| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
subsequently, to specify potential behavioural correlates of elevated hippocampal 5-ht arising due to the genetic lesion, we compared 39,x(y*)o mf1 mice to 40,xy mf1 mice on behavioural tasks taxing hippocampal and/or 5-ht function (a 'foraging' task, an object-location task, and the 1-choice serial reaction time task of impulsivity). |
2014-01-31 |
2023-08-12 |
mouse |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
although sts/asmt deficiency did not influence foraging behaviour, reactivity to familiar objects in novel locations, or 'ability to wait', it did result in markedly increased response rates; these rates correlated with hippocampal 5-ht levels and are likely to index behavioural perseveration, a frequent feature of neurodevelopmental disorders. |
2014-01-31 |
2023-08-12 |
mouse |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
additionally, we show that whilst there was no systematic relationship between serum dhea levels and hippocampal 5-ht levels across 39,x(y*)o and 40,xy mice, there was a significant inverse linear correlation between serum dhea levels and activity. |
2014-01-31 |
2023-08-12 |
mouse |
| Shinsuke Uchihashi, Miyu Nishikawa, Toshiyuki Sakaki, Shin-ichi Ikushir. Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain. Drug metabolism and pharmacokinetics. vol 28. issue 3. 2014-01-30. PMID:23089803. |
however, the difference in expression levels between ugt1a6a and ugt1a6b in the hippocampus led us to speculate that ugt1a6a is likely the predominant catalyst of serotonin glucuronidation in the mouse brain. |
2014-01-30 |
2023-08-12 |
mouse |
| Yinghua Yu, Yizhen Wu, Craig Patch, Zhixiang Wu, Alexander Szabo, Duo Li, Xu-Feng Huan. DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. The Journal of nutritional biochemistry. vol 24. issue 7. 2014-01-29. PMID:23337348. |
in the hippocampus, the 5-ht(1a), cb1 and gaba(a) receptor binding densities significantly increased in response to an hf diet, while in the hypothalamus, 5-ht(1a) and cb1 binding densities significantly increased in hf-fed rats. |
2014-01-29 |
2023-08-12 |
rat |
| E Venzala, A L García-García, N Elizalde, R M Torder. Social vs. environmental stress models of depression from a behavioural and neurochemical approach. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22743048. |
subsequently, we examined glutamate, gaba, 5-ht and dopamine levels in the prefrontal cortex, hippocampus and brainstem. |
2014-01-23 |
2023-08-12 |
mouse |
| Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Junko Sajiki, Eiji Shimiz. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice. Hormones and behavior. vol 63. issue 5. 2014-01-17. PMID:23567477. |
bpa enhanced fear memory and increased serotonin metabolite (5-hiaa) levels and 5-hiaa/5-ht in the hippocampus, the striatum, the midbrain, the pons, and the medulla oblongata of juvenile female mice. |
2014-01-17 |
2023-08-12 |
mouse |
| Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Junko Sajiki, Eiji Shimiz. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice. Hormones and behavior. vol 63. issue 5. 2014-01-17. PMID:23567477. |
furthermore, bpa induced increases in the expression levels of tph2, slc6a4, and maoa mrna in the hippocampus of juvenile females, indicating that bpa induces hyper 5-ht turnover in the hippocampus. |
2014-01-17 |
2023-08-12 |
mouse |
| Dasiel O Borroto-Escuela, Fidel Corrales, Manuel Narvaez, Julia Oflijan, Luigi F Agnati, Miklós Palkovits, Kjell Fux. Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochemical and biophysical research communications. vol 441. issue 2. 2014-01-17. PMID:24157794. |
new findings show that neurotrophic and antidepressant effects of 5-ht in brain can, in part, be mediated by activation of the 5-ht1a receptor protomer in the hippocampal and raphe fgfr1-5-ht1a heteroreceptor complexes enhancing the fgfr1 signaling. |
2014-01-17 |
2023-08-12 |
Not clear |
| Lu Zhang, Qian-Dong Wang, Hua-Meng Shi, Jian-Chun Pa. [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 1. 2014-01-16. PMID:23600138. |
the results suggested that reserpine significantly increased the level of nitrite in hippocampus and frontal cortex and reduced the levels of sod, 5-ht and ne in these two brain regions. |
2014-01-16 |
2023-08-12 |
mouse |
| Reiko T Roppongi, Nobuhiko Kojima, Kenji Hanamura, Hiroyuki Yamazaki, Tomoaki Shira. Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors. Neuroscience letters. vol 547. 2014-01-16. PMID:23684573. |
selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-ht(2a) receptors. |
2014-01-16 |
2023-08-12 |
Not clear |
| Reiko T Roppongi, Nobuhiko Kojima, Kenji Hanamura, Hiroyuki Yamazaki, Tomoaki Shira. Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors. Neuroscience letters. vol 547. 2014-01-16. PMID:23684573. |
in the present study, we examined the effect of 5-ht(2a) receptor activation on the actin cytoskeleton in dendritic spines of mature hippocampal neurons in low-density culture. |
2014-01-16 |
2023-08-12 |
Not clear |
| Simona Spinelli, Tanja Müller, Miriam Friedel, Hannes Sigrist, Klaus-Peter Lesch, Mark Henkelman, Markus Rudin, Erich Seifritz, Christopher R Pryc. Effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression. Frontiers in behavioral neuroscience. vol 7. 2014-01-15. PMID:24427124. |
in humans, exposure to stress during development is associated with structural and functional alterations of the prefrontal cortex (pfc), amygdala (amy), and hippocampus (hc) and their circuits of connectivity, and with an increased risk for developing major depressive disorder particularly in carriers of the short (s) variant of the serotonin transporter (5-htt) gene-linked polymorphic region (5-httlpr). |
2014-01-15 |
2023-08-12 |
mouse |
| Stéphanie Pain, Alice Gochard, Sylvie Bodard, Zuhal Gulhan, Caroline Prunier-Aesch, Sylvie Chalo. Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:23083629. |
moreover, a decrease of serotonin level was observed in midbrain and hippocampus of acute and sub-acute intoxicated-mice. |
2014-01-07 |
2023-08-12 |
mouse |
| G Clarke, S Grenham, P Scully, P Fitzgerald, R D Moloney, F Shanahan, T G Dinan, J F Crya. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular psychiatry. vol 18. issue 6. 2014-01-03. PMID:22688187. |
here we show that male gf animals have a significant elevation in the hippocampal concentration of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid, its main metabolite, compared with conventionally colonised control animals. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuencisla Pilar-Cuéllar, Rebeca Vidal, Alvaro Díaz, Elena Castro, Severiano dos Anjos, Jesús Pascual-Brazo, Raquel Linge, Veronica Vargas, Helena Blanco, Beatriz Martínez-Villayandre, Ángel Pazos, Elsa M Valdizá. Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication. Neural plasticity. vol 2013. 2013-12-30. PMID:23862076. |
we will especially focus on the hippocampal cellularity and plasticity modulation by serotonin, trophic factors as brain-derived neurotrophic factor (bdnf), and vascular endothelial growth factor (vegf) through intracellular signalling pathways-camp, wnt/ β -catenin, and mtor. |
2013-12-30 |
2023-08-12 |
Not clear |
| Margherita Zotti, Marilena Colaianna, Maria Grazia Morgese, Paolo Tucci, Stefania Schiavone, Pinarosa Avato, Luigia Trabac. Carvacrol: from ancient flavoring to neuromodulatory agent. Molecules (Basel, Switzerland). vol 18. issue 6. 2013-12-24. PMID:23708230. |
), was able to increase dopamine and serotonin levels in the prefrontal cortex and hippocampus. |
2013-12-24 |
2023-08-12 |
rat |
| Margherita Zotti, Marilena Colaianna, Maria Grazia Morgese, Paolo Tucci, Stefania Schiavone, Pinarosa Avato, Luigia Trabac. Carvacrol: from ancient flavoring to neuromodulatory agent. Molecules (Basel, Switzerland). vol 18. issue 6. 2013-12-24. PMID:23708230. |
acute carvacrol administration only significantly reduced serotonin content in either the prefrontal cortex or in the hippocampus at the highest dose. |
2013-12-24 |
2023-08-12 |
rat |
| G Quesseveur, D J David, M C Gaillard, P Pla, M V Wu, H T Nguyen, V Nicolas, G Auregan, I David, A Dranovsky, P Hantraye, R Hen, A M Gardier, N Déglon, B P Guiar. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Translational psychiatry. vol 3. 2013-12-23. PMID:23632457. |
at nerve terminal such as the hippocampus, the enhancement of 5-ht availability increases brain-derived neurotrophic factor (bdnf) synthesis and signaling, a major event in the stimulation of adult neurogenesis. |
2013-12-23 |
2023-08-12 |
mouse |
| Man Tang, Jieyu Lei, Xiao Sun, Guojun Liu, Shulei Zha. Stress-induced anhedonia correlates with lower hippocampal serotonin transporter protein expression. Brain research. vol 1513. 2013-12-16. PMID:23558306. |
stress-induced anhedonia correlates with lower hippocampal serotonin transporter protein expression. |
2013-12-16 |
2023-08-12 |
mouse |