| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pavlina Sobrova, Marketa Ryvolova, Vojtech Adam, Rene Kize. Capillary electromigration based techniques in diagnostics of prion protein caused diseases. Electrophoresis. vol 33. issue 24. 2013-04-29. PMID:23161211. |
on the other hand, using of ce for prp(sc) detection in body fluids is an attractive alternative; it has been already applied for the blood samples of infected sheep, elk, chimpanzee, as well as humans. |
2013-04-29 |
2023-08-12 |
human |
| Leonardo M Cortez, Jitendra Kumar, Ludovic Renault, Howard S Young, Valerie L Si. Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23283973. |
prion diseases are fatal neurodegenerative disorders associated with the polymerization of the cellular form of prion protein (prp(c)) into an amyloidogenic β-sheet infectious form (prp(sc)). |
2013-04-29 |
2023-08-12 |
mouse |
| Leonardo M Cortez, Jitendra Kumar, Ludovic Renault, Howard S Young, Valerie L Si. Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23283973. |
in mice, the presence of allele a (prnp(a), encoding the polymorphism leu-108/thr-189) or b (prnp(b), phe-108/val-189) is associated with short or long incubation times, respectively, following infection with prp(sc). |
2013-04-29 |
2023-08-12 |
mouse |
| Leonardo M Cortez, Jitendra Kumar, Ludovic Renault, Howard S Young, Valerie L Si. Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23283973. |
the molecular bases linking prp sequence, infection susceptibility, and convertibility of prp(c) into prp(sc) remain unclear. |
2013-04-29 |
2023-08-12 |
mouse |
| Jorge Pimenta, Ana Domingos, Pedro Santos, Carla C Marques, Cátia Cantante, Ana Santos, João P Barbas, Maria C Baptista, António E M Horta, Aldino Viegas, Patrícia Mesquita, João Gonçalves, Carlos A Fontes, José A M Prates, Rosa M L N Pereir. Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa. PloS one. vol 7. issue 8. 2013-04-25. PMID:22937002. |
a hallmark of prion diseases or transmissible spongiform encephalopaties is the conversion of the cellular prion protein (prp(c)), expressed by the prion gene (prnp), into an abnormally folded isoform (prp(sc)) with amyloid-like features that causes scrapie in sheep among other diseases. |
2013-04-25 |
2023-08-12 |
mouse |
| Fabio Moda, Silvia Suardi, Giuseppe Di Fede, Antonio Indaco, Lucia Limido, Chiara Vimercati, Margherita Ruggerone, Ilaria Campagnani, Jan Langeveld, Alessandro Terruzzi, Antonio Brambilla, Pietro Zerbi, Paolo Fociani, Matthew T Bishop, Robert G Will, Jean C Manson, Giorgio Giaccone, Fabrizio Tagliavin. MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain pathology (Zurich, Switzerland). vol 22. issue 5. 2013-04-24. PMID:22288561. |
in creutzfeldt-jakob disease (cjd), molecular typing based on the size of the protease resistant core of the disease-associated prion protein (prp(sc) ) and the m/v polymorphism at codon 129 of the prnp gene correlates with the clinico-pathologic subtypes. |
2013-04-24 |
2023-08-12 |
mouse |
| Fabio Moda, Silvia Suardi, Giuseppe Di Fede, Antonio Indaco, Lucia Limido, Chiara Vimercati, Margherita Ruggerone, Ilaria Campagnani, Jan Langeveld, Alessandro Terruzzi, Antonio Brambilla, Pietro Zerbi, Paolo Fociani, Matthew T Bishop, Robert G Will, Jean C Manson, Giorgio Giaccone, Fabrizio Tagliavin. MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain pathology (Zurich, Switzerland). vol 22. issue 5. 2013-04-24. PMID:22288561. |
approximately 95% of the sporadic 129mm cjd patients are characterized by cerebral deposition of type 1 prp(sc) and correspond to the classic clinical cjd phenotype. |
2013-04-24 |
2023-08-12 |
mouse |
| Fabio Moda, Silvia Suardi, Giuseppe Di Fede, Antonio Indaco, Lucia Limido, Chiara Vimercati, Margherita Ruggerone, Ilaria Campagnani, Jan Langeveld, Alessandro Terruzzi, Antonio Brambilla, Pietro Zerbi, Paolo Fociani, Matthew T Bishop, Robert G Will, Jean C Manson, Giorgio Giaccone, Fabrizio Tagliavin. MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain pathology (Zurich, Switzerland). vol 22. issue 5. 2013-04-24. PMID:22288561. |
the rare 129mm cjd patients with type 2 prp(sc) are further subdivided in a cortical and a thalamic form also indicated as sporadic fatal insomnia. |
2013-04-24 |
2023-08-12 |
mouse |
| Fabio Moda, Silvia Suardi, Giuseppe Di Fede, Antonio Indaco, Lucia Limido, Chiara Vimercati, Margherita Ruggerone, Ilaria Campagnani, Jan Langeveld, Alessandro Terruzzi, Antonio Brambilla, Pietro Zerbi, Paolo Fociani, Matthew T Bishop, Robert G Will, Jean C Manson, Giorgio Giaccone, Fabrizio Tagliavin. MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain pathology (Zurich, Switzerland). vol 22. issue 5. 2013-04-24. PMID:22288561. |
western blot analysis showed the presence of type 2a prp(sc) . |
2013-04-24 |
2023-08-12 |
mouse |
| Fabio Moda, Silvia Suardi, Giuseppe Di Fede, Antonio Indaco, Lucia Limido, Chiara Vimercati, Margherita Ruggerone, Ilaria Campagnani, Jan Langeveld, Alessandro Terruzzi, Antonio Brambilla, Pietro Zerbi, Paolo Fociani, Matthew T Bishop, Robert G Will, Jean C Manson, Giorgio Giaccone, Fabrizio Tagliavin. MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain pathology (Zurich, Switzerland). vol 22. issue 5. 2013-04-24. PMID:22288561. |
the affected mice showed deposition of type 2a prp(sc) , a scenario that is unprecedented in this mouse line. |
2013-04-24 |
2023-08-12 |
mouse |
| Samia Hannaoui, Layal Maatouk, Nicolas Privat, Etienne Levavasseur, Baptiste A Faucheux, Stéphane Haï. Prion propagation and toxicity occur in vitro with two-phase kinetics specific to strain and neuronal type. Journal of virology. vol 87. issue 5. 2013-04-24. PMID:23255799. |
the only known specific molecular marker of tses is the abnormal isoform (prp(sc)) of the host-encoded prion protein (prp(c)), which accumulates in the brain of infected subjects and forms infectious prion particles. |
2013-04-24 |
2023-08-12 |
human |
| Samia Hannaoui, Layal Maatouk, Nicolas Privat, Etienne Levavasseur, Baptiste A Faucheux, Stéphane Haï. Prion propagation and toxicity occur in vitro with two-phase kinetics specific to strain and neuronal type. Journal of virology. vol 87. issue 5. 2013-04-24. PMID:23255799. |
prion strains are characterized by differences in disease outcome, prp(sc) distribution patterns, and brain lesion profiles at the terminal stage of the disease. |
2013-04-24 |
2023-08-12 |
human |
| Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughe. Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139828. |
prp(sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. |
2013-04-23 |
2023-08-12 |
mouse |
| Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughe. Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139828. |
prp(sc) propagation involves conversion from its normal isoform, prp(c), by a seeded or templated polymerization mechanism. |
2013-04-23 |
2023-08-12 |
mouse |
| Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughe. Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139828. |
here we have adapted rt-quic and equic to various murine prions and evaluated how seeding activity depends on glycophosphatidylinositol (gpi) anchoring and the abundance of amyloid plaques and protease-resistant prp(sc) (prp(res)). |
2013-04-23 |
2023-08-12 |
mouse |
| Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughe. Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139828. |
we also found that equic, which incorporates a prp(sc) immunoprecipitation step, detected seeding activity in plasma from wild-type and anchorless prp transgenic mice inoculated with 22l, 79a and/or rml scrapie strains. |
2013-04-23 |
2023-08-12 |
mouse |
| Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughe. Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139828. |
overall, we conclude that these new mouse-adapted prion seeding assays detect diverse types of prp(sc). |
2013-04-23 |
2023-08-12 |
mouse |
| Enrico Cancellotti, Sukhvir P Mahal, Robert Somerville, Abigail Diack, Deborah Brown, Pedro Piccardo, Charles Weissmann, Jean C Manso. Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties. The EMBO journal. vol 32. issue 5. 2013-04-23. PMID:23395905. |
the agents responsible for transmissible spongiform encephalopathies (tses), or prion diseases, contain as a major component prp(sc), an abnormal conformer of the host glycoprotein prp(c). |
2013-04-23 |
2023-08-12 |
mouse |
| Enrico Cancellotti, Sukhvir P Mahal, Robert Somerville, Abigail Diack, Deborah Brown, Pedro Piccardo, Charles Weissmann, Jean C Manso. Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties. The EMBO journal. vol 32. issue 5. 2013-04-23. PMID:23395905. |
tse agents are distinguished by differences in phenotypic properties in the host, which nevertheless can contain prp(sc) with the same amino-acid sequence. |
2013-04-23 |
2023-08-12 |
mouse |
| Enrico Cancellotti, Sukhvir P Mahal, Robert Somerville, Abigail Diack, Deborah Brown, Pedro Piccardo, Charles Weissmann, Jean C Manso. Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties. The EMBO journal. vol 32. issue 5. 2013-04-23. PMID:23395905. |
strain-specific characteristics of the 79a tse strain changed when prp(sc) was devoid of one or both glycans. |
2013-04-23 |
2023-08-12 |
mouse |