| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mari Yoshid. Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 6. 2015-08-03. PMID:25124031. |
the characteristics of tau accumulation in both neurons and glia suggest a different underlying mechanism with regard to the sites of tau aggregation and fibril formation between psp and cbd: proximal-dominant aggregation of tas and formation of filamentous nfts in psp in contrast to the distal-dominant aggregation of aps and formation of less filamentous pretangles in cbd. |
2015-08-03 |
2023-08-13 |
Not clear |
| Isidre Ferrer, Andrea Legati, J Carlos García-Monco, Marian Gomez-Beldarrain, Margarita Carmona, Rosa Blanco, William W Seeley, Giovanni Coppol. Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756587. |
the neuropathologic examination revealed massive accumulation of abnormally hyperphosphorylated, conformational, truncated tau at aspartic acid 421, ubiquitinated and nitrated tau at tyr29 in cortical astrocyte (including their perivascular foot processes), and bergmann glia. |
2015-06-15 |
2023-08-13 |
Not clear |
| Takahiko Tokud. [Differential diagnosis of corticobasal syndrome (CBS) and its biomarkers]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291870. |
abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and cbd is thus considered one of the tauopathies. |
2015-04-13 |
2023-08-12 |
Not clear |
| Sanju Lama, Roland N Auer, Randy Tyson, Clare N Gallagher, Boguslaw Tomanek, Garnette R Sutherlan. Lactate storm marks cerebral metabolism following brain trauma. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24849602. |
histopathology of the model showed severe brain injury with subarachnoid and hemorrhage together with glial cell activation and positive staining for tau at 90 min post-trauma. |
2014-10-06 |
2023-08-13 |
Not clear |
| Mariangela Iovino, Ulrich Pfisterer, Janice L Holton, Tammaryn Lashley, Robert J Swingler, Laura Calo, Rebecca Treacy, Tamas Revesz, Malin Parmar, Michel Goedert, Miratul M K Muqit, Maria Grazia Spillantin. The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons. Acta neuropathologica. vol 127. issue 2. 2014-09-30. PMID:24292008. |
neuropathological studies of post-mortem brain showed widespread neuronal loss and gliosis and abundant deposition of hyperphosphorylated tau in neurons and glia. |
2014-09-30 |
2023-08-12 |
Not clear |
| D Seilhean, F Bielle, I Plu, C Duyckaert. Frontotemporal lobar degeneration: diversity of FTLD lesions. Revue neurologique. vol 169. issue 10. 2014-07-31. PMID:24035575. |
the neuropathologic classification is now based on identification of the protein that accumulates in neurons and glia: tau, tar dna binding protein 43 (tdp-43), and fused in sarcoma (fus). |
2014-07-31 |
2023-08-12 |
Not clear |
| Naoki Fujii, Tomihiro Wakamiya, Akihiro Watanabe, Hirokazu Furuya, Kensuke Sasaki, Toru Iwak. [An autopsy case of Alzheimer's disease presenting with corticobasal syndrome]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 10. 2014-06-23. PMID:24225565. |
the findings of tauopathy of the glia were poor, and the tau lesion of the brainstem was milder than that of the cerebral cortex. |
2014-06-23 |
2023-08-12 |
Not clear |
| Mari Yoshid. [Neuropathology of tauopathy]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 12. 2014-05-06. PMID:24323931. |
although psp and cbd sometimes share certain pathological distribution, which makes clinical diagnosis difficult, cellular tau pathology and aggregation patterns in neurons and glia are different between the two diseases. |
2014-05-06 |
2023-08-12 |
Not clear |
| Naomi Kouri, Kenichi Oshima, Makio Takahashi, Melissa E Murray, Zeshan Ahmed, Joseph E Parisi, Shu-Hui C Yen, Dennis W Dickso. Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD. Acta neuropathologica. vol 125. issue 5. 2013-10-31. PMID:23371366. |
corticobasal degeneration (cbd) is a disorder affecting cognition and movement due to a progressive neurodegeneration associated with distinctive neuropathologic features, including abnormal phosphorylated tau protein in neurons and glia in cortex, basal ganglia, diencephalon, and brainstem, as well as ballooned neurons and astrocytic plaques. |
2013-10-31 |
2023-08-12 |
Not clear |
| Takahiko Tokud. [Biomarkers for the differential diagnosis of corticobasal syndrome]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 1. 2013-09-03. PMID:23300103. |
abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and cbd is thus considered one of the tauopathies. |
2013-09-03 |
2023-08-12 |
Not clear |
| Dennis W Dickso. Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harbor perspectives in medicine. vol 2. issue 8. 2013-06-26. PMID:22908195. |
the tau pathology of psp also affects both neurons and glia. |
2013-06-26 |
2023-08-12 |
Not clear |
| Agneta Mewes, Heike Franke, David Singe. Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies. PloS one. vol 7. issue 9. 2013-03-05. PMID:22984603. |
deposits of hyperphosphorylated tau, called neurofibrillary tangles (nfts), surrounded by activated glia are modeled in transgenic mice, e.g. |
2013-03-05 |
2023-08-12 |
mouse |
| Takaaki Mori, Jun Maeda, Hitoshi Shimada, Makoto Higuchi, Hitoshi Shinotoh, Shu-ichi Ueno, Tetsuya Suhar. Molecular imaging of dementia. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 12. issue 2. 2012-10-29. PMID:22712644. |
furthermore, beneficial outcomes of aβ and tau immunization in humans and mouse models have highlighted crucial roles of immunocompetent glia in the protection of neurons against amyloid toxicities. |
2012-10-29 |
2023-08-12 |
mouse |
| Yasumasa Kokubo, Akira Taniguchi, Masato Hasegawa, Yuma Hayakawa, Satoru Morimoto, Misao Yoneda, Yoshihumi Hirokawa, Taizo Shiraishi, Yuko Saito, Shigeo Murayama, Shigeki Kuzuhar. α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan. Journal of neuropathology and experimental neurology. vol 71. issue 7. 2012-09-04. PMID:22710962. |
phosphorylated α-synuclein frequently colocalized with tau in neuron cell bodies, neurites, and glia. |
2012-09-04 |
2023-08-12 |
Not clear |
| Yazi D Ke, Alexandra K Suchowerska, Julia van der Hoven, Dineeka M De Silva, Christopher W Wu, Janet van Eersel, Arne Ittner, Lars M Ittne. Lessons from tau-deficient mice. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720190. |
both alzheimer's disease (ad) and frontotemporal dementia (ftd) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. |
2012-08-23 |
2023-08-12 |
mouse |
| Diana A T Nijholt, Elise S van Haastert, Annemieke J M Rozemuller, Wiep Scheper, Jeroen J M Hoozeman. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22102449. |
increased presence of upr activation markers pperk and pire1 was observed in neurons and glia in ftld-tau cases, in contrast to ftld subtypes negative for tau pathology or in non-neurological controls. |
2012-04-27 |
2023-08-12 |
Not clear |
| Dennis W Dickson, Naomi Kouri, Melissa E Murray, Keith A Joseph. Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau). Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21720721. |
a clinically and pathologically heterogeneous type of frontotemporal lobar degeneration has abnormal tau pathology in neurons and glia (ftld-tau). |
2012-03-19 |
2023-08-12 |
Not clear |
| Bradley F Boev. The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study. Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21853287. |
microscopically, abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and this disorder is now considered one of the "tauopathies." |
2012-03-19 |
2023-08-12 |
Not clear |
| Arne Ittner, Yazi D Ke, Janet van Eersel, Amadeus Gladbach, Jürgen Götz, Lars M Ittne. Brief update on different roles of tau in neurodegeneration. IUBMB life. vol 63. issue 7. 2012-01-11. PMID:21698753. |
both alzheimer's disease (ad) and almost every second case of frontotemporal lobar degeneration (ftld) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. |
2012-01-11 |
2023-08-12 |
Not clear |
| Masaya Nagaishi, Hideaki Yokoo, Yoichi Nakazat. Tau-positive glial cytoplasmic granules in multiple system atrophy. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 3. 2011-09-22. PMID:21062361. |
these results indicate that tau-positive granules in glia are common findings in msa and that tau aggregation might be another pathway to neurodegeneration in msa. |
2011-09-22 |
2023-08-12 |
Not clear |