| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Magri, Angela Messin. Interactions of VDAC with Proteins Involved in Neurodegenerative Aggregation: An Opportunity for Advancement on Therapeutic Molecules. Current medicinal chemistry. vol 24. issue 40. 2018-10-25. PMID:28571556. |
in particular, the principal isoform vdac1 represents the main mitochondrial docking site of many misfolded proteins, such as amyloid β and tau in alzheimer's disease, α-synuclein in parkinson's disease and several sod1 mutants in amyotrophic lateral sclerosis. |
2018-10-25 |
2023-08-13 |
Not clear |
| Sarah S Darwish, Mohammad Abdel-Halim, Mohamed Salah, Ashraf H Abadi, Walter Becker, Matthias Enge. Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. European journal of medicinal chemistry. vol 157. 2018-10-22. PMID:30193214. |
the protein kinase dyrk1a modulates several processes relevant to the development or progression of alzheimer's disease (ad), e. g. through phosphorylation of tau protein, amyloid precursor protein (app) as well as proteins involved in the regulation of alternative splicing of tau pre-mrna. |
2018-10-22 |
2023-08-13 |
Not clear |
| Zhongbao Zhang, Zhibin Liang, Longfei Yin, Qing X Li, Zhongyi W. Distribution of Four Bioactive Flavonoids in Maize Tissues of Five Varieties and Correlation with Expression of the Biosynthetic Genes. Journal of agricultural and food chemistry. vol 66. issue 40. 2018-10-19. PMID:30240197. |
c-glycosylflavones are neuroprotective against β-amyloid-induced tau hyperphosphorylation and neurotoxicity in sh-sy5y cells, which is relevant to alzheimer's disease prevention and treatment. |
2018-10-19 |
2023-08-13 |
Not clear |
| Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E Ehrnhoefe. A validated antibody panel for the characterization of tau post-translational modifications. Molecular neurodegeneration. vol 12. issue 1. 2018-10-18. PMID:29157277. |
aberrant ptms such as hyperphosphorylation result in tau aggregation and the formation of neurofibrillary tangles, which are a hallmark of alzheimer's disease (ad). |
2018-10-18 |
2023-08-13 |
human |
| Biyue Zhu, Ting Zhang, Qian Jiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi, Yan Chen. Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models. Chemical communications (Cambridge, England). vol 54. issue 82. 2018-10-17. PMID:30204164. |
synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in alzheimer's models. |
2018-10-17 |
2023-08-13 |
mouse |
| Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum. Neurobiology of aging. vol 68. 2018-10-16. PMID:29751288. |
predicted sequence of cortical tau and amyloid-β deposition in alzheimer disease spectrum. |
2018-10-16 |
2023-08-13 |
human |
| Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum. Neurobiology of aging. vol 68. 2018-10-16. PMID:29751288. |
we investigated sequential order between tau and amyloid-β (aβ) deposition in alzheimer disease spectrum using a conditional probability method. |
2018-10-16 |
2023-08-13 |
human |
| Faten A Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, Axel Hauduc, Connor Ludwig, Fuying Gao, Claire Clelland, Lihong Zhan, Yonatan A Cooper, Dimitrios Davalos, Katerina Akassoglou, Giovanni Coppola, Li Ga. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 40. 2018-10-16. PMID:30232263. |
alzheimer's disease (ad), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. |
2018-10-16 |
2023-08-13 |
Not clear |
| T West, Y Hu, P B Verghese, R J Bateman, J B Braunstein, I Fogelman, K Budur, H Florian, N Mendonca, D M Holtzma. Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies. The journal of prevention of Alzheimer's disease. vol 4. issue 4. 2018-10-11. PMID:29181488. |
tau neurofibrillary tangles are found in the brains of patients suffering from alzheimer's disease and other tauopathies. |
2018-10-11 |
2023-08-13 |
human |
| Young Kyoung Jang, Chul Hyoung Lyoo, Seongbeom Park, Seung Jun Oh, Hanna Cho, Minyoung Oh, Young Hoon Ryu, Jae Yong Choi, Gil D Rabinovici, Hee Jin Kim, Seung Hwan Moon, Hyemin Jang, Jin San Lee, William J Jagust, Duk L Na, Jae Seung Kim, Sang Won Se. Head to head comparison of [ European journal of nuclear medicine and molecular imaging. vol 45. issue 3. 2018-10-09. PMID:29143870. |
head to head comparison of [ tau accumulation is a core pathologic change in various neurodegenerative diseases including alzheimer's disease and frontotemporal lobar degeneration-tau. |
2018-10-09 |
2023-08-13 |
Not clear |
| Tina Bilousova, Chris Elias, Emily Miyoshi, Mohammad Parvez Alam, Chunni Zhu, Jesus Campagna, Kanagasabai Vadivel, Barbara Jagodzinska, Karen Hoppens Gylys, Varghese Joh. Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29604274. |
targeting of molecular pathways involved in the cell-to-cell propagation of pathological tau species is a novel approach for development of disease-modifying therapies that could block tau pathology and attenuate cognitive decline in patients with alzheimer's disease and other tauopathies. |
2018-10-09 |
2023-08-13 |
Not clear |
| Fong Ping Chong, Khuen Yen Ng, Rhun Yian Koh, Soi Moi Chy. Tau Proteins and Tauopathies in Alzheimer's Disease. Cellular and molecular neurobiology. vol 38. issue 5. 2018-10-05. PMID:29299792. |
tau proteins and tauopathies in alzheimer's disease. |
2018-10-05 |
2023-08-13 |
human |
| Shuquan Rao, Mahdi Ghani, Zhiyun Guo, Yuetiva Deming, Kesheng Wang, Rebecca Sims, Canquan Mao, Yao Yao, Carlos Cruchaga, Dietrich A Stephan, Ekaterina Rogaev. An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Neurobiology of aging. vol 66. 2018-10-05. PMID:29395286. |
an apoe-independent cis-esnp on chromosome 19q13.32 influences tau levels and late-onset alzheimer's disease risk. |
2018-10-05 |
2023-08-13 |
Not clear |
| Andrei G Vlassenko, Brian A Gordon, Manu S Goyal, Yi Su, Tyler M Blazey, Tony J Durbin, Lars E Couture, Jon J Christensen, Hussain Jafri, John C Morris, Marcus E Raichle, Tammie L-S Benzinge. Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease. Neurobiology of aging. vol 67. 2018-10-04. PMID:29655050. |
aerobic glycolysis and tau deposition in preclinical alzheimer's disease. |
2018-10-04 |
2023-08-13 |
human |
| Alban Chauderlier, Melissa Gilles, Andrea Spolcova, Raphaelle Caillierez, Maggy Chwastyniak, Michel Kress, Herve Drobecq, Eliette Bonnefoy, Florence Pinet, Dominique Weil, Luc Buée, Marie-Christine Galas, Bruno Lefebvr. Tau/DDX6 interaction increases microRNA activity. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1861. issue 8. 2018-10-04. PMID:29966762. |
tauopathies, such as alzheimer's disease, are characterized by intracellular aggregates of insoluble tau proteins. |
2018-10-04 |
2023-08-13 |
Not clear |
| Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A Lashue. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29162800. |
the microtubule-associated protein tau plays a central role in the pathogenesis of alzheimer's disease. |
2018-10-01 |
2023-08-13 |
Not clear |
| Lary C Walke. Prion-like mechanisms in Alzheimer disease. Handbook of clinical neurology. vol 153. 2018-09-27. PMID:29887142. |
in alzheimer disease, current evidence indicates that the pathogenic cascade follows from the endogenous, sequential corruption of aβ and then tau. |
2018-09-27 |
2023-08-13 |
Not clear |
| Marjolein Bulk, Walid M Abdelmoula, Rob J A Nabuurs, Linda M van der Graaf, Coen W H Mulders, Aat A Mulder, Carolina R Jost, Abraham J Koster, Mark A van Buchem, Remco Natté, Jouke Dijkstra, Louise van der Weer. Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease. Neurobiology of aging. vol 62. 2018-09-26. PMID:29195086. |
neuropathologically, subtypes of alzheimer's disease showed different patterns of iron accumulation and cortical myelin changes independent of amyloid and tau that may be detected by high-field susceptibility-based mri. |
2018-09-26 |
2023-08-13 |
Not clear |
| David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düze. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of aging. vol 65. 2018-09-26. PMID:29454154. |
future experiments will elucidate whether the 2 pathways are differentially affected in early stages of alzheimer's disease in relation to amyloid or tau pathology. |
2018-09-26 |
2023-08-13 |
human |
| Sandra Pelleieux, Cynthia Picard, Louise Lamarre-Théroux, Doris Dea, Valérie Leduc, Youla S Tsantrizos, Judes Poirie. Isoprenoids and tau pathology in sporadic Alzheimer's disease. Neurobiology of aging. vol 65. 2018-09-26. PMID:29476987. |
isoprenoids and tau pathology in sporadic alzheimer's disease. |
2018-09-26 |
2023-08-13 |
human |