| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyu Dong, Dongxue Zha. Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies. CNS neuroscience & therapeutics. 2023-05-15. PMID:37183361. |
the mechanisms are achieved by enhancing monoamine oxidase a (moa) activity, inhibiting microglia activation and inflammatory factor release, anti-oxidative stress, promoting hippocampal nerve regeneration, increasing brain-derived neurotrophic factor secretion, regulating gut microbiome, and activating protein kinase b/collapsin response mediator protein 2 (akt/crmp2) signaling pathway. |
2023-05-15 |
2023-08-14 |
human |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
however, some other putative mechanisms underlying the pathogenesis of the disease have been proposed, including inflammation in the brain, microglia activation, impaired hippocampus neurogenesis and alterations in the production and release of neurotrophic factors. |
2023-05-14 |
2023-08-14 |
Not clear |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
the results of immunohistochemical studies confirmed a significant activation of microglia in the hippocampus three weeks after tmt injection. |
2023-05-14 |
2023-08-14 |
rat |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
moreover, in the ca1 field of the hippocampus of the animals of the mem + vu group, the amount of such microglia was close to the control. |
2023-05-14 |
2023-08-14 |
rat |
| Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Teruki Matsuoka, Ryoma Matsuzaki, Syogo Kakimoto, Nao Nojima, Yuta Tachibe, Yuki Kato, Masaki Inadome, Riho Kitazato, Shotaro Otsuka, Seiya Takada, Megumi Sumizono, Harutoshi Sakakim. Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. Neuroscience letters. 2023-05-14. PMID:37182575. |
age-related cognitive decline was prevented in the lt-ex group compared with the no-ex group through the suppression of neuronal loss, enhanced brain-derived neurotrophic factor (bdnf), and inhibition of neuroinflammation corresponding to reduced m1 and increased m2 microglia in the hippocampus. |
2023-05-14 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
sexually differentiated microglia and ca1 hippocampal synaptic connectivity. |
2023-05-12 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
in this study, we tested whether sexual differentiation of microglia results in sex-dependent postnatal reorganization of ca1 synaptic connectivity in the hippocampus. |
2023-05-12 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
sexual differentiation of microglia, however, does not substantially affect long-term synaptic reorganization in the hippocampus. |
2023-05-12 |
2023-08-14 |
mouse |
| Natalie R Ricciardi, Farzaneh Modarresi, Ines Lohse, Nadja S Andrade, Ian R Newman, Jonathan M Brown, Caroline Borja, Brian Marples, Claes R Wahlestedt, Claude-Henry Volma. Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer's Disease Models. Molecular neurobiology. 2023-05-12. PMID:37171575. |
were assessed in the hippocampus (hip) and prefrontal cortex (pfc).ldct induced a tolerant, anti-inflammatory innate immune response in microglia and increased non-amyloidogenic app processing in vitro. |
2023-05-12 |
2023-08-14 |
mouse |
| Marianna Tassinari, Beatrice Uguagliati, Stefania Trazzi, Camilla Bruna Cerchier, Ottavia Vera Cavina, Nicola Mottolese, Manuela Loi, Giulia Candini, Giorgio Medici, Elisabetta Cian. Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder. Neurobiology of disease. 2023-05-10. PMID:37164289. |
studies of brain morphogenesis in adult cdkl5 ko mice showed defects in dendritic arborization of pyramidal neurons and in synaptic connectivity, a hypocellularity of the hippocampal dentate gyrus, and a generalized microglia over-activation. |
2023-05-10 |
2023-08-14 |
mouse |
| Marianna Tassinari, Beatrice Uguagliati, Stefania Trazzi, Camilla Bruna Cerchier, Ottavia Vera Cavina, Nicola Mottolese, Manuela Loi, Giulia Candini, Giorgio Medici, Elisabetta Cian. Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder. Neurobiology of disease. 2023-05-10. PMID:37164289. |
in sight of this, we comparatively evaluated the dendritic arborization and spines of cortical pyramidal neurons, cortical excitatory and inhibitory connectivity, microglia activation, and proliferation and survival of granule cells of the hippocampal dentate gyrus in hemizygous cdkl5 ko male (-/y) mice aged 7, 14, 21, and 60 days. |
2023-05-10 |
2023-08-14 |
mouse |
| Isabel Carreras, Younghun Jung, Jonathan Lopez-Benitez, Christina M Tognoni, Alpaslan Dedeogl. Fingolimod mitigates memory loss in a mouse model of Gulf War Illness amid decreasing the activation of microglia, protein kinase R, and NFκB. Neurotoxicology. 2023-05-09. PMID:37160207. |
immunohistochemical analysis of brain sections with antibodies to iba1 and gfap revealed that gwi mice had increased microglia activation in the hippocampal dentate gyrus, but no difference in reactive astrocytes was detected. |
2023-05-09 |
2023-08-14 |
mouse |
| Rong-Jun Ni, Yi-Yan Wang, Tian-Hao Gao, Qi-Run Wang, Jin-Xue Wei, Lian-Sheng Zhao, Yang-Rui Ma, Xiao-Hong Ma, Tao L. Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain. Zoological research. vol 44. issue 3. 2023-05-06. PMID:37147908. |
here, we found rapid elimination of microglia in the prefrontal cortex (pfc) and hippocampus (hpc) of mice following administration of the dual colony-stimulating factor 1 receptor (csf1r)/c-kit kinase inhibitor plx3397 (pexidartinib) in drinking water. |
2023-05-06 |
2023-08-14 |
mouse |
| Chunchun Tang, Xue Zheng, Yuanping Zhong, Dongqin Chen, Yuhang Zhu, Sihui Wang, Liulin Xiong, Zhaoqiong Zh. The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders. Journal of neuroimmunology. vol 379. 2023-05-06. PMID:37148600. |
we applied aav knockdown trem1 in hippocampal microglia in aging mice. |
2023-05-06 |
2023-08-14 |
mouse |
| Chunchun Tang, Xue Zheng, Yuanping Zhong, Dongqin Chen, Yuhang Zhu, Sihui Wang, Liulin Xiong, Zhaoqiong Zh. The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders. Journal of neuroimmunology. vol 379. 2023-05-06. PMID:37148600. |
we found that sevoflurane inhalation can cause pnd in mice, increase hippocampal trem1 expression, polarize microglia to m1 type, upregulate tnf-α and il-1β expression (pro-inflammatory), and inhibit tgf-β and il-10 expression (anti-inflammatory). |
2023-05-06 |
2023-08-14 |
mouse |
| Jodi L Pawluski, Pauline Murail, Florine Grudet, Lena Bys, Anna V Golubeva, Thomaz Bastiaanssen, Tim F Oberlander, John F Cryan, Siobhain M O'Mahony, Thierry D Charlie. Gestational stress and perinatal SSRIs differentially impact the maternal and neonatal microbiome-gut-brain axis. Journal of neuroendocrinology. 2023-05-02. PMID:37129177. |
on postpartum day 2 brains were collected for measurement of plasticity (neurogenesis and microglia content) in the maternal hippocampus and in the neonatal brain. |
2023-05-02 |
2023-08-14 |
rat |
| Zeng-Hui Wei, Jagadish Koya, Nikita Acharekar, Jesus Trejos, Xing-Duo Dong, Francis A Schanne, Charles R Ashby, Sandra E Rezni. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models. Scientific reports. vol 13. issue 1. 2023-05-01. PMID:37127686. |
we show that dma significantly suppresses the production of inflammatory mediators, such as reactive oxygen species (ros), nitric oxide (no) and various cytokines and chemokines, as well as amyloid-β (aβ), in cultured microglia and organotypic hippocampal slices induced by lipopolysaccharide (lps). |
2023-05-01 |
2023-08-14 |
Not clear |
| Ryosuke Kamei, Shigeo Okab. In vivo imaging of the phagocytic dynamics underlying efficient clearance of adult-born hippocampal granule cells by ramified microglia. Glia. 2023-04-27. PMID:37102766. |
in vivo imaging of the phagocytic dynamics underlying efficient clearance of adult-born hippocampal granule cells by ramified microglia. |
2023-04-27 |
2023-08-14 |
Not clear |
| Ryosuke Kamei, Shigeo Okab. In vivo imaging of the phagocytic dynamics underlying efficient clearance of adult-born hippocampal granule cells by ramified microglia. Glia. 2023-04-27. PMID:37102766. |
here, we investigated the phagocytosis of dead cells by ramified microglia in the hippocampal dentate gyrus, where adult neurogenesis and homeostatic cell clearance occur. |
2023-04-27 |
2023-08-14 |
Not clear |
| Yang Xu, Wei Li, Mengmeng Shi, Xiaofan Xu, Dongmin Guo, Zhenghai Liu, Ling Chen, Xiaolin Zhong, Wenyu Ca. Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model. Neuropharmacology. 2023-04-24. PMID:37094770. |
interestingly, we found that the peripheral gnrh treatment prevented the microglia activation mediated inflammation in the hippocampus of mice. |
2023-04-24 |
2023-08-14 |
mouse |