| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinjian Zhang, Taku Nagai, Rijwan Uddin Ahammad, Keisuke Kuroda, Shinichi Nakamuta, Takashi Nakano, Naoto Yukinawa, Yasuhiro Funahashi, Yukie Yamahashi, Mutsuki Amano, Junichiro Yoshimoto, Kiyofumi Yamada, Kozo Kaibuch. Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. Neurochemistry international. vol 122. 2019-12-26. PMID:30336179. |
balance between dopamine and adenosine signals regulates the pka/rap1 pathway in striatal medium spiny neurons. |
2019-12-26 |
2023-08-13 |
Not clear |
| Xinjian Zhang, Taku Nagai, Rijwan Uddin Ahammad, Keisuke Kuroda, Shinichi Nakamuta, Takashi Nakano, Naoto Yukinawa, Yasuhiro Funahashi, Yukie Yamahashi, Mutsuki Amano, Junichiro Yoshimoto, Kiyofumi Yamada, Kozo Kaibuch. Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. Neurochemistry international. vol 122. 2019-12-26. PMID:30336179. |
medium spiny neurons (msns) expressing dopamine d1 receptor (d1r) or d2 receptor (d2r) are major components of the striatum. |
2019-12-26 |
2023-08-13 |
Not clear |
| Jiayi Lu, Yifeng Cheng, Xuehua Wang, Kayla Woodson, Craig Kemper, Emily Disney, Jun Wan. Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 6. 2019-12-20. PMID:30733568. |
this modulation is mainly mediated by dopamine d1 receptors (d1rs) and d2rs, which are highly expressed in medium spiny neurons (msns) of the dorsomedial striatum (dms), a brain region essential for goal-directed behaviors and addiction. |
2019-12-20 |
2023-08-13 |
mouse |
| Orhan Tansel Korkmaz, Neşe Tunçe. Advantages of Vasoactive Intestinal Peptide for the Future Treatment of Parkinson's Disease. Current pharmaceutical design. vol 24. issue 39. 2019-11-21. PMID:30636594. |
the characteristic symptoms of parkinson's disease, such as resting tremor, muscular rigidity, bradykinesia, postural instability and gait imbalance, are thought to be a result of the progressive degeneration of the dopaminergic neurons of the substantia nigra compacta, resulting in insufficient dopamine integrated signalling on gabaergic medium spiny neurons in the striatum. |
2019-11-21 |
2023-08-13 |
Not clear |
| Alessandra Bonito-Oliva, Caitlin DuPont, Nather Madjid, Sven Ove Ögren, Gilberto Fison. Involvement of the Striatal Medium Spiny Neurons of the Direct Pathway in the Motor Stimulant Effects of Phencyclidine. The international journal of neuropsychopharmacology. vol 19. issue 6. 2019-11-20. PMID:26657176. |
the dopamine and adenosine 3',5'-cyclic monophosphate-regulated phosphoprotein of 32kda (darpp-32) is enriched in the medium spiny neurons (msns) of the striatum and has been implicated in the actions of pcp. |
2019-11-20 |
2023-08-13 |
Not clear |
| Douglas Roberts-Wolfe, Ana-Clara Bobadilla, Jasper A Heinsbroek, Daniela Neuhofer, Peter W Kaliva. Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 32. 2019-11-12. PMID:29976626. |
the nacore contains two populations of medium spiny neurons (msns) that differentially express d1 or d2 dopamine receptors. |
2019-11-12 |
2023-08-13 |
mouse |
| Hossein Aleyasin, Meghan E Flanigan, Sam A Golden, Aki Takahashi, Caroline Menard, Madeline L Pfau, Jacob Multer, Jacqueline Pina, Kathryn A McCabe, Naemal Bhatti, Georgia E Hodes, Mitra Heshmati, Rachael L Neve, Eric J Nestler, Elizabeth A Heller, Scott J Russ. Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 26. 2019-10-28. PMID:29891732. |
we show that Δfosb is specifically increased in dopamine d1 receptor (drd1)-expressing medium spiny neurons (d1-msns) in nac after repeated aggressive encounters. |
2019-10-28 |
2023-08-13 |
mouse |
| Cédric Yapo, Anu G Nair, Jeanette Hellgren Kotaleski, Pierre Vincent, Liliana R V Castr. Switch-like PKA responses in the nucleus of striatal neurons. Journal of cell science. vol 131. issue 14. 2019-10-23. PMID:29967033. |
here, we combined computational modeling and live-cell imaging of pka-dependent phosphorylation in mouse brain slices to investigate how transient dopamine signals are translated into nuclear pka activity in cortical pyramidal neurons and striatal medium spiny neurons. |
2019-10-23 |
2023-08-13 |
mouse |
| Stephanie M Perez, Daniel J Lodg. Convergent Inputs from the Hippocampus and Thalamus to the Nucleus Accumbens Regulate Dopamine Neuron Activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355626. |
here, using male sprague dawley rats, we demonstrate that a subset of nac medium spiny neurons receive convergent inputs from the vhipp and paraventricular nucleus of the thalamus (pvt), with both regions working synergistically to regulate dopamine neuron activity. |
2019-10-09 |
2023-08-13 |
rat |
| Cindy Barrientos, Daniel Knowland, Mingche M J Wu, Varoth Lilascharoen, Kee Wui Huang, Robert C Malenka, Byung Kook Li. Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens. Biological psychiatry. vol 84. issue 12. 2019-10-07. PMID:29921416. |
the nucleus accumbens (nac) is a brain region implicated in pathological motivated behaviors such as drug addiction and is composed predominantly of two discrete populations of neurons, dopamine receptor-1- and dopamine receptor-2-expressing medium spiny neurons (d1-msns and d2-msns, respectively). |
2019-10-07 |
2023-08-13 |
Not clear |
| Alexandra G DiFeliceantonio, Paul J Kenn. Melanocortin 4 receptors switch reward to aversion. The Journal of clinical investigation. vol 128. issue 7. 2019-09-04. PMID:29911995. |
moreover, the authors provide evidence that avoidance behaviors are mediated by hypothalamic pomc neurons signaling to striatal dopamine d1 receptor-expressing medium spiny neurons. |
2019-09-04 |
2023-08-13 |
mouse |
| Anna Podleśny-Drabiniok, Joanna Sobska, Angel R de Lera, Krystyna Gołembiowska, Katarzyna Kamińska, Pascal Dollé, Małgorzata Cebrat, Wojciech Kręże. Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons. Scientific reports. vol 7. issue 1. 2019-08-06. PMID:29057906. |
here we show that ra treatment during ec embryoid body formation is a highly robust protocol for generation of striatal-like gabaergic neurons which display molecular characteristics of striatopallidal medium spiny neurons (msns), including expression of functional dopamine d2 receptor. |
2019-08-06 |
2023-08-13 |
Not clear |
| Pamela F Marcott, Sheng Gong, Prashant Donthamsetti, Steven G Grinnell, Melissa N Nelson, Amy H Newman, Lutz Birnbaumer, Kirill A Martemyanov, Jonathan A Javitch, Christopher P For. Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. Neuron. vol 98. issue 3. 2019-07-15. PMID:29656874. |
despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (msns) across striatal subregions. |
2019-07-15 |
2023-08-13 |
Not clear |
| Ramesh Chandra, Michel Engeln, Christopher Schiefer, Mary H Patton, Jennifer A Martin, Craig T Werner, Lace M Riggs, T Chase Francis, Madeleine McGlincy, Brianna Evans, Hyungwoo Nam, Shweta Das, Kasey Girven, Prasad Konkalmatt, Amy M Gancarz, Sam A Golden, Sergio D Iñiguez, Scott J Russo, Gustavo Turecki, Brian N Mathur, Meaghan Creed, David M Dietz, Mary Kay Lob. Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. Neuron. vol 96. issue 6. 2019-07-05. PMID:29268097. |
mdivi-1, a demonstrated fission inhibitor, blunts cocaine seeking and locomotor sensitization, while blocking c-fos induction and excitatory input onto dopamine receptor-1 (d1) containing nac medium spiny neurons (msns). |
2019-07-05 |
2023-08-13 |
Not clear |
| Nadia Giordano, Attilio Iemolo, Maria Mancini, Fabrizio Cacace, Maria De Risi, Emanuele Claudio Latagliata, Veronica Ghiglieri, Gian Carlo Bellenchi, Stefano Puglisi-Allegra, Paolo Calabresi, Barbara Picconi, Elvira De Leonibu. Motor learning and metaplasticity in striatal neurons: relevance for Parkinson's disease. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29281030. |
we found that the initial acquisition of motor learning induced a dopamine active transporter and d1 receptors mediated long-term potentiation, under a protocol of long-term depression in striatal medium spiny neurons. |
2019-05-30 |
2023-08-13 |
human |
| Takatoshi Hikid. [Homeostatic regulation of basal ganglia circuit for flexible behavior]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 6. 2019-05-06. PMID:30531100. |
these processes are guided by the activity of two discrete neuron types, dopamine d1- or d2-receptor expressing medium spiny neurons (d1-/d2-msns) in the basal ganglia circuit. |
2019-05-06 |
2023-08-13 |
mouse |
| Xiao-Bo Wu, Peng-Bo Jing, Zhi-Jun Zhang, De-Li Cao, Ming-Hui Gao, Bao-Chun Jiang, Yong-Jing Ga. Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 11. 2019-03-11. PMID:29993042. |
chemokine receptor ccr2 contributes to neuropathic pain and the associated depression via increasing nr2b-mediated currents in both d1 and d2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. |
2019-03-11 |
2023-08-13 |
mouse |
| Ben Sagot, Li Li, Fu-Ming Zho. Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice. Frontiers in neural circuits. vol 12. 2019-03-04. PMID:30104963. |
dopamine (da) receptor-bypassing, optogenetics- and chemogenetics-induced spike firing of striatal da d1 receptor (d1r)-expressing, direct pathway medium spiny neurons (dspns or dmsns) promotes movements. |
2019-03-04 |
2023-08-13 |
mouse |
| Anca Rădulescu, Joanna Herron, Caitlin Kennedy, Annalisa Scimem. Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28790376. |
the striatum shapes the activity of the cstc pathway through the coordinated activation of two classes of medium spiny neurons (msns) expressing d1 or d2 dopamine receptors. |
2019-02-19 |
2023-08-13 |
Not clear |
| Taku Nagai, Kiyofumi Yamada, Kozo Kaibuch. Reward signals downstream of dopamine D1 receptors. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 51. issue 6. 2019-02-11. PMID:30461245. |
the principal target of dopamine is medium spiny neurons (msns), which are a special type of gabaergic inhibitory cell that represents,90% of the neurons within the striatum, including the nucleus accumbens (nac). |
2019-02-11 |
2023-08-13 |
Not clear |