| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Do Carmo, Benjamin Kannel, A Claudio Cuell. Nerve Growth Factor Compromise in Down Syndrome. Frontiers in aging neuroscience. vol 13. 2021-08-27. PMID:34434101. |
as individuals with ds inexorably develop ad, we then review findings that support the existence of a similar ngf dysmetabolism in ds coinciding with atrophy of the basal forebrain cholinergic system. |
2021-08-27 |
2023-08-13 |
Not clear |
| Michael J Castle, Fernando C Baltanás, Imre Kovacs, Alan H Nagahara, David Barba, Mark H Tuszynsk. Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery. Human gene therapy. vol 31. issue 7-8. 2021-08-18. PMID:32126838. |
nerve growth factor (ngf) gene therapy rescues and stimulates cholinergic neurons, which degenerate in alzheimer's disease (ad). |
2021-08-18 |
2023-08-13 |
Not clear |
| Michael J Castle, Fernando C Baltanás, Imre Kovacs, Alan H Nagahara, David Barba, Mark H Tuszynsk. Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery. Human gene therapy. vol 31. issue 7-8. 2021-08-18. PMID:32126838. |
before concluding that ngf gene therapy is ineffective, it must be shown that aav2-ngf successfully engaged the target cholinergic neurons of the basal forebrain. |
2021-08-18 |
2023-08-13 |
Not clear |
| Agustin Benitez, Raul Riquelme, Miguel Del Campo, Camila Araya, Hernan E Lar. Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary. Frontiers in endocrinology. vol 12. 2021-08-10. PMID:33716987. |
the nerve growth factor (ngf) was the first neurotrophic factor found to regulate ovarian noradrenergic neurons and the cholinergic neurons in the central nervous system. |
2021-08-10 |
2023-08-13 |
rat |
| Agustin Benitez, Raul Riquelme, Miguel Del Campo, Camila Araya, Hernan E Lar. Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary. Frontiers in endocrinology. vol 12. 2021-08-10. PMID:33716987. |
the aim of this study was to determine whether ngf is one of the participating neurotrophic factors in the activation of the sympathetic and cholinergic system of the ovary |
2021-08-10 |
2023-08-13 |
rat |
| Maria Eriksdotter, Sumonto Mitr. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225964. |
in recent years, other approaches to influence the degenerating cholinergic system in ad focusing on nerve growth factor (ngf) have been undertaken. |
2021-07-28 |
2023-08-13 |
Not clear |
| Maria Eriksdotter, Sumonto Mitr. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225964. |
ngf is required for the survival and function of the basal forebrain cholinergic neurons, the most important being the nucleus basalis of meynert (nbm). |
2021-07-28 |
2023-08-13 |
Not clear |
| Maria Eriksdotter, Sumonto Mitr. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225964. |
since there is a lack of ngf and its receptors in the ad forebrain, the hypothesis is that local delivery of ngf to the nbm could revive the cholinergic circuitry and thereby restore cognitive functions. |
2021-07-28 |
2023-08-13 |
Not clear |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
both ngf and the cholinergic system play important roles in learning and memory. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
ngf is essential for maintaining cholinergic innervation of the hippocampus, but it is unclear whether the supportive effect of ngf on learning and memory is specifically dependent upon intact hippocampal cholinergic innervation. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
overexpression of ngf in the hippocampus of ngf gene knockout mice rescued spatial memory and partially restored cholinergic innervations, but not anxiety. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
however, ngf overexpression in the hippocampus failed to rescue spatial memory in mice with hippocampal-selective cholinergic fiber depletion. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
in conclusion, we demonstrate the impact of ngf deficiency in the brain and provide evidence that the effect of ngf on spatial memory is reliant on intact cholinergic innervations in the hippocampus. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N Carter, Guo-Jen Huan. The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723225. |
these results suggest that adequate cholinergic targeting may be a critical requirement for successful use of ngf gene therapy of alzheimer's disease. |
2021-06-28 |
2023-08-13 |
mouse |
| Rowan Pentz, M Florencia Iulita, Adriana Ducatenzeiler, David A Bennett, A Claudio Cuell. The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease. Molecular psychiatry. 2021-06-02. PMID:32488129. |
basal forebrain cholinergic neurons require ngf for maintenance of cholinergic phenotype, are critical for cognition, and degenerate early in alzheimer's disease (ad). |
2021-06-02 |
2023-08-13 |
human |
| Lan-Ting Zhou, Juan Zhang, Lu Tan, He-Zhou Huang, Yang Zhou, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Chengye Yao, Dan Li. Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-04-28. PMID:33898468. |
elevated levels of mir-144-3p induce cholinergic degeneration by impairing the maturation of ngf in alzheimer's disease. |
2021-04-28 |
2023-08-13 |
mouse |
| Lan-Ting Zhou, Juan Zhang, Lu Tan, He-Zhou Huang, Yang Zhou, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Chengye Yao, Dan Li. Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-04-28. PMID:33898468. |
nerve growth factor (ngf) is secreted in brain regions that receive projections from the basal forebrain cholinergic neurons. |
2021-04-28 |
2023-08-13 |
mouse |
| Lan-Ting Zhou, Juan Zhang, Lu Tan, He-Zhou Huang, Yang Zhou, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Chengye Yao, Dan Li. Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-04-28. PMID:33898468. |
collectively, our research revealed potential mechanisms for the disturbance of ngf maturation and cholinergic degeneration in ad and identified a potential therapeutic target for ad. |
2021-04-28 |
2023-08-13 |
mouse |
| Viviana Triaca, Elena Fico, Valentina Sposato, Silvia Caioli, Maria Teresa Ciotti, Cristina Zona, Delio Mercanti, Diego La Mendola, Cristina Satriano, Enrico Rizzarelli, Paola Tirassa, Pietro Calissan. hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay. Biomolecules. vol 10. issue 2. 2021-03-29. PMID:32024191. |
here we investigated the ngf mimetic properties of the human ngf 1-14 sequence (hngf1-14) and its derivatives, by resorting to primary cholinergic and dorsal root ganglia (drg) neurons. |
2021-03-29 |
2023-08-13 |
human |
| Viviana Triaca, Elena Fico, Valentina Sposato, Silvia Caioli, Maria Teresa Ciotti, Cristina Zona, Delio Mercanti, Diego La Mendola, Cristina Satriano, Enrico Rizzarelli, Paola Tirassa, Pietro Calissan. hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay. Biomolecules. vol 10. issue 2. 2021-03-29. PMID:32024191. |
briefly, we observed that: 1) hngf1-14 peptides engage the ngf pathway through trka phosphorylation at tyrosine 490 (y490), and activation of shcc/pi3k and plc-γ/mapk signalling, promoting akt-dependent survival and creb-driven neuronal activity, as seen by levels of the immediate early gene c-fos, of the cholinergic marker choline acetyltransferase (chat), and of brain derived neurotrophic factor (bdnf); 2) their ngf mimetic activity is lost upon selective trka inhibition by means of gw441756; 3) hngf1-14 peptides are able to sustain drg survival and differentiation in absence of ngf. |
2021-03-29 |
2023-08-13 |
human |