| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Guru KrishnaKumar, Ashim Paul, Ehud Gazit, Daniel Sega. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Scientific reports. vol 8. issue 1. 2018-11-16. PMID:29311706. |
intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of alzheimer's disease (ad), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded β-sheet rich aggregates. |
2018-11-16 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. |
ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. |
2018-11-16 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. |
the best known out of these diseases is alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. |
2018-11-16 |
2023-08-13 |
Not clear |
| Daniel Miguel Ángel Villalobos Acosta, Brenda Chimal Vega, José Correa Basurto, Leticia Guadalupe Fragoso Morales, Martha Cecilia Rosales Hernánde. Recent Advances by In Silico and In Vitro Studies of Amyloid-β 1-42 Fibril Depicted a S-Shape Conformation. International journal of molecular sciences. vol 19. issue 8. 2018-11-16. PMID:30115846. |
aβ1-42, together with the tau protein are two principal hallmarks of alzheimer's disease (ad) that are related to disease genesis and progression. |
2018-11-16 |
2023-08-13 |
Not clear |
| Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M Wander, Victoria Madden, Ashutosh Tripathy, Chao-Xing Yuan, Todd J Cohe. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Scientific reports. vol 7. 2018-11-13. PMID:28287136. |
tau acetylation has recently emerged as a dominant post-translational modification (ptm) in alzheimer's disease (ad) and related tauopathies. |
2018-11-13 |
2023-08-13 |
Not clear |
| Marina Chemerovski-Glikman, Moran Frenkel-Pinter, Ragad Mdah, Amjaad Abu-Mokh, Ehud Gazit, Daniel Sega. Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 40. 2018-11-12. PMID:28544138. |
inhibiting the toxic aggregation of amyloid-β and the tau protein, the key pathological agents involved in alzheimer's, is a leading approach in modulating disease progression. |
2018-11-12 |
2023-08-13 |
Not clear |
| Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therése Klingstedt, Nigel J Cairns, K Peter R Nilsso. Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 67. 2018-11-12. PMID:28926133. |
synthesis of thiophene-based optical ligands that selectively detect tau pathology in alzheimer's disease. |
2018-11-12 |
2023-08-13 |
Not clear |
| Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therése Klingstedt, Nigel J Cairns, K Peter R Nilsso. Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 67. 2018-11-12. PMID:28926133. |
here, the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (btvbts) that can be utilized for selective assignment of tau aggregates in brain tissue with alzheimer's disease (ad) pathology is reported. |
2018-11-12 |
2023-08-13 |
Not clear |
| Laura M Taylor, Pamela J McMillan, Nicole F Liachko, Timothy J Strovas, Bernardino Ghetti, Thomas D Bird, C Dirk Keene, Brian C Kraeme. Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29409526. |
both ttbk1 and ttbk2 were initially identified as tau kinases and ttbk1 has been shown to phosphorylate tau epitopes commonly observed in alzheimer's disease and other tauopathies. |
2018-11-09 |
2023-08-13 |
human |
| Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. |
prion-like propagation of post-translationally modified tau in alzheimer's disease: a hypothesis. |
2018-11-08 |
2023-08-13 |
Not clear |
| Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. |
the microtubule-associated protein tau plays a key role in the neuropathology of alzheimer's disease by forming intracellular neurofibrillary tangles. |
2018-11-08 |
2023-08-13 |
Not clear |
| Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chian. Untangling the Tauopathy for Alzheimer's disease and parkinsonism. Journal of biomedical science. vol 25. issue 1. 2018-11-08. PMID:29991349. |
tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including alzheimer's disease (ad), and various parkinsonism. |
2018-11-08 |
2023-08-13 |
Not clear |
| Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E Ehrlich, Philip L De Jager, David A Bennett, Eric E Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M Iijim. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome medicine. vol 10. issue 1. 2018-11-06. PMID:29598827. |
integrated biology approach reveals molecular and pathological interactions among alzheimer's aβ42, tau, trem2, and tyrobp in drosophila models. |
2018-11-06 |
2023-08-13 |
drosophila_melanogaster |
| Shu-Hui Xin, Lin Tan, Xipeng Cao, Jin-Tai Yu, Lan Ta. Clearance of Amyloid Beta and Tau in Alzheimer's Disease: from Mechanisms to Therapy. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29626319. |
clearance of amyloid beta and tau in alzheimer's disease: from mechanisms to therapy. |
2018-11-06 |
2023-08-13 |
Not clear |
| Heike J Wobst, Franziska Denk, Peter L Oliver, Achilleas Livieratos, Tonya N Taylor, Maria H Knudsen, Nora Bengoa-Vergniory, David Bannerman, Richard Wade-Martin. Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific reports. vol 7. 2018-11-05. PMID:28233851. |
the microtubule-associated protein tau is implicated in various neurodegenerative diseases including alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. |
2018-11-05 |
2023-08-13 |
mouse |
| Yang Jiang, Bing Xu, Jing Chen, Yi Sui, Li Ren, Jing Li, Huiyu Zhang, Liqing Guo, Xiaohong Su. Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30102687. |
micro-rna-137 inhibits tau hyperphosphorylation in alzheimer's disease and targets the cacna1c gene in transgenic mice and human neuroblastoma sh-sy5y cells. |
2018-11-05 |
2023-08-13 |
mouse |
| Joseph C Masde. Tau and Cortical Thickness in Alzheimer Disease. JAMA neurology. vol 74. issue 4. 2018-10-30. PMID:28241165. |
tau and cortical thickness in alzheimer disease. |
2018-10-30 |
2023-08-13 |
Not clear |
| Nour K Majbour, Davide Chiasserini, Nishant N Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma van de Berg, Lucilla Parnetti, Paolo Calabresi, Omar M A El-Agna. Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease. Scientific reports. vol 7. 2018-10-29. PMID:28071698. |
several studies reported an association between csf alpha-synuclein (α-syn) and tau in alzheimer's disease (ad), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical ad csf biomarkers. |
2018-10-29 |
2023-08-13 |
Not clear |
| Ankita Pathak, Ankit Rohilla, Tanya Gupta, Md Jawaid Akhtar, Md Rafi Haider, Kalicharan Sharma, Kashif Haider, M Shahar Ya. DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspective. European journal of medicinal chemistry. vol 158. 2018-10-29. PMID:30243157. |
modern research had proposed that the over expression of dyrk1a (dual specificity tyrosine phosphorylation regulated kinase1a, a family of protein kinases, positioned within the down's syndrome critical region (dscr) on human chromosome 21causes phosphorylation of app protein resulting in its cleavage to aβ 40, 42 and tau proteins (regulated by beta and gamma secretase) which plays critical role in early onset of alzheimer's disease (ad) detected in down's syndrome (ds), leading to permanent functional and structural deformities which results ultimately into neuro-degeneration and neuronal death. |
2018-10-29 |
2023-08-13 |
human |
| Rik Ossenkoppele, Gil D Rabinovici, Ruben Smith, Hanna Cho, Michael Schöll, Olof Strandberg, Sebastian Palmqvist, Niklas Mattsson, Shorena Janelidze, Alexander Santillo, Tomas Ohlsson, Jonas Jögi, Richard Tsai, Renaud La Joie, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, Jae Y Choi, Young H Ryu, Chul H Lyoo, Oskar Hansso. Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA. vol 320. issue 11. 2018-10-29. PMID:30326496. |
the positron emission tomography (pet) tracer [18f]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of alzheimer disease (ad), but its diagnostic utility is unclear. |
2018-10-29 |
2023-08-13 |
Not clear |