| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalie S Ryan, Shiva Keihaninejad, Timothy J Shakespeare, Manja Lehmann, Sebastian J Crutch, Ian B Malone, John S Thornton, Laura Mancini, Harpreet Hyare, Tarek Yousry, Gerard R Ridgway, Hui Zhang, Marc Modat, Daniel C Alexander, Martin N Rossor, Sebastien Ourselin, Nick C Fo. Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease. Brain : a journal of neurology. vol 136. issue Pt 5. 2013-06-24. PMID:23539189. |
amyloid imaging studies of presymptomatic familial alzheimer's disease have revealed the striatum and thalamus to be the earliest sites of amyloid deposition. |
2013-06-24 |
2023-08-12 |
human |
| Sultan Darves. Butyrylcholinesterase radioligands to image Alzheimer's disease brain. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22935510. |
neurons containing buche are particularly located in the amygdala, hippocampal formation and the thalamus, structures involved in the normal functions of cognition and behavior that typically become compromised in alzheimer's disease (ad). |
2013-05-28 |
2023-08-12 |
Not clear |
| Davide V Moretti, Donata Paternicò, Giuliano Binetti, Orazio Zanetti, Giovanni B Frison. Analysis of grey matter in thalamus and basal ganglia based on EEG α3/α2 frequency ratio reveals specific changes in subjects with mild cognitive impairment. ASN neuro. vol 4. issue 7. 2013-05-24. PMID:23126239. |
gm (grey matter) changes of thalamus and basal ganglia have been demonstrated to be involved in ad (alzheimer's disease). |
2013-05-24 |
2023-08-12 |
human |
| M W Fariss, V R Mumaw, L P Walto. Tetrahydroaminoacridine-induced apoptosis in rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. vol 10. issue 4. 2012-10-02. PMID:20650219. |
tacrine (tetrahydroaminoacridine, tha) is currently administered to thousands of patients for the treatment of alzheimer's disease. |
2012-10-02 |
2023-08-12 |
rat |
| M W Fariss, V R Mumaw, L P Walto. Tetrahydroaminoacridine-induced apoptosis in rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. vol 10. issue 4. 2012-10-02. PMID:20650219. |
we speculate that tha's ability to inhibit hepatocyte protein synthesis (>50%) and induce apoptosis may have an important role in the hepatotoxic episodes experienced by alzheimer's patients taking this drug. |
2012-10-02 |
2023-08-12 |
rat |
| D V Moretti, D Paternicò, G Binetti, O Zanetti, G B Frison. EEG markers are associated to gray matter changes in thalamus and basal ganglia in subjects with mild cognitive impairment. NeuroImage. vol 60. issue 1. 2012-07-03. PMID:22166796. |
gray matter (gm) changes of thalamus and basal ganglia have been demonstrated to be involved in alzheimer's disease (ad). |
2012-07-03 |
2023-08-12 |
human |
| Jan Korabecny, Kamil Musilek, Filip Zemek, Anna Horova, Ondrej Holas, Eugenie Nepovimova, Veronika Opletalova, Jana Hroudova, Zdenek Fisar, Young-Sik Jung, Kamil Kuc. Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties. Bioorganic & medicinal chemistry letters. vol 21. issue 21. 2012-01-31. PMID:21920739. |
tacrine (tha) is a potent acetylcholinesterase inhibitor that was used in the treatment of alzheimer's disease for a long time. |
2012-01-31 |
2023-08-12 |
Not clear |
| M S de Oliveira, M L F Balthazar, A D'Abreu, C L Yasuda, B P Damasceno, F Cendes, G Castellan. MR imaging texture analysis of the corpus callosum and thalamus in amnestic mild cognitive impairment and mild Alzheimer disease. AJNR. American journal of neuroradiology. vol 32. issue 1. 2011-05-10. PMID:20966061. |
mr imaging texture analysis of the corpus callosum and thalamus in amnestic mild cognitive impairment and mild alzheimer disease. |
2011-05-10 |
2023-08-12 |
human |
| Jarmila Nahalkova, Inga Volkmann, Mikio Aoki, Bengt Winblad, Nenad Bogdanovic, Lars O Tjernberg, Homira Behbahan. CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19751784. |
by immunoblotting of postnuclear pellets from alzheimer's disease and control human brain tissues we showed that cd147 with molecular weight 75 kda is upregulated in frontal cortex and thalamus of the alzheimer's disease brains. |
2010-05-04 |
2023-08-12 |
mouse |
| Jarmila Nahalkova, Inga Volkmann, Mikio Aoki, Bengt Winblad, Nenad Bogdanovic, Lars O Tjernberg, Homira Behbahan. CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19751784. |
immunohistochemistry of brain tissues from alzheimer's disease and control revealed specific upregulation of cd147 in neurons, axons and capillaries of alzheimer's disease frontal cortex and thalamus. |
2010-05-04 |
2023-08-12 |
mouse |
| Jun Toyohara, Muneyuki Sakata, Kiichi Ishiwat. Imaging of sigma1 receptors in the human brain using PET and [11C]SA4503. Central nervous system agents in medicinal chemistry. vol 9. issue 3. 2010-03-04. PMID:20021353. |
the sigma(1) receptors were distributed throughout the brain in normal subjects, but decreased in the frontal, temporal, and occipital lobes, cerebellum and thalamus in patients with early alzheimer's disease and in the putamen in patients with parkinson's disease. |
2010-03-04 |
2023-08-12 |
human |
| Mojtaba Zarei, Brian Patenaude, Jessica Damoiseaux, Ciro Morgese, Steve Smith, Paul M Matthews, Frederik Barkhof, Serge A R B Rombouts, Ernesto Sanz-Arigita, Mark Jenkinso. Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimer's disease. NeuroImage. vol 49. issue 1. 2010-01-04. PMID:19744568. |
alzheimer's disease (ad) is associated with neuronal loss not only in the hippocampus and amygdala but also in the thalamus. |
2010-01-04 |
2023-08-12 |
human |
| Anqi Qiu, Christine Fennema-Notestine, Anders M Dale, Michael I Mille. Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. NeuroImage. vol 45. issue 3. 2009-05-12. PMID:19280688. |
we assessed the surface deformation of seven structures (amygdala, hippocampus, thalamus, caudate, putamen, globus pallidus, body and temporal horn of the lateral ventricles) in 383 mri volumes, based on data shared through the publicly available alzheimer's disease neuroimaging initiative (adni), to identify regionally-specific shape abnormalities in mci and ad. |
2009-05-12 |
2023-08-12 |
human |
| Balázs Gulyás, Boglárka Makkai, Péter Kása, Károly Gulya, Lidia Bakota, Szilvia Várszegi, Zsuzsa Beliczai, Jan Andersson, László Csiba, Andrea Thiele, Thomas Dyrks, Tetsua Suhara, Kazutoshi Suzuki, Makato Higuchi, Christer Halldi. A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system. Neurochemistry international. vol 54. issue 1. 2009-04-24. PMID:18984021. |
compared with age-matched control brains, specific binding in several brain structures (temporal and parietal lobes, thalamus and white matter) in alzheimer brains was significantly higher, indicating that the radioligands can effectively label-activated microglia and the up-regulated pbr/tspo system in ad. |
2009-04-24 |
2023-08-12 |
human |
| L W de Jong, K van der Hiele, I M Veer, J J Houwing, R G J Westendorp, E L E M Bollen, P W de Bruin, H A M Middelkoop, M A van Buchem, J van der Gron. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:19022861. |
strongly reduced volumes of putamen and thalamus in alzheimer's disease: an mri study. |
2009-02-02 |
2023-08-12 |
human |
| L W de Jong, K van der Hiele, I M Veer, J J Houwing, R G J Westendorp, E L E M Bollen, P W de Bruin, H A M Middelkoop, M A van Buchem, J van der Gron. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:19022861. |
in addition to finding the expected association between hippocampal atrophy and cognitive decline in alzheimer's disease, volumes of putamen and thalamus were significantly reduced in patients diagnosed with probable alzheimer's disease. |
2009-02-02 |
2023-08-12 |
human |
| L W de Jong, K van der Hiele, I M Veer, J J Houwing, R G J Westendorp, E L E M Bollen, P W de Bruin, H A M Middelkoop, M A van Buchem, J van der Gron. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:19022861. |
these findings strongly suggest that, beside neo-cortical atrophy, deep grey matter structures in alzheimer's disease suffer atrophy as well and that degenerative processes in the putamen and thalamus, like the hippocampus, may contribute to cognitive decline in alzheimer's disease. |
2009-02-02 |
2023-08-12 |
human |
| Emilie Beaufils, Caroline Hommet, Danièle Perrier, Alain Autret, Bertrand De Toffol, Thierry Constans, Karl Mondo. Cognitive syndrome of the thalamus: a misleading differential diagnosis of Alzheimer's disease. Journal of the American Geriatrics Society. vol 56. issue 10. 2008-12-24. PMID:19054209. |
cognitive syndrome of the thalamus: a misleading differential diagnosis of alzheimer's disease. |
2008-12-24 |
2023-08-12 |
Not clear |
| Jian-Guo Cui, James M Hill, Yuhai Zhao, Walter J Luki. Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer's disease. Neuroreport. vol 18. issue 2. 2007-04-10. PMID:17301674. |
in this study, using dna arrays and western immunoassay, gene expression patterns were examined in the thalamus and primary visual cortex of moderate-stage and late-stage alzheimer's disease and age-matched controls using a set of proinflammatory genes known to be upregulated in the temporal lobe neocortex and hippocampus of moderate-stage alzheimer's disease. |
2007-04-10 |
2023-08-12 |
Not clear |
| Stavros J Baloyanni. Mitochondrial alterations in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 9. issue 2. 2006-12-06. PMID:16873959. |
in a series of studies on the morphological and morphometric estimation of mitochondria in alzheimer's disease, by electron microscopy we noticed substantial morphological and morphometric changes in the neurons of the hippocampus, the acoustic cortex, the frontal cortex, the cerebellar cortex, the climbing fibers, the thalamus, the globus pallidus, the red nucleus and the locus coeruleus. |
2006-12-06 |
2023-08-12 |
Not clear |