| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bjoern O Schelter, Helen Shiells, Thomas C Baddeley, Christopher M Rubino, Harish Ganesan, Jeffrey Hammel, Vesna Vuksanovic, Roger T Staff, Alison D Murray, Luc Bracoud, Gernot Riedel, Serge Gauthier, Jianping Jia, Peter Bentham, Karin Kook, John M D Storey, Charles R Harrington, Claude M Wischi. Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31658058. |
although hydromethylthionine is a potent tau aggregation inhibitor, no difference was found in either of two phase iii trials in mild to moderate alzheimer's disease (ad) comparing doses in the range 150-250 mg/day with 8 mg/day intended as a control. |
2020-11-30 |
2023-08-13 |
Not clear |
| Laibaik Park, Karin Hochrainer, Yorito Hattori, Sung Ji Ahn, Antoine Anfray, Gang Wang, Ken Uekawa, James Seo, Victoria Palfini, Ismary Blanco, Diana Acosta, David Eliezer, Ping Zhou, Josef Anrather, Costantino Iadecol. Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. vol 23. issue 9. 2020-11-30. PMID:32778793. |
cerebrovascular abnormalities have emerged as a preclinical manifestation of alzheimer's disease and frontotemporal dementia, diseases characterized by the accumulation of hyperphosphorylated forms of the microtubule-associated protein tau. |
2020-11-30 |
2023-08-13 |
mouse |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Janusz Kocki, Jacek Bogucki, Sławomir Januszewski, Anna Bogucka-Kocka, Stanisław J Czuczwa. Expression of the Tau Protein and Amyloid Protein Precursor Processing Genes in the CA3 Area of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31713815. |
expression of the tau protein and amyloid protein precursor processing genes in the ca3 area of the hippocampus in the ischemic model of alzheimer's disease in the rat. |
2020-11-25 |
2023-08-13 |
rat |
| S Weickert, M Wawrzyniuk, L H John, S G D Rüdiger, M Dresche. The mechanism of Hsp90-induced oligomerizaton of Tau. Science advances. vol 6. issue 11. 2020-11-25. PMID:32201713. |
aggregation of the microtubule-associated protein tau is a hallmark of alzheimer's disease with tau oligomers suspected as the most toxic agent. |
2020-11-25 |
2023-08-13 |
Not clear |
| Christopher Sackmann, Martin Hallbec. Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons. Scientific reports. vol 10. issue 1. 2020-11-25. PMID:32300132. |
alzheimer's disease (ad) is the most common form of dementia globally and is characterized by aberrant accumulations of amyloid-beta (aβ) and tau proteins. |
2020-11-25 |
2023-08-13 |
human |
| Minyoung Oh, Seung Jun Oh, Sang Ju Lee, Jungsu S Oh, Jee Hoon Roh, Sun Ju Chung, Jae-Hong Lee, Chong Sik Lee, Jae Seung Ki. Clinical Evaluation of 18F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With 18F-THK-5351. Clinical nuclear medicine. vol 45. issue 11. 2020-11-25. PMID:32910050. |
clinical evaluation of 18f-pi-2620 as a potent pet radiotracer imaging tau protein in alzheimer disease and other neurodegenerative diseases compared with 18f-thk-5351. |
2020-11-25 |
2023-08-13 |
Not clear |
| Xi Sun, Binbin Nie, Shujun Zhao, Lin Ai, Qian Chen, Tianhao Zhang, Tingting Pan, Luying Wang, Xiaolong Yin, Wei Zhang, Baoci Shan, Hua Liu, Shengxiang Liang, Guihong Wan. Distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in Alzheimer's disease. Neuroscience letters. vol 717. 2020-11-24. PMID:31874218. |
distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in alzheimer's disease. |
2020-11-24 |
2023-08-13 |
human |
| Xi Sun, Binbin Nie, Shujun Zhao, Lin Ai, Qian Chen, Tianhao Zhang, Tingting Pan, Luying Wang, Xiaolong Yin, Wei Zhang, Baoci Shan, Hua Liu, Shengxiang Liang, Guihong Wan. Distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in Alzheimer's disease. Neuroscience letters. vol 717. 2020-11-24. PMID:31874218. |
extracellular accumulation of amyloid-beta peptides and intracellular neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins are the two cardinally pathological hallmarks of alzheimer's disease (ad). |
2020-11-24 |
2023-08-13 |
human |
| Colleen Pappas, Brandon S Klinedinst, Scott Le, Qian Wang, Brittany Larsen, Kelsey McLimans, Samuel N Lockhart, Karin Allenspach-Jorn, Jonathan P Mochel, Auriel A Willett. CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors. Alzheimer's & dementia (New York, N. Y.). vol 6. issue 1. 2020-11-23. PMID:32864418. |
csf glucose tracks regional tau progression based on alzheimer's disease risk factors. |
2020-11-23 |
2023-08-13 |
Not clear |
| Colleen Pappas, Brandon S Klinedinst, Scott Le, Qian Wang, Brittany Larsen, Kelsey McLimans, Samuel N Lockhart, Karin Allenspach-Jorn, Jonathan P Mochel, Auriel A Willett. CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors. Alzheimer's & dementia (New York, N. Y.). vol 6. issue 1. 2020-11-23. PMID:32864418. |
glucose hypometabolism and tau formation are key features of alzheimer's disease (ad). |
2020-11-23 |
2023-08-13 |
Not clear |
| Hang-Rai Kim, Taeyeop Lee, Jung Kyoon Choi, Yong Jeon. Genetic variants beyond amyloid and tau associated with cognitive decline: A cohort study. Neurology. vol 95. issue 17. 2020-11-23. PMID:32938779. |
to identify single nucleotide polymorphisms (snps) associated with cognitive decline independent of β-amyloid (aβ) and tau pathology in alzheimer disease (ad). |
2020-11-23 |
2023-08-13 |
Not clear |
| Ju-Xian Song, Sandeep Malampati, Yu Zeng, Siva Sundara Kumar Durairajan, Chuan-Bin Yang, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Bin Shang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, King-Ho Cheung, Jia-Hong Lu, Chunzhi Tang, Nenggui Xu, Min L. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging cell. vol 19. issue 2. 2020-11-20. PMID:31858697. |
a small molecule transcription factor eb activator ameliorates beta-amyloid precursor protein and tau pathology in alzheimer's disease models. |
2020-11-20 |
2023-08-13 |
mouse |
| Jorge A Trejo-Lopez, Zachary A Sorrentino, Cara J Riffe, Stefan Prokop, Dennis W Dickson, Anthony T Yachnis, Benoit I Giasso. Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. Journal of neuropathology and experimental neurology. vol 79. issue 4. 2020-11-20. PMID:32106300. |
both 5g3 and 2a5 revealed incidental astrocytic tau immunoreactivity in cases of alzheimer disease and lewy body disease with resolution superior to 7f2. |
2020-11-20 |
2023-08-13 |
human |
| Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V Riddick, Michelle S Itano, Ashutosh Tripathy, Sheryl S Moy, Virginia M Y Lee, John Q Trojanowski, David J Irwin, Todd J Cohe. An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline. Nature communications. vol 11. issue 1. 2020-11-20. PMID:33139698. |
tauopathies including alzheimer's disease (ad) are marked by the accumulation of aberrantly modified tau proteins. |
2020-11-20 |
2023-08-13 |
mouse |
| Daniel Tward, Timothy Brown, Yusuke Kageyama, Jaymin Patel, Zhipeng Hou, Susumu Mori, Marilyn Albert, Juan Troncoso, Michael Mille. Diffeomorphic Registration With Intensity Transformation and Missing Data: Application to 3D Digital Pathology of Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-11-19. PMID:32116503. |
by using a standard convolutional neural network to detect tau tangles in histology slices, this registration method enabled us to quantify the 3d density distribution of tauopathy throughout the medial temporal lobe of an alzheimer's disease postmortem specimen. |
2020-11-19 |
2023-08-13 |
Not clear |
| Daichi Sone, Yoko Shigemoto, Masayo Ogawa, Norihide Maikusa, Kyoji Okita, Harumasa Takano, Koichi Kato, Noriko Sato, Hiroshi Matsud. Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-11-19. PMID:33204813. |
the molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in alzheimer's disease (ad) research. |
2020-11-19 |
2023-08-13 |
Not clear |
| Armine Hovakimyan, Tatevik Antonyan, Sepideh Kiani Shabestari, Olga Svystun, Gor Chailyan, Morgan A Coburn, William Carlen-Jones, Irina Petrushina, Jean Paul Chadarevian, Karen Zagorski, Nikolai Petrovsky, David H Cribbs, Michael G Agadjanyan, Anahit Ghochikyan, Hayk Davtya. A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice. Scientific reports. vol 9. issue 1. 2020-11-18. PMID:31664089. |
pathological tau correlates well with cognitive impairments in alzheimer's disease (ad) patients and therefore represents a promising target for immunotherapy. |
2020-11-18 |
2023-08-13 |
mouse |
| Shuo Xiao, Lin-Lin Song, Jiang-Tao Li, He Wang, Na Yu, Zi-Qi Wang, Ying Zhang, Jin-Sheng He, Tao Hun. Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice. Journal of Alzheimer's disease : JAD. vol 73. issue 2. 2020-11-18. PMID:31839610. |
alzheimer's disease (ad) is the most common form of dementia, characterized by amyloid-β peptide (aβ) aggregates, phosphorylated tau protein (p-tau), and progressive neurodegeneration. |
2020-11-18 |
2023-08-13 |
mouse |
| Ece Kocagoncu, Andrew Quinn, Azadeh Firouzian, Elisa Cooper, Andrea Greve, Roger Gunn, Gary Green, Mark W Woolrich, Richard N Henson, Simon Lovestone, James B Row. Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of aging. vol 92. 2020-11-18. PMID:32280029. |
tau pathology in early alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. |
2020-11-18 |
2023-08-13 |
Not clear |
| Ece Kocagoncu, Andrew Quinn, Azadeh Firouzian, Elisa Cooper, Andrea Greve, Roger Gunn, Gary Green, Mark W Woolrich, Richard N Henson, Simon Lovestone, James B Row. Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of aging. vol 92. 2020-11-18. PMID:32280029. |
understanding the role of tau protein aggregation in the pathogenesis of alzheimer's disease is critical for the development of new tau-based therapeutic strategies to slow or prevent dementia. |
2020-11-18 |
2023-08-13 |
Not clear |