS) for management of tauopathy. Life sciences. 2022-01-02. PMID:34974076. |
tauopathy is a term that has been used to represent a pathological condition in which hyperphosphorylated tau protein aggregates in neurons and glia which results in neurodegeneration, synapse loss and dysfunction and cognitive impairments. |
2022-01-02 |
2023-08-13 |
Not clear |
| YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morro. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Brain : a journal of neurology. 2021-12-20. PMID:34928329. |
interestingly, we observe tau deposition in both neurons and glia, as has been reported in cs postmortem studies previously. |
2021-12-20 |
2023-08-13 |
mouse |
| Aviva M Tolkovsky, Maria Grazia Spillantin. Tau aggregation and its relation to selected forms of neuronal cell death. Essays in biochemistry. 2021-12-13. PMID:34897457. |
although alzheimer's disease (ad) is the most prevalent tauopathy, tauopathies comprise an array of over 30 diseases in which the cytoplasmic protein tau aggregates in neurons, and also, in some diseases, in glia. |
2021-12-13 |
2023-08-13 |
Not clear |
| Barbara E Stopschinski, Kelly Del Tredici, Sandi-Jo Estill-Terpack, Estifanos Ghebremdehin, Fang F Yu, Heiko Braak, Marc I Diamon. Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34635189. |
at8 staining in brain regions identified because of tau seeding also revealed pathology in a previously undescribed cell type: bergmann glia of the cerebellar cortex. |
2021-11-05 |
2023-08-13 |
Not clear |
| Alexander Sandberg, Helen Ling, Marla Gearing, Beth Dombroski, Laura Cantwell, Lea R'Bibo, Allan Levey, Gerard D Schellenberg, John Hardy, Nicholas Wood, Josefin Fernius, Sofie Nyström, Samuel Svensson, Stefan Thor, Per Hammarström, Tamas Revesz, Kin Y Mo. Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R. Neurobiology of disease. vol 146. 2021-10-25. PMID:32961270. |
we herein return to pathological examination which demonstrated tau immunoreactivity in neurons and glia consistent of mixed progressive supranuclear palsy (psp) and corticobasal degeneration (cbd) features. |
2021-10-25 |
2023-08-13 |
drosophila_melanogaster |