| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianfeng Wu, Qunxi Dong, Jie Zhang, Yi Su, Teresa Wu, Richard J Caselli, Eric M Reiman, Jieping Ye, Natasha Lepore, Kewei Chen, Paul M Thompson, Yalin Wan. Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. Frontiers in neuroscience. vol 15. 2021-12-13. PMID:34899166. |
amyloid-β (aβ) plaques and tau protein tangles in the brain are now widely recognized as the defining hallmarks of alzheimer's disease (ad), followed by structural atrophy detectable on brain magnetic resonance imaging (mri) scans. |
2021-12-13 |
2023-08-13 |
human |
| Chanting He, Xiaoyan Zhao, Yang Lei, Jisheng Nie, Xiaoting Lu, Jing Song, Linping Wang, Huan Li, Fangqu Liu, Yidan Zhang, Qiao Ni. Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al. Molecular therapy. Nucleic acids. vol 26. 2021-12-13. PMID:34900398. |
aluminum is a known neurotoxin that can induce aβ deposition and abnormal phosphorylation of tau protein, leading to alzheimer disease (ad)-like damages such as neuronal damage and decreased learning and memory functions. |
2021-12-13 |
2023-08-13 |
rat |
| Elisa Colato, Konstantinos Chiotis, Daniel Ferreira, Mariam S Mazrina, Laetitia Lemoine, Rosaleena Mohanty, Eric Westman, Agneta Nordberg, Elena Rodriguez-Vieite. Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-12. PMID:34511502. |
assessment of tau pathology as measured by 18f-thk5317 and 18f-flortaucipir pet and their relation to brain atrophy and cognition in alzheimer's disease. |
2021-12-12 |
2023-08-13 |
Not clear |
| Elisa Colato, Konstantinos Chiotis, Daniel Ferreira, Mariam S Mazrina, Laetitia Lemoine, Rosaleena Mohanty, Eric Westman, Agneta Nordberg, Elena Rodriguez-Vieite. Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-12. PMID:34511502. |
in alzheimer's disease (ad), the abnormal aggregation of hyperphosphorylated tau leads to synaptic dysfunction and neurodegeneration. |
2021-12-12 |
2023-08-13 |
Not clear |
| Mohammed A Al-Onaizi, Peter Thériault, Sarah Lecordier, Paul Prefontaine, Serge Rivest, Ayman ElAl. Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34343617. |
alzheimer's disease (ad) pathology is characterized by amyloid-β (aβ) deposition and tau hyper-phosphorylation, accompanied by a progressive cognitive decline. |
2021-12-11 |
2023-08-13 |
mouse |
| Akash Saha, Suraiya Saleem, Ramesh Kumar Paidi, Subhas C Biswa. BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β. Cell death discovery. vol 7. issue 1. 2021-12-11. PMID:34782612. |
alzheimer's disease (ad) is characterized by accumulation of senile amyloid-β (aβ) plaques and hyperphosphorylated tau tangles causing progressive loss of synapse and neuronal death. |
2021-12-11 |
2023-08-13 |
mouse |
| Maria C Gonzalez, Nicholas J Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas K Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarslan. Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies. JAMA neurology. 2021-12-11. PMID:34807233. |
plasma phosphorylated tau (p-tau) has proven to be an accurate biomarker for alzheimer disease (ad) pathologic characteristics, offering a less expensive and less invasive alternative to cerebrospinal fluid (csf) and positron emission tomography biomarkers for amyloid-β and tau. |
2021-12-11 |
2023-08-13 |
Not clear |
| Emily J Koller, Kristen R Ibanez, Quan Vo, Karen N McFarland, Elsa Gonzalez De La Cruz, Lillian Zobel, Tristan Williams, Guilian Xu, Daniel Ryu, Preya Patel, Benoit I Giasson, Stefan Prokop, Paramita Chakrabart. Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation. Neuropathology and applied neurobiology. 2021-12-11. PMID:34825397. |
to illuminate the pathological synergy between aβ and tau leading to emergence of neurofibrillary tangles (nft) in alzheimer's disease (ad), here, we have performed a comparative neuropathological study utilising three distinctive variants of human tau (wt tau, p301l mutant tau and s320f mutant tau). |
2021-12-11 |
2023-08-13 |
mouse |
| Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunisse. Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231. Alzheimer's research & therapy. vol 13. issue 1. 2021-12-11. PMID:34863295. |
studies using different assays and technologies showed highly promising diagnostic value of plasma phosphorylated (p-)tau levels for alzheimer's disease (ad). |
2021-12-11 |
2023-08-13 |
Not clear |
| Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Hira E Shah, Aarthi Ethirajulu, Nitin Bhawnani, Jihan A Mostaf. The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications. Cureus. vol 13. issue 11. 2021-12-11. PMID:34877187. |
thirdly, multiple pathological studies showed that insulin and alzheimer's disease share many common lesions in the brain, such as beta-amyloid plaques, amylin-aβ plaques, hyper-phosphorylated tau protein, and brain atrophy, especially in the hippocampus. |
2021-12-11 |
2023-08-13 |
human |
| Xiao-Juan Wang, Lin Qi, Ya-Fang Cheng, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Li-Bo Zo. PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease. Acta pharmacologica Sinica. 2021-12-11. PMID:34893682. |
pink1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of alzheimer's disease. |
2021-12-11 |
2023-08-13 |
rat |
| Xiao-Juan Wang, Lin Qi, Ya-Fang Cheng, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Li-Bo Zo. PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease. Acta pharmacologica Sinica. 2021-12-11. PMID:34893682. |
our data support a critical role of pink1-mediated mitophagy in controlling mitochondrial quality, tau hyperphosphorylation, and oxidative stress in a rat model of alzheimer's disease. |
2021-12-11 |
2023-08-13 |
rat |
| Alby Elias, Christopher Rowe, Malcolm Hopwoo. Risk of Dementia in Posttraumatic Stress Disorder. Journal of geriatric psychiatry and neurology. vol 34. issue 6. 2021-12-10. PMID:32912067. |
laboratory studies reported the accelerated formation of β-amyloid and tau, which represent the primary pathology of alzheimer's dementia in animal models of ptsd. |
2021-12-10 |
2023-08-13 |
Not clear |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
both magl and faah inhibitors possess fascinating properties that may offer a multi-faceted approach for the treatment of alzheimer's disease such as potential to protect neurons from deleterious effect of amyloid-β, reducing phosphorylation of tau, reducing amyloid-β induced oxidative stress, stimulating neurotrophin to support brain intrinsic repair mechanism etc. |
2021-12-10 |
2023-08-13 |
Not clear |
| Lei Xia, Yayan Pang, Junjie Li, Bin Wu, Yehong Du, Yuxin Chen, Man Luo, Yan Wang, Zhifang Don. Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-10. PMID:34511503. |
tauopathies are a group of neurodegenerative disorders, including alzheimer's disease (ad) and frontotemporal lobar degeneration with tau pathology. |
2021-12-10 |
2023-08-13 |
mouse |
| Katherine E Prater, Caitlin S Latimer, Suman Jayade. Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes. Glia. vol 70. issue 2. 2021-12-10. PMID:34558120. |
studies in human tissue and model systems demonstrate that tdp-43 may potentiate other proteinopathies such as the amyloid or tau pathology seen in alzheimer's disease (ad) in the combination of ad+late. |
2021-12-10 |
2023-08-13 |
human |
| Biju Bhargavan, Shawna M Woollard, Jo Ellyn McMillan, Georgette D Kanmogn. CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice. Molecular neurodegeneration. vol 16. issue 1. 2021-12-10. PMID:34809709. |
neurocognitive impairment is present in 50% of hiv-infected individuals and is often associated with alzheimer's disease (ad)-like brain pathologies, including increased amyloid-beta (aβ) and tau hyperphosphorylation. |
2021-12-10 |
2023-08-13 |
mouse |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
abnormal accumulation of tau protein is closely associated with neurodegeneration and cognitive impairment and it is a biomarker of neurodegeneration in the dementia field, especially in alzheimer's disease (ad); therefore, it is crucial to be able to assess the tau deposits in vivo. |
2021-12-10 |
2023-08-13 |
Not clear |
| Galina Limorenko, Hilal A Lashue. Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society reviews. 2021-12-10. PMID:34889934. |
converging evidence continues to point towards tau aggregation and pathology formation as central events in the pathogenesis of alzheimer's disease and other tauopathies. |
2021-12-10 |
2023-08-13 |
Not clear |
| Galina Limorenko, Hilal A Lashue. Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society reviews. 2021-12-10. PMID:34889934. |
thirdly, we discuss the importance of adopting new experimental approaches that embrace the complexity of tau aggregation and pathology as an important first step towards developing mechanism- and structure-based therapies that account for the pathological and clinical heterogeneity of alzheimer's disease and tauopathies. |
2021-12-10 |
2023-08-13 |
Not clear |