Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Ren-Shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishi. Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270353. |
biochemical analyses revealed that this was the result of suppression of two hydrolases involved in endocannabinoid degradation (fatty acid amide hydrolase [faah] and monoacylglycerol lipase [magl]). |
2020-10-26 |
2023-08-13 |
Not clear |
Eva J van Rooden, Annelot C M van Esbroeck, Marc P Baggelaar, Hui Deng, Bogdan I Florea, André R A Marques, Roelof Ottenhoff, Rolf G Boot, Herman S Overkleeft, Johannes M F G Aerts, Mario van der Stel. Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30018533. |
the activities of the following endocannabinoid enzymes were quantified: diacylglycerol lipase (dagl) α, α/β-hydrolase domain-containing protein 4, α/β-hydrolase domain-containing protein 6, α/β-hydrolase domain-containing protein 12, fatty acid amide hydrolase, and monoacylglycerol lipase. |
2020-10-01 |
2023-08-13 |
mouse |
Pinja Leimuranta, Leonard Khiroug, Rashid Giniatulli. Emerging Role of (Endo)Cannabinoids in Migraine. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29740328. |
individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ecs) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive cb1 and cb2 and pro-nociceptive trpv1 receptors. |
2020-09-30 |
2023-08-13 |
Not clear |
Sally Miller, Shashank Kulkarni, Alex Ciesielski, Spyros P Nikas, Ken Mackie, Alexandros Makriyannis, Alex Straike. Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure. Pharmaceuticals (Basel, Switzerland). vol 11. issue 2. 2020-09-30. PMID:29786643. |
we have recently shown that blocking monoacylglycerol lipase (magl), an enzyme that breaks the endocannabinoid 2-arachidonoyl glycerol (2-ag), substantially lowers iop. |
2020-09-30 |
2023-08-13 |
mouse |
Nathan J Kolla, Achal Mishr. The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders. Frontiers in behavioral neuroscience. vol 12. 2020-09-29. PMID:29636670. |
the first main objective of this review is to dissect components of the endocannabinoid system, including cannabinoid 1 and cannabinoid 2 receptors; the endogenous cannabinoids anandamide and 2-arachidonoylglycerol; and the indirect cannabinoid modulators fatty acid amide hydrolase and monoacylglycerol lipase; that have shown abnormalities in basic research studies investigating mechanisms of aggression. |
2020-09-29 |
2023-08-13 |
human |
Abhilash Perisetti, Afrina Hossain Rimu, Salman Ali Khan, Pardeep Bansal, Hemant Goya. Role of cannabis in inflammatory bowel diseases. Annals of gastroenterology. vol 33. issue 2. 2020-09-28. PMID:32127734. |
endogenous circulating cannabinoids, or endocannabinoids, such as anandamide and 2-arachidonoyl-glycerol, their metabolizing enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) and 2 g-protein coupled cannabinoid receptors, cb1 and cb2, together represent the endocannabinoid system and are present throughout the human body. |
2020-09-28 |
2023-08-13 |
human |
Marie Fitzgibbon, Daniel M Kerr, Rebecca J Henry, David P Finn, Michelle Roch. Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31505257. |
furthermore, repeated ifn-α and/or formalin administration did not alter mrna expression of genes encoding the endocannabinoid catabolic enzymes (fatty acid amide hydrolase or monoacylglycerol lipase) or endocannabinoid receptor targets (cb |
2020-09-16 |
2023-08-13 |
mouse |
Zhen Chen, Wakana Mori, Xiaoyun Deng, Ran Cheng, Daisuke Ogasawara, Genwei Zhang, Michael A Schafroth, Kenneth Dahl, Hualong Fu, Akiko Hatori, Tuo Shao, Yiding Zhang, Tomoteru Yamasaki, Xiaofei Zhang, Jian Rong, Qingzhen Yu, Kuan Hu, Masayuki Fujinaga, Lin Xie, Katsushi Kumata, Yuancheng Gou, Jingjin Chen, Shuyin Gu, Liang Bao, Lu Wang, Thomas Lee Collier, Neil Vasdev, Yihan Shao, Jun-An Ma, Benjamin F Cravatt, Christopher Fowler, Lee Josephson, Ming-Rong Zhang, Steven H Lian. Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. Journal of medicinal chemistry. vol 62. issue 7. 2020-09-14. PMID:30829483. |
monoacylglycerol lipase (magl) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-ag) in the endocannabinoid system (ecb). |
2020-09-14 |
2023-08-13 |
Not clear |
Sara Martínez-Torres, Laura Cutando, Antoni Pastor, Ako Kato, Kenji Sakimura, Rafael de la Torre, Emmanuel Valjent, Rafael Maldonado, Masanobu Kano, Andrés Ozait. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31251974. |
monoacylglycerol lipase (magl) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-ag), producing arachidonic acid (aa) and glycerol. |
2020-08-14 |
2023-08-13 |
mouse |
Riccardo Castelli, Laura Scalvini, Federica Vacondio, Alessio Lodola, Mattia Anselmi, Stefano Vezzosi, Caterina Carmi, Michele Bassi, Francesca Ferlenghi, Silvia Rivara, Ingvar R Møller, Kasper D Rand, Jennifer Daglian, Don Wei, Emmanuel Y Dotsey, Faizy Ahmed, Kwang-Mook Jung, Nephi Stella, Simar Singh, Marco Mor, Daniele Piomell. Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines. Journal of medicinal chemistry. vol 63. issue 3. 2020-08-03. PMID:31714779. |
we describe a set of benzisothiazolinone (btz) derivatives that are potent inhibitors of monoacylglycerol lipase (mgl), the primary degrading enzyme for the endocannabinoid 2-arachidonoyl- |
2020-08-03 |
2023-08-13 |
Not clear |
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy Lovenberg, Pascal Bonaventur. Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor. The Journal of pharmacology and experimental therapeutics. vol 372. issue 3. 2020-07-06. PMID:31818916. |
the serine hydrolase monoacylglycerol lipase (magl) is the rate-limiting enzyme responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-ag) into arachidonic acid and glycerol. |
2020-07-06 |
2023-08-13 |
human |
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy Lovenberg, Pascal Bonaventur. Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor. The Journal of pharmacology and experimental therapeutics. vol 372. issue 3. 2020-07-06. PMID:31818916. |
significance statement: potentiation of endocannabinoid signaling activity via inhibition of the serine hydrolase monoacylglycerol lipase (magl) is an appealing strategy in the development of treatments for several disorders, including ones related to mood, pain, and inflammation. |
2020-07-06 |
2023-08-13 |
human |
Lei Zhang, Christopher R Butler, Kevin P Maresca, Akihiro Takano, Sangram Nag, Zhisheng Jia, Ryosuke Arakawa, Justin R Piro, Tarek Samad, Deborah L Smith, Deane M Nason, Steven O'Neil, Laura McAllister, Klaas Schildknegt, Patrick Trapa, Timothy J McCarthy, Anabella Villalobos, Christer Halldi. Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity. Journal of medicinal chemistry. vol 62. issue 18. 2020-06-22. PMID:31483137. |
monoacylglycerol lipase (magl), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. |
2020-06-22 |
2023-08-13 |
Not clear |
Jia Sun, Ya-Qun Zhou, Shu-Ping Chen, Xiao-Mei Wang, Bing-Yang Xu, Dan-Yang Li, Yu-Ke Tian, Da-Wei Y. The endocannabinoid system: Novel targets for treating cancer induced bone pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-23. PMID:31627091. |
targeting non-selective cannabinoid 1 receptors or selective cannabinoid 2 receptors, and modulation of peripheral aea and 2-ag, as well as the inhibition the function of fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have produced analgesic effects in animal models of cibp. |
2020-04-23 |
2023-08-13 |
Not clear |
Yasushi Hattori, Kazunobu Aoyama, Jun Maeda, Naoto Arimura, Yasuko Takahashi, Masako Sasaki, Masayuki Fujinaga, Chie Seki, Yuji Nagai, Kazunori Kawamura, Tomoteru Yamasaki, Ming-Rong Zhang, Makoto Higuchi, Tatsuki Koik. Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-( Journal of medicinal chemistry. vol 62. issue 5. 2020-04-13. PMID:30753069. |
design, synthesis, and evaluation of (4 r)-1-{3-[2-( monoacylglycerol lipase (magl) is a cytosolic serine hydrolase involved in endocannabinoid and inflammatory signaling. |
2020-04-13 |
2023-08-13 |
mouse |
Abir T El-Alfy, Ehab A Abourashed, Christina Patel, Nunmoula Mazhari, HeaRe An, Andrew Jeo. Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase. The Journal of pharmacy and pharmacology. vol 71. issue 12. 2020-03-27. PMID:31595522. |
the study aimed to identify nutmeg compounds that indirectly interact with the endocannabinoid system through inhibition of the fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) enzymes. |
2020-03-27 |
2023-08-13 |
Not clear |
Yuki Ito, Motohiro Tomizawa, Kazutaka Suzuki, Yuichi Shirakawa, Hiromasa Ono, Keishi Adachi, Himiko Suzuki, Kenji Shimomura, Toshitaka Nabeshima, Michihiro Kamijim. Organophosphate Agent Induces ADHD-Like Behaviors via Inhibition of Brain Endocannabinoid-Hydrolyzing Enzyme(s) in Adolescent Male Rats. Journal of agricultural and food chemistry. vol 68. issue 8. 2020-03-11. PMID:31995978. |
the present investigation employs ethyl octylphosphonofluoridate (eopf) as an op-probe, which is an extremely potent inhibitor of endocannabinoid (ec, anandamide and 2-arachidonoylglycerol)-hydrolyzing enzymes: that is, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2020-03-11 |
2023-08-13 |
rat |
Carlotta Granchi, Margherita Lapillo, Sandra Glasmacher, Giulia Bononi, Cristina Licari, Giulio Poli, Maguie El Boustani, Isabella Caligiuri, Flavio Rizzolio, Jürg Gertsch, Marco Macchia, Filippo Minutolo, Tiziano Tuccinardi, Andrea Chicc. Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor. Journal of medicinal chemistry. vol 62. issue 4. 2020-03-03. PMID:30715876. |
monoacylglycerol lipase (magl) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes. |
2020-03-03 |
2023-08-13 |
Not clear |
Janis Szeremeta, Jessica Karlsson, Mireille Alhouayek, Christopher J Fowle. Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells. Prostaglandins & other lipid mediators. vol 142. 2020-01-27. PMID:30978461. |
the expression of mgll, the gene coding for the 2-arachidonoylglycerol hydrolytic enzyme monoacylglycerol lipase (magl), was found to be 85 and 340 fold lower than the expression levels for the genes coding for alpha/beta-hydrolase domain containing 6 and 12 (abhd6, abhd12), which are alternative hydrolytic enzymes for this endocannabinoid. |
2020-01-27 |
2023-08-13 |
human |
Sara K Dempsey, Ashley M Gesseck, Ashfaq Ahmad, Zdravka Daneva, Joseph K Ritter, Justin L Pokli. Formation of HETE-EAs and dihydroxy derivatives in mouse kidney tissue and analysis by high-performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1126-1127. 2019-12-30. PMID:31437772. |
the endocannabinoid system consists of the two major cannabinoid receptor agonists, anandamide (aea) and 2-arachidonylglycerol (2-ag), their hydrolyzing enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), and the cannabinoid receptors, cb |
2019-12-30 |
2023-08-13 |
mouse |