| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emma R L C Vardy, Katherine A B Kellett, Sarah L Cocklin, Nigel M Hoope. Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease. Neuro-degenerative diseases. vol 9. issue 1. 2012-03-20. PMID:22024719. |
tissue non-specific alkaline phosphatase (tnap) has been shown to promote the neurotoxicity of extracellular tau which contributes to the spread of pathology in alzheimer's disease (ad). |
2012-03-20 |
2023-08-12 |
Not clear |
| Kellen Voss, Benjamin Combs, Kristina R Patterson, Lester I Binder, T Chris Gambli. Hsp70 alters tau function and aggregation in an isoform specific manner. Biochemistry. vol 51. issue 4. 2012-03-20. PMID:22236337. |
tau exists as six alternatively spliced isoforms, and all six isoforms appear capable of forming the pathological aggregates seen in alzheimer's disease. |
2012-03-20 |
2023-08-12 |
Not clear |
| Tara L Spires-Jones, Katherine J Kopeikina, Robert M Koffie, Alix de Calignon, Bradley T Hyma. Are tangles as toxic as they look? Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21638071. |
neurofibrillary tangles are intracellular accumulations of hyperphosphorylated and misfolded tau protein characteristic of alzheimer's disease and other tauopathies. |
2012-03-19 |
2023-08-12 |
mouse |
| Jiaping Gu, Einar M Sigurdsso. Immunotherapy for tauopathies. Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21739165. |
pathological tau protein is found in alzheimer's disease and related tauopathies. |
2012-03-19 |
2023-08-12 |
mouse |
| Xi Li, Ying Liu, Hai-Feng Yuan, Qian-Kun Qua. [Effects of gensenoside Rg1 on tau protein phosphorylation induced by okadaic acid in rat brain slices]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 8. issue 10. 2012-03-07. PMID:20939986. |
to investigate the effects of gensenoside rg1 on expressions of phosphorylated tau protein (p-tau), protein phosphatase 2a (pp2a) and tau protein in alzheimer's disease-like tau phosphorylation rat brain slices, and to explore the mechanisms of gensenoside rg1 in inhibiting tau phosphorylation. |
2012-03-07 |
2023-08-12 |
rat |
| Eliana Venturelli, Chiara Villa, Chiara Fenoglio, Francesca Clerici, Alessandra Marcone, Luisa Benussi, Roberta Ghidoni, Salvatore Gallone, Francesca Cortini, Maria Serpente, Claudia Cantoni, Giorgio Fumagalli, Elisa Ridolfi, Stefano Cappa, Giuliano Binetti, Massimo Franceschi, Innocenzo Rainero, Maria Teresa Giordana, Claudio Mariani, Nereo Bresolin, Elio Scarpini, Daniela Galimbert. BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 23. issue 4. 2012-03-06. PMID:21157029. |
a significant increase of the bag-1m isoform was found in alzheimer's disease (ad) brains, and the protein co-localized with tau and amyloid. |
2012-03-06 |
2023-08-12 |
Not clear |
| Wei Qian, Xiaomin Yin, Wen Hu, Jianhua Shi, Jianlan Gu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 23. issue 4. 2012-03-06. PMID:21157033. |
activation of protein phosphatase 2b and hyperphosphorylation of tau in alzheimer's disease. |
2012-03-06 |
2023-08-12 |
human |
| Evelin L Schaeffer, Micheli Figueiro, Wagner F Gatta. Insights into Alzheimer disease pathogenesis from studies in transgenic animal models. Clinics (Sao Paulo, Brazil). vol 66 Suppl 1. 2012-03-05. PMID:21779722. |
the neuropathological hallmarks of alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles (containing hyperphosphorylated tau protein), along with neuronal loss. |
2012-03-05 |
2023-08-12 |
mouse |
| Evelin L Schaeffer, Micheli Figueiro, Wagner F Gatta. Insights into Alzheimer disease pathogenesis from studies in transgenic animal models. Clinics (Sao Paulo, Brazil). vol 66 Suppl 1. 2012-03-05. PMID:21779722. |
in summary, the alzheimer disease mouse models have been the key to understanding the roles of soluble b-amyloid oligomers in disease pathogenesis, as well as of the relationship between p-amyloid and tau pathologies. |
2012-03-05 |
2023-08-12 |
mouse |
| C J Garwood, A M Pooler, J Atherton, D P Hanger, W Nobl. Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell death & disease. vol 2. 2012-03-01. PMID:21633390. |
alzheimer's disease (ad) is pathologically characterised by the age-dependent deposition of β-amyloid (aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. |
2012-03-01 |
2023-08-12 |
rat |
| Lucilla Parnetti, Davide Chiasserini, Gianni Bellomo, David Giannandrea, Claudia De Carlo, Mohamed M Qureshi, Mustafa T Ardah, Shiji Varghese, Laura Bonanni, Barbara Borroni, Nicola Tambasco, Paolo Eusebi, Aroldo Rossi, Marco Onofrj, Alessandro Padovani, Paolo Calabresi, Omar El-Agna. Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 8. 2012-02-29. PMID:21469206. |
we evaluated whether the combination of classical biomarkers, aβ(1-42) , total tau, phosphorylated tau, and α-synuclein can improve discrimination of parkinson's disease, dementia with lewy bodies, alzheimer's disease, and frontotemporal dementia. |
2012-02-29 |
2023-08-12 |
human |
| Lucilla Parnetti, Davide Chiasserini, Gianni Bellomo, David Giannandrea, Claudia De Carlo, Mohamed M Qureshi, Mustafa T Ardah, Shiji Varghese, Laura Bonanni, Barbara Borroni, Nicola Tambasco, Paolo Eusebi, Aroldo Rossi, Marco Onofrj, Alessandro Padovani, Paolo Calabresi, Omar El-Agna. Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 8. 2012-02-29. PMID:21469206. |
aβ(1-42) , total tau, phosphorylated tau, and α-synuclein were measured in a series of patients with parkinson's disease (n = 38), dementia with lewy bodies (n = 32), alzheimer's disease (n = 48), frontotemporal dementia (n = 31), and age-matched control patients with other neurological diseases (n = 32). |
2012-02-29 |
2023-08-12 |
human |
| Alberto Cornejo, José M Jiménez, Leonardo Caballero, Francisco Melo, Ricardo B Maccion. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 1. 2012-02-27. PMID:21785188. |
fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with alzheimer's disease. |
2012-02-27 |
2023-08-12 |
Not clear |
| Alberto Cornejo, José M Jiménez, Leonardo Caballero, Francisco Melo, Ricardo B Maccion. Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 1. 2012-02-27. PMID:21785188. |
alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau protein. |
2012-02-27 |
2023-08-12 |
Not clear |
| Peder Buchhave, Lennart Minthon, Henrik Zetterberg, Asa K Wallin, Kaj Blennow, Oskar Hansso. Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Archives of general psychiatry. vol 69. issue 1. 2012-02-22. PMID:22213792. |
cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of alzheimer dementia. |
2012-02-22 |
2023-08-12 |
Not clear |
| Xiaoyu Li, Yatender Kumar, Hans Zempel, Eva-Maria Mandelkow, Jacek Biernat, Eckhard Mandelko. Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. The EMBO journal. vol 30. issue 23. 2012-02-21. PMID:22009197. |
missorting of tau from axons to the somatodendritic compartment of neurons is a hallmark of alzheimer's disease, but the mechanisms underlying normal sorting and pathological failure are poorly understood. |
2012-02-21 |
2023-08-12 |
Not clear |
| James B Reinecke, Sarah L DeVos, James P McGrath, Amanda M Shepard, Dustin K Goncharoff, Don N Tait, Samantha R Fleming, Michael P Vincent, Michelle L Steinhil. Implicating calpain in tau-mediated toxicity in vivo. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858230. |
alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. |
2012-02-15 |
2023-08-12 |
human |
| Duygu Tosun, Norbert Schuff, Leslie M Shaw, John Q Trojanowski, Michael W Weine. Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data. Journal of Alzheimer's disease : JAD. vol 26 Suppl 3. 2012-02-09. PMID:21971452. |
previously it was reported that alzheimer's disease (ad) patients have reduced amyloid (aβ 1-42) and elevated total tau (t-tau) and phosphorylated tau (p-tau 181p) in the cerebro-spinal fluid (csf), suggesting that these same measures could be used to detect early ad pathology in healthy elderly (cn) and mild cognitive impairment (mci). |
2012-02-09 |
2023-08-12 |
Not clear |
| Abdenour Belkacemi, Sihem Doggui, Lé Dao, Charles Ramassam. Challenges associated with curcumin therapy in Alzheimer disease. Expert reviews in molecular medicine. vol 13. 2012-02-09. PMID:22051121. |
in vitro and in vivo studies have demonstrated that curcumin could target pathways involved in the pathophysiology of alzheimer disease (ad), such as the β-amyloid cascade, tau phosphorylation, neuroinflammation or oxidative stress. |
2012-02-09 |
2023-08-12 |
Not clear |
| Kristina R Patterson, Sarah M Ward, Benjamin Combs, Kellen Voss, Nicholas M Kanaan, Gerardo Morfini, Scott T Brady, T Chris Gamblin, Lester I Binde. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. vol 50. issue 47. 2012-02-07. PMID:22039833. |
aggregation and accumulation of the microtubule-associated protein tau are associated with cognitive decline and neuronal degeneration in alzheimer's disease and other tauopathies. |
2012-02-07 |
2023-08-12 |
Not clear |