| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Sagües-Sesé, José Rioja, Francisco J Garzón-Maldonado, Manuel Narváez, Juan A García-Arnés, Natalia García-Casare. Insulin-Related Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2022-09-12. PMID:36093712. |
glucose metabolism and insulin signaling alterations play an important role in alzheimer's disease (ad) pathogenesis. |
2022-09-12 |
2023-08-14 |
Not clear |
| Elisa Maffioli, Giulia Murtas, Valentina Rabattoni, Beatrice Badone, Farida Tripodi, Filomena Iannuzzi, Danilo Licastro, Simona Nonnis, Anna Maria Rinaldi, Zoraide Motta, Silvia Sacchi, Nadia Canu, Gabriella Tedeschi, Paola Coccetti, Loredano Pollegion. Insulin and serine metabolism as sex-specific hallmarks of Alzheimer's disease in the human hippocampus. Cell reports. vol 40. issue 10. 2022-09-07. PMID:36070700. |
insulin and serine metabolism as sex-specific hallmarks of alzheimer's disease in the human hippocampus. |
2022-09-07 |
2023-08-14 |
human |
| Omer Kucu. Walk More, Eat Less, Don't Stress. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 31. issue 9. 2022-09-02. PMID:36052489. |
unhealthy diet, obesity, lack of physical activity, and psychologic stress are associated with increased inflammation, oxidative stress, insulin resistance, and dna methylation, which are the main mechanisms of chronic diseases such as cancer, hypertension, diabetes, cardiovascular disease, and alzheimer's disease. |
2022-09-02 |
2023-08-14 |
Not clear |
| Lauren McClure Yauch, Kathleen Ennis-Czerniak, William H Frey Ii, Ivan Tkac, Raghavendra B Ra. Intranasal Insulin Attenuates the Long-term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats. Developmental neuroscience. 2022-08-30. PMID:36041414. |
intranasal insulin (ins) bypasses the blood-brain barrier, targets the brain and improves synaptogenesis in rodent models, and memory in adult humans with alzheimer's disease or type 2 diabetes, without altering the blood levels of insulin or glucose. |
2022-08-30 |
2023-08-14 |
rat |
| Mélissa Gentreau, Christelle Reynes, Robert Sabatier, Jerome J Maller, Chantal Meslin, Jeremy Deverdun, Emmanuelle Le Bars, Michel Raymond, Claire Berticat, Sylvaine Arter. Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia. Journal of Alzheimer's disease : JAD. 2022-08-29. PMID:36031896. |
glucometabolic changes, such as high glycemic load (gl) diet and insulin resistance (ir), are potential risk factor of alzheimer's disease (ad). |
2022-08-29 |
2023-08-14 |
Not clear |
| Yolanda Martín-Martín, Ana Pérez-García, Marta Torrecilla-Parra, Mario Fernández-de Frutos, Virginia Pardo-Marqués, María José Casarejos, Rebeca Busto, Cristina M Ramíre. New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs. Cells. vol 11. issue 16. 2022-08-26. PMID:36010613. |
the evident implication of the insulin-degrading enzyme (ide) in alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm), among its capacity to degrade insulin and amyloid-β peptide (aβ), suggests that ide could be an essential link in the relation between hyperinsulinemia, insulin resistance and ad. |
2022-08-26 |
2023-08-14 |
human |
| João M N Duart. Serine racemase modulation for improving brain insulin resistance: An Editorial Highlight for "Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers". Journal of neurochemistry. 2022-08-23. PMID:35996309. |
the authors explored some of the possible mechanisms mediating the interaction between dampening production of d-serine and the local synthesis of insulin, and they further propose that stimulating insulin production could counteract hippocampal insulin resistance in alzheimer's disease (ad). |
2022-08-23 |
2023-08-14 |
Not clear |
| Zengtao Wang, Xiaojia Tang, Suresh K Swaminathan, Karunya K Kandimalla, Krishna R Kalar. Mapping the dynamics of insulin-responsive pathways in the blood-brain barrier endothelium using time-series transcriptomics data. NPJ systems biology and applications. vol 8. issue 1. 2022-08-16. PMID:35974022. |
therefore, endothelial insulin resistance could lead to bbb dysfunction, which is associated with neurodegenerative diseases such as alzheimer's disease (ad). |
2022-08-16 |
2023-08-14 |
human |
| Ricardo Augusto Leoni De Sousa, Caíque Olegário Diniz de Magalhães, Isabella Rocha Dias, Lucas Renan Sena de Oliveira, Alex Cleber Improta-Caria, Ricardo Cardoso Cassilha. Cross talk mechanisms of aerobic exercise training on obesity, type 2 diabetes, and Alzheimer's disease: the role of insulin resistance. Revista da Associacao Medica Brasileira (1992). vol 68. issue 7. 2022-08-10. PMID:35946775. |
cross talk mechanisms of aerobic exercise training on obesity, type 2 diabetes, and alzheimer's disease: the role of insulin resistance. |
2022-08-10 |
2023-08-14 |
Not clear |
| Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. |
deep studies showed that multi-target compounds from hericium erinaceus could target the gut microbiota, regulate the metabolism, inflammation, immunity and insulin to slow the progression of alzheimer's disease. |
2022-08-07 |
2023-08-14 |
mouse |
| Elizabeth M Rhea, William A Banks, Jacob Rabe. Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35884888. |
in other ways, it is the worst of times as insulin resistance is implicated in devastating diseases, including diabetes mellitus, obesity, and alzheimer's disease (ad) that affect the brain. |
2022-07-27 |
2023-08-14 |
Not clear |
| Xia Xu, Pishui Qi, Ying Zhang, Huihuan Sun, Yong Yan, Wenxiu Sun, Shudong Li. Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice. Frontiers in molecular neuroscience. vol 15. 2022-07-25. PMID:35875664. |
prior studies have demonstrated a close association between brain insulin resistance and alzheimer's disease (ad), while selenium supplementation was shown to improve insulin homeostasis in ad patients and to exert neuroprotective effects in a mouse model of ad. |
2022-07-25 |
2023-08-14 |
mouse |
| Jing Zhou, Zhiwen Zhang, Yuanhong Yang, Fei Liao, Piansi Zhou, Yan Wang, He Zhang, Haiyan Jiang, Tahereh Alinejad, Ge Shan, Shengzhou W. Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers. Journal of neurochemistry. 2022-07-15. PMID:35839294. |
dysregulation of insulin signaling in the alzheimer's (ad) brain has been extensively reported. |
2022-07-15 |
2023-08-14 |
Not clear |
| Joseph Blommer, Toni Pitcher, Maja Mustapic, Erden Eren, Pamela J Yao, Michael P Vreones, Krishna A Pucha, John Dalrymple-Alford, Reza Shoorangiz, Wassilios G Meissner, Tim Anderson, Dimitrios Kapogianni. Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease. Brain : a journal of neurology. 2022-07-14. PMID:35833836. |
besides motor symptoms, many individuals with parkinson's disease develop cognitive impairment perhaps due to co-existing α-synuclein and alzheimer's disease pathologies and impaired brain insulin signaling. |
2022-07-14 |
2023-08-14 |
human |
| Fei Yan, Ju Liu, Mei-Xiang Chen, Ying Zhang, Sheng-Jiao Wei, Hai Jin, Jing Nie, Xiao-Long Fu, Jing-Shan Shi, Shao-Yu Zhou, Feng Ji. Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799540. |
these findings suggest that icariin can improve learning and memory impairments in the mouse model of alzheimer's disease by regulating brain insulin signaling and glucose transporters, which lays the foundation for potential clinical application of icariin in the prevention and treatment of alzheimer's disease. |
2022-07-08 |
2023-08-14 |
mouse |
| Shatw Khalid Ali, Rojgar H Al. Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. PloS one. vol 17. issue 7. 2022-07-08. PMID:35802659. |
increasing evidence shows that the disturbance of insulin signalling in the brain may contribute to the pathophysiology of alzheimer's disease. |
2022-07-08 |
2023-08-14 |
rat |
| Junhao Huang, Zhiwei Xu, Hongshu Chen, Yiyou Lin, Jiale Wei, Sichen Wang, Hongxia Yu, Shuo Huang, Yehui Zhang, Changyu Li, Xiaojie Zho. Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741643. |
alzheimer's disease is the most common form of neurodegenerative disease, and increasing evidence shows that insulin signaling has crucial roles in ad initiation and progression. |
2022-06-24 |
2023-08-14 |
rat |
| Mengyi Guo, Jiaokun Jia, Jia Zhang, Mingyue Zhou, Anxin Wang, Shengyun Chen, Xingquan Zha. Association of β-cell function and cognitive impairment in patients with abnormal glucose metabolism. BMC neurology. vol 22. issue 1. 2022-06-23. PMID:35739484. |
insulin has been demonstrated to play an important role in the occurrence and development of alzheimer's disease, especially in those with diabetes. |
2022-06-23 |
2023-08-14 |
human |
| Eren Canbolat, Funda Pınar Cakırogl. The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review. Critical reviews in food science and nutrition. 2022-06-16. PMID:35708095. |
it can be stated that ampk is inhibited in many pathological conditions such as inflammation, diabetes, aging and cancer, and ampk activation has positive effects in many diseases such as insulin resistance, diabetes, obesity, cancer and alzheimer's. |
2022-06-16 |
2023-08-14 |
human |
| Rajalakshmi R, Chinnappa A Uthaiah, Ramya C M, SubbaRao V Madhunapantula, Paramahans V Salimath, Praveen K, Srinath K M, Kishor M . Comparative assessment of cognitive impairment and oxidative stress markers among vitamin D insufficient elderly patients with and without type 2 diabetes mellitus (T2DM). PloS one. vol 17. issue 6. 2022-06-16. PMID:35709193. |
impaired glucose metabolism, insulin resistance, vitamin-d deficiency and oxidative stress are some of the key early events reported to be involved in the pathogenesis of most common cognitive disorders, which include alzheimer's disease. |
2022-06-16 |
2023-08-14 |
Not clear |