| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R H Swartz, S E Blac. Anterior-medial thalamic lesions in dementia: frequent, and volume dependently associated with sudden cognitive decline. Journal of neurology, neurosurgery, and psychiatry. vol 77. issue 12. 2006-12-04. PMID:16868066. |
the anterior-medial thalamus (amt), which is associated with memory processing, is severely affected by alzheimer's disease pathology and, when damaged, can be the sole cause of dementia. |
2006-12-04 |
2023-08-12 |
Not clear |
| Luca Ferrarini, Walter M Palm, Hans Olofsen, Mark A van Buchem, Johan H C Reiber, Faiza Admiraal-Behlou. Shape differences of the brain ventricles in Alzheimer's disease. NeuroImage. vol 32. issue 3. 2006-10-30. PMID:16839779. |
we found out that in patients with alzheimer disease, not only the lateral horns were significantly affected, but also the areas adjacent to the anterior corpus callosum, the splenium of the corpus callosum, the amygdala, the thalamus, the tale of the caudate nuclei (especially the left one), and the head of the left caudate nucleus. |
2006-10-30 |
2023-08-12 |
human |
| Walter J Lukiw, Jian-Guo Cui, Victor L Marcheselli, Merete Bodker, Anja Botkjaer, Katherine Gotlinger, Charles N Serhan, Nicolas G Baza. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. The Journal of clinical investigation. vol 115. issue 10. 2005-12-12. PMID:16151530. |
dha and npd1 were reduced in alzheimer disease (ad) hippocampal cornu ammonis region 1, but not in the thalamus or occipital lobes from the same brains. |
2005-12-12 |
2023-08-12 |
human |
| E J Kim, S S Cho, Y Jeong, K C Park, S J Kang, E Kang, S E Kim, K H Lee, D L N. Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients. Brain : a journal of neurology. vol 128. issue Pt 8. 2005-08-16. PMID:15888536. |
overall glucose hypometabolism of early onset alzheimer's disease patients was much greater in magnitude and extent than that of late onset patients, though both groups were similar in dementia severity: the early onset group showed more severe hypometabolism in parietal, frontal and subcortical (basal ganglia and thalamus) areas. |
2005-08-16 |
2023-08-12 |
human |
| Tao Gong, Yuan Huang, Zhi-Rong Zhang, Li-Li L. Synthesis and characterization of 9-[P-(N, N-dipropyl sulfamide)] benzoylamino-1,2,3,4-4H-acridine--a potential prodrug for the CNS delivery of tacrine. Journal of drug targeting. vol 12. issue 3. 2005-01-31. PMID:15203897. |
in-vivo experiment showed the concentrations of tha in brain and liver kept stable for about 4 h, which was beneficial for the treatment of alzheimer's disease (ad). |
2005-01-31 |
2023-08-12 |
Not clear |
| J Schmaljohann, M Minnerop, P Karwath, D Gündisch, P Falkai, S Guhlke, U Wüllne. Imaging of central nAChReceptors with 2-[18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 61. issue 6. 2004-12-22. PMID:15388115. |
in human brain sections of alzheimer's disease (ad) a decrease of 2-[18f]f-a85380 uptake to 36% of the control group was measured in the thalamus and also in the occipital cortex. |
2004-12-22 |
2023-08-12 |
human |
| Christian Brenneis, Gregor K Wenning, Karl E Egger, Michael Schocke, Thomas Trieb, Klaus Seppi, Josef Marksteiner, Gerhard Ransmayr, Thomas Benke, Werner Poew. Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodies. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257132. |
compared to controls, atrophy of lateral prefrontal cortex and left premotor cortex was seen in dementia with lewy bodies whereas atrophy of the medial temporal cortex, posterior parietal cortex, thalamus and temporo-occipital areas was observed in alzheimer's disease. |
2004-10-21 |
2023-08-12 |
Not clear |
| C Engeland, C Mahoney, E Mohr, V Ilivitsky, V Knot. Nicotine and sensory memory in Alzheimer's disease: an event-related potential study. Brain and cognition. vol 49. issue 2. 2004-08-19. PMID:15259398. |
thirteen patients with probable alzheimer's disease (ad), 6 receiving treatment with the cholinesterase inhibitor (chei) tacrine (tetrahydroaminoacridine, tha) and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. |
2004-08-19 |
2023-08-12 |
Not clear |
| K SIMM. [Modifications of the thalamus in senile dementia and Alzheimer's disease]. Monatsschrift fur Psychiatrie und Neurologie. vol 122. issue 3. 2004-02-15. PMID:14863319. |
[modifications of the thalamus in senile dementia and alzheimer's disease]. |
2004-02-15 |
2023-08-12 |
Not clear |
| C Engeland, C Mahoney, E Mohr, V Ilivitsky, Verner J Knot. Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study. Pharmacology, biochemistry, and behavior. vol 72. issue 1-2. 2003-10-21. PMID:11900820. |
thirteen patients with alzheimer's disease (ad), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (tha)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. |
2003-10-21 |
2023-08-12 |
Not clear |
| E Schuller, T Gulesserian, R Seidl, N Cairns, G Lub. Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease. Life sciences. vol 69. issue 3. 2001-07-26. PMID:11441917. |
when t-complex polypeptide i was related to its natural and specific substrate beta 1 tubulin, the ratio was significantly decreased in the temporal, frontal, parietal cortex and in thalamus of patients with alzheimer's disease. |
2001-07-26 |
2023-08-12 |
human |
| J Court, C Martin-Ruiz, M Piggott, D Spurden, M Griffiths, E Perr. Nicotinic receptor abnormalities in Alzheimer's disease. Biological psychiatry. vol 49. issue 3. 2001-06-07. PMID:11230868. |
in the thalamus, there was a trend for reduced [(3)h]nicotine binding in the majority of nuclei (0-20%) in alzheimer's disease; however, there was a significant decline in [(125)i]alpha-bungarotoxin binding in the reticular nucleus. |
2001-06-07 |
2023-08-12 |
Not clear |
| R Seidl, N Cairns, N Singewald, S T Kaehler, G Lube. Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218066. |
a number of amino acids [glutamate, aspartate, gamma-aminobutyrate (gaba), glycine, taurine, glutamine, serine, arginine] were investigated in post-mortem tissue samples from temporal, occipital cortex, thalamus, caudate nucleus, and cerebellum of adult patients with down syndrome (ds) exhibiting alzheimer-like neuropatholgy, alzheimer's disease (ad) and from controls by use of high performance liquid chromatography (hplc). |
2001-05-03 |
2023-08-12 |
human |
| E Hellström-Lindahl, J A Cour. Nicotinic acetylcholine receptors during prenatal development and brain pathology in human aging. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942042. |
by contrast no loss in nachr binding with aging is observed in the thalamus and only after the 70th decade in the striatum, although in alzheimer's disease, parkinson's disease and lewy body dementia deficits in nachrs are observed in these areas and may be associated with specific disease-related processes. |
2001-01-03 |
2023-08-12 |
human |
| R M Cohen, R E Carson, T Sunderlan. Opiate receptor avidity in the thalamus is sexually dimorphic in the elderly. Synapse (New York, N.Y.). vol 38. issue 2. 2000-11-28. PMID:11018796. |
cf avidity was 27.5% less in the thalamus of healthy women compared to healthy men and 48.5% less in alzheimer disease female patients compared to male patients. |
2000-11-28 |
2023-08-12 |
human |
| V Knott, E Mohr, C Mahoney, V Ilivitsk. Pharmaco-EEG test dose response predicts cholinesterase inhibitor treatment outcome in Alzheimer's disease. Methods and findings in experimental and clinical pharmacology. vol 22. issue 2. 2000-09-07. PMID:10849895. |
previous investigations have indicated that a single dose pharmaco-eeg may predict the outcome of 4-7 weeks of tetrahydroaminoacridine (tha) treatment in dementia of the alzheimer type (dat). |
2000-09-07 |
2023-08-12 |
Not clear |
| M Galisteo, M Rissel, O Sergent, M Chevanne, J Cillard, A Guillouzo, D Lagadic-Gossman. Hepatotoxicity of tacrine: occurrence of membrane fluidity alterations without involvement of lipid peroxidation. The Journal of pharmacology and experimental therapeutics. vol 294. issue 1. 2000-07-24. PMID:10871308. |
tacrine (tha), used in the treatment of alzheimer's disease, is known to induce hepatotoxicity, the mechanisms of which remain to be fully established. |
2000-07-24 |
2023-08-12 |
rat |
| W F Li. Effects of cholinesterase inhibitors on a two-component chained schedule performance in rats. Neurotoxicology and teratology. vol 22. issue 3. 2000-07-12. PMID:10840182. |
the acetylcholinesterase (ache) inhibitors physostigmine (phy), tacrine (tha), and heptylphysostigmine (hep) have been evaluated as potential therapeutics for treatment of alzheimer's disease (ad) and as prophylactics against organophosphate (op) poisoning. |
2000-07-12 |
2023-08-12 |
rat |
| L Traykov, B Tavitian, A Jobert, F Boller, F Forette, C Crouzel, L Di Giamberardino, S Pappat. In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects. European journal of neurology. vol 6. issue 3. 2000-06-26. PMID:10210906. |
it is unclear whether the palliative effects of tetrahydroaminoacridine (tha) (tacrine, cognex) on the clinical symptoms of patients affected by alzheimer's disease (ad) are the result of its inhibitory activity on acetylcholinesterase or on other complex sites of action. |
2000-06-26 |
2023-08-12 |
human |
| E Falke, L Y Han, S E Arnol. Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia. Psychiatry research. vol 93. issue 2. 2000-05-09. PMID:10725527. |
neurodegeneration and neural injury in the caudate nucleus and mediodorsal nucleus of the thalamus were investigated in a postmortem study of 11 prospectively accrued, clinically well-characterized elderly people with schizophrenia, 11 elderly control subjects with no neuropsychiatric illness, and 12 subjects with alzheimer's disease. |
2000-05-09 |
2023-08-12 |
human |