| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Viviana Triaca, Elena Fico, Valentina Sposato, Silvia Caioli, Maria Teresa Ciotti, Cristina Zona, Delio Mercanti, Diego La Mendola, Cristina Satriano, Enrico Rizzarelli, Paola Tirassa, Pietro Calissan. hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay. Biomolecules. vol 10. issue 2. 2021-03-29. PMID:32024191. |
furthermore, the acetylated derivative ac-hngf1-14 demonstrated an optimal ngf mimetic activity in both neuronal paradigms and an electrophysiological profile similar to ngf in cholinergic neurons. |
2021-03-29 |
2023-08-13 |
human |
| Rowan Pentz, M Florencia Iulita, Maya Mikutra-Cencora, Adriana Ducatenzeiler, David A Bennett, A Claudio Cuell. A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology. Neurobiology of disease. vol 148. 2021-03-23. PMID:33130223. |
these results suggest that mmp-3 upregulation in ad might contribute to ngf dysmetabolism, and therefore to cholinergic atrophy and cognitive deficits, in a sex-specific manner. |
2021-03-23 |
2023-08-13 |
rat |
| Joseph M Hall, Fernando Gomez-Pinilla, Lisa M Savag. Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30443202. |
to determine which neurotrophin, brain-derived neurotrophic factor (bdnf) or nerve growth factor (ngf), is critical for exercise-induced cholinergic improvements, control and amnestic rats had either ngf or bdnf sequestered by trka-igg or trkb-igg coated microbeads placed within the dorsal hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Kenneth E Miller, Gregory E Frierdich, Robert H Dillard, Robert H Soriano, Dikla G Rouf. Intermittent vs Continuous Administration of Nerve Growth Factor to Injured Medial Septal Cholinergic Neurons in Rat Basal Forebrain. Neuroscience and medicine. vol 5. issue 2. 2020-10-01. PMID:30473908. |
many medial septal neurons of the basal forebrain are dependent on nerve growth factor (ngf) from the hippocampus for survival and maintenance of a cholinergic phenotype. |
2020-10-01 |
2023-08-13 |
rat |
| Kenneth E Miller, Gregory E Frierdich, Robert H Dillard, Robert H Soriano, Dikla G Rouf. Intermittent vs Continuous Administration of Nerve Growth Factor to Injured Medial Septal Cholinergic Neurons in Rat Basal Forebrain. Neuroscience and medicine. vol 5. issue 2. 2020-10-01. PMID:30473908. |
when deprived of their source of ngf by axotomy, medial septal neuronal cell bodies atrophy and lose their cholinergic markers. |
2020-10-01 |
2023-08-13 |
rat |
| Valentina Latina, Silvia Caioli, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amador. NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618634. |
basal forebrain cholinergic neurons (bfcns) depend on nerve growth factor (ngf) for their survival/differentiation and innervate cortical and hippocampal regions involved in memory/learning processes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sumonto Mitra, Homira Behbahani, Maria Eriksdotte. Innovative Therapy for Alzheimer's Disease-With Focus on Biodelivery of NGF. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30804738. |
the neurotrophic molecule, nerve growth factor (ngf), plays a major role in the maintenance of cholinergic neurons integrity and function, both during development and adulthood. |
2020-10-01 |
2023-08-13 |
Not clear |
| A Claudio Cuello, Rowan Pentz, Hélène Hal. The Brain NGF Metabolic Pathway in Health and in Alzheimer's Pathology. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30809111. |
basal forebrain (bf) cholinergic nuclei depend on target-derived ngf for survival during development and for the maintenance of a classical cholinergic phenotype during adulthood. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xu-Qiao Chen, William C Moble. Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31133787. |
a second hypothesis, prompted by the selective loss of cholinergic neurons and the discovery of central nervous system (cns) neurotrophic factors, including nerve growth factor (ngf), prompted the "deficient neurotrophic hypothesis" (chen et al., 2018). |
2020-10-01 |
2023-08-13 |
Not clear |
| Viviana Triaca, Pietro Calissan. Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story? Neural regeneration research. vol 11. issue 10. 2020-09-30. PMID:27904476. |
this could be also true in the case of nerve growth factor (ngf) alterations in sporadic alzheimer's disease (ad), an age-related pathology characterized by cholinergic loss, amyloid plaques and neurofibrillary tangles. |
2020-09-30 |
2023-08-13 |
Not clear |
| Viviana Triaca, Pietro Calissan. Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story? Neural regeneration research. vol 11. issue 10. 2020-09-30. PMID:27904476. |
in fact, the pathway activated by ngf, a key neurotrophin for the metabolism of basal forebrain cholinergic neurons (bfcn), is one of the first homeostatic systems affected in prodromal ad. |
2020-09-30 |
2023-08-13 |
Not clear |
| Neta Zilony-Hanin, Michal Rosenberg, Michal Richman, Ronen Yehuda, Hadas Schori, Menachem Motiei, Shai Rahimipour, Alexander Groisman, Ester Segal, Orit Shef. Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain. Small (Weinheim an der Bergstrasse, Germany). vol 15. issue 45. 2020-09-28. PMID:31482695. |
nerve growth factor (ngf) plays a vital role in reducing the loss of cholinergic neurons in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Shahram Darabi, Taki Tiraihi, Maryam Nazm Bojnordi, Hatef Ghasemi Hamidabadi, Nourollah Rezaei, Maria Zahiri, Rafieh Alizade. Trans-Differentiation of Human Dental Pulp Stem Cells Into Cholinergic-Like Neurons Via Nerve Growth Factor. Basic and clinical neuroscience. vol 10. issue 6. 2020-09-28. PMID:32477478. |
in this study, human dental pulp stem cells (hdpscs) were differentiated into the cholinergic neurons by β-mercaptoethanol in the preinduction phase and also by the nerve growth factor (ngf) in the induction phase. |
2020-09-28 |
2023-08-13 |
human |
| Paolo de Girolamo, Adele Leggieri, Antonio Palladino, Carla Lucini, Chiara Attanasio, Livia D'Angel. Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Brain sciences. vol 10. issue 6. 2020-09-28. PMID:32575701. |
cholinergic system and ngf receptors: insights from the brain of the short-lived fish nerve growth factor (ngf) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yong-Cheng Wang, Du-Fang Ma, Ping Jiang, Yi-Mei Zhang, Guo-Feng Zhou, Jin-Long Yang, Zhao-Yu Li, Xiao L. Guizhi Decoction () Inhibits Cholinergic Transdifferentiation by Regulating Imbalance of NGF and LIF in Salt-Sensitive Hypertensive Heart Failure Rats. Chinese journal of integrative medicine. vol 26. issue 3. 2020-09-24. PMID:31111424. |
guizhi decoction () inhibits cholinergic transdifferentiation by regulating imbalance of ngf and lif in salt-sensitive hypertensive heart failure rats. |
2020-09-24 |
2023-08-13 |
rat |
| Yong-Cheng Wang, Du-Fang Ma, Ping Jiang, Yi-Mei Zhang, Guo-Feng Zhou, Jin-Long Yang, Zhao-Yu Li, Xiao L. Guizhi Decoction () Inhibits Cholinergic Transdifferentiation by Regulating Imbalance of NGF and LIF in Salt-Sensitive Hypertensive Heart Failure Rats. Chinese journal of integrative medicine. vol 26. issue 3. 2020-09-24. PMID:31111424. |
to observe the imbalance of anatomical and functional innervation factors of sympathetic nerves, nerve growth factor (ngf) and leukemia inhibitory factor (lif), in salt-sensitive hypertensive heart failure rats and to explore the effects of treatment with guizhi decoction () on sympathetic remodeling by inhibiting cholinergic transdifferentiation. |
2020-09-24 |
2023-08-13 |
rat |
| K Xhima, K Markham-Coultes, H Nedev, S Heinen, H U Saragovi, K Hynynen, I Auber. Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease. Science advances. vol 6. issue 4. 2020-09-23. PMID:32010781. |
in animal models of injury and aging, nerve growth factor (ngf) enhances cholinergic cell survival and function, contributing to improved memory. |
2020-09-23 |
2023-08-13 |
mouse |
| Märta Dahlström, Gunnar Nordvall, Erik Sundström, Elisabet Åkesson, Gunilla Tegerstedt, Maria Eriksdotter, Pontus Forsel. Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons. The European journal of neuroscience. vol 50. issue 9. 2020-09-14. PMID:31301255. |
ngf deficiency in the basal forebrain precedes degeneration of basal forebrain cholinergic neurons in alzheimer's disease, contributing to memory decline. |
2020-09-14 |
2023-08-13 |
human |
| Giovanna Testa, Marco Mainardi, Chiara Morelli, Francesco Olimpico, Laura Pancrazi, Carla Petrella, Cinzia Severini, Rita Florio, Francesca Malerba, Antonia Stefanov, Enrica Strettoi, Rossella Brandi, Ivan Arisi, Paul Heppenstall, Mario Costa, Simona Capsoni, Antonino Cattane. The NGF The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 49. 2020-07-06. PMID:31685654. |
ngf also has central actions in the brain, where it regulates the phenotypic maintenance of cholinergic neurons. |
2020-07-06 |
2023-08-13 |
Not clear |
| Virginia Protto, Marzia Soligo, Maria Egle De Stefano, Stefano Farioli-Vecchioli, Lionel N J L Marlier, Robert Nisticò, Luigi Mann. Electroacupuncture in rats normalizes the diabetes-induced alterations in the septo-hippocampal cholinergic system. Hippocampus. vol 29. issue 10. 2020-05-27. PMID:30870587. |
these alterations are associated with dysregulation of several cholinergic markers, such as the ngf receptor system and the acetylcholine biosynthetic enzyme choline-acetyl transferase (chat), in the medial septum and its target, the hippocampus. |
2020-05-27 |
2023-08-13 |
rat |