| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine E Prater, Caitlin S Latimer, Suman Jayade. Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes. Glia. vol 70. issue 2. 2021-12-10. PMID:34558120. |
studies in human tissue and model systems demonstrate that tdp-43 may potentiate other proteinopathies such as the amyloid or tau pathology seen in alzheimer's disease (ad) in the combination of ad+late. |
2021-12-10 |
2023-08-13 |
human |
| Biju Bhargavan, Shawna M Woollard, Jo Ellyn McMillan, Georgette D Kanmogn. CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice. Molecular neurodegeneration. vol 16. issue 1. 2021-12-10. PMID:34809709. |
neurocognitive impairment is present in 50% of hiv-infected individuals and is often associated with alzheimer's disease (ad)-like brain pathologies, including increased amyloid-beta (aβ) and tau hyperphosphorylation. |
2021-12-10 |
2023-08-13 |
mouse |
| Maria Ricci, Andrea Cimini, Riccardo Camedda, Agostino Chiaravalloti, Orazio Schillac. Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884804. |
abnormal accumulation of tau protein is closely associated with neurodegeneration and cognitive impairment and it is a biomarker of neurodegeneration in the dementia field, especially in alzheimer's disease (ad); therefore, it is crucial to be able to assess the tau deposits in vivo. |
2021-12-10 |
2023-08-13 |
Not clear |
| Galina Limorenko, Hilal A Lashue. Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society reviews. 2021-12-10. PMID:34889934. |
converging evidence continues to point towards tau aggregation and pathology formation as central events in the pathogenesis of alzheimer's disease and other tauopathies. |
2021-12-10 |
2023-08-13 |
Not clear |
| Galina Limorenko, Hilal A Lashue. Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society reviews. 2021-12-10. PMID:34889934. |
thirdly, we discuss the importance of adopting new experimental approaches that embrace the complexity of tau aggregation and pathology as an important first step towards developing mechanism- and structure-based therapies that account for the pathological and clinical heterogeneity of alzheimer's disease and tauopathies. |
2021-12-10 |
2023-08-13 |
Not clear |
| Bruno P Imbimbo, Mark Watlin. What have we learned from past failures of investigational drugs for Alzheimer's disease? Expert opinion on investigational drugs. 2021-12-10. PMID:34890262. |
in the last 15 years, huge efforts against alzheimer's disease (ad) with drugs targeting β-amyloid (aβ) and tau have produced poor clinical results. |
2021-12-10 |
2023-08-13 |
Not clear |
| Jian-Hong Wang, Lei Guo, Su Wang, Neng-Wei Yu, Fu-Qiang Gu. The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions. Current opinion in pharmacology. vol 62. 2021-12-10. PMID:34891124. |
β-hydroxybutyl acid (βohb), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially alzheimer's dementia (ad), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histone acetylation, affecting the metabolism of aβ and tau proteins, inhibiting inflammation and lipid metabolism, and regulating intestinal microbes. |
2021-12-10 |
2023-08-13 |
human |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Yanxiao Li, Weihua Li, Xiuying Wang, Tammie L S Benzinger, Jie Lu, Yun Zho. Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33876815. |
preprocessed 18f-flortaucipir tau pet images, t1-weighted structural mri, demographic information, global cortical amyloid-β burden measured by 18f-florbetapir pet, csf total tau and phosphorylated tau measurements were obtained from the alzheimer's disease neuroimaging initiative database. |
2021-12-09 |
2023-08-13 |
Not clear |
| Joana B Pereira, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Danielle van Westen, Jeffrey L Dage, Niklas Mattsson-Carlgren, Oskar Hansso. Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34077494. |
to achieve this, plasma amyloid-β 42/40 (aβ42/40), phosphorylated-tau181, phosphorylated-tau217 and neurofilament light were determined in 159 non-demented individuals, 123 patients with alzheimer's disease dementia and 35 patients with a non-alzheimer's dementia from the swedish biofinder-2 study, who underwent longitudinal amyloid (18f-flutemetamol) and tau (18f-ro948) pet, structural mri (t1-weighted) and cognitive testing. |
2021-12-09 |
2023-08-13 |
human |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
dementia with lewy bodies (dlb) is neuropathologically defined by the presence of α-synuclein aggregates, but many dlb cases show concurrent alzheimer's disease pathology in the form of amyloid-β plaques and tau neurofibrillary tangles. |
2021-12-09 |
2023-08-13 |
human |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
higher functional connectivity between regions was associated with higher tau covariance in cognitively unimpaired, alzheimer's disease and dlb. |
2021-12-09 |
2023-08-13 |
human |
| Julia Schumacher, Jeffrey L Gunter, Scott A Przybelski, David T Jones, Jonathan Graff-Radford, Rodolfo Savica, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, David S Knopman, Julie A Fields, Walter K Kremers, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Alan J Thomas, John-Paul Taylor, Kejal Kantarc. Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:34114602. |
furthermore, we found an association between the brain's functional network architecture and the distribution of tau pathology that has recently been described in alzheimer's disease. |
2021-12-09 |
2023-08-13 |
human |
| Paul A Yushkevich, Mónica Muñoz López, María Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R Das, Emilio Artacho-Pérula, Marı'a Del Mar Arroyo Jiménez, Marı'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, Edward B Lee, John Q Trojanowski, Daniel T Ohm, Laura E M Wisse, David A Wolk, David J Irwin, Ricardo Insaust. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34259858. |
tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in alzheimer's disease and related dementias. |
2021-12-09 |
2023-08-13 |
human |
| Ali R Khan, Julie Ottoy, Maged Goubra. Towards a comprehensive 3D mapping of tau progression in early Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34424288. |
towards a comprehensive 3d mapping of tau progression in early alzheimer's disease. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yalun Zhang, Yi Zhang, Yahyah Aman, Cheung Toa Ng, Wing-Hin Chau, Zhigang Zhang, Ming Yue, Christopher Bohm, Yizhen Jia, Siwen Li, Qiuju Yuan, Jennifer Griffin, Kin Chiu, Dana S M Wong, Binbin Wang, Dongyan Jin, Ekaterina Rogaeva, Paul E Fraser, Evandro F Fang, Peter St George-Hyslop, You-Qiang Son. Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34428276. |
here, we show that pax6, a transcription factor essential for eye and brain development which is quiescent in adults, is increased in the brains of patients with alzheimer's disease and in app transgenic mice, and plays a key role between amyloid-β and tau hyperphosphorylation. |
2021-12-09 |
2023-08-13 |
mouse |
| Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlar. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 2. 2021-12-08. PMID:33410108. |
the accumulation of neurofibrillary tangles (nfts), which is composed of abnormally hyperphosphorylated tau aggregates, is the classic neuropathology associated with cognitive dysfunction in tauopathies such as alzheimer's disease (ad). |
2021-12-08 |
2023-08-13 |
mouse |
| Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Andrew C Robinson, David M A Mann, Taisuke Tomita, Masato Hasegaw. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33693528. |
specifically, three-repeat tau and four-repeat tau in alzheimer's disease, three-repeat tau in pick's disease (pid) and four-repeat tau in progressive supranuclear palsy (psp) and corticobasal degeneration (cbd) form amyloid-like fibrous structures that accumulate in neurons and/or glial cells. |
2021-12-08 |
2023-08-13 |
human |
| Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Andrew C Robinson, David M A Mann, Taisuke Tomita, Masato Hasegaw. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33693528. |
the seeding activity towards full-length four-repeat tau substrate was highest in cbd-tau seeds, followed by psp-tau and alzheimer's disease (ad)-tau seeds, while ad-tau seeds showed higher seeding activity than pid-tau seeds towards three-repeat tau substrate. |
2021-12-08 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
discriminatory ability of next-generation tau pet tracers for alzheimer's disease. |
2021-12-08 |
2023-08-13 |
human |
| Steven Y Yap, Barbara Frias, Melissa C Wren, Michael Schöll, Nick C Fox, Erik Årstad, Tammaryn Lashley, Kerstin Sande. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33742656. |
a next generation of tau pet tracers for the imaging of alzheimer's disease and other dementias has recently been developed. |
2021-12-08 |
2023-08-13 |
human |