| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
consistent with the "loss of trophic factor hypothesis of ad," we propose that ache inhibitors enhance acetylcholine-dependent release and uptake of ngf, thereby sustaining cholinergic neuronal viability and thus lowing ad-associated degeneration of the cbf, to delay dementia progression ultimately. |
2021-12-16 |
2023-08-13 |
Not clear |
| Yulia V Dobryakova, Yulia S Spivak, Maria I Zaichenko, Alena A Koryagina, Vladimir A Markevich, Mikhail Yu Stepanichev, Alexey P Bolshako. Intrahippocampal Adeno-Associated Virus-Mediated Overexpression of Nerve Growth Factor Reverses 192IgG-Saporin-Induced Impairments of Hippocampal Plasticity and Behavior. Frontiers in neuroscience. vol 15. 2021-12-07. PMID:34867156. |
here, we used a model of cholinergic deficit caused by immunotoxin 192igg-saporin to study possible beneficial effects of adeno-associated virus (aav)-mediated overexpression of nerve growth factor (ngf) in the hippocampus of rats with cholinergic deficit. |
2021-12-07 |
2023-08-13 |
rat |
| Yulia V Dobryakova, Yulia S Spivak, Maria I Zaichenko, Alena A Koryagina, Vladimir A Markevich, Mikhail Yu Stepanichev, Alexey P Bolshako. Intrahippocampal Adeno-Associated Virus-Mediated Overexpression of Nerve Growth Factor Reverses 192IgG-Saporin-Induced Impairments of Hippocampal Plasticity and Behavior. Frontiers in neuroscience. vol 15. 2021-12-07. PMID:34867156. |
suspension of recombinant aav carrying control cassette or cassette with ngf was injected into both hippocampi of control rats or rats with cholinergic deficit induced by intraseptal injection of 192igg-saporin. |
2021-12-07 |
2023-08-13 |
rat |
| Yulia V Dobryakova, Yulia S Spivak, Maria I Zaichenko, Alena A Koryagina, Vladimir A Markevich, Mikhail Yu Stepanichev, Alexey P Bolshako. Intrahippocampal Adeno-Associated Virus-Mediated Overexpression of Nerve Growth Factor Reverses 192IgG-Saporin-Induced Impairments of Hippocampal Plasticity and Behavior. Frontiers in neuroscience. vol 15. 2021-12-07. PMID:34867156. |
ngf overexpression in the rats with cholinergic deficit restored normal animal behavior in y-maze and beam-walking test. |
2021-12-07 |
2023-08-13 |
rat |
| Katharina Steiner, Christian Humpe. Microcontact Printing of Cholinergic Neurons in Organotypic Brain Slices. Frontiers in neurology. vol 12. 2021-12-07. PMID:34867765. |
the reasons for the damage of the cholinergic neurons are not clear, but the nerve growth factor (ngf) is the most potent trophic factor to support the survival of these neurons. |
2021-12-07 |
2023-08-13 |
mouse |
| Katharina Steiner, Christian Humpe. Microcontact Printing of Cholinergic Neurons in Organotypic Brain Slices. Frontiers in neurology. vol 12. 2021-12-07. PMID:34867765. |
as ngf alone could not be printed on the membranes, ngf was embedded into collagen hydrogels and the brain slices were placed at the center of the microprints and the cholinergic neurons that survived. |
2021-12-07 |
2023-08-13 |
mouse |
| Tugba Gulsun, Buket Ucar, Selma Sahin, Christian Humpe. The Organic Cation Transporter 2 Inhibitor Quinidine Modulates the Neuroprotective Effect of Nerve Growth Factor and Memantine on Cholinergic Neurons of the Basal Nucleus of Meynert in Organotypic Brain Slices. Pharmacology. vol 106. issue 7-8. 2021-11-23. PMID:33979803. |
nerve growth factor (ngf) is the most potent protective factor for cholinergic neurons, additionally the nmda antagonist memantine blocks glutamate-mediated excitotoxic activity. |
2021-11-23 |
2023-08-13 |
Not clear |
| Tugba Gulsun, Buket Ucar, Selma Sahin, Christian Humpe. The Organic Cation Transporter 2 Inhibitor Quinidine Modulates the Neuroprotective Effect of Nerve Growth Factor and Memantine on Cholinergic Neurons of the Basal Nucleus of Meynert in Organotypic Brain Slices. Pharmacology. vol 106. issue 7-8. 2021-11-23. PMID:33979803. |
we hypothesize that quinidine can modulate the protective effects of ngf and memantine on cholinergic neurons in organotypic brain slices of the nucleus basalis of meynert (nbm). |
2021-11-23 |
2023-08-13 |
Not clear |
| Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki, Yonehiro Kanemur. Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro. Molecular brain. vol 14. issue 1. 2021-11-18. PMID:34629097. |
the presence or absence of ngf, which is required for the survival of cholinergic neurons, had no effect on their cell fractionation. |
2021-11-18 |
2023-08-13 |
human |
| Giuseppina Amadoro, Valentina Latina, Bijorn Omar Balzamino, Rosanna Squitti, Monica Varano, Pietro Calissano, Alessandra Micer. Nerve Growth Factor-Based Therapy in Alzheimer's Disease and Age-Related Macular Degeneration. Frontiers in neuroscience. vol 15. 2021-09-29. PMID:34566573. |
imbalance in nerve growth factor (ngf) signaling, metabolism, and/or defect in ngf transport to the basal forebrain cholinergic neurons occurs in patients affected with ad. |
2021-09-29 |
2023-08-13 |
Not clear |
| Giuseppina Amadoro, Valentina Latina, Bijorn Omar Balzamino, Rosanna Squitti, Monica Varano, Pietro Calissano, Alessandra Micer. Nerve Growth Factor-Based Therapy in Alzheimer's Disease and Age-Related Macular Degeneration. Frontiers in neuroscience. vol 15. 2021-09-29. PMID:34566573. |
the neuroprotective and regenerative effects of ngf on cholinergic neurons have been largely demonstrated, both in animal models of ad and in living patients. |
2021-09-29 |
2023-08-13 |
Not clear |
| Yue Zhao, Yifei Dong, Qi Ge, Pengbo Cui, Na Sun, Songyi Li. Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway. Food & function. vol 12. issue 17. 2021-09-02. PMID:34259275. |
our results demonstrated that ndeelnk supplementation alleviated scopolamine-induced pc12 cell damage by improving the cholinergic system, increasing energy metabolism and upregulating the expression of phosphorylated protein kinase a (p-pka), brain-derived neurotrophic factor (bndf) and nerve growth factor (ngf) signaling proteins in in vitro experiments. |
2021-09-02 |
2023-08-13 |
Not clear |
| Rowan Pentz, M Florencia Iulit. The NGF Metabolic Pathway: New Opportunities for Biomarker Research and Drug Target Discovery : NGF Pathway Biomarkers and Drug Targets. Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453291. |
a novel model that explains the preferential vulnerability of basal forebrain cholinergic neurons in ad as the result of pathological alterations to nerve growth factor (ngf) metabolism offers an integrated investigative platform for the development of such biomarkers and therapeutics. |
2021-08-31 |
2023-08-13 |
Not clear |
| Rowan Pentz, M Florencia Iulit. The NGF Metabolic Pathway: New Opportunities for Biomarker Research and Drug Target Discovery : NGF Pathway Biomarkers and Drug Targets. Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453291. |
by positing a reciprocal trophic interaction between the basal forebrain and its target tissues, this model can also explain the disease-modifying nature of the cholinergic deficit in ad and can incorporate other key factors in basal forebrain cholinergic degeneration, including ngf receptor changes and retrograde transport deficits in ad. |
2021-08-31 |
2023-08-13 |
Not clear |
| A Claudio Cuell. Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer's Pathology. Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453296. |
this work from studies on potentially neuro-reparative gangliosides, their interactions with ngf, the role of exogenous ngf in the recovery of degenerating cholinergic neurons of the basal forebrain to the evidence that endogenous ngf maintains the "day-to-day" cortical synaptic phenotype and the discovery of a novel cns "ngf metabolic pathway." |
2021-08-31 |
2023-08-13 |
Not clear |
| Viviana Triaca, Francesca Ruberti, Nadia Can. NGF and the Amyloid Precursor Protein in Alzheimer's Disease: From Molecular Players to Neuronal Circuits. Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453297. |
in addition, the neurotrophic factor hypothesis posits that the loss nerve growth factor (ngf) signalling in ad may account for the vulnerability to atrophy of bfcns and consequent impairment of cholinergic functions. |
2021-08-31 |
2023-08-13 |
mouse |
| Christian Humpe. NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimer's Disease? Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453299. |
nerve growth factor (ngf) is the most potent growth factor to support the survival of these cholinergic neurons. |
2021-08-31 |
2023-08-13 |
Not clear |
| Christian Humpe. NGF Released from Blood Cells or Collagen Hydrogels as a Therapeutic Target in Alzheimer's Disease? Advances in experimental medicine and biology. vol 1331. 2021-08-31. PMID:34453299. |
thus, researchers are interested to deliver ngf directly into the brain to the cholinergic neurons. |
2021-08-31 |
2023-08-13 |
Not clear |
| Sonia Do Carmo, Benjamin Kannel, A Claudio Cuell. Nerve Growth Factor Compromise in Down Syndrome. Frontiers in aging neuroscience. vol 13. 2021-08-27. PMID:34434101. |
the basal forebrain cholinergic system relies on trophic support by nerve growth factor (ngf) to maintain its phenotype and function. |
2021-08-27 |
2023-08-13 |
Not clear |
| Sonia Do Carmo, Benjamin Kannel, A Claudio Cuell. Nerve Growth Factor Compromise in Down Syndrome. Frontiers in aging neuroscience. vol 13. 2021-08-27. PMID:34434101. |
in alzheimer's disease (ad), basal forebrain cholinergic neurons (bfcns) undergo progressive atrophy, suggesting a deficit in ngf trophic support. |
2021-08-27 |
2023-08-13 |
Not clear |