| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyang Du, Xiaoyu Meng, Yu Yao, Jun X. The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease. Frontiers in endocrinology. vol 13. 2022-12-05. PMID:36465634. |
since type 2 diabetes mellitus (t2dm) is a risk factor for alzheimer's disease (ad) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat t2dm have been gradually found to reduce the progression of ad in ad models. |
2022-12-05 |
2023-08-14 |
Not clear |
| Yujia Zhou, Jingyi Dong, Jingmei Song, Chaojie Lvy, Yuyan Zhan. Efficacy of Glucose Metabolism-Related Indexes on the Risk and Severity of Alzheimer's Disease: A Meta-Analysis. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463446. |
considering the strong correlation made between alzheimer's disease (ad) and the pathology of glucose metabolism disorder, we sought to analyze the effects of fasting blood glucose (fbg) level, fasting plasma insulin (fins) level, and insulin resistance index (homa-ir) on the risk and severity of ad. |
2022-12-04 |
2023-08-14 |
Not clear |
| Jeehye Maeng, Kyunglim Le. Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides. Frontiers in pharmacology. vol 13. 2022-12-01. PMID:36452220. |
some cpps have been applied for the delivery of peptide antidiabetics, including insulin and exendin-4, for treating diabetes and alzheimer's disease. |
2022-12-01 |
2023-08-14 |
Not clear |
| Eduarda Dal Pisol Schwab, Ruliam Queiroz, Anne Karine Bosetto Fiebrantz, Murilo Bastos, Juliana Sartori Bonini, Weber Cláudio Francisco Nunes da Silv. Hypothesis on ontogenesis and pathophysiology of Alzheimer's disease. Einstein (Sao Paulo, Brazil). vol 20. 2022-11-30. PMID:36449761. |
some factors, such as excitotoxicity, cholinergic dysfunctions, oxidative stress, tau protein hyperphosphorylation, changes in amyloid-beta peptide metabolism, herpes viruses, apolipoprotein e, glycogen synthase kinase 3, insulin resistance, and the endocannabinoid system seem to be related to pathophysiology of alzheimer's disease. |
2022-11-30 |
2023-08-14 |
Not clear |
| Karel M Lopez-Vilaret, Marina Fernandez-Alvarez, Ehsan Shokri-Kojori, Dardo Tomasi, Jose L Cantero, Mercedes Atienz. Pre-diabetes is associated with altered functional connectivity density in cortical regions of the default-mode network. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36438011. |
insulin resistance and glucose dysregulation are associated with patterns of regional brain hypometabolism characteristic of alzheimer's disease (ad). |
2022-11-28 |
2023-08-14 |
Not clear |
| Meenakshi Bose, Gabriela Farias Quipildor, Michelle E Ehrlich, Stephen R Salto. Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development. Cells. vol 11. issue 22. 2022-11-26. PMID:36429060. |
here we review a dozen promising in peptide therapeutics in preclinical and clinical development for neurodegenerative (alzheimer's, parkinson's), neuropsychiatric (depression, ptsd, schizophrenia), and neurodevelopmental disorders (autism), with insulin, nap (davunetide), igf-1, pacap, npy, oxytocin, and glp-1 agonists prominent among them. |
2022-11-26 |
2023-08-14 |
human |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. The Role of Insulin Signaling in Hippocampal-Related Diseases: A Focus on Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430894. |
the role of insulin signaling in hippocampal-related diseases: a focus on alzheimer's disease. |
2022-11-26 |
2023-08-14 |
human |
| Pilar Vigil, Jaime Meléndez, Grace Petkovic, Juan Pablo Del Rí. The importance of estradiol for body weight regulation in women. Frontiers in endocrinology. vol 13. 2022-11-24. PMID:36419765. |
this can cause cerebral insulin resistance, which contributes to the development of conditions such as parkinson's or alzheimer's disease. |
2022-11-24 |
2023-08-14 |
Not clear |
| Dena Nuwaylati, Basmah Eldakhakhny, Abdulhadi Bima, Hussein Sakr, Ayman Elsamanoud. Low-Carbohydrate High-Fat Diet: A SWOC Analysis. Metabolites. vol 12. issue 11. 2022-11-24. PMID:36422267. |
insulin resistance (ir) plays a role in the pathogenesis of many diseases, such as type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver disease, obesity, and neurodegenerative diseases, including alzheimer's disease. |
2022-11-24 |
2023-08-14 |
human |
| Henry Querfurth, Angela Slitt, Amy DiCamillo, Nathan Surles, Brenton DeBoef, Han-Kyu Le. A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer's disease. Behavioural brain research. vol 438. 2022-11-21. PMID:36404570. |
diabetes mellitus (dm), peripheral insulin resistance (ir) and obesity are clear risk factors for alzheimer's disease. |
2022-11-21 |
2023-08-14 |
mouse |
| Hanish Singh Jayasingh Chellammal, Mizaton Hazizul Hasan, Rahul P Kshirsagar, Vamshi Krishna Reddy Musukula, Dhani Ramachandran, Prakash V Diwa. Metformin inhibits cardiometabolic syndrome associated cognitive deficits in high fat diet rats. Journal of diabetes and metabolic disorders. vol 21. issue 2. 2022-11-21. PMID:36404813. |
glucose intolerance and insulin resistance are hallmarks of metabolic syndrome and lead to alzheimer's disease (ad). |
2022-11-21 |
2023-08-14 |
rat |
| Chen Meimei, Wang Fengzhen, Lei Huangwei, Li Candong, Yang Zhaoyan. Discovery of Taxus chinensis fruit wine as potentially functional food against Alzheimer's disease by UHPLC-QE-MS/MS, network pharmacology and molecular docking. Journal of food biochemistry. 2022-11-17. PMID:36394096. |
the go and kegg enrichment analyses revealed that tcfw mainly acted on oxidative response, inflammatory response, insulin secretion, amyloid fibril formation, neurodegenerative pathway-multiple diseases, alzheimer's disease, longevity regulation pathway, pi3k-akt signaling pathway, mapk signaling pathway, etc, which were the main pathogenesis of ad. |
2022-11-17 |
2023-08-14 |
human |
| Alpna Tyagi, Musa Musa, Wladimir Labeikovsky, Subbiah Pugazhenth. Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome. Scientific reports. vol 12. issue 1. 2022-11-17. PMID:36396721. |
sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid alzheimer's disease with metabolic syndrome. |
2022-11-17 |
2023-08-14 |
mouse |
| Arzu Ay, Nevra Alkanli, Engin Atli, Hakan Gurkan, Tevfik Gulyasar, Sibel Guler, Tammam Sipahi, Necdet Su. Investigation of Relationship Between Small Noncoding RNA (sncRNA) Expression Levels and Serum Iron, Copper, and Zinc Levels in Clinical Diagnosed Multiple Sclerosis Patients. Molecular neurobiology. 2022-11-16. PMID:36383327. |
according to the findings in our study, hsa-mir-744-5p upregulation has been determined as an early diagnostic biomarker for the development together of insulin resistance, diabetes mellitus associated with insulin signaling, and alzheimer's diseases. |
2022-11-16 |
2023-08-14 |
Not clear |
| Maite Solas, Marta Zamarbide, Carlos G Ardanaz, María J Ramírez, Alberto Pérez-Mediavill. The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362376. |
it has been established that aging is the major risk factor for alzheimer's disease (ad), and it is becoming increasingly evident that obesity and the associated insulin resistance are also notably relevant risk factors. |
2022-11-11 |
2023-08-14 |
mouse |
| Owen Davis Sanders, Lekshmy Rajagopal, Chandler Chase Barton, Jayalekshmi Archa Rajagopal, Olga Lopez, Kalei Lopez, Fayeza Mali. Does oxidative DNA damage trigger histotoxic hypoxia via PARP1/AMP-driven mitochondrial ADP depletion-induced ATP synthase inhibition in Alzheimer's disease? Mitochondrion. vol 67. 2022-11-11. PMID:36367519. |
the low cerebral metabolic rate of oxygen despite the relatively preserved perfusion in alzheimer's disease (ad) patients' medial temporal lobes suggest histotoxic hypoxia due to mitochondrial dysfunction that is independent of, but could precede, insulin resistance. |
2022-11-11 |
2023-08-14 |
Not clear |
| Morten Tange Kristensen, Christian Have Dall, Mette Aadahl, Charlotte Suett. Ugeskrift for laeger. vol 184. issue 43. 2022-11-04. PMID:36331169. |
insulin resistance is an essential metabolic phenomenon that plays an important part in the pathophysiological development of a number of common diseases, such as obesity, type 2 diabetes, arterial hypertension, polycystic ovary syndrome, alzheimer's disease, fatty liver disease, and several types of cancer. |
2022-11-04 |
2023-08-14 |
human |
| Mubeen A Ansari, Muddanna S Rao, Aishah Al-Jarallah, Fawzi M Babike. Early Time Course of Oxidative Stress in Hippocampal Synaptosomes and Cognitive Loss Following Impaired Insulin Signaling in Rats: Development of Sporadic Alzheimer's Disease. Brain research. 2022-11-03. PMID:36328067. |
early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: development of sporadic alzheimer's disease. |
2022-11-03 |
2023-08-14 |
rat |
| Mubeen A Ansari, Muddanna S Rao, Aishah Al-Jarallah, Fawzi M Babike. Early Time Course of Oxidative Stress in Hippocampal Synaptosomes and Cognitive Loss Following Impaired Insulin Signaling in Rats: Development of Sporadic Alzheimer's Disease. Brain research. 2022-11-03. PMID:36328067. |
oxidative stress, caused by impaired insulin signaling, plays a pivotal role in the pathogenesis of sporadic alzheimer's disease (sad). |
2022-11-03 |
2023-08-14 |
rat |
| Karina Sánchez-Alegría, Clorinda Aria. Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage. Endocrinology, diabetes & metabolism. 2022-11-02. PMID:36321333. |
in particular, the reduction in neuronal insulin signaling seems to underlie the development of cognitive impairments and has been considered a risk factor for alzheimer's disease (ad). |
2022-11-02 |
2023-08-14 |
Not clear |