| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A R Kudinov, N V Kudinova, E V Kezlia, K M Kozyrev, A E Medvedev, T T Berezo. [Compensatory mechanisms to heal neuroplasticity impairment under Alzheiemer's disease neurodegeneration. I: The role of amyloid beta and its' precursor protein]. Biomeditsinskaia khimiia. vol 58. issue 4. 2013-03-14. PMID:23413683. |
under such scenario therapeutic block of aggregation and plaque formation of abeta and inhibition of tau phosphorylation, as well as pharmaceutical modification of other secondary neurodegenerative features (such as a cascade of oxidative stress reactions) are unable to provide an effective cure of alzheimer's disease and related pathologies of the central and peripheral nervous systems, because they are not arraying primary pathagenetic cause. |
2013-03-14 |
2023-08-12 |
Not clear |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Marcos J Guerrero-Munoz, Takaki Kiritoshi, Volker Neugebauer, George R Jackson, Rakez Kaye. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Scientific reports. vol 2. 2013-03-05. PMID:23050084. |
alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. |
2013-03-05 |
2023-08-12 |
mouse |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Marcos J Guerrero-Munoz, Takaki Kiritoshi, Volker Neugebauer, George R Jackson, Rakez Kaye. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Scientific reports. vol 2. 2013-03-05. PMID:23050084. |
we extracted pure populations of tau oligomers directly from the cerebral cortex of alzheimer disease (ad) brain. |
2013-03-05 |
2023-08-12 |
mouse |
| Shana Elbaum-Garfinkle, Elizabeth Rhoade. Identification of an aggregation-prone structure of tau. Journal of the American Chemical Society. vol 134. issue 40. 2013-03-01. PMID:22998648. |
for proteins such as tau in alzheimer's disease and α-synuclein in parkinson's disease, aggregation involves a transition from an intrinsically disordered monomer to a highly structured fiber. |
2013-03-01 |
2023-08-12 |
Not clear |
| Yan Chen, Cui Wang, Meili Hu, Jian Pan, Jianhua Chen, Peilu Duan, Tianlong Zhai, Jingna Ding, Cunji X. Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells. Planta medica. vol 78. issue 12. 2013-02-28. PMID:22700047. |
alzheimer's disease is the most common form of dementia leading to the irreversible loss of neurons, and tau hyperphosphorylation has an important role in the pathology of alzheimer's disease. |
2013-02-28 |
2023-08-12 |
Not clear |
| Julie A Harris, Akihiko Koyama, Sumihiro Maeda, Kaitlyn Ho, Nino Devidze, Dena B Dubal, Gui-Qiu Yu, Eliezer Masliah, Lennart Muck. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PloS one. vol 7. issue 9. 2013-02-28. PMID:23029293. |
accumulation of hyperphosphorylated tau in the entorhinal cortex (ec) is one of the earliest pathological hallmarks in patients with alzheimer's disease (ad). |
2013-02-28 |
2023-08-12 |
mouse |
| Weihua Wang, Liangfeng Fan, De'en Xu, Zhongmin Wen, Rong Yu, Quanhong M. Immunotherapy for Alzheimer's disease. Acta biochimica et biophysica Sinica. vol 44. issue 10. 2013-02-27. PMID:22899646. |
alzheimer's disease (ad) is characterized by β-amyloid (aβ) plaques consisted primarily of aggregated aβ proteins and neurofibrillary tangles formed by hyperphosphorylated tau protein. |
2013-02-27 |
2023-08-12 |
Not clear |
| Balu Chakravarthy, Chantal Gaudet, Michel Ménard, Leslie Brown, Trevor Atkinson, Frank M Laferla, Shingo Ito, Ubaldo Armato, Ilaria Dal Prà, James Whitfiel. Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aβ(1-42) and tau. Biochemical and biophysical research communications. vol 427. issue 1. 2013-02-27. PMID:22995307. |
we have found that in 6-24-months-old triple transgenic alzheimer's disease model mice (3xtg-ad) producing both aβ(1-42) and the mutant human tau protein tau(p301l,) the dentate granule cells still had immunostainable sstr3- and p75(ntr)-bearing cilia but they were only half the length of the immunostained cilia in the corresponding wild-type mice. |
2013-02-27 |
2023-08-12 |
mouse |
| David J Irwin, John Q Trojanowski, Murray Grossma. Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease. Frontiers in aging neuroscience. vol 5. 2013-02-27. PMID:23440936. |
several neurodegenerative disease-associated proteins, including the major protein constituents of inclusions in alzheimer's disease (ad) associated with amyloid-beta (aβ(1-42)) plaque and tau neurofibrillary tangle pathology, can be measured in cerebrospinal fluid (csf) for diagnostic applications. |
2013-02-27 |
2023-08-12 |
Not clear |
| Alexander Boländer, Daniel Kieser, Constantin Voss, Silvia Bauer, Christian Schön, Steffen Burgold, Tobias Bittner, Jana Hölzer, Roland Heyny-von Haußen, Gerhard Mall, Valérie Goetschy, Christian Czech, Henner Knust, Robert Berger, Jochen Herms, Ingrid Hilger, Boris Schmid. Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models. Journal of medicinal chemistry. vol 55. issue 21. 2013-02-26. PMID:22913544. |
bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in alzheimer's disease models. |
2013-02-26 |
2023-08-12 |
mouse |
| Matthew Furgerson, Marcus Fechheimer, Ruth Furukaw. Model Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028730. |
the main pathological hallmarks of alzheimer's disease are amyloid-beta plaques and neurofibrillary tangles, which are primarily composed of amyloid precursor protein (app) and tau, respectively. |
2013-02-26 |
2023-08-12 |
Not clear |
| Katharina Flach, Isabel Hilbrich, Andrea Schiffmann, Ulrich Gärtner, Martin Krüger, Marion Leonhardt, Hanka Waschipky, Lukas Wick, Thomas Arendt, Max Holze. Tau oligomers impair artificial membrane integrity and cellular viability. The Journal of biological chemistry. vol 287. issue 52. 2013-02-26. PMID:23129775. |
in alzheimer disease and other tauopathies, tau protein has a reduced affinity toward microtubules. |
2013-02-26 |
2023-08-12 |
Not clear |
| Bradford T Winslow, Mary K Onysko, Christian M Stob, Kathleen A Hazlewoo. Treatment of Alzheimer disease. American family physician. vol 83. issue 12. 2013-02-22. PMID:21671540. |
amyloid plaque accumulation, neurofibrillary tau tangles, and depletion of acetylcholine are among the pathologic manifestations of alzheimer disease. |
2013-02-22 |
2023-08-12 |
Not clear |
| J Attems, A Thomas, K Jellinge. Correlations between cortical and subcortical tau pathology. Neuropathology and applied neurobiology. vol 38. issue 6. 2013-02-22. PMID:22115520. |
recent studies indicate that tau pathology in alzheimer's disease (ad) does not initially manifest in the cerebral cortex but in selected subcortical nuclei, in particular the locus ceruleus (lc). |
2013-02-22 |
2023-08-12 |
Not clear |
| Yi Hong, Chi Bun Chan, Il-Sun Kwon, Xuekun Li, Mingke Song, Hyun-Pil Lee, Xia Liu, Pradoldej Sompol, Peng Jin, Hyoung-gon Lee, Shan Ping Yu, Keqiang Y. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197718. |
srpk2 phosphorylates tau and mediates the cognitive defects in alzheimer's disease. |
2013-02-19 |
2023-08-12 |
mouse |
| Meredith A Chabrier, Mathew Blurton-Jones, Andranik A Agazaryan, Joy L Nerhus, Hilda Martinez-Coria, Frank M LaFerl. Soluble aβ promotes wild-type tau pathology in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197725. |
growing evidence suggests that soluble aβ species can drive alzheimer disease (ad) pathogenesis by inducing a cascade of events including tau hyperphosphorylation, proteasome impairment, and synaptic dysfunction. |
2013-02-19 |
2023-08-12 |
mouse |
| Masahiro Nakamori, Tetsuya Takahashi, Yuu Yamazaki, Takashi Kurashige, Takemori Yamawaki, Masayasu Matsumot. Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration. Neuroreport. vol 23. issue 15. 2013-02-12. PMID:22968343. |
moreover, cdk5-positive granulovacuolar degeneration and phosphorylated tau colocalized in pyramidal neurons in alzheimer's disease and myd cases. |
2013-02-12 |
2023-08-12 |
Not clear |
| Yue Huagn, Yu-ming Xu, Jie-wen Zhang, Xiu-hua Ren, Ai-qin Su. [Effects of estrogen on P-Tau, ChAT and nerve growth factor protein expressions in the brain tissue of rats with Alzheimer's disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 10. 2013-02-11. PMID:20965859. |
to examine the effect of estrogen on the expressions of phosphorylated tau (p-tau), chat and nerve growth factor (ngf) protein in the brain tissue of rat models of alzheimer disease (ad). |
2013-02-11 |
2023-08-12 |
rat |
| Kaj Blennow, John Hardy, Henrik Zetterber. The neuropathology and neurobiology of traumatic brain injury. Neuron. vol 76. issue 5. 2013-02-11. PMID:23217738. |
we also consider how the neuropathology and neurobiology of cte in many ways resembles other neurodegenerative illnesses such as alzheimer's disease, particularly with respect to mismetabolism and aggregation of tau, β-amyloid, and tdp-43. |
2013-02-11 |
2023-08-12 |
Not clear |
| Hwan-Ching Tai, Alberto Serrano-Pozo, Tadafumi Hashimoto, Matthew P Frosch, Tara L Spires-Jones, Bradley T Hyma. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22867711. |
the synaptic accumulation of hyperphosphorylated tau oligomers in alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. |
2013-02-06 |
2023-08-12 |
human |