| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ortman. The 5-HT syndrome and the drug discrimination paradigm in rats: application in behavioral studies on the central 5-HT system. Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3875109. |
the use of two behavioral tests, the 5-ht motor syndrome in rats and the drug discrimination paradigm for behavioral analysis of the central 5-ht system are discussed. |
1985-09-03 |
2023-08-11 |
rat |
| R Ortman. The 5-HT syndrome and the drug discrimination paradigm in rats: application in behavioral studies on the central 5-HT system. Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3875109. |
the degree of selectivity of 5-ht agonists for the 5-ht system can be determined by the use of specific 5-ht-antagonists, or by testing drugs in mao-inhibited or 5,7-dht-lesioned animals. |
1985-09-03 |
2023-08-11 |
rat |
| N H Majeed, W Lasoń, B Przewłocka, R Przewłock. Differential regulation of the brain and gut immunoreactive dynorphin by the serotonin system. Life sciences. vol 37. issue 4. 1985-08-16. PMID:2861553. |
these results suggest that the brain and gut ir-dyn is independently regulated by the serotonin system and that a serotonin mechanism might stimulate release of the gut dynorphin content. |
1985-08-16 |
2023-08-11 |
Not clear |
| N H Majeed, W Lason, B Przewłocka, R Przewłock. Differential modulation of the beta-endorphin and dynorphin systems by serotonergic stimulation in the rat. Neuropeptides. vol 5. issue 4-6. 1985-07-09. PMID:2860613. |
the obtained results suggest that the serotonin system might stimulate the release of the anterior pituitary beta-endorphin and gut dynorphin pools, while the brain beta-endorphin system appears to be inhibited by activation of serotonin neurons. |
1985-07-09 |
2023-08-11 |
rat |
| M H Robert. 5-Hydroxytryptamine and antinociception. Neuropharmacology. vol 23. issue 12B. 1985-04-17. PMID:6098854. |
damage to, or selective depletion of 5-ht from the raphe-spinal 5-ht system has been reported not to alter nociceptive thresholds or the effects of stimulation of the periaqueductal gray. |
1985-04-17 |
2023-08-12 |
Not clear |
| C K Mitchell, D A Redbur. Analysis of pre- and postsynaptic factors of the serotonin system in rabbit retina. The Journal of cell biology. vol 100. issue 1. 1985-02-15. PMID:3965480. |
the only significant difference between the serotonin system in rabbit retina and that in the well-established serotonin transmitter systems in nonmammalin retinas and in brains of most species is the relatively low concentration of endogenous serotonin in rabbit retinas, as demonstrated by high-performance liquid chromatography, histofluorescence, or immunocytochemistry. |
1985-02-15 |
2023-08-11 |
rabbit |
| Y Brandys, S Yehud. Indolamine hallucinogens as MAO inhibitor agents--theoretical approach. The International journal of neuroscience. vol 21. issue 3-4. 1984-05-18. PMID:6671882. |
in view of the suggestions that lsd acts both on the 5-ht system as an antagonist and on the da system as an agonist, we suggest that in addition to 5-ht blocking capacity, lsd and the other indolamine hallucinogens act as mao inhibitors. |
1984-05-18 |
2023-08-12 |
Not clear |
| R M Cohen, C S Aulakh, D L Murph. Long-term clorgyline treatment antagonizes the eating and motor function responses to m-chlorophenylpiperazine. European journal of pharmacology. vol 94. issue 1-2. 1984-02-14. PMID:6653658. |
these findings support the prior reports of functional serotonin pathway adaptational changes in the motor system in response to antidepressant treatment and extend these findings to serotonin pathways involved in eating behavior. |
1984-02-14 |
2023-08-12 |
rat |
| A McRae-Degueurce, J M Lauder, A Priva. Adult age destruction versus neonatal age destruction of the serotonin system: two models to investigate the survival of serotonin neurons transplanted in adult rats. Neuroscience letters. vol 40. issue 1. 1983-12-20. PMID:6633965. |
adult age destruction versus neonatal age destruction of the serotonin system: two models to investigate the survival of serotonin neurons transplanted in adult rats. |
1983-12-20 |
2023-08-12 |
rat |
| M Shaarawy, M Fayad, A R Nagui, S Abdel-Azi. Serotonin metabolism and depression in oral contraceptive users. Contraception. vol 26. issue 2. 1983-01-19. PMID:7140295. |
twenty-four-hour urinary excretion of serotonin, 5-hydroxyindole acetic acid and total 5-hydroxyindoles were estimated as indices of serotonin pathway metabolites, while xanthrenate excretion was determined as an index of tryptophan oxygenase pathway. |
1983-01-19 |
2023-08-12 |
Not clear |
| Y Takeuchi, H Kimura, Y San. Immunohistochemical demonstration of the distribution of serotonin neurons in the brainstem of the rat and cat. Cell and tissue research. vol 224. issue 2. 1982-10-21. PMID:7049395. |
the wide distribution of serotonin neurons demonstrated in this study should be considered when interpreting experiments dealing with the serotonin system. |
1982-10-21 |
2023-08-12 |
rat |
| S Stine, C Kellog. Inhibition of tryptophan hydroxylase: neurochemical action of catecholamide seizure-inducing agent. Neurochemical research. vol 7. issue 1. 1982-06-14. PMID:7070582. |
the lack of any effect on na in vitro is consistent with the hypothesis that the primary biochemical action of the drug is on the 5-ht system and that the action on na in vivo is an indirect effect possibly secondary to the inhibition of 5-ht synthesis. |
1982-06-14 |
2023-08-12 |
mouse |
| C De Montign. Enhancement of the 5-HT neurotransmission by antidepressant treatments. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6270317. |
the hypothesis of an etiopathogenic role of 5-ht and that of a mediation by the 5-ht system in the effect of antidepressant treatments have often been confused. |
1981-12-22 |
2023-08-12 |
human |
| C De Montign. Enhancement of the 5-HT neurotransmission by antidepressant treatments. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6270317. |
it is possible that the presynaptic enhancing effect of lithium on the 5-ht system might unveil the tca-induced sensitization of the postsynaptic 5-ht receptors. |
1981-12-22 |
2023-08-12 |
human |
| A Minegishi, R Fukumori, T Satoh, H Kitagawa, S Yanaur. Interaction of lithium and disulfiram in hexobarbital hypnosis: possible role of the 5-HT system. The Journal of pharmacology and experimental therapeutics. vol 218. issue 2. 1981-09-25. PMID:6166742. |
these results suggest that lithium and disulfiram exert their synergistic effect on hx hypnosis by acting on the 5-ht system and that an accumulation of 5-hydroxyindoleacetaldehyde, an active metabolite of 5-ht, may be responsible for the increase in the brain sensitivity to barbiturates caused by these drugs. |
1981-09-25 |
2023-08-12 |
rat |
| I I Lobacheva, N K Popov. [Interstrain differences in the serotonin and 5-hydroxyindoleacetic acid levels in the postnatal ontogeny of C57BL/6J and BALB/cLac strain mice]. Ontogenez. vol 12. issue 3. 1981-09-25. PMID:6166915. |
the characteristic dynamics of serotonin and its metabolite content related to the age was found in different brain regions and proved to be similar in both the strains, but the rate of serotonin system development in c57bl/6j mice was higher than in balb/c lac mice. |
1981-09-25 |
2023-08-12 |
mouse |
| I I Lobacheva, N K Popov. [Interstrain differences in the serotonin and 5-hydroxyindoleacetic acid levels in the postnatal ontogeny of C57BL/6J and BALB/cLac strain mice]. Ontogenez. vol 12. issue 3. 1981-09-25. PMID:6166915. |
sex differences in the rate of serotonin system maturation and serotonin and 5-hiaa content were shown for 12--16 days old mice: 12 days old males were characterized by more intensive metabolism than females while 16 days old males had less serotonin than females. |
1981-09-25 |
2023-08-12 |
mouse |
| H Fujiwara, M Uemoto, C Tanak. Stimulation of the rat dorsal raphe in vivo releases labeled serotonin from the parietal cortex. Brain research. vol 216. issue 2. 1981-09-25. PMID:7248780. |
these findings are a direct demonstration of the in vivo release of [3h]5-ht from the parietal cortex with stimulation of the dorsal raphe, particularly the rostral two-thirds of the nucleus and provide the neurochemical evidence for the dorsal raphe-cortical 5-ht pathway via the lateral 5-ht bundle. |
1981-09-25 |
2023-08-12 |
rat |
| Z Roliński, M Herbu. The role of the serotonergic system in foot shock-induced behavior in mice. Psychopharmacology. vol 73. issue 3. 1981-08-10. PMID:6454158. |
stimulation of the brain 5-hydroxytryptamine (5-ht) neurons with different serotonergic agents, such as l-tryptophan, 5-hydroxytryptophan, imipramine, fluoxetine, 5-methoxy-tryptamine, quipazine, and fenfluramine, showed the inhibiting role of the 5-ht system in fsif. |
1981-08-10 |
2023-08-12 |
mouse |
| Y Sakai, Y Matsu. [Neurochemical and electroencephalographical studies on the central actions of mianserin (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 76. issue 6. 1981-05-28. PMID:7203282. |
these results suggest that mianserin activated both the ne and 5-ht metabolic systems, imp activated the ne system in general, but activated the 5-ht system only at low doses and tended to suppress the formation of 5-ht, in high doses; cip had no effect on the ne system and suppressed 5-ht system, in high doses. |
1981-05-28 |
2023-08-12 |
mouse |