| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Chelliah, J D Smith, M W Faris. Inhibition of cholinesterase activity by tetrahydroaminoacridine and the hemisuccinate esters of tocopherol and cholesterol. Biochimica et biophysica acta. vol 1206. issue 1. 1994-06-21. PMID:8186246. |
such potent and synergistic inhibition of ache suggest that ts or cs, alone and in combination with tha, may prove beneficial in the treatment of organophosphate poisoning and alzheimer's disease. |
1994-06-21 |
2023-08-12 |
Not clear |
| H Nybäck, M Hassan, T Junthé, A Ahli. Clinical experiences and biochemical findings with tacrine (THA). Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:7510447. |
a clinical comparison of tacrine (tha) and placebo was performed in 15 alzheimer patients using a double blind crossover technique over 4 plus 4 weeks with one drug-free week in between. |
1994-04-14 |
2023-08-12 |
human |
| A Ade. The next generation of cholinesterase inhibitors. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128831. |
clinical trials with tacrine (tha) have resulted in elevations of liver enzymes in alzheimer patients that showed improvement. |
1994-04-14 |
2023-08-12 |
rat |
| A Ade. The next generation of cholinesterase inhibitors. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128831. |
it is possible that some of these analogues with more potent cholinergic effect than tha might be the next generation of cholinesterase inhibitors which can be useful in the treatment of alzheimer's disease. |
1994-04-14 |
2023-08-12 |
rat |
| B J Sahakian, J T Coul. Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128835. |
tetrahydroaminoacridine (tha) in alzheimer's disease: an assessment of attentional and mnemonic function using cantab. |
1994-04-14 |
2023-08-12 |
Not clear |
| B J Sahakian, J T Coul. Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128835. |
a placebo-controlled cross-over trial (n = 89) investigated the use of a chronic dose of the cholinesterase inhibitor tha, as a treatment for dementia of the alzheimer type (dat). |
1994-04-14 |
2023-08-12 |
Not clear |
| K Amberla, A Nordberg, M Viitanen, B Winbla. Long-term treatment with tacrine (THA) in Alzheimer's disease--evaluation of neuropsychological data. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128841. |
long-term treatment with tacrine (tha) in alzheimer's disease--evaluation of neuropsychological data. |
1994-04-14 |
2023-08-12 |
Not clear |
| M Shigeta, A Persson, M Viitanen, B Winblad, A Nordber. EEG regional changes during long-term treatment with tetrahydroaminoacridine (THA) in Alzheimer's disease. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128842. |
eeg regional changes during long-term treatment with tetrahydroaminoacridine (tha) in alzheimer's disease. |
1994-04-14 |
2023-08-12 |
Not clear |
| M Shigeta, A Persson, M Viitanen, B Winblad, A Nordber. EEG regional changes during long-term treatment with tetrahydroaminoacridine (THA) in Alzheimer's disease. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128842. |
three patients with alzheimer's disease of mild type received long-term treatment with tha at doses between 40 mg to 160 mg daily. |
1994-04-14 |
2023-08-12 |
Not clear |
| A Nordber. Effect of long-term treatment with tacrine (THA) in Alzheimer's disease as visualized by PET. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128843. |
effect of long-term treatment with tacrine (tha) in alzheimer's disease as visualized by pet. |
1994-04-14 |
2023-08-12 |
Not clear |
| G K Wilcock, D J Surmon, M Scott, M Boyle, K Mulligan, K A Neubauer, D O'Neill, V H Roysto. An evaluation of the efficacy and safety of tetrahydroaminoacridine (THA) without lecithin in the treatment of Alzheimer's disease. Age and ageing. vol 22. issue 5. 1993-12-17. PMID:8237620. |
an evaluation of the efficacy and safety of tetrahydroaminoacridine (tha) without lecithin in the treatment of alzheimer's disease. |
1993-12-17 |
2023-08-12 |
human |
| G K Wilcock, D J Surmon, M Scott, M Boyle, K Mulligan, K A Neubauer, D O'Neill, V H Roysto. An evaluation of the efficacy and safety of tetrahydroaminoacridine (THA) without lecithin in the treatment of Alzheimer's disease. Age and ageing. vol 22. issue 5. 1993-12-17. PMID:8237620. |
seventy-nine patients with probable alzheimer's disease were enrolled into a double-blind, placebo-controlled cross-over study to assess the therapeutic effect and safety of tha (tetrahydroaminoacridine; tacrine) without concomitant lecithin administration. |
1993-12-17 |
2023-08-12 |
human |
| C J Viau, R D Curren, K Wallac. Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. Drug and chemical toxicology. vol 16. issue 3. 1993-11-04. PMID:8404544. |
clinical trials with tacrine (tha) and its principal (1-oh) metabolite (velnacrine) for the treatment of alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies. |
1993-11-04 |
2023-08-12 |
human |
| K Alhainen, E L Helkala, K Reinikainen, P Riekkine. The relationship of cerebrospinal fluid monoamine metabolites with clinical response to tetrahydroaminoacridine in patients with Alzheimer's disease. Journal of neural transmission. Parkinson's disease and dementia section. vol 5. issue 3. 1993-10-12. PMID:7690228. |
the effect of tetrahydroaminoacridine (tha) on the cerebrospinal fluid (csf) monoamine metabolites was studied in 22 patients with alzheimer's disease in an open treatment trial. |
1993-10-12 |
2023-08-12 |
Not clear |
| K Alhainen, E L Helkala, P Riekkine. Psychometric discrimination of tetrahydroaminoacridine responders in Alzheimer patients. Dementia (Basel, Switzerland). vol 4. issue 1. 1993-09-30. PMID:8358507. |
fourteen patients with probable alzheimer's disease (ad) participated in an open tetrahydroaminoacridine (tha) treatment trial. |
1993-09-30 |
2023-08-12 |
Not clear |
| D Petit, J Montplaisir, D Lorrain, S Gauthie. THA does not affect sleep or EEG spectral power in Alzheimer's disease. Biological psychiatry. vol 33. issue 10. 1993-09-22. PMID:8353172. |
tha does not affect sleep or eeg spectral power in alzheimer's disease. |
1993-09-22 |
2023-08-12 |
Not clear |
| D Perani, S Bressi, S F Cappa, G Vallar, M Alberoni, F Grassi, C Caltagirone, L Cipolotti, M Franceschi, G L Lenz. Evidence of multiple memory systems in the human brain. A [18F]FDG PET metabolic study. Brain : a journal of neurology. vol 116 ( Pt 4). 1993-09-21. PMID:8353715. |
on the other hand, significant hypometabolism was found in the thalamus in only global amnesia, and in the frontal, parietal and temporal associative cortex in only alzheimer's disease. |
1993-09-21 |
2023-08-12 |
human |
| K M Perryman, L J Fitte. Delayed matching-to-sample performance during a double-blind trial of tacrine (THA) and lecithin in patients with Alzheimer's disease. Life sciences. vol 53. issue 6. 1993-08-31. PMID:8341134. |
delayed matching-to-sample performance during a double-blind trial of tacrine (tha) and lecithin in patients with alzheimer's disease. |
1993-08-31 |
2023-08-12 |
human |
| K M Perryman, L J Fitte. Delayed matching-to-sample performance during a double-blind trial of tacrine (THA) and lecithin in patients with Alzheimer's disease. Life sciences. vol 53. issue 6. 1993-08-31. PMID:8341134. |
during a double blind, inpatient-outpatient study of tha (tacrine) and lecithin in alzheimer's disease, data on a laboratory-based delayed-matching-to-sample (dms) test was collected on six of 10 subjects. |
1993-08-31 |
2023-08-12 |
human |
| T Nagao, M Hamamoto, A Kanda, T Miyazaki, A Terash. [Clinically diagnosed corticobasal degeneration (CBD)]. Rinsho shinkeigaku = Clinical neurology. vol 33. issue 1. 1993-08-25. PMID:8334774. |
although, it is difficult to distinguish clinically cbd from atypical case of alzheimer's disease, we speculated that in early stage of dementia, significant unilateral hypoperfusion and hypometabolism of basal ganglia and thalamus is characteristic of cbd. |
1993-08-25 |
2023-08-12 |
Not clear |