| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer J Donegan, Angela M Boley, Daniel J Lodg. Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29453447. |
specifically, people with autism have a reduction in parvalbumin (pv)-containing interneurons in the pfc, leading to the suggestion that restoring interneuron function in this region may be a novel therapeutic approach for asd. |
2019-02-14 |
2023-08-13 |
Not clear |
| Ying Zhu, André M M Sousa, Tianliuyun Gao, Mario Skarica, Mingfeng Li, Gabriel Santpere, Paula Esteller-Cucala, David Juan, Luis Ferrández-Peral, Forrest O Gulden, Mo Yang, Daniel J Miller, Tomas Marques-Bonet, Yuka Imamura Kawasawa, Hongyu Zhao, Nenad Sesta. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science (New York, N.Y.). vol 362. issue 6420. 2019-01-14. PMID:30545855. |
genes exhibiting heterotopic and heterochronic divergence included those transiently enriched in the prenatal prefrontal cortex or linked to autism spectrum disorder and schizophrenia. |
2019-01-14 |
2023-08-13 |
human |
| Ruoxin Zhang, Jinlong Zhou, Junrong Ren, Siqi Sun, Yuanyuan Di, Hanyu Wang, Xiaoqin An, Kexin Zhang, Junfeng Zhang, Zhaoqiang Qian, Meimei Shi, Yanning Qiao, Wei Ren, Yingfang Tia. Transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism. Reproductive toxicology (Elmsford, N.Y.). vol 77. 2018-11-02. PMID:29427782. |
transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism. |
2018-11-02 |
2023-08-13 |
rat |
| Ruoxin Zhang, Jinlong Zhou, Junrong Ren, Siqi Sun, Yuanyuan Di, Hanyu Wang, Xiaoqin An, Kexin Zhang, Junfeng Zhang, Zhaoqiang Qian, Meimei Shi, Yanning Qiao, Wei Ren, Yingfang Tia. Transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism. Reproductive toxicology (Elmsford, N.Y.). vol 77. 2018-11-02. PMID:29427782. |
the aim of the current study is to detect the effects of valproic acid on gene expression profiles and alternatively spliced genes in the prefrontal cortex in rat models of autism. |
2018-11-02 |
2023-08-13 |
rat |
| Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chan. No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism. Molecular autism. vol 8. 2018-07-13. PMID:29234492. |
no preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism. |
2018-07-13 |
2023-08-13 |
Not clear |
| Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chan. No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism. Molecular autism. vol 8. 2018-07-13. PMID:29234492. |
we present the first study of astrocyte density and morphology within the white matter of the dorsolateral prefrontal cortex (dlpfc) in individuals with autism. |
2018-07-13 |
2023-08-13 |
Not clear |
| Rebecca Reumann, Ricardo Vierk, Lepu Zhou, Frederice Gries, Vanessa Kraus, Julia Mienert, Eva Romswinkel, Fabio Morellini, Isidre Ferrer, Chiara Nicolini, Margaret Fahnestock, Gabriele Rune, Markus Glatzel, Giovanna Galliciott. The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior. Learning & memory (Cold Spring Harbor, N.Y.). vol 24. issue 12. 2018-06-26. PMID:29142062. |
however, although synaptic dysfunction is implicated in neuropsychiatric disorders, we do not detect alterations in expression of neuroserpin in fusiform gyrus of autism patients or in dorsolateral prefrontal cortex of schizophrenia patients. |
2018-06-26 |
2023-08-13 |
mouse |
| Clodagh M Murphy, Anastasia Christakou, Vincent Giampietro, Michael Brammer, Eileen M Daly, Christine Ecker, Patrick Johnston, Debbie Spain, Dene M Robertson, Declan G Murphy, Katya Rubi. Abnormal functional activation and maturation of ventromedial prefrontal cortex and cerebellum during temporal discounting in autism spectrum disorder. Human brain mapping. vol 38. issue 11. 2018-05-29. PMID:28744969. |
abnormal functional activation and maturation of ventromedial prefrontal cortex and cerebellum during temporal discounting in autism spectrum disorder. |
2018-05-29 |
2023-08-13 |
Not clear |
| Aslihan Selimbeyoglu, Christina K Kim, Masatoshi Inoue, Soo Yeun Lee, Alice S O Hong, Isaac Kauvar, Charu Ramakrishnan, Lief E Fenno, Thomas J Davidson, Matthew Wright, Karl Deisserot. Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in Science translational medicine. vol 9. issue 401. 2018-04-23. PMID:28768803. |
modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in alterations in the balance between neuronal excitation and inhibition (e:i balance) have been implicated in the neural circuit activity-based processes that contribute to autism phenotypes. |
2018-04-23 |
2023-08-13 |
mouse |
| L A Ajram, J Horder, M A Mendez, A Galanopoulos, L P Brennan, R H Wichers, D M Robertson, C M Murphy, J Zinkstok, G Ivin, M Heasman, D Meek, M D Tricklebank, G J Barker, D J Lythgoe, R A E Edden, S C Williams, D G M Murphy, G M McAlona. Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder. Translational psychiatry. vol 7. issue 5. 2018-03-14. PMID:28534874. |
shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder. |
2018-03-14 |
2023-08-13 |
Not clear |
| P E Dickson, J Cairns, D Goldowitz, G Mittlema. Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice. Neuroscience. vol 345. 2017-11-09. PMID:27012612. |
reciprocal pathways connecting the cerebellum to the prefrontal cortex provide a biological substrate through which the cerebellum may modulate higher cognitive functions, and it has been observed that cognitive inflexibility and cerebellar pathology co-occur in psychiatric disorders (e.g., autism, schizophrenia, addiction). |
2017-11-09 |
2023-08-13 |
mouse |
| Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Yunxin Wang, Jin Li, Robert K Moyzis, Jun Li, Qi Dong, Chongde Li. Associations between the CNTNAP2 gene, dorsolateral prefrontal cortex, and cognitive performance on the Stroop task. Neuroscience. vol 343. 2017-11-08. PMID:27916731. |
the cntnap2 (contactin-associated protein-like 2) gene, highly expressed in the human prefrontal cortex, has been linked with autism and language impairment. |
2017-11-08 |
2023-08-13 |
human |
| Hiroshi Ueno, Shunsuke Suemitsu, Motoi Okamoto, Yosuke Matsumoto, Takeshi Ishihar. Parvalbumin neurons and perineuronal nets in the mouse prefrontal cortex. Neuroscience. vol 343. 2017-11-08. PMID:27923740. |
alterations in parvalbumin interneurons (pv neurons) and perineuronal nets (pnns) within the pfc have been implicated in schizophrenia and autism spectrum disorder pathology. |
2017-11-08 |
2023-08-13 |
mouse |
| Tianqi Wang, Xiaolong Zhang, Ang Li, Meifang Zhu, Shu Liu, Wen Qin, Jin Li, Chunshui Yu, Tianzi Jiang, Bing Li. Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations. NeuroImage. Clinical. vol 14. 2017-11-03. PMID:28275544. |
consistent altered functional connectivity was found with the bilateral insula: for the left supplementary motor area and the left superior temporal gyrus with the cross-disorder pgrs, for the left insula and right middle and superior temporal lobe associated with the pgrs for autism, for the bilateral midbrain, posterior cingulate, cuneus, and precuneus associated with the pgrs for bd, and for the left angular gyrus and the left dorsolateral prefrontal cortex associated with the pgrs for schizophrenia. |
2017-11-03 |
2023-08-13 |
Not clear |
| Joshua H Balsters, Matthew A J Apps, Dimitris Bolis, Rea Lehner, Louise Gallagher, Nicole Wenderot. Disrupted prediction errors index social deficits in autism spectrum disorder. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:28031223. |
effective connectivity analyses further revealed that, in typically developing individuals but not in autism spectrum disorder, the magnitude of social prediction errors was driven by input from the ventromedial prefrontal cortex. |
2017-06-05 |
2023-08-13 |
Not clear |
| Joshua H Balsters, Matthew A J Apps, Dimitris Bolis, Rea Lehner, Louise Gallagher, Nicole Wenderot. Disrupted prediction errors index social deficits in autism spectrum disorder. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:28031223. |
these data provide a novel insight into the neural substrates underlying autism spectrum disorder social symptom severity, and further research into the gyral surface of the anterior cingulate cortex and ventromedial prefrontal cortex could provide more targeted therapies to help ameliorate social deficits in autism spectrum disorder. |
2017-06-05 |
2023-08-13 |
Not clear |
| Chantel S Prat, Andrea Stocco, Emily Neuhaus, Natalia M Kleinhan. Basal ganglia impairments in autism spectrum disorder are related to abnormal signal gating to prefrontal cortex. Neuropsychologia. vol 91. 2017-05-10. PMID:27542318. |
basal ganglia impairments in autism spectrum disorder are related to abnormal signal gating to prefrontal cortex. |
2017-05-10 |
2023-08-13 |
Not clear |
| Chantel S Prat, Andrea Stocco, Emily Neuhaus, Natalia M Kleinhan. Basal ganglia impairments in autism spectrum disorder are related to abnormal signal gating to prefrontal cortex. Neuropsychologia. vol 91. 2017-05-10. PMID:27542318. |
in attempts to integrate the existing literature, the current paper tests the hypothesis that impairments in the basal ganglia's function to flexibly select and route task-relevant neural signals to the prefrontal cortex underpins patterns of abnormal synchronization between the prefrontal cortex and other cortical processing centers observed in individuals with autism spectrum disorder (asd). |
2017-05-10 |
2023-08-13 |
Not clear |
| Chantel S Prat, Andrea Stocco, Emily Neuhaus, Natalia M Kleinhan. Basal ganglia impairments in autism spectrum disorder are related to abnormal signal gating to prefrontal cortex. Neuropsychologia. vol 91. 2017-05-10. PMID:27542318. |
such a failure to prioritize and filter signals to the prefrontal cortex could result in the pervasive impairments in cognitive flexibility and executive functioning that characterize autism spectrum disorder, and may offer a mechanistic explanation of some of the observed abnormalities in patterns of cortical synchronization in asd. |
2017-05-10 |
2023-08-13 |
Not clear |
| Ezzat Hashemi, Jeanelle Ariza, Mirna Lechpammer, Stephen C Noctor, Verónica Martínez-Cerdeñ. Abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report. Journal of medical case reports. vol 10. issue 1. 2017-05-10. PMID:27562638. |
abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (brodmann area 47) in autism: a case report. |
2017-05-10 |
2023-08-13 |
Not clear |