| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janet van Eersel, Mian Bi, Yazi D Ke, John R Hodges, John H Xuereb, Gillian C Gregory, Glenda M Halliday, Jürgen Götz, Jillian J Kril, Lars M Ittne. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 10. 2010-01-14. PMID:19693433. |
although alzheimer's disease (ad) is also characterised by tau lesions, these are both histologically and biochemically distinct from the tau aggregates found in pid. |
2010-01-14 |
2023-08-12 |
Not clear |
| Virginie Rhein, Xiaomin Song, Andreas Wiesner, Lars M Ittner, Ginette Baysang, Fides Meier, Laurence Ozmen, Horst Bluethmann, Stefan Dröse, Ulrich Brandt, Egemen Savaskan, Christian Czech, Jürgen Götz, Anne Ecker. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 47. 2010-01-14. PMID:19897719. |
amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic alzheimer's disease mice. |
2010-01-14 |
2023-08-12 |
mouse |
| Jin-Tai Yu, Raymond Chuen-Chung Chang, Lan Ta. Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities. Progress in neurobiology. vol 89. issue 3. 2010-01-12. PMID:19664678. |
though disturbances in calcium homeostasis in cells from alzheimer's disease (ad) patients have been observed for many years, much more attention was focused on amyloid-beta (abeta) and tau as key causative factors for the disease. |
2010-01-12 |
2023-08-12 |
Not clear |
| Nichole E Lapointe, Peleg M Horowitz, Angela L Guillozet-Bongaarts, Andres Silva, Athena Andreadis, Lester I Binde. Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. Biochemistry. vol 48. issue 51. 2010-01-12. PMID:19919107. |
alzheimer's disease and other tauopathies are characterized by the intracellular accumulation of insoluble filaments of the microtubule-associated protein tau. |
2010-01-12 |
2023-08-12 |
Not clear |
| Ying-Hua Liu, Wei Wei, Jun Yin, Gong-Ping Liu, Qun Wang, Fu-Yuan Cao, Jian-Zhi Wan. Proteasome inhibition increases tau accumulation independent of phosphorylation. Neurobiology of aging. vol 30. issue 12. 2010-01-11. PMID:18403053. |
an intrinsic link between proteasome and tau degradation in alzheimer's disease (ad) has been suggested, however, the role of proteasome in the proteolysis of tau is still uncertain. |
2010-01-11 |
2023-08-12 |
rat |
| Michael A Mastrangelo, Kelly L Sudol, Wade C Narrow, William J Bower. Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19808651. |
using the triple-transgenic mouse model of alzheimer's disease (3xtg-ad), which develops amyloid and tau pathologies in a pattern reminiscent of human alzheimer's disease, we initiated chronic intrahippocampal expression of ifngamma through delivery of a serotype-1 recombinant adeno-associated virus vector (raav1-ifngamma). |
2010-01-11 |
2023-08-12 |
mouse |
| Yanqiu Deng, Bin Li, Ying Liu, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gon. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19815707. |
dysregulation of insulin signaling, glucose transporters, o-glcnacylation, and phosphorylation of tau and neurofilaments in the brain: implication for alzheimer's disease. |
2010-01-11 |
2023-08-12 |
rat |
| Adria Neely, Candice Perry, Birsen Varisli, Anant K Singh, Tahir Arbneshi, Dulal Senapati, Jhansi Rani Kalluri, Paresh Chandra Ra. Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle. ACS nano. vol 3. issue 9. 2009-12-30. PMID:19691350. |
driven by the need, here we demonstrate for the first time that monoclonal anti-tau antibody-coated gold nanoparticle based two-photon scattering assay can be used for the detection of alzheimer's tau protein in the 1 pg/ml level which is about 2 orders of magnitude lower than cutoff values (195 pg/ml) for tau protein in csf (cerebrospinal fluid). |
2009-12-30 |
2023-08-12 |
Not clear |
| Yumiko Uno, Hiroki Iwashita, Tetsuya Tsukamoto, Noriko Uchiyama, Tomohiro Kawamoto, Masakuni Kori, Atsushi Nakanish. Efficacy of a novel, orally active GSK-3 inhibitor 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide in tau transgenic mice. Brain research. vol 1296. 2009-12-29. PMID:19698704. |
neurofibrillary tangles (nfts) composed of hyperphosphorylated and aggregated tau are common pathological characteristics in alzheimer's disease (ad) and other tauopathies. |
2009-12-29 |
2023-08-12 |
mouse |
| Robert A Rissma. Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19584431. |
abnormally phosphorylated tau protein is a key component of the pathology seen in neurodegenerative tauopathies, such as alzheimer's disease (ad). |
2009-12-17 |
2023-08-12 |
Not clear |
| Mengqi Chen, Ralph N Martins, Michael Lardell. Complex splicing and neural expression of duplicated tau genes in zebrafish embryos. Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19584432. |
microtubule-associated protein tau (mapt) is the major component of the neurofibrillary tangles found in the brains of those suffering from alzheimer's disease. |
2009-12-17 |
2023-08-12 |
zebrafish |
| Parekkat M Menon, Jean Paul Vonsattel, Paul R Jolle. Brain imaging and neuropathologic mechanisms in Alzheimer's disease: vascular versus neurodegenerative and amyloid-beta versus tau. Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19625742. |
brain imaging and neuropathologic mechanisms in alzheimer's disease: vascular versus neurodegenerative and amyloid-beta versus tau. |
2009-12-17 |
2023-08-12 |
Not clear |
| Alexei Koudinov, Elena Kezlya, Natalia Koudinova, Temirbolat Berezo. Amyloid-beta, tau protein, and oxidative changes as a physiological compensatory mechanism to maintain CNS plasticity under Alzheimer's disease and other neurodegenerative conditions. Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19749430. |
amyloid-beta, tau protein, and oxidative changes as a physiological compensatory mechanism to maintain cns plasticity under alzheimer's disease and other neurodegenerative conditions. |
2009-12-17 |
2023-08-12 |
Not clear |
| Alexei Koudinov, Elena Kezlya, Natalia Koudinova, Temirbolat Berezo. Amyloid-beta, tau protein, and oxidative changes as a physiological compensatory mechanism to maintain CNS plasticity under Alzheimer's disease and other neurodegenerative conditions. Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19749430. |
in this review, we propose that the neurodegenerative changes in the neurochemistry of amyloid-beta (abeta) aggregation, tau phosphorylation, cytoskeleton rearrangement, oxidative stress, and lipid peroxidation in alzheimer's disease (ad), and a number of other neurodegenerative diseases, are secondary pathological features. |
2009-12-17 |
2023-08-12 |
Not clear |
| Elena Tortosa, Ismael Santa-Maria, Francisco Moreno, Filip Lim, Mar Perez, Jesús Avil. Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363271. |
tau pathology, associated with alzheimer's disease, is characterized by the presence of phosphorylated and aggregated tau. |
2009-12-16 |
2023-08-12 |
Not clear |
| Dylan W Peterson, Roshni C George, Francesca Scaramozzino, Nichole E LaPointe, Richard A Anderson, Donald J Graves, John Le. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19433898. |
cinnamon extract inhibits tau aggregation associated with alzheimer's disease in vitro. |
2009-12-15 |
2023-08-12 |
Not clear |
| Dylan W Peterson, Roshni C George, Francesca Scaramozzino, Nichole E LaPointe, Richard A Anderson, Donald J Graves, John Le. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19433898. |
an aqueous extract of ceylon cinnamon (c. zeylanicum) is found to inhibit tau aggregation and filament formation, hallmarks of alzheimer's disease (ad). |
2009-12-15 |
2023-08-12 |
Not clear |
| Yang Liu, Eleanor Peacey, John Dickson, Christine P Donahue, Suxin Zheng, Gabriele Varani, Michael S Wolf. Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. Journal of medicinal chemistry. vol 52. issue 21. 2009-12-15. PMID:19839622. |
a series of mitoxantrone (mtx) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem-loop structure that serves as a splicing regulatory element in the pre-mrna of tau, which is involved in alzheimer's and other neurodegenerative diseases. |
2009-12-15 |
2023-08-12 |
Not clear |
| Stephanie J Adams, Richard J P Crook, Michael Deture, Suzanne J Randle, Amy E Innes, Xin Z Yu, Wen-Lang Lin, Brittany N Dugger, Melinda McBride, Mike Hutton, Dennis W Dickson, Eileen McGowa. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. The American journal of pathology. vol 175. issue 4. 2009-12-09. PMID:19717642. |
collectively, these results describe a novel model of tauopathy that develops pathological changes reminiscent of early stage alzheimer's disease and other related neurodegenerative diseases, achieved without overexpression of a mutant human tau transgene. |
2009-12-09 |
2023-08-12 |
mouse |
| Ryong-Woon Shin, Koichi Ogino, Alfredo Shimabuku, Takao Taki, Hanae Nakashima, Takeshi Ishihara, Tetsuyuki Kitamot. Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer's disease and its transgenic models: a role to mediate interaction of Abeta and tau. Acta neuropathologica. vol 113. issue 6. 2009-12-07. PMID:17431643. |
amyloid precursor protein cytoplasmic domain with phospho-thr668 accumulates in alzheimer's disease and its transgenic models: a role to mediate interaction of abeta and tau. |
2009-12-07 |
2023-08-12 |
mouse |