| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Inci Kazkayasi, Gokcen Telli, Emirhan Nemutlu, Serdar Um. Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease. Life sciences. 2022-04-08. PMID:35395244. |
intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in icv-stz-induced mice model of alzheimer's disease. |
2022-04-08 |
2023-08-13 |
mouse |
| Inci Kazkayasi, Gokcen Telli, Emirhan Nemutlu, Serdar Um. Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease. Life sciences. 2022-04-08. PMID:35395244. |
the relationship between type 2 diabetes and alzheimer's disease (ad) provides evidence that insulin and insulin sensitizers may be beneficial for the treatment of ad. |
2022-04-08 |
2023-08-13 |
mouse |
| Suélen Santos Alves, Rui Milton Patrício da Silva Junior, Polianna Delfino-Pereira, Marilia Gabriella Alves Goulart Pereira, Israel Vasconcelos, Hanna Schwaemmle, Rodrigo Focosi Mazzei, Maiko Luiz Carlos, Enilza Maria Espreafico, Antônio Claudio Tedesco, Adriano Sebollela, Sebastião Sousa Almeida, José Antônio Cortes de Oliveira, Norberto Garcia-Cairasc. A Genetic Model of Epilepsy with a Partial Alzheimer's Disease-Like Phenotype and Central Insulin Resistance. Molecular neurobiology. 2022-04-05. PMID:35378696. |
a genetic model of epilepsy with a partial alzheimer's disease-like phenotype and central insulin resistance. |
2022-04-05 |
2023-08-13 |
rat |
| Amy Woodfield, Tenielle Porter, Israa Gilani, Siti Noordin, Qiao-Xin Li, Steven Collins, Ralph N Martins, Paul Maruff, Colin L Masters, Christopher C Rowe, Victor L Villemagne, Vincent Dore, Philip Newsholme, Simon M Laws, Giuseppe Verdil. Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of aging. vol 114. 2022-04-05. PMID:35381406. |
insulin resistance, cognition and alzheimer's disease biomarkers: evidence that csf aβ42 moderates the association between insulin resistance and increased csf tau levels. |
2022-04-05 |
2023-08-13 |
Not clear |
| Amy Woodfield, Tenielle Porter, Israa Gilani, Siti Noordin, Qiao-Xin Li, Steven Collins, Ralph N Martins, Paul Maruff, Colin L Masters, Christopher C Rowe, Victor L Villemagne, Vincent Dore, Philip Newsholme, Simon M Laws, Giuseppe Verdil. Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of aging. vol 114. 2022-04-05. PMID:35381406. |
mounting evidence implicates insulin resistance (ir) with reduced cognition, increased dementia risk and changes in alzheimer's disease biomarkers. |
2022-04-05 |
2023-08-13 |
Not clear |
| Seong-Hyun Kim, Sang-Seo Park, Chang-Ju Kim, Tae-Woon Ki. Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice. Journal of exercise rehabilitation. vol 18. issue 1. 2022-03-31. PMID:35356135. |
exercise with 40-hz light flicker improves hippocampal insulin signaling in alzheimer disease mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Seong-Hyun Kim, Sang-Seo Park, Chang-Ju Kim, Tae-Woon Ki. Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice. Journal of exercise rehabilitation. vol 18. issue 1. 2022-03-31. PMID:35356135. |
we examined whether exercise is associated with hippocampus-mediated improvement in insulin signaling and cell differentiation in the triple transgenic mouse model of alzheimer disease (3xtg ad) murine model following exposure to 40-hz light flickering and exercise. |
2022-03-31 |
2023-08-13 |
mouse |
| Angela G Juby, Toni E Blackburn, Diana R Mage. Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double-blind, placebo-controlled, crossover study, with an open-label extension. Alzheimer's & dementia (New York, N. Y.). vol 8. issue 1. 2022-03-21. PMID:35310527. |
cerebral glucose and insulin metabolism is impaired in alzheimer's disease (ad). |
2022-03-21 |
2023-08-13 |
human |
| Alexandra J Malbon, Lorena Sordo, Liam A Wilson, Danièlle Gunn-Moore, Georgios Paraschou, Neil Macintyre, Tobias Schwarz, Bruce McGorum, Caroline Hah. Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys. Neurobiology of aging. vol 113. 2022-03-12. PMID:35278749. |
altered insulin signaling and type ii diabetes have been linked to the development of alzheimer's disease (ad) in humans and ad-like neurodegeneration in other long-lived animals. |
2022-03-12 |
2023-08-13 |
Not clear |
| Abdeslem El Idrissi, Alejandra Del Carmen Alons. Pathological Human Tau Induces Alterations in the Brain Insulin Signaling Cascade. Frontiers in neuroscience. vol 16. 2022-03-10. PMID:35264925. |
the process of neurodegeneration in alzheimer's disease has been associated with a disruption of insulin signaling cascade in neurons, and to insulin resistance. |
2022-03-10 |
2023-08-13 |
mouse |
| Abdeslem El Idrissi, Alejandra Del Carmen Alons. Pathological Human Tau Induces Alterations in the Brain Insulin Signaling Cascade. Frontiers in neuroscience. vol 16. 2022-03-10. PMID:35264925. |
we propose that the appearance of abnormal tau might potentiate the toxic environment by interfering with the insulin signaling cascade in the brain of patients with alzheimer's disease. |
2022-03-10 |
2023-08-13 |
mouse |
| Steven R Alves, Cristóvão da Cruz E Silva, Ilka Martins, Ana Gabriela Henriques, Odete A B da Cruz E Silv. A Bioinformatics Approach Toward Unravelling the Synaptic Molecular Crosstalk Between Alzheimer's Disease and Diabetes. Journal of Alzheimer's disease : JAD. 2022-03-07. PMID:35253743. |
increasing evidence links impaired brain insulin signaling and insulin resistance to the development of alzheimer's disease (ad). |
2022-03-07 |
2023-08-13 |
Not clear |
| Fernanda G De Felice, Rafaella A Gonçalves, Sergio T Ferreir. Impaired insulin signalling and allostatic load in Alzheimer disease. Nature reviews. Neuroscience. 2022-03-01. PMID:35228741. |
impaired insulin signalling and allostatic load in alzheimer disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Fernanda G De Felice, Rafaella A Gonçalves, Sergio T Ferreir. Impaired insulin signalling and allostatic load in Alzheimer disease. Nature reviews. Neuroscience. 2022-03-01. PMID:35228741. |
impaired insulin signalling, a hallmark of diabetes, is now established as a key component of alzheimer disease (ad) pathology. |
2022-03-01 |
2023-08-13 |
Not clear |
| Ancuta-Veronica Lupaescu, Monica Iavorschi, Mihai Covas. The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer's Disease. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35213966. |
it has become increasingly apparent that defective insulin signaling may increase the risk for developing alzheimer's disease (ad), influence neurodegeneration through promotion of amyloid formation or by increasing inflammatory responses to intraneuronal β-amyloid. |
2022-02-26 |
2023-08-13 |
Not clear |
| Ana Pérez-García, Marta Torrecilla-Parra, Mario Fernández-de Frutos, Yolanda Martín-Martín, Virginia Pardo-Marqués, Cristina M Ramíre. Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204710. |
insulin resistance affects physiology in many ways, causing hyperglycemia, hypertension, dyslipidemia, visceral adiposity, hyperinsulinemia, elevated inflammatory markers, and endothelial dysfunction, and its persistence leads to the development metabolic disease, including diabetes, obesity, cardiovascular disease, or nonalcoholic fatty liver disease (nafld), as well as neurological disorders such as alzheimer's disease. |
2022-02-25 |
2023-08-13 |
human |
| Shengnan Shen, Qiwen Liao, Yin Kwan Wong, Xiao Chen, Chuanbin Yang, Chengchao Xu, Jichao Sun, Jigang Wan. The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease. International journal of biological sciences. vol 18. issue 3. 2022-02-17. PMID:35173531. |
studies have shown that such inflammation and impaired insulin signaling contribute to the development of alzheimer's disease (ad). |
2022-02-17 |
2023-08-13 |
Not clear |
| Caitlin Brown, Sarah Pemberton, Alice Babin, Noor Abdulhameed, Cassidy Noonan, Mary Beth Brown, William A Banks, Elizabeth Meredith Rhe. Insulin blood-brain barrier transport and interactions are greater following exercise in mice. Journal of applied physiology (Bethesda, Md. : 1985). 2022-02-17. PMID:35175106. |
central nervous system (cns) insulin resistance is a common feature of cognitive impairment, including alzheimer's disease. |
2022-02-17 |
2023-08-13 |
mouse |
| Priyanka Sengupta, Debashis Mukhopadhya. Insulin dysregulation as a prominent driver of cell cycle re-entry in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108922. |
insulin dysregulation as a prominent driver of cell cycle re-entry in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
mouse |
| Maria Elizabeth de Sousa Rodrigues, Jianjun Chang, Timothy R Sampson, Malu Gamez Tanse. The role of soluble TNF in mediating immune and metabolic alterations in a mouse model of amyloid-beta pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109081. |
insulin resistance (ir) and systemic inflammation are risk factors for alzheimer's disease (ad); however, the molecular and signaling mechanisms underlying this relationship are not well understood. |
2022-02-03 |
2023-08-13 |
mouse |