| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sydney Sunna, Christine A Bowen, Christina C Ramelow, Juliet V Santiago, Prateek Kumar, Srikant Rangaraj. Advances in proteomic phenotyping of microglia in neurodegeneration. Proteomics. 2023-04-15. PMID:37060300. |
in this review, we discuss molecular insights gained from transcriptomic studies of microglia in the context of alzheimer's disease as a prototypic neurodegenerative disease, and highlight existing and emerging approaches for proteomic profiling of microglia derived from in vivo model systems and human brain. |
2023-04-15 |
2023-08-14 |
human |
| Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazaré, Sergio Oddi, Mauro Maccarron. Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047663. |
dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate alzheimer's disease (ad) pathogenesis by releasing proinflammatory factors, such as nitric oxide (no). |
2023-04-13 |
2023-08-14 |
Not clear |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
trem2 encoding the transmembrane receptor protein trem2 is a risk gene of alzheimer's disease (ad), and the impairment of trem2 functions in microglia due to mutations in trem2 may significantly increase the risk of ad by promoting ad pathologies. |
2023-04-12 |
2023-08-14 |
mouse |
| b' Siting Gan, Danilo G Macalinao, Sayyed Hamed Shahoei, Lin Tian, Xin Jin, Harihar Basnet, James T Muller, Pranita Atri, Evan Seffar, Walid Chatila, Anna-Katerina Hadjantonakis, Nikolaus Schultz, Edi Brogi, Tejus A Bale, Dana Pe\'er, Joan Massagu\\xc3\\xa. Distinct tumor architectures for metastatic colonization of the brain. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034672.' |
single-cell transcriptomic dissection reveals canonical alzheimer's disease-associated microglia (dam) responses. |
2023-04-10 |
2023-08-14 |
Not clear |
| Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomit. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. vol 26. issue 4. 2023-04-10. PMID:37035000. |
the genetic associations of trem2 loss-of-function variants with alzheimer disease (ad) indicate the protective roles of microglia in ad pathogenesis. |
2023-04-10 |
2023-08-14 |
mouse |
| Tiantian Li, Dianyi Li, Qingyuan Wei, Minghong Shi, Jiakun Xiang, Ruiwei Gao, Chao Chen, Zhi-Xiang X. Dissecting the neurovascular unit in physiology and Alzheimer's disease: Functions, imaging tools and genetic mouse models. Neurobiology of disease. 2023-04-06. PMID:37023830. |
here, we aim to describe the current knowledge of the nvu cellular elements, including endothelial cells, pericytes, astrocytes, and microglia, in regulating the blood-brain barrier integrity and functions in physiology as well as alterations encountered in alzheimer's disease. |
2023-04-06 |
2023-08-14 |
mouse |
| Anniina Snellman, Laura L Ekblad, Jouni Tuisku, Mikko Koivumäki, Nicholas J Ashton, Juan Lantero-Rodriguez, Thomas K Karikari, Semi Helin, Marco Bucci, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Juha O Rinn. APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly. Alzheimer's research & therapy. vol 15. issue 1. 2023-04-04. PMID:37016464. |
neuroinflammation, characterized by increased reactivity of microglia and astrocytes in the brain, is known to be present at various stages of the alzheimer's disease (ad) continuum. |
2023-04-04 |
2023-08-14 |
Not clear |
| Kelsey Carter, Steven Cicero, Eero Rissanen, Shipra Dubey, Howard L Weiner, Tarun Singha. Assessment of Microglial Activation in Alzheimer Disease Using 18F-PBR06 PET. Clinical nuclear medicine. 2023-03-28. PMID:36976711. |
a 69-year-old woman with progressive short-term memory deficits was diagnosed with alzheimer disease (mmse 26/30, cdr 0.5) and underwent pet using 18f-pbr06, a second-generation 18-kda translocator protein ligand, targeting brain microglia and astrocytes. |
2023-03-28 |
2023-08-14 |
Not clear |
| Chloe G McKee, Madison Hoffos, Haley A Vecchiarelli, Marie-Ève Trembla. Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease. Frontiers in pharmacology. vol 14. 2023-03-27. PMID:36969855. |
microglia: a pharmacological target for the treatment of age-related cognitive decline and alzheimer's disease. |
2023-03-27 |
2023-08-14 |
Not clear |
| Soraya Meftah, Jian Ga. Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression. Frontiers in synaptic neuroscience. vol 15. 2023-03-27. PMID:36970154. |
other important future avenues of note in this field include the role of non-neuronal cell types such as astrocytes and microglia, and mechanisms of dysfunction independent of amyloid and tau in alzheimer's disease. |
2023-03-27 |
2023-08-14 |
mouse |
| Emily R Mason, Disha M Soni, Shaoyou Ch. Microglial Phagocytosis/Cell Health High-Content Assay. Current protocols. vol 3. issue 3. 2023-03-27. PMID:36971657. |
we report a microglial phagocytosis/cell health high-content assay that has been used to test small molecule chemical probes and support our drug discovery projects targeting microglia for alzheimer's disease therapy. |
2023-03-27 |
2023-08-14 |
mouse |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression associations with alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Sang Won Jeon, Yong-Ku Ki. Neuron-Microglia Crosstalk in Neuropsychiatric Disorders. Advances in experimental medicine and biology. vol 1411. 2023-03-23. PMID:36949303. |
this review aims to describe the relationships between microglia and major psychiatric disorders and to specifically examine studies of gene expression and function of microglia in depression, schizophrenia, and alzheimer's disease. |
2023-03-23 |
2023-08-14 |
human |
| Meng Cheng, Caihua Ye, Chunxiao Tian, Dongju Zhao, Haonan Li, Zuhao Sun, Yuyang Miao, Qiang Zhang, Junping Wang, Yan Do. Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression. Bioactive materials. vol 26. 2023-03-23. PMID:36950153. |
immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain, leading to neurodegeneration in alzheimer's disease (ad). |
2023-03-23 |
2023-08-14 |
mouse |
| Sarah R Ocañas, Kevin D Pham, Jillian E J Cox, Alex W Keck, Sunghwan Ko, Felix A Ampadu, Hunter L Porter, Victor A Ansere, Adam Kulpa, Collyn M Kellogg, Adeline H Machalinski, Ana J Chucair-Elliott, Willard M Freema. Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945656. |
microglia, the brain's principal immune cells, have been implicated in the pathogenesis of alzheimer's disease (ad), a condition shown to affect more females than males. |
2023-03-22 |
2023-08-14 |
mouse |
| C Zhang, X Zhong, L Yi, Z Zhao, Y Zhang, G Tan, Y Zhang, Y Zhang, Y Xu, N W. Exploring the Associations between Alzheimer's Disease and GBM Mediated by Microglia Based on Network Analysis. The journal of prevention of Alzheimer's disease. vol 10. issue 2. 2023-03-22. PMID:36946454. |
exploring the associations between alzheimer's disease and gbm mediated by microglia based on network analysis. |
2023-03-22 |
2023-08-14 |
human |
| Ryan K Shahidehpour, Abraham S Nelson, Lydia G Sanders, Chloe R Embry, Peter T Nelson, Adam D Bachstette. The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER. Acta neuropathologica communications. vol 11. issue 1. 2023-03-19. PMID:36934255. |
the localization of molecularly distinct microglia populations to alzheimer's disease pathologies using quiver. |
2023-03-19 |
2023-08-14 |
human |
| Ryan K Shahidehpour, Abraham S Nelson, Lydia G Sanders, Chloe R Embry, Peter T Nelson, Adam D Bachstette. The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER. Acta neuropathologica communications. vol 11. issue 1. 2023-03-19. PMID:36934255. |
next, the study asked if the tissue environment, specifically the amyloid plaques and neurofibrillary tangles characteristic of alzheimer's disease, has any bearing on microglia's cellular and molecular phenotypes. |
2023-03-19 |
2023-08-14 |
human |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
tgf-β-mediated regulation occurs at the level of neuronal survival and differentiation, glial activation (astrocyte and microglia), amyloid production-distribution-clearance and neurofibrillary tangle formation, all of which contributes to alzheimer's pathophysiology. |
2023-03-14 |
2023-08-14 |
Not clear |