| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, David A Bennett, Frederic Calo. Alterations of neurovascular insulin receptor in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109311. |
the hypothesis that central insulin resistance plays a role in alzheimer's disease (ad) is gaining interest. |
2022-02-03 |
2023-08-13 |
human |
| Ruixue Huan. Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance. Frontiers in cellular and infection microbiology. vol 11. 2022-02-03. PMID:35111696. |
insulin resistance is a hallmark of alzheimer's disease (ad), type ii diabetes (t2d), and parkinson's disease (pd). |
2022-02-03 |
2023-08-13 |
human |
| Mingyue Chen, Min Zhang, Shenglin Wang, Xiaomi Ding, Yujun Lee, Guohui Jian. Association between Insulin Resistance and Cognitive Impairment. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 32. issue 2. 2022-02-02. PMID:35108792. |
key words: insulin resistance, insulin, cognition, cognitive impairment, systematic review, alzheimer's disease. |
2022-02-02 |
2023-08-13 |
human |
| Derek Kellar, Thomas Register, Samuel N Lockhart, Paul Aisen, Rema Raman, Robert A Rissman, James Brewer, Suzanne Craf. Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial. Scientific reports. vol 12. issue 1. 2022-01-26. PMID:35079029. |
intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and alzheimer's disease: a randomized trial. |
2022-01-26 |
2023-08-13 |
human |
| Derek Kellar, Thomas Register, Samuel N Lockhart, Paul Aisen, Rema Raman, Robert A Rissman, James Brewer, Suzanne Craf. Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial. Scientific reports. vol 12. issue 1. 2022-01-26. PMID:35079029. |
intranasal insulin (ini) has shown promise as a treatment for alzheimer's disease (ad) in pilot clinical trials. |
2022-01-26 |
2023-08-13 |
human |
| Violina Kakoty, Sarathlal K C, Sunil Kumar Dubey, Chih-Hao Yang, Sandhya Amol Marathe, Rajeev Taliya. Epigenetic regulation and autophagy modulation debilitates insulin resistance associated Alzheimer's disease condition in rats. Metabolic brain disease. 2022-01-22. PMID:35064868. |
epigenetic regulation and autophagy modulation debilitates insulin resistance associated alzheimer's disease condition in rats. |
2022-01-22 |
2023-08-13 |
rat |
| Violina Kakoty, Sarathlal K C, Sunil Kumar Dubey, Chih-Hao Yang, Sandhya Amol Marathe, Rajeev Taliya. Epigenetic regulation and autophagy modulation debilitates insulin resistance associated Alzheimer's disease condition in rats. Metabolic brain disease. 2022-01-22. PMID:35064868. |
insulin resistance (ir) and accumulation of amyloid beta (aβ) oligomers are potential causative factor for alzheimer's disease (ad). |
2022-01-22 |
2023-08-13 |
rat |
| Dayea Kim, Yeon Suk Jo, Han-Seul Jo, Sungwon Bae, Yang Woo Kwon, Yong-Seok Oh, Jong Hyuk Yoo. Comparative Phosphoproteomics of Neuro-2a Cells under Insulin Resistance Reveals New Molecular Signatures of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055191. |
comparative phosphoproteomics of neuro-2a cells under insulin resistance reveals new molecular signatures of alzheimer's disease. |
2022-01-21 |
2023-08-13 |
mouse |
| Dayea Kim, Yeon Suk Jo, Han-Seul Jo, Sungwon Bae, Yang Woo Kwon, Yong-Seok Oh, Jong Hyuk Yoo. Comparative Phosphoproteomics of Neuro-2a Cells under Insulin Resistance Reveals New Molecular Signatures of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055191. |
the abnormality of brain insulin signaling is associated with the aging process and altered brain plasticity, and could promote neurodegeneration in the late stage of alzheimer's disease (ad). |
2022-01-21 |
2023-08-13 |
mouse |
| Henry Querfurth, John Marshall, Keykavous Parang, Mengia S Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Le. A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro. PloS one. vol 17. issue 1. 2022-01-21. PMID:35061720. |
the alzheimer's brain is affected by multiple pathophysiological processes, which include a unique, organ-specific form of insulin resistance that begins early in its course. |
2022-01-21 |
2023-08-13 |
rat |
| Mustafa A Maher, Wafaa Kandeel, Olfat A Hammam, Yasmeen M Attia, Soheir Mahmoud, Mohamed Sala. Histopathological evaluation of insulin-DMSO formula designed for direct nose-to-brain delivery. Histology and histopathology. 2022-01-18. PMID:35040114. |
the combination of insulin and dmso is a patented (publication no us8987199b2), noninvasive, pharmaceutically strategized preparation for direct nose-to-brain delivery (dn2bd) suggested for the treatment of alzheimer's disease (ad). |
2022-01-18 |
2023-08-13 |
rat |
| Elena S George, Surbhi Sood, Robin M Daly, Sze-Yen Ta. Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review. BMC geriatrics. vol 22. issue 1. 2022-01-12. PMID:35016619. |
nafld is associated with metabolic risk factors underpinned by insulin resistance, inflammation and endothelial dysfunction, leading to extrahepatic changes in central nervous diseases such as cognitive impairment, alzheimer's disease and dementia. |
2022-01-12 |
2023-08-13 |
Not clear |
| Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisi. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008973. |
this study aimed to explore the roles of central glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic alzheimer's disease (sad). |
2022-01-11 |
2023-08-13 |
rat |
| Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R Kreut. Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-01-06. PMID:34986876. |
neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and alzheimer's disease. |
2022-01-06 |
2023-08-13 |
Not clear |
| Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R Kreut. Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-01-06. PMID:34986876. |
the metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for alzheimer's disease. |
2022-01-06 |
2023-08-13 |
Not clear |
| Sarathlal K C, Violina K Kakoty, Rajeev Taliya. Development and Validation of PEG-PCL Based Nanoformulation of Rosiglitazone and Evaluation of its Brain Selectivity in Mice Model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 12. 2021-12-31. PMID:34971085. |
type-2 diabetes mellitus and insulin resistance increases the risk of alzheimer's disease (ad). |
2021-12-31 |
2023-08-13 |
mouse |
| Clayton Connor McIntyre, Ozioma C Okonkwo, Julian M Gaitán, Barbara B Bendlin, Kyle J Edmund. Effect of insulin resistance on the association between cardiorespiratory fitness and cognition in adults at risk for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 12. 2021-12-31. PMID:34971110. |
effect of insulin resistance on the association between cardiorespiratory fitness and cognition in adults at risk for alzheimer's disease. |
2021-12-31 |
2023-08-13 |
Not clear |
| Smriti Gupta, Vishal Singh, Subramaniam Ganesh, Nitin K Singhal, Rajat Sandhi. siRNA Mediated GSK3β Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimer's Disease Pathology: Evidence from ACS applied materials & interfaces. 2021-12-30. PMID:34967205. |
sirna mediated gsk3β knockdown targets insulin signaling pathway and rescues alzheimer's disease pathology: evidence from sporadic alzheimer's disease (sad) is a progressive neurodegenerative disorder with dysfunctional insulin signaling and energy metabolism. |
2021-12-30 |
2023-08-13 |
Not clear |
| Ting Chen, Lan Shou, Xiaowen Guo, Mingyang Wei, Hui Zheng, Tao Ta. Magnolol attenuates the locomotor impairment, cognitive deficit, and neuroinflammation in Alzheimer's disease mice with brain insulin resistance via up-regulating miR-200c. Bioengineered. vol 13. issue 1. 2021-12-30. PMID:34968163. |
magnolol attenuates the locomotor impairment, cognitive deficit, and neuroinflammation in alzheimer's disease mice with brain insulin resistance via up-regulating mir-200c. |
2021-12-30 |
2023-08-13 |
mouse |
| Chandani V Chandarana, Salona Ro. Comprehensive Review on Neuro-Degenerative Type 3DM. Current diabetes reviews. 2021-12-28. PMID:34961464. |
alzheimer disease (ad) is thought to be the metabolic illness raised by defective insulin signaling, insulin resistance, and low insulin levels in the brain, according to a growing body of research. |
2021-12-28 |
2023-08-13 |
Not clear |