| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María José Pérez, Katiana Vergara-Pulgar, Claudia Jara, Fabian Cabezas-Opazo, Rodrigo A Quintanill. Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer's Disease. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28084594. |
caspase-cleaved tau impairs mitochondrial dynamics in alzheimer's disease. |
2019-01-01 |
2023-08-13 |
mouse |
| María José Pérez, Katiana Vergara-Pulgar, Claudia Jara, Fabian Cabezas-Opazo, Rodrigo A Quintanill. Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer's Disease. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28084594. |
alzheimer's disease (ad) is characterized by the presence of aggregates of tau protein. |
2019-01-01 |
2023-08-13 |
mouse |
| Fang Fang, Wanlin Yang, Jazmin B Florio, Edward Rockenstein, Brian Spencer, Xavier M Orain, Stephanie X Dong, Huayan Li, Xuqiao Chen, Kijung Sung, Robert A Rissman, Eliezer Masliah, Jianqing Ding, Chengbiao W. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28634349. |
recent studies have demonstrated that hyperphosphorylation of tau protein plays a role in neuronal toxicities of α-synuclein (asyn) in neurodegenerative disease such as familial alzheimer's disease (ad), dementia with lewy bodies (dlb) and parkinson's disease. |
2018-12-31 |
2023-08-13 |
mouse |
| Susanne Wegmann, Bahareh Eftekharzadeh, Katharina Tepper, Katarzyna M Zoltowska, Rachel E Bennett, Simon Dujardin, Pawel R Laskowski, Danny MacKenzie, Tarun Kamath, Caitlin Commins, Charles Vanderburg, Allyson D Roe, Zhanyun Fan, Amandine M Molliex, Amayra Hernandez-Vega, Daniel Muller, Anthony A Hyman, Eckhard Mandelkow, J Paul Taylor, Bradley T Hyma. Tau protein liquid-liquid phase separation can initiate tau aggregation. The EMBO journal. vol 37. issue 7. 2018-12-28. PMID:29472250. |
the transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in alzheimer's disease is unknown. |
2018-12-28 |
2023-08-13 |
human |
| Susanne Wegmann, Bahareh Eftekharzadeh, Katharina Tepper, Katarzyna M Zoltowska, Rachel E Bennett, Simon Dujardin, Pawel R Laskowski, Danny MacKenzie, Tarun Kamath, Caitlin Commins, Charles Vanderburg, Allyson D Roe, Zhanyun Fan, Amandine M Molliex, Amayra Hernandez-Vega, Daniel Muller, Anthony A Hyman, Eckhard Mandelkow, J Paul Taylor, Bradley T Hyma. Tau protein liquid-liquid phase separation can initiate tau aggregation. The EMBO journal. vol 37. issue 7. 2018-12-28. PMID:29472250. |
we demonstrate that phosphorylated or mutant aggregation prone recombinant tau undergoes llps, as does high molecular weight soluble phospho-tau isolated from human alzheimer brain. |
2018-12-28 |
2023-08-13 |
human |
| Nir Lipsman, Ying Meng, Allison J Bethune, Yuexi Huang, Benjamin Lam, Mario Masellis, Nathan Herrmann, Chinthaka Heyn, Isabelle Aubert, Alexandre Boutet, Gwenn S Smith, Kullervo Hynynen, Sandra E Blac. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nature communications. vol 9. issue 1. 2018-12-26. PMID:30046032. |
magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood-brain barrier, and reduce beta-amyloid and tau pathology in animal models of alzheimer's disease. |
2018-12-26 |
2023-08-13 |
Not clear |
| Hannah E R Baughman, Amanda F Clouser, Rachel E Klevit, Abhinav Nat. HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation. The Journal of biological chemistry. vol 293. issue 8. 2018-12-18. PMID:29298892. |
the microtubule-associated protein tau forms insoluble, amyloid-type aggregates in various dementias, most notably alzheimer's disease. |
2018-12-18 |
2023-08-13 |
Not clear |
| Masato Hosokawa, Hiromi Kondo, Geidy E Serrano, Thomas G Beach, Andrew C Robinson, David M Mann, Haruhiko Akiyama, Masato Hasegawa, Tetsuaki Ara. Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation. Scientific reports. vol 7. issue 1. 2018-12-17. PMID:28473694. |
granulin mutations were initially found in tau-negative patients, though recent findings indicate that these mutations are associated with other neurodegenerative disorders with tau pathology, including alzheimer's disease and corticobasal degeneration. |
2018-12-17 |
2023-08-13 |
mouse |
| Masato Hosokawa, Hiromi Kondo, Geidy E Serrano, Thomas G Beach, Andrew C Robinson, David M Mann, Haruhiko Akiyama, Masato Hasegawa, Tetsuaki Ara. Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation. Scientific reports. vol 7. issue 1. 2018-12-17. PMID:28473694. |
immunoblot analysis of fresh frozen brain tissues revealed that tau was present in the sarkosyl-insoluble fraction, and composed of three- and four-repeat tau isoforms, resembling alzheimer's disease. |
2018-12-17 |
2023-08-13 |
mouse |
| Teresa Trotta, Maria Antonietta Panaro, Antonia Cianciulli, Giorgio Mori, Adriana Di Benedetto, Chiara Porr. Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword. Biochemical pharmacology. vol 148. 2018-12-17. PMID:29305855. |
in the central nervous system (cns), evs have been suggested as potential carriers in the intercellular delivery of misfolded proteins associated to neurodegenerative disorders, such as tau and amyloid β in alzheimer's disease (ad), α-synuclein in parkinson's disease (pd), superoxide dismutase (sod)1 in amyotrophic lateral sclerosis and huntingtin in huntington's disease. |
2018-12-17 |
2023-08-13 |
Not clear |
| Junxiang Yin, Pengcheng Han, Melissa Song, Megan Nielsen, Thomas G Beach, Geidy E Serrano, Winnie S Liang, Richard J Caselli, Jiong Sh. Amyloid-β Increases Tau by Mediating Sirtuin 3 in Alzheimer's Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29574628. |
amyloid-β increases tau by mediating sirtuin 3 in alzheimer's disease. |
2018-12-17 |
2023-08-13 |
mouse |
| Stefania A Mari, Susanne Wegmann, Katharina Tepper, Bradley T Hyman, Eva-Maria Mandelkow, Eckhard Mandelkow, Daniel J Mülle. Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. Nano letters. vol 18. issue 5. 2018-12-17. PMID:29644863. |
misfolding and aggregation of the neuronal, microtubule-associated protein tau is involved in the pathogenesis of alzheimer's disease and tauopathies. |
2018-12-17 |
2023-08-13 |
human |
| Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. Molecular nutrition & food research. vol 62. issue 12. 2018-12-17. PMID:29714053. |
sulforaphane upregulates the heat shock protein co-chaperone chip and clears amyloid-β and tau in a mouse model of alzheimer's disease. |
2018-12-17 |
2023-08-13 |
mouse |
| Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. Molecular nutrition & food research. vol 62. issue 12. 2018-12-17. PMID:29714053. |
here, the authors investigate whether sulforaphane modulates the production of amyloid-β (aβ) and tau, the two main pathological factors in alzheimer's disease (ad). |
2018-12-17 |
2023-08-13 |
mouse |
| Ankit Parikh, Krishna Kathawala, Jintao Li, Chi Chen, Zhengnan Shan, Xia Cao, Xin-Fu Zhou, Sanjay Gar. Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease. Drug delivery and translational research. vol 8. issue 5. 2018-12-17. PMID:30117120. |
curcumin (cur), a natural polyphenolic compound, is considered as one of the most potential candidates against alzheimer disease (ad) by targeting multiple pathologies such as amyloid-beta, tau phosphorylation, and oxidative stress. |
2018-12-17 |
2023-08-13 |
human |
| Tania Ismail, Mathumai Kanapathipilla. Effect of cellular polyanion mimetics on tau peptide aggregation. Journal of peptide science : an official publication of the European Peptide Society. vol 24. issue 11. 2018-12-17. PMID:30251388. |
tau protein aggregation is believed to be one of the key drivers of alzheimer's disease. |
2018-12-17 |
2023-08-13 |
Not clear |
| Tharick A Pascoal, Sulantha Mathotaarachchi, Monica Shin, Ah Yeon Park, Sara Mohades, Andrea L Benedet, Min Su Kang, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 45. issue 6. 2018-12-14. PMID:29396637. |
amyloid and tau signatures of brain metabolic decline in preclinical alzheimer's disease. |
2018-12-14 |
2023-08-13 |
Not clear |
| Tharick A Pascoal, Sulantha Mathotaarachchi, Monica Shin, Ah Yeon Park, Sara Mohades, Andrea L Benedet, Min Su Kang, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 45. issue 6. 2018-12-14. PMID:29396637. |
we aimed to determine the amyloid (aβ) and tau biomarker levels associated with imminent alzheimer's disease (ad) - related metabolic decline in cognitively normal individuals. |
2018-12-14 |
2023-08-13 |
Not clear |
| Jeffery W Kell. The two shapes of the Tau protein. eLife. vol 7. 2018-12-14. PMID:29988017. |
tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of alzheimer's disease. |
2018-12-14 |
2023-08-13 |
Not clear |
| Ji-Ying Hu, De-Lin Zhang, Xiao-Ling Liu, Xue-Shou Li, Xiao-Qing Cheng, Jie Chen, Hai-Ning Du, Yi Lian. Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 2. 2018-12-11. PMID:27890528. |
a pathological hallmark of alzheimer disease and other tauopathies is the formation of neurofibrillary tangles mainly composed of bundles of fibrils formed by microtubule-associated protein tau. |
2018-12-11 |
2023-08-13 |
human |