| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federico Verd. Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-17. PMID:35175385. |
alzheimer's disease (ad), the most common age-dependent neurodegenerative disorder, is characterized neuropathologically by extracellular aβ plaques and intracellular tau neurofibrillary tangles. |
2022-02-17 |
2023-08-13 |
human |
| Federico Verd. Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-17. PMID:35175385. |
this review discusses the recent developments in the field of plasma tau proteins as diagnostic, pathophysiological and prognostic biomarkers of alzheimer's disease; additional findings from the fields of genetic forms of ad and of non-ad proteinopathies are also summarized. |
2022-02-17 |
2023-08-13 |
human |
| Shaqayeq Roqanian, Shahin Ahmadian, Seyed Masood Nabavi, Hossein Pakdaman, Mahshid Shafiezadeh, Ghazaleh Goudarzi, Koorosh Shahpasan. Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion. Journal of neuroscience research. 2022-02-16. PMID:35170061. |
tau protein abnormalities are associated with various neurodegenerative disorders, including alzheimer's disease (ad) and traumatic brain injury (tbi). |
2022-02-16 |
2023-08-13 |
mouse |
| Carolyn N Mann, Shamulailatpam Shreedarshanee Devi, Corey T Kersting, Amber V Bleem, Celeste M Karch, David M Holtzman, Gilbert Gallard. Astrocytic α2-Na Science translational medicine. vol 14. issue 632. 2022-02-16. PMID:35171651. |
astrocytic α2-na alzheimer's disease (ad) is the most dominant form of dementia characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tau tangles (nfts). |
2022-02-16 |
2023-08-13 |
Not clear |
| Yu Zhang, Lin Qian, Yuzhu Kuang, Junting Liu, Diqi Wang, Wenqi Xie, Linbo Zhang, Lu F. An adeno-associated virus-mediated immunotherapy for Alzheimer's disease. Molecular immunology. vol 144. 2022-02-16. PMID:35172225. |
disease-modifying passive immunotherapies focusing on removal of abnormal phosphorylated tau (p-tau) constitute promising treatments for alzheimer's disease (ad). |
2022-02-16 |
2023-08-13 |
mouse |
| Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G Lyketsos, Esther S Oh, Dimitrios Kapogianni. Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer's Disease. Cells. vol 11. issue 3. 2022-02-15. PMID:35159246. |
the hallmarks of alzheimer's disease (ad) pathology are senile plaques containing amyloid-beta (aβ) and neurofibrillary tangles containing hyperphosphorylated tau. |
2022-02-15 |
2023-08-13 |
Not clear |
| Fang Du, Qing Yu, Shirley ShiDu Ya. Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer's disease. Human molecular genetics. 2022-02-15. PMID:35165721. |
mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in alzheimer's disease. |
2022-02-15 |
2023-08-13 |
mouse |
| Fang Du, Qing Yu, Shirley ShiDu Ya. Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer's disease. Human molecular genetics. 2022-02-15. PMID:35165721. |
first, we determined whether elevated oxidative stress correlates with aggregation of tau oligomers in the brain and platelets of human alzheimer's disease (ad) patient, tauopathy mice, primary cortical neurons from tau mice, and human trans-mitochondrial 'cybrid' (cytoplasmic hybrid) neuronal cells, whose mitochondria are derived from platelets of patients with sporadic ad- or mild cognitive impairment (mci)-derived mitochondria. |
2022-02-15 |
2023-08-13 |
mouse |
| Mariana G Fronza, Manoela Sacramento, Diego Alves, Domenico Praticò, Lucielli Savegnag. 1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Aβ Formation and Tau Phosphorylation in Cellular Models of Alzheimer's Disease. Neurochemical research. 2022-02-15. PMID:35165799. |
1-(7-chloroquinolin-4-yl)-n-(4-methoxybenzyl)-5-methyl-1h-1,2, 3-triazole-4- carboxamide reduces aβ formation and tau phosphorylation in cellular models of alzheimer's disease. |
2022-02-15 |
2023-08-13 |
human |
| Yanxiao Li, Yee Ling Ng, Manish D Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zho. Tracer-specific reference tissues selection improves detection of Human brain mapping. 2022-02-15. PMID:35165964. |
tracer-specific reference tissues selection improves detection of this study sought to identify a reference tissue-based quantification approach for improving the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in alzheimer's disease studies. |
2022-02-15 |
2023-08-13 |
Not clear |
| Sourin Bhuniya, Manish Goyal, Nilotpal Chowdhury, Priyadarshini Mishr. Intermittent hypoxia and sleep disruption in obstructive sleep apnea increase serum tau and amyloid-beta levels. Journal of sleep research. 2022-02-15. PMID:35165967. |
serum amyloid-beta and tau proteins, which are markers for alzheimer's disease, have been reported to increase in patients with obstructive sleep apnea. |
2022-02-15 |
2023-08-13 |
Not clear |
| Jana Tureckova, Monika Kamenicka, Denisa Kolenicova, Tereza Filipi, Zuzana Hermanova, Jan Kriska, Lenka Meszarosova, Barbora Pukajova, Lukas Valihrach, Peter Androvic, Daniel Zucha, Martina Chmelova, Lydia Vargova, Miroslava Anderov. Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2022-02-14. PMID:35153718. |
in this study, we aimed to disclose the impact of amyloid-β toxicity and tau pathology on astrocyte swelling, their volume recovery and extracellular space (ecs) diffusion parameters, namely volume fraction (α) and tortuosity (λ), in a triple transgenic mouse model of alzheimer's disease (3xtg-ad). |
2022-02-14 |
2023-08-13 |
mouse |
| Baofeng Gong, Wenbo Ji, Xiaohan Chen, Peng Li, Wenbin Cheng, Yuchen Zhao, Bin He, Jianhua Zhuang, Jie Gao, You Yi. Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease. Mini reviews in medicinal chemistry. 2022-02-14. PMID:35156576. |
alzheimer's disease (ad) is a intricate neurodegenerative disease with chronic and progressive development whose typical neuropathological features encompasses senile plaques and neurofibrillary tangles respectively formed by the extracellular deposition of amyloid-beta (aβ) and the intracellular accumulation of hyperphosphorylated tau protein in the brain, particularly in limbic and cortical regions. |
2022-02-14 |
2023-08-13 |
Not clear |
| Dustin R Wakeman, Michael R Weed, Sylvia E Perez, Erika N Cline, Kirsten L Viola, Kyle C Wilcox, David S Moddrelle, Ernell Z Nisbett, Anish M Kurian, Amanda F Bell, Ricaldo Pike, Peer B Jacobson, William L Klein, Elliott J Mufson, Matthew S Lawrence, John D Elswort. Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: a nonhuman primate model of Alzheimer's disease. Neuropathology and applied neurobiology. 2022-02-14. PMID:35156715. |
intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the african green monkey: a nonhuman primate model of alzheimer's disease. |
2022-02-14 |
2023-08-13 |
monkey |
| Nicholas J Ashton, Andréa L Benedet, Tharick A Pascoal, Thomas K Karikari, Juan Lantero-Rodriguez, Wagner S Brum, Sulantha Mathotaarachchi, Joseph Therriault, Melissa Savard, Mira Chamoun, Erik Stoops, Cindy Francois, Eugeen Vanmechelen, Serge Gauthier, Eduardo R Zimmer, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease. EBioMedicine. vol 76. 2022-02-14. PMID:35158308. |
phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (csf) are accurate biomarkers for a pathological and clinical diagnosis of alzheimer's disease (ad) and are seen to be increased in preclinical stage of the disease. |
2022-02-14 |
2023-08-13 |
human |
| Zhijun He, Xiaoqian Li, Zi Wang, Sixin Tu, Jiale Feng, Xiubo Du, Jiazuan Ni, Nan Li, Qiong Li. Esculentoside A alleviates cognitive deficits and amyloid pathology through peroxisome proliferator-activated receptor γ-dependent mechanism in an Alzheimer's disease model. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 98. 2022-02-12. PMID:35151213. |
alzheimer's disease (ad) is characterized clinically by cognitive deficits and pathologically by amyloid-β (aβ) deposition and tau aggregation, as well as the brain atrophy. |
2022-02-12 |
2023-08-13 |
mouse |
| Ruiqing N. Magnetic Resonance Imaging in Tauopathy Animal Models. Frontiers in aging neuroscience. vol 13. 2022-02-11. PMID:35145392. |
the microtubule-associated protein tau plays an important role in tauopathic diseases such as alzheimer's disease and primary tauopathies such as progressive supranuclear palsy and corticobasal degeneration. |
2022-02-11 |
2023-08-13 |
mouse |
| Soomaayeh Heysieattalab, Leila Sadegh. Avicenna journal of phytomedicine. vol 12. issue 1. 2022-02-11. PMID:35145898. |
sustained inflammation, which could be promoted by aβ aggregation and tau hyperphosphorylation, is a critical player in alzheimer's disease (ad) pathogenesis. |
2022-02-11 |
2023-08-13 |
Not clear |
| Michael A Kelberman, Claire R Anderson, Eli Chlan, Jacki M Rorabaugh, Katharine E McCann, David Weinshenke. Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-02-11. PMID:35147547. |
consequences of hyperphosphorylated tau in the locus coeruleus on behavior and cognition in a rat model of alzheimer's disease. |
2022-02-11 |
2023-08-13 |
rat |
| Michael A Kelberman, Claire R Anderson, Eli Chlan, Jacki M Rorabaugh, Katharine E McCann, David Weinshenke. Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-02-11. PMID:35147547. |
the locus coeruleus (lc) is one of the earliest brain regions to accumulate hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has hampered our understanding of its contributions to alzheimer's disease (ad) pathophysiology. |
2022-02-11 |
2023-08-13 |
rat |