| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kee Chan Ahn, Cameron R Learman, Glen B Baker, Charles L Weaver, Phil Sang Chung, Hyung Gun Kim, Mee Sook Son. Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease? Journal of Korean medical science. vol 34. issue 46. 2020-05-14. PMID:31779058. |
in this article, we will discuss the well-known pathologies of ad, including aβ plaques and tau tangles, as well as other mechanisms shared in ad and diabetes including reactive glia and the breakdown of blood brain barrier in order to evaluate the presence of any potential, indirect or direct links of pre-diabetic conditions to ad pathology. |
2020-05-14 |
2023-08-13 |
Not clear |
| Momoko Ebashi, Yoshinori Ito, Miho Uematsu, Ayako Nakamura, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihar. How to demix Alzheimer-type and PSP-type tau lesions out of their mixture -hybrid approach to dissect comorbidity. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31060611. |
tau-positive lesions were sorted based on their cell type (neuron versus glia), and tau isoforms: three-repeat (3r) versus four-repeat (4r) tau. |
2020-04-21 |
2023-08-13 |
Not clear |
| Dah-Eun Chloe Chung, Yari Carlomagno, Casey N Cook, Karen Jansen-West, Lillian Daughrity, Laura J Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W Dickson, Leonard Petrucell. Tau exhibits unique seeding properties in globular glial tauopathy. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30845985. |
tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. |
2020-03-30 |
2023-08-13 |
Not clear |
| Jürgen Götz, Glenda Halliday, Rebecca M Nisbe. Molecular Pathogenesis of the Tauopathies. Annual review of pathology. vol 14. 2020-03-04. PMID:30355155. |
the tauopathies constitute a group of diseases that have tau inclusions in neurons or glia as their common denominator. |
2020-03-04 |
2023-08-13 |
Not clear |
| Radu Constantinescu, Kaj Blennow, Lars Rosengren, Barbro Eriksson, Thordis Gudmundsdottir, Yvonne Jansson, Bo Johnels, Annika Renck, Filip Bergquis. Cerebrospinal fluid protein markers in PD patients after DBS-STN surgery-A retrospective analysis of patients that underwent surgery between 1993 and 2001. Clinical neurology and neurosurgery. vol 174. 2019-11-25. PMID:30248592. |
cerebrospinal fluid (csf) markers of neurodegeneration [neurofilament light chain (nfl), total tau (t-tau)], tau pathology [phosphorylated tau (p-tau)], glial cell damage or activation [glial fibrillary acidic protein (gfap)], and brain amyloidosis [β-amyloid 1-42 (aβ42)] are useful for diagnosis and prognosis in several neurodegenerative disorders. |
2019-11-25 |
2023-08-13 |
Not clear |
| Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J James, Pyry Koivula, John Q Trojanowski, Amos B Smith, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30404654. |
alzheimer's disease (ad) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. |
2019-04-12 |
2023-08-13 |
mouse |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
in these diseases, intracellular tau is secreted to the extracellular space, where it interacts with other cells, such as neurons and glia, promoting inflammation. |
2019-03-21 |
2023-08-13 |
Not clear |
| Chunxia Huang, John Man-Tak Chu, Yan Liu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology. vol 143. 2019-02-25. PMID:30273594. |
glia activation, aberrant tau phosphorylation (at8) and accumulation of phosphorylated h2ax in the hippocampus were detectable up to postoperative day 14, with neuronal apoptosis seen in the hippocampus. |
2019-02-25 |
2023-08-13 |
mouse |
| Mansi R Khanna, Jane Kovalevich, Virginia M-Y Lee, John Q Trojanowski, Kurt R Brunde. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27751442. |
tau is normally a microtubule (mt)-associated protein that appears to play an important role in ensuring proper axonal transport, but in tauopathies tau becomes hyperphosphorylated and disengages from mts, with consequent misfolding and deposition into inclusions that mainly affect neurons but also glia. |
2017-10-30 |
2023-08-13 |
Not clear |
| Najiba Mammadova, Shivani Ghaisas, Gary Zenitsky, Donald S Sakaguchi, Anumantha G Kanthasamy, Justin J Greenlee, M Heather West Greenle. Lasting Retinal Injury in a Mouse Model of Blast-Induced Trauma. The American journal of pathology. vol 187. issue 7. 2017-10-13. PMID:28606756. |
primary blast wave pressure resulted in activation of müller glia, loss of photoreceptor cells, and an increase in phosphorylated tau in retinal neurons and glia. |
2017-10-13 |
2023-08-13 |
mouse |
| Rui Lu, Qian He, Junfeng Wan. TRPC Channels and Alzheimer's Disease. Advances in experimental medicine and biology. vol 976. 2017-09-22. PMID:28508314. |
besides, tau protein accumulation, calcium homeostasis disruption, and glial cell activation are also remarkable features in ad. |
2017-09-22 |
2023-08-13 |
Not clear |
| Hongjun Fu, S Abid Hussaini, Susanne Wegmann, Caterina Profaci, Jacob D Daniels, Mathieu Herman, Sheina Emrani, Helen Y Figueroa, Bradley T Hyman, Peter Davies, Karen E Duf. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. PloS one. vol 11. issue 7. 2017-07-18. PMID:27466814. |
no evidence for uptake and accumulation of tau by glia was observed. |
2017-07-18 |
2023-08-13 |
mouse |
| Jennifer S Yokoyama, Celeste M Karch, Chun C Fan, Luke W Bonham, Naomi Kouri, Owen A Ross, Rosa Rademakers, Jungsu Kim, Yunpeng Wang, Günter U Höglinger, Ulrich Müller, Raffaele Ferrari, John Hardy, Parastoo Momeni, Leo P Sugrue, Christopher P Hess, A James Barkovich, Adam L Boxer, William W Seeley, Gil D Rabinovici, Howard J Rosen, Bruce L Miller, Nicholas J Schmansky, Bruce Fischl, Bradley T Hyman, Dennis W Dickson, Gerard D Schellenberg, Ole A Andreassen, Anders M Dale, Rahul S Desika. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28271184. |
corticobasal degeneration (cbd), progressive supranuclear palsy (psp) and a subset of frontotemporal dementia (ftd) are neurodegenerative disorders characterized by tau inclusions in neurons and glia (tauopathies). |
2017-04-20 |
2023-08-13 |
human |
| R Constantinescu, D Krýsl, F Bergquist, K Andrén, C Malmeström, F Asztély, M Axelsson, E B Menachem, K Blennow, L Rosengren, H Zetterber. Cerebrospinal fluid markers of neuronal and glial cell damage to monitor disease activity and predict long-term outcome in patients with autoimmune encephalitis. European journal of neurology. vol 23. issue 4. 2016-12-13. PMID:26822123. |
the value of cerebrospinal fluid (csf) markers of neuronal [neurofilament light chain protein (nfl), and total tau protein (t-tau)] and glial cell [glial fibrillary acidic protein (gfap)] damage in patients with autoimmune encephalitis was investigated. |
2016-12-13 |
2023-08-13 |
Not clear |
| Lars Krüger, Eva Maria Mandelko. Tau neurotoxicity and rescue in animal models of human Tauopathies. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26431808. |
beside tau's main function in stabilizing microtubules for axonal transport, a variety of novel functions for neurons and glia have emerged recently. |
2016-11-01 |
2023-08-13 |
human |
| Gabor G Kovacs, Isidro Ferrer, Lea T Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J Cairns, John F Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M Halliday, James W Ironside, Seth Love, Ian R Mackenzie, David G Munoz, Melissa E Murray, Peter T Nelson, Hitoshi Takahashi, John Q Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G Beach, Kevin F Bieniek, Eileen H Bigio, Istvan Bodi, Brittany N Dugger, Mel Feany, Ellen Gelpi, Stephen M Gentleman, Giorgio Giaccone, Kimmo J Hatanpaa, Richard Heale, Patrick R Hof, Monika Hofer, Tibor Hortobágyi, Kurt Jellinger, Gregory A Jicha, Paul Ince, Julia Kofler, Enikö Kövari, Jillian J Kril, David M Mann, Radoslav Matej, Ann C McKee, Catriona McLean, Ivan Milenkovic, Thomas J Montine, Shigeo Murayama, Edward B Lee, Jasmin Rahimi, Roberta D Rodriguez, Annemieke Rozemüller, Julie A Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B Toledo, Markus Tolnay, Juan C Troncoso, Harry V Vinters, Serge Weis, Stephen B Wharton, Charles L White, Thomas Wisniewski, John M Woulfe, Masahito Yamada, Dennis W Dickso. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta neuropathologica. vol 131. issue 1. 2016-09-29. PMID:26659578. |
tau-immunoreactive astrocytes in artag include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. |
2016-09-29 |
2023-08-13 |
Not clear |
| Pawel Tacik, Monica Sanchez-Contreras, Rosa Rademakers, Dennis W Dickson, Zbigniew K Wszole. Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories. Neuro-degenerative diseases. vol 16. issue 1-2. 2016-09-20. PMID:26550830. |
tauopathies are a group of neurodegenerative disorders characterized by the pathological accumulation of hyperphosphorylated and insoluble tau protein within neurons and glia. |
2016-09-20 |
2023-08-13 |
Not clear |
| Vanessa J Hall, Maiken M Lindblad, Jannik E Jakobsen, Anders Gunnarsson, Mette Schmidt, Mikkel A Rasmussen, Daniela Volke, Thole Zuchner, Poul Hytte. Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Disease models & mechanisms. vol 8. issue 10. 2016-07-19. PMID:26398935. |
these outcomes also highlight that radial glia could be a potentially useful population of cells for drug discovery, and that altered app expression and altered tau phosphorylation can be detected in an in vitro model of the disease. |
2016-07-19 |
2023-08-13 |
human |
| Zhihui Yang, Ping Wang, Drake Morgan, Dan Lin, Jianchun Pan, Fan Lin, Kevin H Strang, Tyler M Selig, Pablo D Perez, Marcelo Febo, Binggong Chang, Richard Rubenstein, Kevin K W Wan. Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model. Scientific reports. vol 5. 2016-04-12. PMID:26058556. |
dynamic changes in mri, neurobiochemical markers (tau hyperphosphorylation and glia activation in brain tissues) and neurobehavioral functions such as anxiety, depression, motor function and cognitive function at various acute/subacute (1-7 day post-injury) and chronic (14-60 days post-injury) time points were examined. |
2016-04-12 |
2023-08-13 |
mouse |
| Bess Frost, Jürgen Götz, Mel B Fean. Connecting the dots between tau dysfunction and neurodegeneration. Trends in cell biology. vol 25. issue 1. 2015-08-17. PMID:25172552. |
tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. |
2015-08-17 |
2023-08-13 |
Not clear |