| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emanuele Pesavento, Simona Capsoni, Luciano Domenici, Antonino Cattane. Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice. The European journal of neuroscience. vol 15. issue 6. 2002-06-12. PMID:11918663. |
basal forebrain cholinergic neurons are a major target for nerve-growth factor (ngf). |
2002-06-12 |
2023-08-12 |
mouse |
| Emanuele Pesavento, Simona Capsoni, Luciano Domenici, Antonino Cattane. Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice. The European journal of neuroscience. vol 15. issue 6. 2002-06-12. PMID:11918663. |
in order to investigate the relationship between cholinergic innervation and cortical synaptic plasticity, we exploited a transgenic mouse model in which the activity of ngf in the adult nervous system is neutralized by the expression of blocking antibodies to ngf itself (anti-ngf mice) [ruberti, f. et al. |
2002-06-12 |
2023-08-12 |
mouse |
| Emanuele Pesavento, Simona Capsoni, Luciano Domenici, Antonino Cattane. Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice. The European journal of neuroscience. vol 15. issue 6. 2002-06-12. PMID:11918663. |
a local, acute increase in the availability of acetylcholine rescues these synaptic plasticity deficits, thus indicating that a cholinergic system mediates the impairment of cortical plasticity at this early stage of the neurodegenerative process triggered by ngf neutralization. |
2002-06-12 |
2023-08-12 |
mouse |
| C E E M van der Zee, T Hag. Delayed NGF infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75(LNTR)-deficient mice. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934472. |
delayed ngf infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75(lntr)-deficient mice. |
2002-06-12 |
2023-08-12 |
mouse |
| C E E M van der Zee, T Hag. Delayed NGF infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75(LNTR)-deficient mice. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934472. |
p75(lntr)-deficient cholinergic neurons can respond to ngf as they were protected by ngf infusions that started immediately after the injury. |
2002-06-12 |
2023-08-12 |
mouse |
| C E E M van der Zee, T Hag. Delayed NGF infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75(LNTR)-deficient mice. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934472. |
these observations, the fact that lesioned p75(lntr)-deficient neurons atrophy faster, and that non-lesioned neurons hypertrophy in response to ngf in control but not in p75(lntr)-deficient mice, suggest that p75(lntr) is needed for tyrosine kinase a and ngf signaling efficiency.in conclusion, during adulthood p75(lntr) appears to play a beneficial role in the response of cholinergic neurons to injury, consistent with the proposed role of p75(lntr) in the enhancement of trka signaling and the transport of neurotrophins by these neurons. |
2002-06-12 |
2023-08-12 |
mouse |
| R L Klein, A C Hirko, C A Meyers, J R Grimes, N Muzyczka, E M Meye. NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats. Brain research. vol 875. issue 1-2. 2002-05-07. PMID:10967308. |
ngf gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats. |
2002-05-07 |
2023-08-12 |
rat |
| Hyemyung Seo, Andrew W Ferree, Ole Isacso. Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. The European journal of neuroscience. vol 15. issue 3. 2002-05-07. PMID:11876777. |
cortico-hippocampal app and ngf levels are dynamically altered by cholinergic muscarinic antagonist or m1 agonist treatment in normal mice. |
2002-05-07 |
2023-08-12 |
mouse |
| Hyemyung Seo, Andrew W Ferree, Ole Isacso. Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. The European journal of neuroscience. vol 15. issue 3. 2002-05-07. PMID:11876777. |
to determine whether altered cholinergic neurotransmission can modify the long-term secretion of amyloid precursor protein (app), endogenous levels of app and nerve growth factor (ngf), we administered a selective m1 muscarinic receptor agonist (rs86) or the muscarinic antagonist, atropine, for 7 days in vivo into young adult mice (c57bl/6j). |
2002-05-07 |
2023-08-12 |
mouse |
| Hyemyung Seo, Andrew W Ferree, Ole Isacso. Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. The European journal of neuroscience. vol 15. issue 3. 2002-05-07. PMID:11876777. |
these data suggest that a sustained increased cholinergic, m1-mediated neurotransmission will enhance secretion of alpha-apps in csf and adaptively reduce the levels of total app and ngf in the corticohippocampal regions of normal mice. |
2002-05-07 |
2023-08-12 |
mouse |
| Hyemyung Seo, Andrew W Ferree, Ole Isacso. Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. The European journal of neuroscience. vol 15. issue 3. 2002-05-07. PMID:11876777. |
the dynamic and adaptive regulation linking total app and ngf levels in normal adult mice is relevant for understanding the pathophysiology of conditions with cholinergic and app related pathologies, like alzheimer's disease and down's syndrome. |
2002-05-07 |
2023-08-12 |
mouse |
| Ramamohana R Jonnala, Alvin V Terry, Jerry J Buccafusc. Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo. Life sciences. vol 70. issue 13. 2002-03-27. PMID:11895105. |
impairment in nerve growth factor (ngf)-mediated support to basal forebrain cholinergic neurons may represent an initial insult to certain neural cells in alzheimer's disease (ad). |
2002-03-27 |
2023-08-12 |
rat |
| M A Silver, M Fagiolini, D C Gillespie, C L Howe, M G Frank, N P Issa, A Antonini, M P Stryke. Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738495. |
we conclude that ngf delivered locally to axon terminals of cholinergic basal forebrain neurons resulted in increases in protein expression at the cell body through retrograde signaling. |
2002-03-14 |
2023-08-12 |
human |
| Jennifer Ott Reilly, Irina D Karavanova, Kevin P Williams, Nagesh K Mahanthappa, Karen L Allendoerfe. Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons. Molecular and cellular neurosciences. vol 19. issue 1. 2002-03-12. PMID:11817900. |
cooperative effects of sonic hedgehog and ngf on basal forebrain cholinergic neurons. |
2002-03-12 |
2023-08-12 |
rat |
| Jennifer Ott Reilly, Irina D Karavanova, Kevin P Williams, Nagesh K Mahanthappa, Karen L Allendoerfe. Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons. Molecular and cellular neurosciences. vol 19. issue 1. 2002-03-12. PMID:11817900. |
in basal forebrain cultures, shh was added alone and in combination with nerve growth factor (ngf), and the number of cholinergic neurons was determined by choline acetyltransferase (chat) immunocytochemistry. |
2002-03-12 |
2023-08-12 |
rat |
| Francesco Mattia Rossi, Roberta Sala, Lamberto Maffe. Expression of the nerve growth factor receptors TrkA and p75NTR in the visual cortex of the rat: development and regulation by the cholinergic input. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 3. 2002-02-27. PMID:11826120. |
these results indicate that the cholinergic input is an important mediator of visual cortex responsiveness to ngf action. |
2002-02-27 |
2023-08-12 |
rat |
| M M Paula-Barbosa, S M Silva, J P Andrade, A Cadete-Leite, M D Madeir. Nerve growth factor restores mRNA levels and the expression of neuropeptides in the suprachiasmatic nucleus of rats submitted to chronic ethanol treatment and withdrawal. Journal of neurocytology. vol 30. issue 3. 2002-02-21. PMID:11709626. |
because suprachiasmatic neurons do not express trka, ngf might have exerted its effects either through direct signalling of suprachiasmatic neurons via p75(ntr) activation or, indirectly, by enhancing the activity of the cholinergic and/or glutamatergic afferents to the suprachiasmatic nucleus, or both. |
2002-02-21 |
2023-08-12 |
rat |
| M Fahnestock, B Michalski, B Xu, M D Coughli. The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Molecular and cellular neurosciences. vol 18. issue 2. 2001-12-04. PMID:11520181. |
nerve growth factor (ngf) is important for regulation, differentiation, and survival of peripheral and central nervous system neurons, including basal forebrain cholinergic neurons (bfcn) which degenerate in alzheimer's disease (ad). |
2001-12-04 |
2023-08-12 |
mouse |
| O Rahimi, S L Julian. Transplants of NGF-secreting fibroblasts restore stimulus-evoked activity in barrel cortex of basal-forebrain-lesioned rats. Journal of neurophysiology. vol 86. issue 4. 2001-12-04. PMID:11600663. |
we showed previously that exogenous delivery of nerve growth factor (ngf) to the lateral ventricle restores reduced functional activity toward normal despite persistent reductions in cortical cholinergic activity. |
2001-12-04 |
2023-08-12 |
rat |
| O Rahimi, S L Julian. Transplants of NGF-secreting fibroblasts restore stimulus-evoked activity in barrel cortex of basal-forebrain-lesioned rats. Journal of neurophysiology. vol 86. issue 4. 2001-12-04. PMID:11600663. |
these data support the idea that ngf can act directly on the cerebral cortex following reductions in cholinergic innervation. |
2001-12-04 |
2023-08-12 |
rat |