| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S Aymeric. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Biomolecules. vol 10. issue 8. 2021-06-14. PMID:32824740. |
monoacylglycerol lipase inhibition (magl) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. |
2021-06-14 |
2023-08-13 |
rat |
| Jan Lukas Prüser, Robert Ramer, Felix Wittig, Igor Ivanov, Jutta Merkord, Burkhard Hin. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB Molecular cancer therapeutics. vol 20. issue 5. 2021-06-11. PMID:33632876. |
the monoacylglycerol lipase inhibitor jzl184 inhibits lung cancer cell invasion and metastasis via the cb a targeted modulation of the endocannabinoid system is currently discussed as a promising strategy for cancer treatment. |
2021-06-11 |
2023-08-13 |
mouse |
| Jan Lukas Prüser, Robert Ramer, Felix Wittig, Igor Ivanov, Jutta Merkord, Burkhard Hin. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB Molecular cancer therapeutics. vol 20. issue 5. 2021-06-11. PMID:33632876. |
an important enzyme for the endocannabinoid metabolism is the monoacylglycerol lipase (magl), which catalyzes the degradation of 2-arachidonoylglycerol (2-ag) to glycerol and free fatty acids. |
2021-06-11 |
2023-08-13 |
mouse |
| Bin Zhu, Peter J Connolly, Yue-Mei Zhang, Mark E McDonnell, Haiyan Bian, Shu-Chen Lin, Li Liu, Sui-Po Zhang, Kristen M Chevalier, Michael R Brandt, Cynthia M Milligan, Christopher M Flores, Mark J Maciela. The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorganic & medicinal chemistry letters. vol 30. issue 14. 2021-06-01. PMID:32527545. |
monoacylglycerol lipase (magl) is the enzyme that is primarily responsible for hydrolyzing the endocannabinoid 2-arachidononylglycerol (2-ag) to arachidonic acid (aa). |
2021-06-01 |
2023-08-13 |
rat |
| Cherry P Ho, Abdolsamad Borazjani, Matthew K Ross, Chinling Wan. Effects of the monoacylglycerol lipase inhibitor JZL184 on chickens infected with avian pathogenic Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. vol 84. issue 3. 2021-05-18. PMID:32801453. |
effects of the monoacylglycerol lipase inhibitor jzl184 on chickens infected with avian pathogenic the endocannabinoid (ecb) system modulates the degree of injury caused by inflammation, while enhancing the activity of phagocytes that promote resolution of inflammation and tissue repair. |
2021-05-18 |
2023-08-13 |
Not clear |
| Jinming Zhang, Lizi Zhang, Yuan Chang, Qiaofen Gu, Junmin Zhang, Zhou Zhu, Zhaoqiang Qian, Chunling Wei, Zhiqiang Liu, Wei Ren, Jing Ha. The Endocannabinoid System Contributes to Memory Deficits Induced by Rapid-eye-movement Sleep Deprivation in Adolescent Mice. Neuroscience. vol 433. 2021-05-14. PMID:32198011. |
remsd downregulated monoacylglycerol lipase, a hydrolase for the endocannabinoid 2-arachidonoylglycerol (2-ag), suggesting the involvement of ecb accumulation and the consequent synaptic plasticity in remsd-elicited memory impairment in adolescent mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Matteo Tardell. Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease. World journal of gastroenterology. vol 26. issue 25. 2021-05-14. PMID:32742127. |
notably, monoacylglycerol lipase (mgl) also hydrolyzes 2-arachidonoylglycerol, which is a potent ligand within the endocannabinoid system, into arachidonic acid - a precursor for prostaglandin synthesis; thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from fa metabolism to inflammation, pain and appetite. |
2021-05-14 |
2023-08-13 |
Not clear |
| C M Diester, A H Lichtman, S S Negu. Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics. vol 377. issue 2. 2021-05-13. PMID:33622769. |
enhanced signaling of the endocannabinoid (ecb) system through inhibition of the catabolic enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) has received increasing interest for development of candidate analgesics. |
2021-05-13 |
2023-08-13 |
mouse |
| Bin Zhu, Peter J Connolly, Sui-Po Zhang, Kristen M Chevalier, Cynthia M Milligan, Christopher M Flores, Mark J Maciela. The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL). Bioorganic & medicinal chemistry letters. vol 30. issue 12. 2021-05-12. PMID:32334914. |
monoacylglycerol lipase (magl) has emerged as an attractive drug target because of its important role in regulating the endocannabinoid 2-arachidonoylglycerol (2-ag) and its hydrolysis product arachidonic acid (aa) in the brain. |
2021-05-12 |
2023-08-13 |
rat |
| Natasha L Grimsey, Juha R Savinainen, Bala Attili, Muneer Ahame. Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications. Drug discovery today. vol 25. issue 2. 2021-04-30. PMID:31622747. |
monoacylglycerol lipase (magl) is a major endocannabinoid hydrolyzing enzyme and can be regulated to control endogenous lipid levels in the brain. |
2021-04-30 |
2023-08-13 |
Not clear |
| Carlotta Granchi, Giulia Bononi, Rebecca Ferrisi, Eleonora Gori, Giulia Mantini, Sandra Glasmacher, Giulio Poli, Stefano Palazzolo, Isabella Caligiuri, Flavio Rizzolio, Vincenzo Canzonieri, Tiziana Perin, Jürg Gertsch, Andrea Sodi, Elisa Giovannetti, Marco Macchia, Filippo Minutolo, Tiziano Tuccinardi, Andrea Chicc. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. European journal of medicinal chemistry. vol 209. 2021-04-20. PMID:33045662. |
an interesting enzyme of the endocannabinoid system is monoacylglycerol lipase (magl). |
2021-04-20 |
2023-08-13 |
mouse |
| Giulia Bononi, Giulio Poli, Flavio Rizzolio, Tiziano Tuccinardi, Marco Macchia, Filippo Minutolo, Carlotta Granch. An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present). Expert opinion on therapeutic patents. vol 31. issue 2. 2021-04-06. PMID:33085920. |
monoacylglycerol lipase (magl) belongs to the endocannabinoid system and is responsible for the inactivation of endocannabinoid 2-arachidonoylglycerol. |
2021-04-06 |
2023-08-13 |
Not clear |
| Lu Hou, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Cassis Varlow, Michael A Schafroth, Linjing Mu, Jiefeng Gan, Hao Xu, Christopher J Fowler, Ming-Rong Zhang, Neil Vasdev, Simon Ametamey, Benjamin F Cravatt, Lu Wang, Steven H Lian. Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. Journal of medicinal chemistry. vol 64. issue 1. 2021-03-08. PMID:33379862. |
herein, we summarized the recent development of pet tracers for imaging cannabinoid receptors 1 (cb1r) and 2 (cb2r) as well as the key enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), particularly focusing on pet neuroimaging applications. |
2021-03-08 |
2023-08-13 |
human |
| Gaurav Bedse, Mathew N Hill, Sachin Pate. 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. Biological psychiatry. vol 88. issue 7. 2021-03-03. PMID:32197779. |
although initial preclinical and clinical development efforts focused on pharmacological inhibition of fatty acid amide hydrolase to elevate levels of the endocannabinoid anandamide, more recent efforts have focused on inhibition of monoacylglycerol lipase (magl) to enhance signaling of the most abundant and efficacious endocannabinoid ligand, 2-arachidonoylglycerol (2-ag). |
2021-03-03 |
2023-08-13 |
Not clear |
| Amal Thomas, Bright N Okine, David P Finn, Willias Masoch. Peripheral deficiency and antiallodynic effects of 2-arachidonoyl glycerol in a mouse model of paclitaxel-induced neuropathic pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-03-01. PMID:32603895. |
we also evaluated the peripheral antiallodynic activity of the endocannabinoid 2-arachidonoyl glycerol (2-ag) and an inhibitor of monoacylglycerol lipase (magl), an enzyme responsible for 2-ag hydrolysis. |
2021-03-01 |
2023-08-13 |
mouse |
| Oakleigh M Folkes, Rita Báldi, Veronika Kondev, David J Marcus, Nolan D Hartley, Brandon D Turner, Jade K Ayers, Jordan J Baechle, Maya P Misra, Megan Altemus, Carrie A Grueter, Brad A Grueter, Sachin Pate. An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability. The Journal of clinical investigation. vol 130. issue 4. 2020-12-30. PMID:31874107. |
furthermore, we found that 2-arachidonoylglycerol (2-ag) endocannabinoid signaling reduced bla-nac glutamatergic activity and that pharmacological 2-ag augmentation via administration of jzl184, a monoacylglycerol lipase inhibitor, blocked si deficits associated with in vivo bla-nac stimulation. |
2020-12-30 |
2023-08-13 |
mouse |
| Jing Wang, Xiaohua Zhang, Chongmei Yang, Shulei Zha. Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32173532. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) is an anti-nociceptive lipid, which is inactivated through cellular uptake and subsequent catabolism by monoacylglycerol lipase (magl). |
2020-12-28 |
2023-08-13 |
rat |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders. Human reproduction update. vol 26. issue 4. 2020-12-08. PMID:32347309. |
the endocannabinoid system (ecs) consists of the cannabinoid receptors cb1 and cb2, the main endocannabinoids anandamide (aea) and 2-arachidonoylglycerol (2-ag) and their metabolic enzymes n-acylphosphatidylethanolamine-specific phospholipase d, fatty acid amide hydrolase, diacylglycerol lipase and monoacylglycerol lipase. |
2020-12-08 |
2023-08-13 |
Not clear |
| Emily Kabeiseman, Riley Paulsen, Brian D Burrel. Characterization of a monoacylglycerol lipase in the medicinal leech, Hirudo verbana. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 243-244. 2020-11-11. PMID:32205202. |
among the endocannabinoids, 2-arachydonoyl glycerol (2-ag) is the most prevalent endocannabinoid and monoacylglycerol lipase (magl) is a serine hydrolase primarily responsible for metabolizing 2-ag in mammals. |
2020-11-11 |
2023-08-13 |
Not clear |
| Qin Yang, Shunli Sun, Wei Liu, Qingguang Liu, Jibing Wan. Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice. Biochemical and biophysical research communications. vol 525. issue 3. 2020-11-04. PMID:32122652. |
the present study investigated the effects of ht, a new prospective weight-loss method, on nutritionally obese mice and demonstrated that ht significantly reduced body weight, fat mass, transcriptional expression of liver endocannabinoid receptor 1 (cb1), biosynthetic enzyme diacylglycerol lipase α (daglα) and improved the transcriptional expression of degrading enzyme monoacylglycerol lipase (magl). |
2020-11-04 |
2023-08-13 |
mouse |