| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianling Chen, Wei Wu, Yingmei Fu, Shunying Yu, Donghong Cui, Min Zhao, Yasong Du, Jijun Li, Xiaohong L. Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27602061. |
increased expression of fatty acid synthase and acetyl-coa carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. |
2020-09-29 |
2023-08-13 |
rat |
| Jianling Chen, Wei Wu, Yingmei Fu, Shunying Yu, Donghong Cui, Min Zhao, Yasong Du, Jijun Li, Xiaohong L. Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27602061. |
the primary aim of the present study was to investigate alterations in enzymes associated with fatty acid synthesis, namely fatty acid synthase (fasn) and acetyl-coa carboxylase (acc), in the prefrontal cortex and cerebellum of the valproic acid (vpa)-induced animal model of autism. |
2020-09-29 |
2023-08-13 |
rat |
| Jianling Chen, Wei Wu, Yingmei Fu, Shunying Yu, Donghong Cui, Min Zhao, Yasong Du, Jijun Li, Xiaohong L. Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27602061. |
the results of western blotting and reverse transcription-quantitative polymerase chain reaction analyses demonstrated that the protein and mrna expression levels of fasn, acc and phospho-acc (pacc) were increased in the prefrontal cortex and cerebellum of the vpa model of autism. |
2020-09-29 |
2023-08-13 |
rat |
| Jianling Chen, Wei Wu, Yingmei Fu, Shunying Yu, Donghong Cui, Min Zhao, Yasong Du, Jijun Li, Xiaohong L. Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27602061. |
furthermore, in the prefrontal cortex and cerebellum of the vpa model of autism, ampk expression is increased, whereas pi3k and akt expression are unchanged. |
2020-09-29 |
2023-08-13 |
rat |
| Branka Hrvoj-Mihic, Kari L Hanson, Caroline H Lew, Lisa Stefanacci, Bob Jacobs, Ursula Bellugi, Katerina Semendefer. Basal Dendritic Morphology of Cortical Pyramidal Neurons in Williams Syndrome: Prefrontal Cortex and Beyond. Frontiers in neuroscience. vol 11. 2020-09-29. PMID:28848376. |
although this study utilized tissue held in formalin for a prolonged period of time and the number of neurons available for analysis was limited, our findings indicate that ws cortex, similar to that in other neurodevelopmental disorders such as down syndrome, rett syndrome, fragile x, and idiopathic autism, has altered morphology of basal dendrites on pyramidal neurons, which appears more prominent in selected areas of the pfc. |
2020-09-29 |
2023-08-13 |
human |
| Donald Pfaff, Helen Barba. Mechanisms for the Approach/Avoidance Decision Applied to Autism. Trends in neurosciences. vol 42. issue 7. 2020-09-21. PMID:31253250. |
we present a hypothesis of mechanisms plausibly affected during brain development in autism, based on neural pathways that are associated with social behavior and connect the prefrontal cortex (pfc) to the basal ganglia (bg). |
2020-09-21 |
2023-08-13 |
Not clear |
| Fumi Masuda, Shinichiro Nakajima, Takahiro Miyazaki, Ryosuke Tarumi, Kamiyu Ogyu, Masataka Wada, Sakiko Tsugawa, Paul E Croarkin, Masaru Mimura, Yoshihiro Nod. Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review. Autism : the international journal of research and practice. vol 23. issue 7. 2020-08-04. PMID:30663323. |
in patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. |
2020-08-04 |
2023-08-13 |
Not clear |
| Ilia Kurochkin, Ekaterina Khrameeva, Anna Tkachev, Vita Stepanova, Anna Vanyushkina, Elena Stekolshchikova, Qian Li, Dmitry Zubkov, Polina Shichkova, Tobias Halene, Lothar Willmitzer, Patrick Giavalisco, Schahram Akbarian, Philipp Khaitovic. Metabolome signature of autism in the human prefrontal cortex. Communications biology. vol 2. 2020-04-23. PMID:31263778. |
metabolome signature of autism in the human prefrontal cortex. |
2020-04-23 |
2023-08-13 |
human |
| Iris Margalit Trutzer, Miguel Ángel García-Cabezas, Basilis Zikopoulo. Postnatal development and maturation of layer 1 in the lateral prefrontal cortex and its disruption in autism. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30867066. |
postnatal development and maturation of layer 1 in the lateral prefrontal cortex and its disruption in autism. |
2020-03-30 |
2023-08-13 |
Not clear |
| Iris Margalit Trutzer, Miguel Ángel García-Cabezas, Basilis Zikopoulo. Postnatal development and maturation of layer 1 in the lateral prefrontal cortex and its disruption in autism. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30867066. |
to begin to address these issues, we examined layer 1 of the lateral prefrontal cortex (lpfc), an area with prolonged development and maturation that is affected in autism. |
2020-03-30 |
2023-08-13 |
Not clear |
| Paola Odriozola, Dina R Dajani, Catherine A Burrows, Laurel J Gabard-Durnam, Emma Goodman, Adriana C Baez, Nim Tottenham, Lucina Q Uddin, Dylan G Ge. Atypical frontoamygdala functional connectivity in youth with autism. Developmental cognitive neuroscience. vol 37. 2019-11-22. PMID:30581125. |
functional connectivity (fc) between the amygdala and the ventromedial prefrontal cortex underlies socioemotional functioning, a core domain of impairment in autism spectrum disorder (asd). |
2019-11-22 |
2023-08-13 |
Not clear |
| Jian Wang, Yu Tao, Fan Song, Yue Sun, Jurg Ott, David Saffe. Common Regulatory Variants of CYFIP1 Contribute to Susceptibility for Autism Spectrum Disorder (ASD) and Classical Autism. Annals of human genetics. vol 79. issue 5. 2019-11-20. PMID:26094621. |
based on the analysis of mrna expression and genotype data from the "brain cloud" database, we identified seven snps within or near the autism candidate gene cyfip1 that show nominally significant correlations between genotype and cyfip1 mrna expression in human dorsolateral prefrontal cortex. |
2019-11-20 |
2023-08-13 |
human |
| Xiling Liu, Dingding Han, Mehmet Somel, Xi Jiang, Haiyang Hu, Patricia Guijarro, Ning Zhang, Amanda Mitchell, Tobias Halene, John J Ely, Chet C Sherwood, Patrick R Hof, Zilong Qiu, Svante Pääbo, Schahram Akbarian, Philipp Khaitovic. Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. PLoS biology. vol 14. issue 9. 2019-11-20. PMID:27685936. |
here, we analyze gene expression in the prefrontal cortex of 63 autism patients and control individuals, as well as 62 chimpanzees and macaques, from natal to adult age. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ezzat Hashemi, Jeanelle Ariza, Haille Rogers, Stephen C Noctor, Verónica Martínez-Cerdeñ. The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 2. 2019-11-20. PMID:28334402. |
the number of parvalbumin-expressing interneurons is decreased in the prefrontal cortex in autism. |
2019-11-20 |
2023-08-13 |
Not clear |
| Isabel Barón-Mendoza, Ireri Del Moral-Sánchez, Mónica Martínez-Marcial, Octavio García, Daniel Garzón-Cortés, Aliesha González-Arena. Dendritic complexity in prefrontal cortex and hippocampus of the autistic-like mice C58/J. Neuroscience letters. vol 703. 2019-10-29. PMID:30885632. |
autism spectrum disorder (asd) has been associated to atypical neuronal connectivity in the prefrontal cortex (pfc) and the hippocampus, in part, due to an alteration in neuroplasticity processes such as dendritic remodeling. |
2019-10-29 |
2023-08-13 |
mouse |
| Daoyin Dong, Horst Ronald Zielke, David Yeh, Peixin Yan. Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. vol 11. issue 7. 2019-10-02. PMID:29761862. |
this study compared the activation of er stress signals (protein kinase r-like endoplasmic reticulum kinase [perk], activating transcription factor 6 [atf6], inositol-requiring enzyme 1 alpha [ire1α]) in different brain regions (prefrontal cortex, hippocampus, cerebellum) in subjects with autism and in age-matched controls. |
2019-10-02 |
2023-08-13 |
human |
| Yuping Luo, Bo Zhou, Fen Liu, Rong Ai, Min Wen, Xuetao Ton. [Enhanced autophagy activates p38/MEF2C pathway to regulate the expression of synapse-associated proteins and improve the symptoms of autistic rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 3. 2019-08-15. PMID:31030717. |
conclusion the p38/mef2c signaling pathway is inhibited in the prefrontal cortex of rats with autism, which can regulate the expression of synaptic related proteins and improve autistic behavior by enhancing autophagy to activate the p38/mef2c signaling pathway. |
2019-08-15 |
2023-08-13 |
rat |
| Jeanelle Ariza, Haille Rogers, Ezzat Hashemi, Stephen C Noctor, Verónica Martínez-Cerdeñ. The Number of Chandelier and Basket Cells Are Differentially Decreased in Prefrontal Cortex in Autism. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 2. 2019-05-08. PMID:28122807. |
the number of chandelier and basket cells are differentially decreased in prefrontal cortex in autism. |
2019-05-08 |
2023-08-13 |
human |
| Jeanelle Ariza, Haille Rogers, Ezzat Hashemi, Stephen C Noctor, Verónica Martínez-Cerdeñ. The Number of Chandelier and Basket Cells Are Differentially Decreased in Prefrontal Cortex in Autism. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 2. 2019-05-08. PMID:28122807. |
we previously demonstrated a decreased number of parvalbumin (pv)-expressing interneurons in prefrontal cortex in autism. |
2019-05-08 |
2023-08-13 |
human |
| Brielle R Ferguson, Wen-Jun Ga. PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders. Frontiers in neural circuits. vol 12. 2019-02-27. PMID:29867371. |
further, their function is heavily diminished in the prefrontal cortex (pfc) in numerous psychiatric diseases, including schizophrenia and autism. |
2019-02-27 |
2023-08-13 |
Not clear |