| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Zak, J A Miller, D V Sheehan, B S Fanou. The potential role of serotonin reuptake inhibitors in the treatment of obsessive compulsive disorder. The Journal of clinical psychiatry. vol 49 Suppl. 1988-10-13. PMID:3045108. |
(5) are the effects of the serotonin reuptake inhibitors that are effective in treating ocd mediated via the serotonin system or via another mechanism? |
1988-10-13 |
2023-08-11 |
human |
| P Blier, Y Chaput, C de Montign. Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 3. 1988-08-22. PMID:3260661. |
the function of the terminal 5-ht autoreceptors was assessed by comparing the effectiveness of the electrical stimulation of the ascending 5-ht pathway on the firing activity of hippocampus pyramidal neurons prior to, and following, the administration of methiothepin, an antagonist of the terminal 5-ht autoreceptor, and, by determining the ratio of effectiveness of 0.8 hz (s1) and 5 hz (s2) stimulations. |
1988-08-22 |
2023-08-11 |
rat |
| Y Chaput, C de Montign. Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2839669. |
to assess whether endogenous 5-ht also could be antagonized, the response of pyramidal neurons to electrical activation of the 5-ht pathway was determined before and after i.v. |
1988-08-17 |
2023-08-11 |
rat |
| b' P Plenge, E T Mellerup, T Honor\\xc3\\xa9, P L Honor\\xc3\\xa. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. The Journal of pharmacy and pharmacology. vol 39. issue 11. 1988-02-26. PMID:2892909.' |
three parameters related to the 5-ht system were investigated: (i) the inhibition of [3h]5-ht uptake into rat brain synaptosomes, (ii) the inhibition of [3h]paroxetine binding to rat neuronal membranes and (iii) the effect of the compounds on the affinity of [3h]imipramine for the human platelet membrane binding site, measured as the dissociation rate of the [3h]imipramine human platelet membrane binding site complex. |
1988-02-26 |
2023-08-11 |
human |
| C Foresta, M Indino, C Scandellar. Role of gonadal steroids in the serotoninergic control of prolactin secretion in men. Clinical endocrinology. vol 26. issue 5. 1987-12-01. PMID:3665121. |
the physiological regulation of prl secretion seems to involve the central serotonin system, since plasma prl levels are enhanced by serotoninergic agonists and serotonin re-uptake blockers. |
1987-12-01 |
2023-08-11 |
Not clear |
| D G Morga. The dopamine and serotonin systems during aging in human and rodent brain. A brief review. Progress in neuro-psychopharmacology & biological psychiatry. vol 11. issue 2-3. 1987-10-15. PMID:2819950. |
in the serotonin system, the concentration of serotonin remains stable during nonpathological aging in both rodents and humans. |
1987-10-15 |
2023-08-11 |
mouse |
| B Costall, M E Kelly, R J Naylor, C C Tan, F D Tattersal. 5-Hydroxytryptamine M-receptor antagonism in the hypothalamus facilitates gastric emptying in the guinea-pig. Neuropharmacology. vol 25. issue 11. 1987-02-11. PMID:3099224. |
it is concluded that an endogenous hypothalamic 5-ht system may inhibit gastric emptying through a 5-ht m-receptor mechanism which may afford a site of action for 5-ht agonist and antagonist drugs to modify gastric emptying. |
1987-02-11 |
2023-08-11 |
Not clear |
| C G Gottfries, T Bartfai, A Carlsson, S Eckernäs, L Svennerhol. Multiple biochemical deficits in both gray and white matter of Alzheimer brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3797685. |
in the brains from the alzheimer patients a disturbance was found in the 5-ht system in the form of reduced levels of 5-ht and 5-hydroxyindolacetic acid (5-hiaa). |
1987-02-06 |
2023-08-11 |
cat |
| Y Chaput, C de Montigny, P Blie. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 333. issue 4. 1986-12-12. PMID:3022157. |
for 14 days, the suppression of firing activity of ca3 hippocampal pyramidal neurons produced by microiontophoretically-applied 5-ht and by the electrical activation of the ascending 5-ht pathway was measured. |
1986-12-12 |
2023-08-11 |
rat |
| L Antkiewicz-Michalu. The influence of chronic treatment with antidepressant neuroleptics on the central serotonin system. Polish journal of pharmacology and pharmacy. vol 38. issue 4. 1986-12-10. PMID:3774629. |
they also indicate that antidepressant neuroleptics, which are potent serotonin 5-ht2 and alpha 1-adrenergic blocking agents, after chronic administration affect the serotonin system in a manner similar to that produced by chronic treatment with classical antidepressant drugs. |
1986-12-10 |
2023-08-11 |
rat |
| Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 10. 1986-11-12. PMID:3020184. |
in a first series of experiments, the effect of the electrical activation of the ascending 5-ht pathway on the firing activity of ca3 hippocampal pyramidal neurons was measured before and after the intravenous administration of methiothepin, a terminal 5-ht autoreceptor antagonist. |
1986-11-12 |
2023-08-11 |
Not clear |
| Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 10. 1986-11-12. PMID:3020184. |
methiothepin significantly increased the duration of the suppression of firing activity of these neurons by the electrical stimulation of the 5-ht pathway, without modifying their responsiveness to microiontophoretically applied 5-ht. |
1986-11-12 |
2023-08-11 |
Not clear |
| Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 10. 1986-11-12. PMID:3020184. |
in a second series of experiments, further evidence for the activation of terminal 5-ht autoreceptors by 5-ht released by the electrical stimulation was sought by assessing the effectiveness of 2 series of stimulations of the ascending 5-ht pathway delivered at different frequencies while recording the same postsynaptic neuron. |
1986-11-12 |
2023-08-11 |
Not clear |
| L Brodin, J T Buchanan, T Hökfelt, S Grillner, A A Verhofsta. A spinal projection of 5-hydroxytryptamine neurons in the lamprey brainstem; evidence from combined retrograde tracing and immunohistochemistry. Neuroscience letters. vol 67. issue 1. 1986-08-13. PMID:3725200. |
these findings suggest that in addition to the well-described local intraspinal 5-ht system, there is also, as in higher vertebrates, a descending 5-ht projection from the brainstem which extends at least 20 segments into the spinal cord. |
1986-08-13 |
2023-08-11 |
Not clear |
| S M Lasley, J B Thurmon. Interaction of dietary tryptophan and social isolation on territorial aggression, motor activity, and neurochemistry in mice. Psychopharmacology. vol 87. issue 3. 1986-01-28. PMID:3936087. |
neurochemical measures indicated increased da and 5-ht turnover in isolated mice, with the 5-ht system most affected by dietary trp. |
1986-01-28 |
2023-08-11 |
mouse |
| S Finklestein, A Campbell, R J Baldessarini, K L Moya, S N Habe. Late changes in cerebral monoamine metabolism following focal ventrolateral cerebrocortical lesions in rats. Brain research. vol 344. issue 2. 1985-11-20. PMID:2412650. |
the changes of greatest magnitude and anatomical extent were found in the serotonin system: 5-ht was generally increased, and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) and the 5-hiaa:5-ht ratio were decreased throughout the cerebral hemispheres ipsilateral to lesions. |
1985-11-20 |
2023-08-11 |
rat |
| S Finklestein, A Campbell, R J Baldessarini, K L Moya, S N Habe. Late changes in cerebral monoamine metabolism following focal ventrolateral cerebrocortical lesions in rats. Brain research. vol 344. issue 2. 1985-11-20. PMID:2412650. |
these widespread changes in cerebral 5-ht metabolism were qualitatively different and smaller than those previously found at 6 days after cortical lesions, and suggest a biphasic response of the ipsilateral 5-ht system to ventrolateral cortical injury. |
1985-11-20 |
2023-08-11 |
rat |
| P Blier, C De Montign. Short-term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. European journal of pharmacology. vol 113. issue 1. 1985-11-12. PMID:2995061. |
the responsiveness to 5-ht and ne was not modified whereas the effect of activation of the ascending 5-ht pathway was increased two-fold by the lithium treatment. |
1985-11-12 |
2023-08-11 |
rat |
| E T MacKenzie, L Edvinsson, B Scatto. Functional bases for a central serotonergic involvement in classic migraine: a speculative view. Cephalalgia : an international journal of headache. vol 5. issue 2. 1985-09-04. PMID:3893731. |
the findings, marked changes in plasma levels of 5-ht and in cerebral blood flow during a classic migraine attack, are suggestive of an involvement of the 5-ht system. |
1985-09-04 |
2023-08-11 |
human |
| R Ortman. The 5-HT syndrome and the drug discrimination paradigm in rats: application in behavioral studies on the central 5-HT system. Pharmacopsychiatry. vol 18. issue 2. 1985-09-03. PMID:3875109. |
the 5-ht syndrome and the drug discrimination paradigm in rats: application in behavioral studies on the central 5-ht system. |
1985-09-03 |
2023-08-11 |
rat |