| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James M McCarthy, Markus Franke, Ulrike K Resenberger, Sibeal Waldron, Jeremy C Simpson, Jörg Tatzelt, Dietmar Appelhans, Mark S Roger. Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). PloS one. vol 8. issue 1. 2013-07-22. PMID:23383136. |
the 'protein only hypothesis' advocates that prp(sc), an abnormal isoform of the cellular protein prp(c), is the main and possibly sole component of prion infectious agents. |
2013-07-22 |
2023-08-12 |
cattle |
| James M McCarthy, Markus Franke, Ulrike K Resenberger, Sibeal Waldron, Jeremy C Simpson, Jörg Tatzelt, Dietmar Appelhans, Mark S Roger. Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). PloS one. vol 8. issue 1. 2013-07-22. PMID:23383136. |
of particular interest are synthetic polymers known as dendrimers which possess the unique ability to eliminate prp(sc) in both an intracellular and in vitro setting. |
2013-07-22 |
2023-08-12 |
cattle |
| James M McCarthy, Markus Franke, Ulrike K Resenberger, Sibeal Waldron, Jeremy C Simpson, Jörg Tatzelt, Dietmar Appelhans, Mark S Roger. Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). PloS one. vol 8. issue 1. 2013-07-22. PMID:23383136. |
these assays were used to demonstrate that mppig5 is a highly effective anti-prion drug which acts, at least in part, through the inhibition of prp(c) to prp(sc) conversion. |
2013-07-22 |
2023-08-12 |
cattle |
| Derek Silvius, Rose Pitstick, Misol Ahn, Delisha Meishery, Abby Oehler, Gregory S Barsh, Stephen J DeArmond, George A Carlson, Teresa M Gun. Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383230. |
while the primary cause is recognized as conversion of the normal form of prion protein (prp(c)) to a conformationally distinct, pathogenic form (prp(sc)), the cellular pathways and mechanisms that lead to spongiform change, neuronal dysfunction and death are not known. |
2013-07-17 |
2023-08-12 |
mouse |
| Derek Silvius, Rose Pitstick, Misol Ahn, Delisha Meishery, Abby Oehler, Gregory S Barsh, Stephen J DeArmond, George A Carlson, Teresa M Gun. Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383230. |
as these defects were rescued by over-expression of mgrn1, we investigated whether reduced or elevated mgrn1 expression influences the onset, progression or pathology of disease in mice inoculated with prp(sc). |
2013-07-17 |
2023-08-12 |
mouse |
| Ayodeji A Asuni, Joanna E Pankiewicz, Martin J Sadowsk. Differential molecular chaperone response associated with various mouse adapted scrapie strains. Neuroscience letters. vol 538. 2013-07-11. PMID:23370284. |
prionoses are a group of neurodegenerative diseases characterized by misfolding of cellular prion protein (prp(c)) and accumulation of its diseases specific conformer prp(sc) in the brain and neuropathologically, they can be associated with presence or absence of prp amyloid deposits. |
2013-07-11 |
2023-08-12 |
mouse |
| Yin Xu, Chan Tian, Shao-Bin Wang, Wu-Ling Xie, Yan Guo, Jin Zhang, Qi Shi, Cao Chen, Xiao-Ping Don. Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases. Autophagy. vol 8. issue 11. 2013-07-10. PMID:22874564. |
dynamic assays of the autophagic system in the brains of scrapie experimental hamsters after inoculation showed that alterations of the autophagic system appeared along with the deposits of prp(sc) in the infected brains. |
2013-07-10 |
2023-08-12 |
human |
| Yin Xu, Chan Tian, Shao-Bin Wang, Wu-Ling Xie, Yan Guo, Jin Zhang, Qi Shi, Cao Chen, Xiao-Ping Don. Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases. Autophagy. vol 8. issue 11. 2013-07-10. PMID:22874564. |
immunofluorescent assays revealed specific staining of autophagosomes in neurons that were not colocalized with deposits of prp(sc) in the brains of scrapie infected hamsters, however, autophagosome did colocalize with prp(sc) in a prion-infected cell line after treatment with bafilomycin a(1). |
2013-07-10 |
2023-08-12 |
human |
| Nives Skrlj, Gorazd Drevenšek, Samo Hudoklin, Rok Romih, Vladka Curin Šerbec, Marko Dolina. Recombinant single-chain antibody with the Trojan peptide penetratin positioned in the linker region enables cargo transfer across the blood-brain barrier. Applied biochemistry and biotechnology. vol 169. issue 1. 2013-07-01. PMID:23160949. |
we designed and prepared a single-chain antibody fragment (scfvs), specific for the pathological form of the prion protein (prp(sc)), where a cell-penetrating peptide (cpp) was used as a linker between the two variable domains of the scfv. |
2013-07-01 |
2023-08-12 |
mouse |
| Maddalena Costanzo, Chiara Zurzol. The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration. The Biochemical journal. vol 452. issue 1. 2013-06-27. PMID:23614720. |
by seeding misfolding of the prp(c) (normal conformer prion protein) into prp(sc) (abnormal disease-specific conformation of prion protein), prions spread from the periphery of the body to the central nervous system and can also be transmitted between individuals of the same or different species. |
2013-06-27 |
2023-08-12 |
Not clear |
| Karen Dobie, Rona Barro. Dissociation between transmissible spongiform encephalopathy (TSE) infectivity and proteinase K-resistant PrP(Sc) levels in peripheral tissue from a murine transgenic model of TSE disease. Journal of virology. vol 87. issue 10. 2013-06-21. PMID:23487470. |
dissociation between transmissible spongiform encephalopathy (tse) infectivity and proteinase k-resistant prp(sc) levels in peripheral tissue from a murine transgenic model of tse disease. |
2013-06-21 |
2023-08-12 |
mouse |
| Karen Dobie, Rona Barro. Dissociation between transmissible spongiform encephalopathy (TSE) infectivity and proteinase K-resistant PrP(Sc) levels in peripheral tissue from a murine transgenic model of TSE disease. Journal of virology. vol 87. issue 10. 2013-06-21. PMID:23487470. |
most current diagnostic tests for transmissible spongiform encephalopathies (tse) rely on the presence of proteinase k (pk)-resistant prp(sc) (prp-res) in postmortem tissues as an indication of tse disease. |
2013-06-21 |
2023-08-12 |
mouse |
| Peter Hedlin, Ryan Taschuk, Andrew Potter, Philip Griebel, Scott Nappe. Detection and control of prion diseases in food animals. ISRN veterinary science. vol 2012. 2013-06-06. PMID:23738120. |
transmissible spongiform encephalopathies (tses), or prion diseases, represent a unique form of infectious disease based on misfolding of a self-protein (prp(c)) into a pathological, infectious conformation (prp(sc)). |
2013-06-06 |
2023-08-12 |
cattle |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (prp(c)) to disease-associated prion protein (prp(sc)). |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
using a prp(sc)-specific elisa we discovered a monocationic phenyl-furan-benzimidazole (db772), which has previously demonstrated anti-pestiviral activity and represents a chemical category previously untested for anti-prion activity, that inhibited prp(sc) accumulation and prion infectivity in primary sheep microglial cell cultures (prnp 136vv/154rr/171qq) and rov9 cultures (vrq-ovinized rk13 cells). |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
results demonstrate at least an approximate two-log inhibition of prp(sc) accumulation in the two cell systems and confirmed that the inhibition of prp(sc) accumulation correlates with inhibition of prion infectivity. |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
prnp transcripts and total prp protein concentrations within cell lysates were not decreased; thus, decreased prp(c) expression is not the mechanism of prp(sc) inhibition. |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
prp(sc) accumulation was multiple logs more resistant than pestivirus to db772, suggesting that the anti-prp(sc) activity was independent of anti-pestivirus activity. |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
the results describe a new chemical category that inhibits ovine prp(sc) accumulation in primary sheep microglia and rov9 cells, and can be used for future studies into the treatment and mechanism of prion diseases. |
2013-05-28 |
2023-08-12 |
Not clear |
| Richard Rubenstein, Allen Chiu, Binggong Chang, Thomas Wisniewsk. Role of CD40 in prion disease and the immune response to recombinant PrP. Journal of neuroimmunology. vol 257. issue 1-2. 2013-05-21. PMID:23419881. |
in the current study, we clarify the effect of cd40 on: (i) replication, progression to clinical disease, prp(sc) profile, and neuropathology associated with infection of a single host genotype with three distinct mouse-adapted scrapie strains, and (ii) the immune response of double knockout (prp, cd40) transgenic mice to recombinant prp as assessed by the generation of anti-prp antibodies. |
2013-05-21 |
2023-08-12 |
mouse |