| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Märta Dahlström, Gunnar Nordvall, Erik Sundström, Elisabet Åkesson, Gunilla Tegerstedt, Maria Eriksdotter, Pontus Forsel. Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons. The European journal of neuroscience. vol 50. issue 9. 2020-09-14. PMID:31301255. |
ngf deficiency in the basal forebrain precedes degeneration of basal forebrain cholinergic neurons in alzheimer's disease, contributing to memory decline. |
2020-09-14 |
2023-08-13 |
human |
| Giovanna Testa, Marco Mainardi, Chiara Morelli, Francesco Olimpico, Laura Pancrazi, Carla Petrella, Cinzia Severini, Rita Florio, Francesca Malerba, Antonia Stefanov, Enrica Strettoi, Rossella Brandi, Ivan Arisi, Paul Heppenstall, Mario Costa, Simona Capsoni, Antonino Cattane. The NGF The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 49. 2020-07-06. PMID:31685654. |
ngf also has central actions in the brain, where it regulates the phenotypic maintenance of cholinergic neurons. |
2020-07-06 |
2023-08-13 |
Not clear |
| Virginia Protto, Marzia Soligo, Maria Egle De Stefano, Stefano Farioli-Vecchioli, Lionel N J L Marlier, Robert Nisticò, Luigi Mann. Electroacupuncture in rats normalizes the diabetes-induced alterations in the septo-hippocampal cholinergic system. Hippocampus. vol 29. issue 10. 2020-05-27. PMID:30870587. |
these alterations are associated with dysregulation of several cholinergic markers, such as the ngf receptor system and the acetylcholine biosynthetic enzyme choline-acetyl transferase (chat), in the medial septum and its target, the hippocampus. |
2020-05-27 |
2023-08-13 |
rat |
| Virginia Protto, Marzia Soligo, Maria Egle De Stefano, Stefano Farioli-Vecchioli, Lionel N J L Marlier, Robert Nisticò, Luigi Mann. Electroacupuncture in rats normalizes the diabetes-induced alterations in the septo-hippocampal cholinergic system. Hippocampus. vol 29. issue 10. 2020-05-27. PMID:30870587. |
we then evaluated the effects of a 3-week treatment with low-frequency electroacupuncture on: (a) the expression and protein distribution of prongf in the hippocampus, (b) the tissue distribution and content of ngf receptors in the medial septum, (c) the neuronal cholinergic and glial phenotype in the septo-hippocampal circuitry. |
2020-05-27 |
2023-08-13 |
rat |
| Virginia Protto, Marzia Soligo, Maria Egle De Stefano, Stefano Farioli-Vecchioli, Lionel N J L Marlier, Robert Nisticò, Luigi Mann. Electroacupuncture in rats normalizes the diabetes-induced alterations in the septo-hippocampal cholinergic system. Hippocampus. vol 29. issue 10. 2020-05-27. PMID:30870587. |
in addition, electroacupuncture recovered to basal level the pro-neurotrophic ngf receptor tropomyosin receptor kinase-a content, down-regulated in medial septum cholinergic neurons by diabetes. |
2020-05-27 |
2023-08-13 |
rat |
| Virginia Protto, Marzia Soligo, Maria Egle De Stefano, Stefano Farioli-Vecchioli, Lionel N J L Marlier, Robert Nisticò, Luigi Mann. Electroacupuncture in rats normalizes the diabetes-induced alterations in the septo-hippocampal cholinergic system. Hippocampus. vol 29. issue 10. 2020-05-27. PMID:30870587. |
electroacupuncture could exert its effects on the septo-hippocampal cholinergic neurotransmission in diabetic rats, not only by rescuing the hippocampal muscarinic responsivity, as previously described, but also normalizing acetylcholine biosynthesis and ngf metabolism in the hippocampus. |
2020-05-27 |
2023-08-13 |
rat |
| Sylvia Josephy-Hernandez, Iulia Pirvulescu, Mario Maira, Tahar Aboulkassim, Tak Pan Wong, R Anne McKinney, H Uri Saragov. Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation. PloS one. vol 14. issue 6. 2020-02-11. PMID:31233568. |
in the brain, the trka receptor for nerve growth factor (ngf) is expressed primarily in the cholinergic system. |
2020-02-11 |
2023-08-13 |
mouse |
| Matthias Spranger, Dan Lindholm, Christine Bandtlow, Rolf Heumann, Hannes Gnahn, Martina Näher-Noé, Hans Thoene. Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin-1 and Various Growth Factors in Astrocyte Cultures and in vivo. The European journal of neuroscience. vol 2. issue 1. 2019-11-20. PMID:12106104. |
this, in turn, is an attractive alternative to the (long-term) infusion of ngf or the transplantation of ngf-secreting cells with the goal of providing trophic support to the cholinergic neurons of the basal forebrain nuclei. |
2019-11-20 |
2023-08-12 |
rat |
| L. Cavicchioli, T. P. Flanigan, G. Vantini, M. Fusco, P. Polato, G. Toffano, F. S. Walsh, A. Leo. NGF Amplifies Expression of NGF Receptor Messenger RNA in Forebrain Cholinergic Neurons of Rats. The European journal of neuroscience. vol 1. issue 3. 2019-11-20. PMID:12106156. |
ngf amplifies expression of ngf receptor messenger rna in forebrain cholinergic neurons of rats. |
2019-11-20 |
2023-08-12 |
rat |
| L. Cavicchioli, T. P. Flanigan, G. Vantini, M. Fusco, P. Polato, G. Toffano, F. S. Walsh, A. Leo. NGF Amplifies Expression of NGF Receptor Messenger RNA in Forebrain Cholinergic Neurons of Rats. The European journal of neuroscience. vol 1. issue 3. 2019-11-20. PMID:12106156. |
in addition, in this latter case, the increase in ngf receptor mrna was associated with an increase in ngf receptor-related immunoreactivity, most likely associated with the cholinergic neurons, in the septal area. |
2019-11-20 |
2023-08-12 |
rat |
| L. Cavicchioli, T. P. Flanigan, G. Vantini, M. Fusco, P. Polato, G. Toffano, F. S. Walsh, A. Leo. NGF Amplifies Expression of NGF Receptor Messenger RNA in Forebrain Cholinergic Neurons of Rats. The European journal of neuroscience. vol 1. issue 3. 2019-11-20. PMID:12106156. |
these results show that ngf itself may regulate expression of ngf receptor mrna and corresponding protein levels in forebrain cholinergic neurons and suggest that ngf effects in the cns may be mediated by an up-regulation of ngf receptors. |
2019-11-20 |
2023-08-12 |
rat |
| Michael S Rafii, Mark H Tuszynski, Ronald G Thomas, David Barba, James B Brewer, Robert A Rissman, Joao Siffert, Paul S Aise. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA neurology. vol 75. issue 7. 2019-10-21. PMID:29582053. |
nerve growth factor (ngf) is an endogenous neurotrophic factor that prevents the death and augments the functional state of cholinergic neurons of the basal forebrain, a cell population that undergoes extensive degeneration in alzheimer disease (ad). |
2019-10-21 |
2023-08-13 |
Not clear |
| Jinhong Wu, Bing Chen, Wenxian Li, Yanan Xia. Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma. Iranian journal of allergy, asthma, and immunology. vol 17. issue 2. 2019-09-18. PMID:29757584. |
immunohistochemistry semi-quantitative analysis of muscarinic acetylcholine receptor m3 (machr m3) and alpha-smooth muscle actin (a-sma) were measured by image pro plus (ipp), and qrt-pcr analysis of mrnas of cholinergic receptors, muscarinic 3 (chrm3), ngf and tropomyosin receptor kinase a (trka) were performed. |
2019-09-18 |
2023-08-13 |
mouse |
| Maria Eriksdotter, Manuel Navarro-Oviedo, Sumonto Mitra, Lars Wahlberg, Bengt Linderoth, Lars O Tjernberg, Homira Behbahan. Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro. Experimental cell research. vol 371. issue 1. 2019-09-18. PMID:30092220. |
alzheimer's disease (ad) is characterized by early degeneration of cholinergic neurons and decreased levels of nerve growth factor (ngf). |
2019-09-18 |
2023-08-13 |
Not clear |
| Maria Eriksdotter, Manuel Navarro-Oviedo, Sumonto Mitra, Lars Wahlberg, Bengt Linderoth, Lars O Tjernberg, Homira Behbahan. Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro. Experimental cell research. vol 371. issue 1. 2019-09-18. PMID:30092220. |
the results from our previous first-in-human studies on ecb of ngf to the basal forebrain cholinergic neurons were promising, but indicated some variability of long-term viability of the encapsulated cells and associated reduced ngf-release. |
2019-09-18 |
2023-08-13 |
Not clear |
| Bettina M Foidl, Buket Ucar, Alina Schwarz, Ana L Rebelo, Abhay Pandit, Christian Humpe. Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices. Journal of neuroscience methods. vol 295. 2019-06-19. PMID:29221639. |
nerve growth factor (ngf) is the most potent protein to support survival of cholinergic neurons. |
2019-06-19 |
2023-08-13 |
Not clear |
| Antonino Cattaneo, Simona Capson. Painless Nerve Growth Factor: A TrkA biased agonist mediating a broad neuroprotection via its actions on microglia cells. Pharmacological research. vol 139. 2019-05-13. PMID:30391352. |
nerve growth factor (ngf) is a therapeutic candidate for alzheimer's disease, based on its well known actions on basal forebrain cholinergic neurons. |
2019-05-13 |
2023-08-13 |
mouse |
| Antonino Cattaneo, Simona Capson. Painless Nerve Growth Factor: A TrkA biased agonist mediating a broad neuroprotection via its actions on microglia cells. Pharmacological research. vol 139. 2019-05-13. PMID:30391352. |
these studies demonstrate that microglia cells are a new target cell of ngf in the brain and have therapeutic significance: i) they establish that the neuroprotective actions of hngfp relies on a widespread exposure of the brain, ii) they identify a new anti-neurodegenerative pathway, linking hngfp to inflammatory chemokines and cytokines via microglia, a common target for new therapeutic opportunities for neurodegenerative diseases, iii) they extend the neuroprotective potential of hngfp beyond its classical cholinergic target, thereby widening the range of neurological diseases for which this neurotrophic factor might be used therapeutically, iv) they help interpreting the results of current ngf clinical trials in ad and the design of future trials with this new potent therapeutic candidate. |
2019-05-13 |
2023-08-13 |
mouse |
| Ryan P Vetreno, Fulton T Crew. Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin. PloS one. vol 13. issue 10. 2019-03-25. PMID:30296276. |
in addition, we find reductions in chat+ir somal size as well as the expression of the high-affinity nerve growth factor (ngf) receptor tropomyosin receptor kinase a (trka) and the low-affinity ngf receptor p75ntr, both of which are expressed on cholinergic neurons. |
2019-03-25 |
2023-08-13 |
human |
| Marc-Antoine Lauzon, Nathalie Faucheu. A small peptide derived from BMP-9 can increase the effect of bFGF and NGF on SH-SY5Y cells differentiation. Molecular and cellular neurosciences. vol 88. 2019-01-31. PMID:29341901. |
since it is known that the native protein, bmp-9, can act in synergy with other growth factors in the context of ad, here we study the potential synergistic effect of various combinations of spbmp-9 with bfgf, egf, igf-2 or ngf on the cholinergic differentiation of human neuroblastoma cells sh-sy5y. |
2019-01-31 |
2023-08-13 |
human |