| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Manfridi, A Clavenna, M G De Simon. Serotonin uptake inhibition: in vivo effect of sertraline in rats. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383885. |
sertraline, a potent and selective serotonin uptake inhibitor, was used to analyze the changes occurring in the serotonin system after uptake inhibition in vivo. |
1992-11-06 |
2023-08-11 |
rat |
| K Yoshimoto, W J McBride, L Lumeng, T K L. Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats. Alcoholism, clinical and experimental research. vol 16. issue 4. 1992-10-20. PMID:1382391. |
overall, the results indicate that (1) the acc da system is more sensitive than the acc 5-ht system to intraperitoneal ethanol administration in both lines and (2) there is no evidence for a relationship between alcohol preference and sensitivity of the acc da and 5-ht systems to acute intraperitoneal ethanol administration. |
1992-10-20 |
2023-08-11 |
rat |
| Y Chaput, C de Montigny, P Blie. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 5. issue 4. 1992-05-05. PMID:1839498. |
repeated electroconvulsive shocks (ecs; administered every other day for 14 days) as well as the sustained 21-day administration of the tricyclic antidepressant imipramine (10 mg/kg/day) and of the selective 5-hydroxytryptamine (5-ht) reuptake blocker paroxetine (5 mg/kg/day), increased the suppressant effect of the electrical stimulation of the afferent 5-ht pathway on the firing activity of ca3 hippocampus pyramidal neurons. |
1992-05-05 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the sustained administration of tandospirone for 14 days (10 mg/kg/day, s.c.) altered neither the effectiveness of microiontophoretically-applied 5-ht and tandospirone nor that of endogenous 5-ht, released by the electrical simulation of the afferent 5-ht pathway, in suppressing the firing activity of pyramidal neurones in the hippocampus, suggesting that postsynaptic 5-ht1a receptors had not desensitized. |
1991-11-04 |
2023-08-11 |
rat |
| A Bouthillier, P Blier, C de Montign. Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain. Psychopharmacology. vol 103. issue 3. 1991-08-01. PMID:1676181. |
given the long-standing notion that the serotonergic (5-ht) system might be involved in the etiology and/or the therapeutics of affective disorders and that this class of adrenergic agents can alter factors regulating 5-ht transmission, the effects of acute and repeated administrations of flerobuterol on the 5-ht system were studied. |
1991-08-01 |
2023-08-11 |
rat |
| S Wieland, I Luck. Altered behavioral responses mediated by serotonin receptors in the genetically dystonic (dt) rat. Brain research bulletin. vol 26. issue 1. 1991-05-22. PMID:2015508. |
since serotonin (5-ht) has been shown to be involved in some animal models of movement disorders, the functional responsiveness of the 5-ht system in dt rats and phenotypical normal littermates was examined by administering 5-ht agonists selective for different receptor subtypes and observing behavioral responses associated with the activation of specific 5-ht receptor subtypes. |
1991-05-22 |
2023-08-11 |
rat |
| P M Whitaker-Azmitia, D Quartermain, A V Sheme. Prenatal treatment with a selective D1 receptor agonist (SKF 38393) alters adult [3H]paroxetine binding and dopamine and serotonin behavioral sensitivity. Brain research. Developmental brain research. vol 57. issue 2. 1991-04-16. PMID:2150012. |
we have previously shown that the development of serotonin neurons can be affected by various pharmacological agents acting on the serotonin system. |
1991-04-16 |
2023-08-11 |
rat |
| Y Chaput, P Lesieur, C de Montign. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse (New York, N.Y.). vol 6. issue 4. 1991-03-25. PMID:1962911. |
the effects of short-term serotonin (5-ht) depletion by p-chlorophenylalanine (pcpa) on the firing activity of dorsal raphe nucleus 5-ht neurons, on the responsiveness of dorsal hippocampus pyramidal neurons to microiontophoretically applied 5-ht and on the efficacy of the electrical stimulation of the ascending 5-ht pathway in suppressing the firing activity of ca3 dorsal hippocampus pyramidal neurons were assessed in chloral hydrate-anesthetized rats. |
1991-03-25 |
2023-08-11 |
rat |
| Y Chaput, P Lesieur, C de Montign. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse (New York, N.Y.). vol 6. issue 4. 1991-03-25. PMID:1962911. |
the effect of afferent 5-ht pathway stimulation was reduced in only 40% of treated rats, whereas the sensitivity of ca3 pyramidal neurons to microiontophoretic 5-ht was not modified. |
1991-03-25 |
2023-08-11 |
rat |
| Y Chaput, P Lesieur, C de Montign. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse (New York, N.Y.). vol 6. issue 4. 1991-03-25. PMID:1962911. |
the present results showing that the 350 mg/kg/day regimen of pcpa, but not the 250 mg/kg/day regimen, reduced the efficacy of the stimulation of the ascending 5-ht pathway suggest that a greater than 90% depletion is required to affect 5-ht neurotransmission significantly. |
1991-03-25 |
2023-08-11 |
rat |
| S Wieland, M S Kreider, P McGonigle, I Luck. Destruction of the nucleus raphe obscurus and potentiation of serotonin-mediated behaviors following administration of the neurotoxin 3-acetylpyridine. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:1698505. |
because the neurotransmitter serotonin (5-ht) has been implicated in various human involuntary movement disorders, the functional and anatomical integrity of the 5-ht system in rats treated with 3-ap were examined. |
1990-11-14 |
2023-08-11 |
human |
| P Gambardella, A M Greco, R Sticchi, D D'Apont. Circadian rhythm variations in the adult rat induced by low and high protein diets administered at various stages of development. Chronobiology international. vol 7. issue 1. 1990-08-28. PMID:1695553. |
the rhythm of the serotonin system was significantly altered by a low protein diet: decreased 5-ht amplitude (low protein diet in the fetal stage and suckling), decreased 5-ht amplitude and deranged 5-hiaa rhythm (low protein in the post-lactation period), deranged 5-hiaa rhythm (low protein diet throughout the experiment). |
1990-08-28 |
2023-08-11 |
rat |
| G E Nilsso. Turnover of serotonin in brain of an anoxia-tolerant vertebrate, the crucian carp. The American journal of physiology. vol 258. issue 6 Pt 2. 1990-08-02. PMID:1694412. |
moreover, the slow 5-ht turnover might be a prerequisite for preserving the functional integrity of the 5-ht system during anoxia. |
1990-08-02 |
2023-08-11 |
Not clear |
| L Lima, B Drujan, R Walde. Cerebral serotonin in viral encephalitis. Journal of neural transmission. Supplementum. vol 29. 1990-08-01. PMID:2358799. |
the results suggest a serotonin presynaptic deficit, a postsynaptic hyperreactivity of serotonin system, and a region-selective distribution of the virus. |
1990-08-01 |
2023-08-11 |
mouse |
| I Inoue, T Shimizu, T Saheki, T Noda, T Fukud. Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation. Biochemical medicine and metabolic biology. vol 42. issue 3. 1990-02-02. PMID:2597437. |
increased flux through the 5-ht pathway during hyperammonemia was indicated by a significant positive correlation between gln concentration and the ratio of 5-hiaa to 5-ht in the brain of spf mice taken after microwave irradiation to prevent postmortem changes in metabolites. |
1990-02-02 |
2023-08-11 |
mouse |
| A Romaniuk, M Strzelczuk, M Wieczore. Is it advisable to use sorbitans in the investigation of the brain mechanisms? Acta neurobiologiae experimentalis. vol 49. issue 5. 1989-12-28. PMID:2480057. |
the content of 5-hydroxyindoleacetic acid (5-hiaa) increased in the hypothalamus, midbrain and amygdala, which indicates the increase in serotonin (5-ht) turnover and the 5-ht system activity. |
1989-12-28 |
2023-08-11 |
cat |
| P Blier, C de Montigny, D Tardi. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.). vol 1. issue 3. 1989-02-21. PMID:2850622. |
in the first part of the present study, the effect of lithium on the function of terminal 5-ht autoreceptors was assessed by comparing in controls and lithium-treated rats the differential effect of two frequencies of stimulation (0.8 and 5 hz) and that of methiothepin, a terminal 5-ht autoreceptor antagonist, on the effectiveness of the electrical activation of the ascending 5-ht pathway in suppressing dorsal hippocampus pyramidal neuron firing activity. |
1989-02-21 |
2023-08-11 |
rat |
| L H Price, D S Charney, P L Delgado, G R Heninge. Lithium treatment and serotoninergic function. Neuroendocrine and behavioral responses to intravenous tryptophan in affective disorder. Archives of general psychiatry. vol 46. issue 1. 1989-01-30. PMID:2910219. |
the present findings suggest that lithium treatment enhances 5-ht function, but that homeostatic responses of the 5-ht system to long-term lithium treatment may differ in patients with affective disorder and healthy subjects. |
1989-01-30 |
2023-08-11 |
human |
| P Blier, C de Montigny, Y Chapu. Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission. Clinical neuropharmacology. vol 11 Suppl 2. 1988-12-20. PMID:2846168. |
the acute administration of 5-ht reuptake blockers does not enhance the efficacy of the stimulation of the 5-ht pathway. |
1988-12-20 |
2023-08-11 |
rat |
| P Blier, C de Montigny, Y Chapu. Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission. Clinical neuropharmacology. vol 11 Suppl 2. 1988-12-20. PMID:2846168. |
the electrophysiological assessment of the effects of these different types of antidepressant treatments on the 5-ht system therefore revealed as a common effect an enhancement of 5-ht neurotransmission, albeit each one achieving this via a different mechanism. |
1988-12-20 |
2023-08-11 |
rat |