| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damian Refojo, Martin Schweizer, Claudia Kuehne, Stefanie Ehrenberg, Christoph Thoeringer, Annette M Vogl, Nina Dedic, Marion Schumacher, Gregor von Wolff, Charilaos Avrabos, Chadi Touma, David Engblom, Günther Schütz, Klaus-Armin Nave, Matthias Eder, Carsten T Wotjak, Inge Sillaber, Florian Holsboer, Wolfgang Wurst, Jan M Deussin. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science (New York, N.Y.). vol 333. issue 6051. 2011-10-18. PMID:21885734. |
selective deletion of crhr1 in midbrain dopaminergic neurons increases anxiety-like behavior and reduces dopamine release in the prefrontal cortex. |
2011-10-18 |
2023-08-12 |
Not clear |
| Ian C Ballard, Vishnu P Murty, R McKell Carter, Jeffrey J MacInnes, Scott A Huettel, R Alison Adcoc. Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 28. 2011-09-12. PMID:21753011. |
motivation to obtain reward is thought to depend on the midbrain [particularly the ventral tegmental area (vta)], the nucleus accumbens (nacc), and the dorsolateral prefrontal cortex (dlpfc), but it is not clear how the interactions among these regions relate to reward-motivated behavior. |
2011-09-12 |
2023-08-12 |
human |
| Susanne Graef, Guido Biele, Lea K Krugel, Frank Marzinzik, Michael Wahl, Johann Wotka, Fabian Klostermann, Hauke R Heekere. Differential influence of levodopa on reward-based learning in Parkinson's disease. Frontiers in human neuroscience. vol 4. 2011-07-14. PMID:21048900. |
the mesocorticolimbic dopamine (da) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. |
2011-07-14 |
2023-08-12 |
Not clear |
| Allan Siegel, John Douar. Who's flying the plane: serotonin levels, aggression and free will. International journal of law and psychiatry. vol 34. issue 1. 2011-06-13. PMID:21112635. |
this framework is based upon classical conditioning of neurons in the prefrontal cortex that allow for a decision making mechanism that provides for prefrontal cortical control of the sites in the brain which express aggressive behavior that include the hypothalamus and midbrain periaqueductal gray. |
2011-06-13 |
2023-08-12 |
human |
| Devin Mueller, Christian Bravo-Rivera, Gregory J Quir. Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses. Biological psychiatry. vol 68. issue 11. 2011-02-25. PMID:20926066. |
fear extinction is dependent on plasticity in the infralimbic prefrontal cortex, an area heavily innervated by midbrain dopaminergic inputs. |
2011-02-25 |
2023-08-12 |
Not clear |
| Laura K Teune, Anna L Bartels, Bauke M de Jong, Antoon T M Willemsen, Silvia A Eshuis, Jeroen J de Vries, Joost C H van Oostrom, Klaus L Leender. Typical cerebral metabolic patterns in neurodegenerative brain diseases. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 14. 2011-02-22. PMID:20669302. |
fdg pet images of each patient group were analyzed and compared to18 healthy controls using statistical parametric mapping (spm5).disease-specific patterns of relatively decreased metabolic activity were found in pd (contralateral parietooccipital and frontal regions), msa (bilateral putamen and cerebellar hemispheres), psp (prefrontal cortex and caudate nucleus, thalamus, and mesencephalon), cbd (contralateral cortical regions), dlb (occipital and parietotemporal regions), ad (parietotemporal regions), and ftd (frontotemporal regions).the integrated method addressing a spectrum of various neurodegenerative brain diseases provided means to discriminate patient groups also at early disease stages. |
2011-02-22 |
2023-08-12 |
human |
| Patricia Rojas, Eliza Joodmardi, Thomas Perlmann, Sven Ove Ogre. Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20175204. |
the nurr1 gene was rapidly and widely up-regulated throughout the brain, including cortical areas (i.e., prefrontal cortex, primary and secondary visual cortex, primary auditory cortex, and secondary somatosensory cortex), hippocampus (dentate gyrus, ca1, ca2, and ca3), and midbrain (substantia nigra pars compacta and ventral tegmental area) at 30 min and 3 hr after the forced swim test. |
2010-10-26 |
2023-08-12 |
mouse |
| Patricia Rojas, Eliza Joodmardi, Thomas Perlmann, Sven Ove Ogre. Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20175204. |
dopamine content was reduced in prefrontal cortex and midbrain following swim stress. |
2010-10-26 |
2023-08-12 |
mouse |
| Ricardo Llorente, Esther O'Shea, M Dolores Gutierrez-Lopez, Alvaro Llorente-Berzal, María Isabel Colado, María-Paz Vivero. Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats. Neuroscience letters. vol 479. issue 2. 2010-09-27. PMID:20493239. |
in this study we have addressed the effects of md on the levels of serotonin (5-ht), dopamine (da) and their respective metabolites in prefrontal cortex, hippocampus, striatum, midbrain and cerebellum of male and female periadolescent wistar rats. |
2010-09-27 |
2023-08-12 |
rat |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that, respectively, project to dorsal and ventral striatum (including prefrontal cortex). |
2010-09-22 |
2023-08-12 |
Not clear |
| L A Ruocco, U A Gironi Carnevale, C Treno, A G Sadile, D Melisi, C Arra, M Ibba, C Schirru, E Carbon. Prepuberal subchronic methylphenidate and atomoxetine induce different long-term effects on adult behaviour and forebrain dopamine, norepinephrine and serotonin in Naples high-excitability rats. Behavioural brain research. vol 210. issue 1. 2010-06-30. PMID:20156489. |
the high-performance liquid chromatography (hplc) tissue content assessment of dopamine, norepinephrine, serotonin and relative metabolites in the prefrontal cortex (pfc), cortical motor area (mc), dorsal striatum (ds), ventral striatum (vs), hippocampus and mesencephalon indicated that methylphenidate decreased (i) dopamine, dopac, norepinephrine, mhpg, 5-ht and 5-hiaa in the pfc, (ii) dopamine, dopac, hva, serotonin, 5-hiaa in the ds, (iii) dopamine, dopac, hva and mhpg (but increased norepinephrine) in the vs and (iv) norepinephrine, mhpg, serotonin and 5-hiaa in the hippocampus. |
2010-06-30 |
2023-08-12 |
rat |
| Stuart T Leonard, John K Hearn, Andrew D Catling, Peter J Winsaue. Gonadal hormones modulate the potency of the disruptive effects of donepezil in male rats responding under a nonspatial operant learning and performance task. Behavioural pharmacology. vol 21. issue 2. 2010-06-17. PMID:20177375. |
in terms of ache activity, gx males had higher levels in the prefrontal cortex, striatum and hippocampus, but lower levels in the midbrain, compared with intact males; hypothalamic and cortical levels were comparable for the gx and intact groups. |
2010-06-17 |
2023-08-12 |
rat |
| Shoji Tanak. Model-based parametric study of frontostriatal abnormalities in schizophrenia patients. BMC psychiatry. vol 10. 2010-05-06. PMID:20187970. |
one would attribute this relationship primarily to the circuitry comprised of the glutamatergic projection from the pfc to the striatum and the gabaergic projection from the striatum to the midbrain da nucleus. |
2010-05-06 |
2023-08-12 |
Not clear |
| Vinay Parikh, Jinzhao Ji, Michael W Decker, Martin Sarte. Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203212. |
transients were recorded in mice lacking beta2 or alpha7 nachrs and in rats after removal of thalamic glutamatergic or midbrain dopaminergic inputs to prefrontal cortex. |
2010-05-05 |
2023-08-12 |
mouse |
| M Leriche, M Ménde. Ethanol exposure selectively alters beta-endorphin content but not [3H]-DAMGO binding in discrete regions of the rat brain. Neuropeptides. vol 44. issue 1. 2010-04-08. PMID:20031207. |
no ethanol effects were observed in the midbrain, ventral tegmental area, substantia nigra, nucleus accumbens, nucleus accumbens-septum and prefrontal cortex. |
2010-04-08 |
2023-08-12 |
rat |
| Suzanne N Haber, Brian Knutso. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 1. 2010-02-24. PMID:19812543. |
the key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. |
2010-02-24 |
2023-08-12 |
human |
| Phil D Livingstone, Susan Wonnacot. Nicotinic acetylcholine receptors and the ascending dopamine pathways. Biochemical pharmacology. vol 78. issue 7. 2009-09-21. PMID:19523928. |
nicotinic acetylcholine receptors (nachrs) are widely expressed in midbrain dopamine neurons that project to dorsal striatum, nucleus accumbens and prefrontal cortex. |
2009-09-21 |
2023-08-12 |
Not clear |
| Ryoji Fukabori, Kazuto Kobayash. [Functional analysis of the roles of direct and indirect pathways by using immunotoxin-mediated cell targeting approach]. Brain and nerve = Shinkei kenkyu no shinpo. vol 61. issue 4. 2009-07-01. PMID:19378811. |
these functions are dependent on midbrain dopamine systems that innervate the prefrontal cortex and the striatum. |
2009-07-01 |
2023-08-12 |
Not clear |
| Robert K McNamara, Jessica Able, Ronald Jandacek, Therese Rider, Patrick Ts. Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition. Lipids. vol 44. issue 1. 2009-05-22. PMID:18923861. |
after correction for multiple comparisons, c57bl/6j mice exhibited significantly lower dha composition in the hippocampus and ventral striatum, but not prefrontal cortex or midbrain, and significantly greater regional arachidonic acid (ara, 20:4n-6):dha ratios, relative to dba/2j mice. |
2009-05-22 |
2023-08-12 |
mouse |
| Robert K McNamara, Jessica Able, Yanhong Liu, Ronald Jandacek, Therese Rider, Patrick Tso, Jack W Lipto. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. Journal of psychiatric research. vol 43. issue 6. 2009-05-13. PMID:18986658. |
omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. |
2009-05-13 |
2023-08-12 |
rat |