| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunyu Zhou, Cha-Gyun Jung, Mi-Jeong Kim, Atsushi Watanabe, Mona Abdelhamid, Ferdous Taslima, Makoto Michikaw. Insulin Deficiency Increases Sirt2 Level in Streptozotocin-Treated Alzheimer's Disease-Like Mouse Model: Increased Sirt2 Induces Tau Phosphorylation Through ERK Activation. Molecular neurobiology. 2022-06-14. PMID:35701718. |
insulin deficiency increases sirt2 level in streptozotocin-treated alzheimer's disease-like mouse model: increased sirt2 induces tau phosphorylation through erk activation. |
2022-06-14 |
2023-08-14 |
mouse |
| Chunyu Zhou, Cha-Gyun Jung, Mi-Jeong Kim, Atsushi Watanabe, Mona Abdelhamid, Ferdous Taslima, Makoto Michikaw. Insulin Deficiency Increases Sirt2 Level in Streptozotocin-Treated Alzheimer's Disease-Like Mouse Model: Increased Sirt2 Induces Tau Phosphorylation Through ERK Activation. Molecular neurobiology. 2022-06-14. PMID:35701718. |
accumulating evidence suggests that insulin deficiency is a risk factor for alzheimer's disease (ad); however, the underlying molecular mechanisms are not completely understood. |
2022-06-14 |
2023-08-14 |
mouse |
| Riane Richard, Shaker Mous. Necroptosis in Alzheimer's disease: Potential therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-06. PMID:35665670. |
these connections lend themselves to the 'starving brain' theory of alzheimer's disease, and insulin resistance exacerbates the role of necroptosis in the development of alzheimer's disease. |
2022-06-06 |
2023-08-14 |
Not clear |
| H Dubey, A Dubey, K Gulati, A Ra. Protective effects of L-arginine on cognitive deficits and biochemical parameters in an experimental model of type-2 diabetes mellitus induced Alzheimer's disease in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 73. issue 1. 2022-05-31. PMID:35639033. |
alzheimer's disease (ad) has been closely linked to type 2 diabetes mellitus (t2dm) and insulin resistance plays a key role in the onset and development of ad. |
2022-05-31 |
2023-08-13 |
rat |
| Flavia Agata Cimini, Marzia Perluigi, Ilaria Barchetta, Maria Gisella Cavallo, Eugenio Baron. Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628384. |
in addition, recent findings demonstrated that reduced bvr-a levels or impaired bvr-a activation contribute to the development of brain insulin resistance and metabolic alterations in alzheimer's disease. |
2022-05-28 |
2023-08-13 |
human |
| Kiana Moayedi, Shirin Orandi, Reyhane Ebrahimi, Maryam Tanhapour, Mona Moradi, Maryam Abbastabar, Abolfazl Golestan. A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease. Journal of cellular physiology. 2022-05-17. PMID:35580144. |
a novel approach to type 3 diabetes mechanism: the interplay between noncoding rnas and insulin signaling pathway in alzheimer's disease. |
2022-05-17 |
2023-08-13 |
Not clear |
| Michalis Michailidis, Despina A Tata, Despina Moraitou, Dimitrios Kavvadas, Sofia Karachrysafi, Theodora Papamitsou, Patroklos Vareltzis, Vasileios Papaliagka. Antidiabetic Drugs in the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563031. |
human studies in patients with mild cognitive impairment and alzheimer's disease have shown that administration of some antidiabetic medications, such as intranasal insulin, metformin, incretins, and thiazolidinediones, can improve cognition and memory. |
2022-05-14 |
2023-08-13 |
human |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
induction of brain insulin resistance and alzheimer's molecular changes by western diet. |
2022-05-14 |
2023-08-13 |
mouse |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
long-term wd feeding leads to insulin resistance, postulated as a risk factor for alzheimer's disease (ad). |
2022-05-14 |
2023-08-13 |
mouse |
| Pai Liu, Zhi-Hao Wang, Seong Su Kang, Xia Liu, Yiyuan Xia, Chi-Bun Chan, Keqiang Y. High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPβ/AEP pathway. Molecular psychiatry. 2022-05-13. PMID:35546632. |
diabetes is a risk factor for alzheimer's disease (ad), which is also called type 3 diabetes with insulin reduction and insulin resistance in ad patient brains. |
2022-05-13 |
2023-08-13 |
mouse |
| Emily Leong, Reena Dosanjh, Johnson Huynh, Yujin Hur, Christiane Cabreros, Yue Tong Lee, Ningkun Wan. Dissecting the Mechanism of Allosteric Regulation of SIRT1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555597. |
the enzyme sirt1 is a lysine deacetylase that plays a part in various pathways in the body, including insulin secretion and neurodegeneration, rendering it as a potential drug target for common diseases such as type ii diabetes and alzheimer's disease. |
2022-05-13 |
2023-08-13 |
Not clear |
| Lian Duan, Xueshen Qian, Qin Wang, Lan Huang, Song G. Experimental Periodontitis Deteriorates Cognitive Function and Impairs Insulin Signaling in a Streptozotocin-Induced Alzheimer's Disease Rat Model. Journal of Alzheimer's disease : JAD. 2022-05-09. PMID:35527550. |
experimental periodontitis deteriorates cognitive function and impairs insulin signaling in a streptozotocin-induced alzheimer's disease rat model. |
2022-05-09 |
2023-08-13 |
rat |
| P Yamini, R S Ray, Sonal Yadav, Jatinder Dhaliwal, Manisha Yadav, Kanthi Kiran Kondepudi, Kanwaljit Chopr. α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease. Pharmacology, biochemistry, and behavior. 2022-05-09. PMID:35533773. |
α7nachr activation protects against oxidative stress, neuroinflammation and central insulin resistance in icv-stz induced sporadic alzheimer's disease. |
2022-05-09 |
2023-08-13 |
mouse |
| P Yamini, R S Ray, Sonal Yadav, Jatinder Dhaliwal, Manisha Yadav, Kanthi Kiran Kondepudi, Kanwaljit Chopr. α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease. Pharmacology, biochemistry, and behavior. 2022-05-09. PMID:35533773. |
central insulin resistance is considered as one of the pathological hallmarks of alzheimer's disease (ad), similar to formation of amyloid plaques and neurofibrillary tangles (nft). |
2022-05-09 |
2023-08-13 |
mouse |
| James J Yan. Brain insulin resistance and the therapeutic value of insulin and insulin-sensitizing drugs in Alzheimer's disease neuropathology. Acta neurologica Belgica. 2022-04-28. PMID:35482277. |
brain insulin resistance and the therapeutic value of insulin and insulin-sensitizing drugs in alzheimer's disease neuropathology. |
2022-04-28 |
2023-08-13 |
Not clear |
| Antonio J López-Gambero, Beatriz Pacheco-Sánchez, Cristina Rosell-Valle, Dina Medina-Vera, Juan Antonio Navarro, María Del Mar Fernández-Arjona, Marialuisa de Ceglia, Carlos Sanjuan, Vincent Simon, Daniela Cota, Patricia Rivera, Fernando Rodríguez de Fonseca, Juan Suáre. Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-28. PMID:35483188. |
increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic alzheimer's disease (ad) with sex differences. |
2022-04-28 |
2023-08-13 |
mouse |
| Antonio J López-Gambero, Beatriz Pacheco-Sánchez, Cristina Rosell-Valle, Dina Medina-Vera, Juan Antonio Navarro, María Del Mar Fernández-Arjona, Marialuisa de Ceglia, Carlos Sanjuan, Vincent Simon, Daniela Cota, Patricia Rivera, Fernando Rodríguez de Fonseca, Juan Suáre. Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-28. PMID:35483188. |
this study aimed to determine the effect of oral dietary administration of d-chiro-inositol (dci), an inositol used against insulin resistance associated with polycystic ovary, on the occurrence of metabolic disorders in the transgenic 5xfad mouse model of ad (fad: family alzheimer's disease). |
2022-04-28 |
2023-08-13 |
mouse |
| Maryam Bazrgar, Pariya Khodabakhsh, Leila Dargahi, Fatemeh Mohagheghi, Abolhassan Ahmadian. MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model. Experimental gerontology. 2022-04-27. PMID:35476966. |
microrna modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced alzheimer's like rat model. |
2022-04-27 |
2023-08-13 |
rat |
| Jillissa C Taubel, Nicholas R Nelson, Aditya Bansal, Geoffrey L Curran, Lushan Wang, Zengtao Wang, Heather M Berg, Cynthia J Vernon, Hoon-Ki Min, Nicholas B Larson, Timothy R DeGrado, Karunya K Kandimalla, Val J Lowe, Mukesh K Pande. Design, Synthesis, and Preliminary Evaluation of [ Bioconjugate chemistry. 2022-04-14. PMID:35420782. |
design, synthesis, and preliminary evaluation of [ aberrant insulin signaling has been considered one of the risk factors for the development of alzheimer's disease (ad) and has drawn considerable attention from the research community to further study its role in ad pathophysiology. |
2022-04-14 |
2023-08-13 |
Not clear |
| Nicolas R Bolo, Alan M Jacobson, Gail Musen, Donald C Simonso. Hyperglycemia and Hyperinsulinemia Effects on Anterior Cingulate Cortex Myoinositol - Relation to Brain Network Functional Connectivity in Healthy Adults. Journal of neurophysiology. 2022-04-13. PMID:35417272. |
increased brain myoinositol and altered functional-connectivity have been found in diabetes, mild cognitive impairment and alzheimer's disease, but the independent effects of plasma glucose and insulin on brain myoinositol and function are not characterized. |
2022-04-13 |
2023-08-13 |
human |