| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noah Leibold, James R Bain, Florin Desp. Type-2 diabetes, pancreatic amylin and neuronal metabolic remodeling in Alzheimer's Disease. Molecular nutrition & food research. 2023-01-28. PMID:36708219. |
amylin, a pancreatic β-cell hormone co-secreted with insulin, participates in the central regulation of satiation, but also forms pancreatic amyloid in persons with type-2 diabetes and synergistically interacts with brain amyloid β (aβ) pathology, in both sporadic and familial alzheimer's disease (ad). |
2023-01-28 |
2023-08-14 |
Not clear |
| Liwei Xu, Xinxin Xu, Hua Kuang, Ye Liu, Chuanlai Xu, Xiaoling W. Transcriptomics and Metabolomics for Co-Exposure to a Cocktail of Neonicotinoids and the Synergist Piperonyl Butoxide. Analytical chemistry. 2023-01-24. PMID:36693709. |
furthermore, diglycerides and metabolic biomarkers demonstrated that the activation of insulin signaling is associated with restricted oxphos, which commonly leads to a high risk of non-alcoholic fatty liver disease (nafld) and alzheimer's disease (ad) as the result of over-synthesis of lipids, low energy supply, and high thermogenesis. |
2023-01-24 |
2023-08-14 |
Not clear |
| Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome. Antioxidants (Basel, Switzerland). vol 12. issue 1. 2023-01-21. PMID:36670973. |
intranasal administration of kyccsrk peptide rescues brain insulin signaling activation and reduces alzheimer's disease-like neuropathology in a mouse model for down syndrome. |
2023-01-21 |
2023-08-14 |
mouse |
| Seyed Amir Hejazi, Kambiz Rohampour, Ehsan Sharifipour, Soruosh Sharifimoghadam, Sepideh Paybast, Abdoreza Ghoreishi, Navid Hassanzadeh, Mostafa Vahedia. Corrigendum to 'The correlation of serum adiponectin and insulin resistance with the presence and severity of dementia in non-obese Alzheimer's patients' [Clin Nutr ESPEN 40 (C) (2020) 376-382]. Clinical nutrition ESPEN. vol 53. 2023-01-19. PMID:36657927. |
corrigendum to 'the correlation of serum adiponectin and insulin resistance with the presence and severity of dementia in non-obese alzheimer's patients' [clin nutr espen 40 (c) (2020) 376-382]. |
2023-01-19 |
2023-08-14 |
Not clear |
| William A Banks, Cassidy Noonan, Elizabeth M Rhe. Evidence for an alternative insulin transporter at the blood-brain barrier. Aging pathobiology and therapeutics. vol 4. issue 4. 2023-01-16. PMID:36644126. |
identifying the transport system for insulin at the bbb would aide in controlling central nervous system (cns) insulin levels in multiple diseases and conditions including alzheimer's disease (ad) and obesity, where availability of insulin to the cns is limited. |
2023-01-16 |
2023-08-14 |
Not clear |
| Ming-Xuan Huo, Qian Wang, Rui-Qing Zhao, Yi-Ru Lin, Bo Fen. [Effect of electroacupuncture at different frequencies on brain insulin signaling transduction pathway in Alzheimer's disease mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 43. issue 1. 2023-01-12. PMID:36633241. |
[effect of electroacupuncture at different frequencies on brain insulin signaling transduction pathway in alzheimer's disease mice]. |
2023-01-12 |
2023-08-14 |
mouse |
| Ming-Xuan Huo, Qian Wang, Rui-Qing Zhao, Yi-Ru Lin, Bo Fen. [Effect of electroacupuncture at different frequencies on brain insulin signaling transduction pathway in Alzheimer's disease mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 43. issue 1. 2023-01-12. PMID:36633241. |
to observe the effect of electroacupuncture (ea) at different frequencies on learning and memory functions, as well as the relevant proteins of brain insulin signal transduction pathway in alzheimer's disease (ad) mice and explore the effect mechanism of ea in treatment of ad. |
2023-01-12 |
2023-08-14 |
mouse |
| Yamini Yadav, Chinmoy Sankar De. PP2Cα aggravates neuronal insulin resistance leading to AD-like phenotype in vitro. Biochemical and biophysical research communications. vol 644. 2023-01-11. PMID:36630734. |
neuronal insulin resistance is a major risk for development of alzheimer's disease (ad). |
2023-01-11 |
2023-08-14 |
Not clear |
| Songcheng Yu, Shengnan Cao, Sitian He, Kaixiang Zhan. Locus-Specific Detection of DNA Methylation: The Advance, Challenge, and Perspective of CRISPR-Cas Assisted Biosensors. Small methods. 2023-01-07. PMID:36609885. |
aberrant methylation occurring at a specific locus was reported to be associated with cancers, insulin resistance, obesity, alzheimer's disease, parkinson's disease, etc. |
2023-01-07 |
2023-08-14 |
Not clear |
| Ana Knezovic, Stjepan Budisa, Ana Babic Perhoc, Jan Homolak, Jelena Osmanovic Barila. From Determining Brain Insulin Resistance in a Sporadic Alzheimer's Disease Model to Exploring the Region-Dependent Effect of Intranasal Insulin. Molecular neurobiology. 2023-01-03. PMID:36596966. |
from determining brain insulin resistance in a sporadic alzheimer's disease model to exploring the region-dependent effect of intranasal insulin. |
2023-01-03 |
2023-08-14 |
rat |
| Ana Knezovic, Stjepan Budisa, Ana Babic Perhoc, Jan Homolak, Jelena Osmanovic Barila. From Determining Brain Insulin Resistance in a Sporadic Alzheimer's Disease Model to Exploring the Region-Dependent Effect of Intranasal Insulin. Molecular neurobiology. 2023-01-03. PMID:36596966. |
impaired response to insulin has been linked to many neurodegenerative disorders like alzheimer's disease (ad). |
2023-01-03 |
2023-08-14 |
rat |
| Arwa M Amin, Hamza Mostafa, Hani M J Khoja. Insulin resistance in Alzheimer's Disease: the genetics and metabolomics links. Clinica chimica acta; international journal of clinical chemistry. 2022-12-25. PMID:36566957. |
insulin resistance in alzheimer's disease: the genetics and metabolomics links. |
2022-12-25 |
2023-08-14 |
Not clear |
| Amy Woodfield, Tatiana Gonzales, Erik Helmerhorst, Simon Laws, Philip Newsholme, Tenielle Porter, Giuseppe Verdil. Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555450. |
current insights on the use of insulin and the potential use of insulin mimetics in targeting insulin signalling in alzheimer's disease. |
2022-12-23 |
2023-08-14 |
human |
| Amy Woodfield, Tatiana Gonzales, Erik Helmerhorst, Simon Laws, Philip Newsholme, Tenielle Porter, Giuseppe Verdil. Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555450. |
alzheimer's disease (ad) and type 2 diabetes (t2d) are chronic diseases that share several pathological mechanisms, including insulin resistance and impaired insulin signalling. |
2022-12-23 |
2023-08-14 |
human |
| Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating "Alzheimer's Disease": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547082. |
the strategies for treating "alzheimer's disease": insulin signaling may be a feasible target. |
2022-12-22 |
2023-08-14 |
Not clear |
| Hussam Jawad Kadhim, Haider Al-Mumen, H H Nahi, S M Hamid. Streptozotocin-induced Alzheimer's disease investigation by one-dimensional plasmonic grating chip. Scientific reports. vol 12. issue 1. 2022-12-19. PMID:36536049. |
recently, there has been significant interest in researching brain insulin resistance as it has been hypothesized that it may play a role in the progression of alzheimer's disease. |
2022-12-19 |
2023-08-14 |
human |
| Vani Jangra, Jeshnu Topl. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus? Cureus. vol 14. issue 11. 2022-12-12. PMID:36505102. |
alzheimer's disease and insulin resistance are prevalent in older adults. insulin's ability to effectively affect target tissues is diminished by ir. |
2022-12-12 |
2023-08-14 |
human |
| Vani Jangra, Jeshnu Topl. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus? Cureus. vol 14. issue 11. 2022-12-12. PMID:36505102. |
thirdly, several pathological research has also shown that beta-amyloid plaques, hyperphosphorylated tau protein, and brain shrinkage, particularly in the hippocampus, are shared brain lesions between insulin and alzheimer's disease. in light of this, type 2 diabetes mellitus may be viewed as a liability for dementia and alzheimer's disease. |
2022-12-12 |
2023-08-14 |
human |
| Rim Hamzé, Etienne Delangre, Stefania Tolu, Manon Moreau, Nathalie Janel, Danielle Bailbé, Jamileh Movassa. Type 2 Diabetes Mellitus and Alzheimer's Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499613. |
in alzheimer's disease, apart from these processes, the alteration of glucose metabolism and insulin signaling in the brain seems to induce early neuronal loss and the impairment of synaptic plasticity, years before the clinical manifestation of the disease. |
2022-12-11 |
2023-08-14 |
Not clear |
| Rim Hamzé, Etienne Delangre, Stefania Tolu, Manon Moreau, Nathalie Janel, Danielle Bailbé, Jamileh Movassa. Type 2 Diabetes Mellitus and Alzheimer's Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499613. |
the large amount of evidence on the existence of insulin resistance in the brain during alzheimer's disease has led to the description of this disease as "type 3 diabetes". |
2022-12-11 |
2023-08-14 |
Not clear |