| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priyadarshi Prajjwal, Shahnaz Asharaf, Dhruvi Makhanasa, Aishwarya Yamparala, Halla Tariq, Soumya Aleti, Srikanth Gadam, Neel Vor. Association of Alzheimer's dementia with oral bacteria, vitamin B12, folate, homocysteine levels, and insulin resistance along with its pathophysiology, genetics, imaging, and biomarkers. Disease-a-month : DM. 2023-03-17. PMID:36931946. |
neuroimaging techniques, including mri, pet, and tau pet, can identify the predictive characteristics of alzheimer's disease, with amyloid pet being the most useful in ruling out the disease. |
2023-03-17 |
2023-08-14 |
Not clear |
| Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C Saido, Minako It. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease. Inflammation and regeneration. vol 43. issue 1. 2023-03-16. PMID:36922861. |
alzheimer's disease (ad) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (aβ) aggregates and phosphorylated tau with aging. |
2023-03-16 |
2023-08-14 |
mouse |
| Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David C Airey, James Scherschel, Sarubini Kananathan, Brian J Eastwood, Suchira Bose, David A Collier, Emma Laing, David Evans, Howard Broughton, Andreas Bende. Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b. Alzheimer's research & therapy. vol 15. issue 1. 2023-03-15. PMID:36918909. |
a key histopathological hallmark of alzheimer's disease (ad) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in neurons. |
2023-03-15 |
2023-08-14 |
mouse |
| Jaclyn Lilek, Kaouther Ajroud, Alexander Z Feldman, Sesha Krishnamachari, Shadi Ghourchian, Tamar Gefen, Callen L Spencer, Allegra Kawles, Qinwen Mao, Jessica F Tranovich, Clifford R Jack, M-Marsel Mesulam, R Ross Reichard, Hui Zhang, Melissa E Murray, David Knopman, Dennis W Dickson, Ronald C Petersen, Benjamin Smith, Karen H Ashe, Michelle M Mielke, Kathryn M Nelson, Margaret E Flanaga. Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 92. issue 1. 2023-03-14. PMID:36744338. |
phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in alzheimer's disease (ad). |
2023-03-14 |
2023-08-16 |
Not clear |
| Sungsu Lim, Seulgi Shin, Yoonsik Sung, Ha Eun Lee, Kyu Hyeon Kim, Ji Yeon Song, Gwan-Ho Lee, Hira Aziz, Nataliia Lukianenko, Dong Min Kang, Nicolette Boesen, Hyeanjeong Jeong, Aizhan Abdildinova, Junghee Lee, Byung-Yong Yu, Sang Min Lim, Jun-Seok Lee, Hoon Ryu, Ae Nim Pae, Yun Kyung Ki. Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in Tau Experimental & molecular medicine. 2023-03-14. PMID:36914856. |
accordingly, preventing tau oligomerization has become an important therapeutic strategy to treat tauopathies, including alzheimer's disease. |
2023-03-14 |
2023-08-14 |
Not clear |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
tgf-β1 signalling in alzheimer's pathology and cytoskeletal reorganization: a specialized tau perspective. |
2023-03-14 |
2023-08-14 |
Not clear |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
microtubule-associated protein, tau has been implicated in alzheimer's disease for its detachment from microtubules and formation of insoluble intracellular aggregates within the neurons. |
2023-03-14 |
2023-08-14 |
Not clear |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
channelizing microglia to target extracellular tau could be a good strategy to combat the prion-like transmission and seeding problem in alzheimer's disease. |
2023-03-14 |
2023-08-14 |
Not clear |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
the current review focuses on reaffirming the role of tgf-β1 signalling in alzheimer's pathology and cytoskeletal reorganization and considers utilizing the approach of tgf-β-triggered microglia-mediated targeting of extracellular patho-protein, tau, as a possible potential strategy to combat alzheimer's disease. |
2023-03-14 |
2023-08-14 |
Not clear |
| Ha-Lim Song, Na-Young Kim, Jaewan Park, Meong Il Kim, Yu-Na Jeon, Se-Jong Lee, Kwangmin Cho, Young-Lim Shim, Kyoung-Hye Lee, Yeon-Seon Mun, Jung-A Song, Min-Seok Kim, Chan-Gi Pack, Minkyo Jung, Hyemin Jang, Duk L Na, Minsun Hong, Dong-Hou Kim, Seung-Yong Yoo. Monoclonal antibody Y01 prevents tauopathy progression induced by lysine280-acetylated tau in cell and mouse models. The Journal of clinical investigation. 2023-03-14. PMID:36917188. |
the spatiotemporal pattern of the spread of pathologically modified tau through brain regions in alzheimer's disease (ad) can be explained by prion-like cell-to-cell seeding and propagation of misfolded tau aggregates. |
2023-03-14 |
2023-08-14 |
mouse |
| Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jocker. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. eLife. vol 12. 2023-03-14. PMID:36917493. |
aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and alzheimer's disease (ad). |
2023-03-14 |
2023-08-14 |
Not clear |
| Yixuan Wang, Hao Hu, Xinyu Liu, Xiangyu Gu. Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism. Frontiers in pharmacology. vol 14. 2023-03-13. PMID:36909158. |
alzheimer's disease (ad) is a global chronic disease in adults with beta-amyloid (aβ) deposits and hyperphosphorylated tau protein as the pathologic characteristics. |
2023-03-13 |
2023-08-14 |
Not clear |
| Anna-Lena Haas, Pauline Olm, Janine Utz, Eva-Maria Siegmann, Philipp Spitzer, Anna Florvaag, Manuel Alexander Schmidt, Arnd Doerfler, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler, Timo Jan Oberstei. PASSED: Brain atrophy in non-demented individuals in a long-term longitudinal study from two independent cohorts. Frontiers in aging neuroscience. vol 15. 2023-03-13. PMID:36909947. |
alzheimer's disease (ad) is indicated by a decrease in amyloid beta 42 (aβ42) level or the aβ42/aβ40 ratio, and by increased levels of tau with phosphorylated threonine at position 181 (ptau181) in cerebrospinal fluid (csf) years before the onset of clinical symptoms. |
2023-03-13 |
2023-08-14 |
human |
| Riki Koike, Yuta Takaichi, Yoshiyuki Soeda, Akihiko Takashim. Memory formation in old age requires GSK-3β. Aging brain. vol 1. 2023-03-13. PMID:36911517. |
it is linked to the two main pathological features of alzheimer's disease (ad), tau and amyloid β (aβ); gsk-3β is a major candidate to pathologically hyperphosphorylate tau and modulate aβ production. |
2023-03-13 |
2023-08-14 |
mouse |
| Chiara Giuseppina Bonomi, Martina Assogna, Martina Gaia Di Donna, Francesca Bernocchi, Vincenzo De Lucia, Marzia Nuccetelli, Denise Fiorelli, Stefano Loizzo, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Mott. Cerebrospinal Fluid sTREM-2, GFAP, and β-S100 in Symptomatic Sporadic Alzheimer's Disease: Microglial, Astrocytic, and APOE Contributions Along the Alzheimer's Disease Continuum. Journal of Alzheimer's disease : JAD. 2023-03-13. PMID:36911936. |
many transversal mechanisms act synergistically at different time-points in the cascade of alzheimer's disease (ad), since amyloid-β (aβ) deposition, tau pathology, and neuroinflammation influence each other. |
2023-03-13 |
2023-08-14 |
Not clear |
| Yanfang Zhao, Yujin Gu, Qili Zhang, Hongliang Liu, Yingying Li. The Potential Roles of Exosomes Carrying APP and Tau Cleavage Products in Alzheimer's Disease. Journal of clinical medicine. vol 12. issue 5. 2023-03-11. PMID:36902671. |
the potential roles of exosomes carrying app and tau cleavage products in alzheimer's disease. |
2023-03-11 |
2023-08-14 |
Not clear |
| Chunying Guo, Ting Wang, Dongmei Zhang, Xiaojing Ge, Jinan L. Plasminogen decreases Aβ42 and Tau deposition, and shows multi-beneficial effects on Alzheimer's disease in mice and humans. Biochemical and biophysical research communications. vol 654. 2023-03-11. PMID:36905760. |
plasminogen decreases aβ42 and tau deposition, and shows multi-beneficial effects on alzheimer's disease in mice and humans. |
2023-03-11 |
2023-08-14 |
mouse |
| Raquel L Arribas, Lucía Viejo, Isaac Bravo, Minerva Martínez, Eva Ramos, Alejandro Romero, Eva M García-Frutos, Veerle Janssens, Carmen Montiel, Cristóbal de Los Río. C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies. European journal of medicinal chemistry. vol 251. 2023-03-11. PMID:36905916. |
for instance, one of the main histopathological features of alzheimer's disease is neurofibrillary tangles, which are mainly comprised by hyperphosphorylated forms of tau protein. |
2023-03-11 |
2023-08-14 |
mouse |
| Brendan P Lucey, Haiyan Liu, Cristina D Toedebusch, David Freund, Tiara Redrick, Samir L Chahin, Kwasi G Mawuenyega, James G Bollinger, Vitaliy Ovod, Nicolas R Barthélemy, Randall J Batema. Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS. Annals of neurology. 2023-03-10. PMID:36897120. |
in alzheimer's disease, hyperphosphorylated tau is associated with formation of insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are associated with neuronal loss and cognitive symptoms. |
2023-03-10 |
2023-08-14 |
mouse |
| Ryan K Betters, Emma Luhmann, Amy C Gottschalk, Zhen Xu, Mallory R Shin, Christopher P Ptak, Kimberly L Fiock, Lilliana C Radoshevich, Marco M Heft. Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins. eNeuro. 2023-03-10. PMID:36898832. |
despite exhibiting tau phosphorylation similar to alzheimer disease, the human fetal brain is remarkably resilient to tau aggregation and toxicity. |
2023-03-10 |
2023-08-14 |
human |