| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine J Kopeikina, George A Carlson, Rose Pitstick, Adam E Ludvigson, Alan Peters, Jennifer I Luebke, Robert M Koffie, Matthew P Frosch, Bradley T Hyman, Tara L Spires-Jone. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. The American journal of pathology. vol 179. issue 4. 2012-01-23. PMID:21854751. |
neurofibrillary tangles (nft), intracellular inclusions of abnormal fibrillar forms of microtubule associated protein tau, accumulate in alzheimer's disease (ad) and other tauopathies and are believed to cause neuronal dysfunction, but the mechanism of tau-mediated toxicity are uncertain. |
2012-01-23 |
2023-08-12 |
mouse |
| Stefan Bibow, Valéry Ozenne, Jacek Biernat, Martin Blackledge, Eckhard Mandelkow, Markus Zweckstette. Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society. vol 133. issue 40. 2012-01-23. PMID:21910444. |
the intrinsically disordered protein tau becomes excessively phosphorylated and aggregates into neurofibrillary tangles in alzheimer's disease. |
2012-01-23 |
2023-08-12 |
Not clear |
| Stefan Bibow, Valéry Ozenne, Jacek Biernat, Martin Blackledge, Eckhard Mandelkow, Markus Zweckstette. Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society. vol 133. issue 40. 2012-01-23. PMID:21910444. |
to obtain insight into the structural consequences of phosphorylation, we characterized a mutant protein of tau in which epitopes recognized by alzheimer diagnostic antibodies were mimicked by mutation to glutamic acid [at8 (s199e, s202e, t205e), at100 (t212e and s214e), and phf1 (s396e and s404e)]. |
2012-01-23 |
2023-08-12 |
Not clear |
| Fumitaka Kawakami, Minori Suzuki, Naoki Shimada, Go Kagiya, Etsuro Ohta, Kei Tamura, Hiroko Maruyama, Takafumi Ichikaw. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. The FEBS journal. vol 278. issue 24. 2012-01-23. PMID:21985244. |
hyperphosphorylation of tau protein (tau) causes neurodegenerative diseases such as alzheimer's disease (ad). |
2012-01-23 |
2023-08-12 |
mouse |
| Ragnhild Eide Skogseth, Tormod Fladby, Ezra Mulugeta, Dag Aarslan. [Biomarkers in spinal fluid of patients with dementia]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 131. issue 22. 2012-01-23. PMID:22085948. |
we wanted to assess whether biomarkers abeta42, tau and p-tau could differentiate between alzheimer's disease and other dementia illnesses. |
2012-01-23 |
2023-08-12 |
Not clear |
| Yasmina Talmat-Amar, Yoan Arribat, Christelle Redt-Clouet, Sébastien Feuillette, Anne-Laure Bougé, Magalie Lecourtois, Marie-Laure Parmentie. Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila. Human molecular genetics. vol 20. issue 19. 2012-01-20. PMID:21705366. |
the microtubule-associated protein tau is found in large amount in axons of neurons and is involved in human neurodegenerative diseases called tauopathies, which include alzheimer's disease. |
2012-01-20 |
2023-08-12 |
human |
| Ludovic Martin, Amandine Magnaudeix, Cornelia M Wilson, Catherine Yardin, Faraj Terr. The new indirubin derivative inhibitors of glycogen synthase kinase-3, 6-BIDECO and 6-BIMYEO, prevent tau phosphorylation and apoptosis induced by the inhibition of protein phosphatase-2A by okadaic acid in cultured neurons. Journal of neuroscience research. vol 89. issue 11. 2012-01-20. PMID:21826701. |
alterations in glycogen synthase kinase-3β (gsk3β) and protein phosphatase-2a (pp2a) have been proposed to be involved in the abnormal tau phosphorylation and aggregation linked to alzheimer's disease (ad). |
2012-01-20 |
2023-08-12 |
Not clear |
| Anna Nogalska, Carla D'Agostino, W King Engel, Valerie Askana. Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers. Neuroscience letters. vol 503. issue 3. 2012-01-20. PMID:21896314. |
its muscle fiber molecular phenotype has close similarities to alzheimer disease (ad) brain, including intra-muscle-fiber accumulations of (a) aβ42 and its oligomers, and (b) large, squiggly or linear, clusters of paired-helical filaments (phfs) that are immunoreactive with various antibodies directed against several epitopes of phosphorylated tau (p-tau), and thereby strongly resembling neurofibrillary tangles of ad brain. |
2012-01-20 |
2023-08-12 |
Not clear |
| N Zilka, M Zilkova, Z Kazmerova, M Sarissky, V Cigankova, M Nova. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience. vol 193. 2012-01-18. PMID:21763758. |
mesenchymal stem cells rescue the alzheimer's disease cell model from cell death induced by misfolded truncated tau. |
2012-01-18 |
2023-08-12 |
human |
| N Zilka, M Zilkova, Z Kazmerova, M Sarissky, V Cigankova, M Nova. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience. vol 193. 2012-01-18. PMID:21763758. |
we have developed a stably transfected human cell model for alzheimer's disease with doxycycline-inducible expression of human misfolded truncated tau protein (at tau). |
2012-01-18 |
2023-08-12 |
human |
| N Zilka, M Zilkova, Z Kazmerova, M Sarissky, V Cigankova, M Nova. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience. vol 193. 2012-01-18. PMID:21763758. |
our results showed that mesenchymal stem cells and their secretome are able to rescue the alzheimer's disease cell model from cell death induced by misfolded truncated tau. |
2012-01-18 |
2023-08-12 |
human |
| Maria Chiara Monti, Luigi Margarucci, Alessandra Tosco, Raffaele Riccio, Agostino Casapull. New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component. Food & function. vol 2. issue 7. 2012-01-18. PMID:21894330. |
in particular, olc has been shown to abrogate fibrillization of tau protein, one of the main causes of alzheimer neurodegeneration. |
2012-01-18 |
2023-08-12 |
human |
| Yang Hui, Dayong Wang, Wenjing Li, Lina Zhang, Jianfeng Jin, Ning Ma, Lingyun Zhou, Osamu Nakajima, Weiming Zhao, Xu Ga. Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation. Journal of Alzheimer's disease : JAD. vol 26. issue 2. 2012-01-17. PMID:21613741. |
intracellular tau aggregates composed of neurofibrillary tangles (nfts) are a defining feature of alzheimer's disease (ad). |
2012-01-17 |
2023-08-12 |
mouse |
| Cristina Ploia, Xanthi Antoniou, Alessandra Sclip, Valentina Grande, Daniele Cardinetti, Alessio Colombo, Nadia Canu, Luisa Benussi, Roberta Ghidoni, Gianluigi Forloni, Tiziana Borsell. JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. Journal of Alzheimer's disease : JAD. vol 26. issue 2. 2012-01-17. PMID:21628793. |
jnk plays a key role in tau hyperphosphorylation in alzheimer's disease models. |
2012-01-17 |
2023-08-12 |
mouse |
| Thimmappa S Anekonda, Joseph F Quin. Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine. Biochimica et biophysica acta. vol 1812. issue 12. 2012-01-17. PMID:21925266. |
this review highlights the importance of ca(v)1.2 channel overexpression, the accumulation of hyperphosphorylated tau and suppression of autophagy in alzheimer's disease and modulation of this pathway by isradipine. |
2012-01-17 |
2023-08-12 |
Not clear |
| Petr Novak, Michal Prcina, Eva Kontsekov. Tauons and prions: infamous cousins? Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21694453. |
the paradigm of alzheimer's disease (ad) is one subject to frequent change: what was thought to be a rare form of pre-senile dementia was revealed as a wide-spread malady; where amyloid-β was deemed the sole causative agent for the better part of 20 years, tau protein was shown to play a crucial role in ad genesis. |
2012-01-11 |
2023-08-12 |
human |
| D Richard Lachno, Martin J Romeo, Eric R Siemers, Hugo Vanderstichele, Els Coart, Robert J Konrad, Joseph J Zajac, Jayne A Talbot, Hans F Jensen, Gopalan Sethuraman, Ronald B Demattos, Patrick C May, Robert A Dea. Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21694458. |
validation of elisa methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two alzheimer's disease studies. |
2012-01-11 |
2023-08-12 |
human |
| D Richard Lachno, Martin J Romeo, Eric R Siemers, Hugo Vanderstichele, Els Coart, Robert J Konrad, Joseph J Zajac, Jayne A Talbot, Hans F Jensen, Gopalan Sethuraman, Ronald B Demattos, Patrick C May, Robert A Dea. Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21694458. |
tau measurements in cerebrospinal fluid (csf) are gaining acceptance as aids to diagnosis of alzheimer's disease (ad) and differentiation from other dementias. |
2012-01-11 |
2023-08-12 |
human |
| Arne Ittner, Yazi D Ke, Janet van Eersel, Amadeus Gladbach, Jürgen Götz, Lars M Ittne. Brief update on different roles of tau in neurodegeneration. IUBMB life. vol 63. issue 7. 2012-01-11. PMID:21698753. |
both alzheimer's disease (ad) and almost every second case of frontotemporal lobar degeneration (ftld) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. |
2012-01-11 |
2023-08-12 |
Not clear |
| Audrey Gabelle, Stéphane Roche, Christian Gény, Karim Bennys, Pierre Labauge, Yannick Tholance, Isabelle Quadrio, Laurent Tiers, Baptiste Gor, Justine Boulanghien, Chloé Chaulet, Alain Vighetto, Bernard Croisile, Pierre Krolak-Salmon, Armand Perret-Liaudet, Jacques Touchon, Sylvain Lehman. Decreased sAβPPβ, Aβ38, and Aβ40 cerebrospinal fluid levels in frontotemporal dementia. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21709372. |
to improve the etiological diagnosis of neurodegenerative dementias like alzheimer's disease (ad) or frontotemporal dementia (ftd), we evaluated the value of individual and combined measurements of the following relevant cerebrospinal fluid (csf) biomarkers: tau, 181p-tau, aβ38, aβ40, aβ42, saβppα, and saβppβ. |
2012-01-11 |
2023-08-12 |
human |