| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norah T Faqih, Albaraa F Ashoor, Sahl A Alshaikh, Alaa F Maglan, Nisreen Jastania. Association of Alzheimer's Disease and Insulin Resistance in King Abdulaziz Medical City, Jeddah. Cureus. vol 13. issue 11. 2021-12-27. PMID:34956794. |
association of alzheimer's disease and insulin resistance in king abdulaziz medical city, jeddah. |
2021-12-27 |
2023-08-13 |
Not clear |
| Norah T Faqih, Albaraa F Ashoor, Sahl A Alshaikh, Alaa F Maglan, Nisreen Jastania. Association of Alzheimer's Disease and Insulin Resistance in King Abdulaziz Medical City, Jeddah. Cureus. vol 13. issue 11. 2021-12-27. PMID:34956794. |
background alzheimer's disease (ad) and insulin resistance (ir) are common in the elderly. |
2021-12-27 |
2023-08-13 |
Not clear |
| Hussein Akel, Ildikó Csóka, Rita Ambrus, Alexandra Bocsik, Ilona Gróf, Mária Mészáros, Anikó Szecskó, Gábor Kozma, Szilvia Veszelka, Mária A Deli, Zoltán Kónya, Gábor Katon. In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948054. |
the brain insulin metabolism alteration has been addressed as a pathophysiological factor underlying alzheimer's disease (ad). |
2021-12-24 |
2023-08-13 |
human |
| Junghee Ha, Dong-Woo Choi, Kwang Joon Kim, So Yeon Cho, Hyunjeong Kim, Keun You Kim, Youngseung Koh, Chung Mo Nam, Eosu Ki. Association of metformin use with Alzheimer's disease in patients with newly diagnosed type 2 diabetes: a population-based nested case-control study. Scientific reports. vol 11. issue 1. 2021-12-16. PMID:34912022. |
metformin reduces insulin resistance, which constitutes a pathophysiological connection of diabetes with alzheimer's disease (ad), but the evidence of metformin on ad development was still insufficient and conflicting. |
2021-12-16 |
2023-08-13 |
Not clear |
| Jill K Morris, Colin S McCoin, Kelly N Fuller, Casey S John, Heather M Wilkins, Zachary D Green, Xiaowan Wang, Palash Sharma, Jeffrey M Burns, Eric D Vidoni, Jonathan D Mahnken, Kartik Shankar, Russell H Swerdlow, John P Thyfaul. Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle. Function (Oxford, England). vol 2. issue 6. 2021-12-11. PMID:34661111. |
alzheimer's disease (ad) associates with insulin resistance and low aerobic capacity, suggestive of impaired skeletal muscle mitochondrial function. |
2021-12-11 |
2023-08-13 |
Not clear |
| Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Hira E Shah, Aarthi Ethirajulu, Nitin Bhawnani, Jihan A Mostaf. The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications. Cureus. vol 13. issue 11. 2021-12-11. PMID:34877187. |
thirdly, multiple pathological studies showed that insulin and alzheimer's disease share many common lesions in the brain, such as beta-amyloid plaques, amylin-aβ plaques, hyper-phosphorylated tau protein, and brain atrophy, especially in the hippocampus. |
2021-12-11 |
2023-08-13 |
human |
| Yijing Tang, Dong Zhang, Yanxian Zhang, Yonglan Liu, Lirong Cai, Eleanor Plaster, Jie Zhen. Fundamentals and exploration of aggregation-induced emission molecules for amyloid protein aggregation. Journal of materials chemistry. B. 2021-12-09. PMID:34724699. |
despite a limited number of studies on aie-amyloid systems, we will survey recent and important developments of aie molecules for different amyloid protein aggregates of aβ (associated with alzheimer's disease), insulin (associated with type 2 diabetes), (α-syn, associated with parkinson's disease), and hewl (associated with familial lysozyme systemic amyloidosis) with a particular focus on the working principle and structural design of four types of aie-based molecules. |
2021-12-09 |
2023-08-13 |
human |
| b' Simona Terzo, Antonella Amato, Flavia Mul\\xc3\\xa. From obesity to Alzheimer\'s disease through insulin resistance. Journal of diabetes and its complications. vol 35. issue 11. 2021-12-08. PMID:34454830.' |
from obesity to alzheimer's disease through insulin resistance. |
2021-12-08 |
2023-08-13 |
human |
| b' Simona Terzo, Antonella Amato, Flavia Mul\\xc3\\xa. From obesity to Alzheimer\'s disease through insulin resistance. Journal of diabetes and its complications. vol 35. issue 11. 2021-12-08. PMID:34454830.' |
there is full scientific evidence that obesity and the metabolic comorbidities (e.g., insulin resistance, hyperglycaemia, and type 2 diabetes) are related to alzheimer's disease and likely in the causative pathway. |
2021-12-08 |
2023-08-13 |
human |
| Mengyuan Zhou, Hao Li, Yongjun Wang, Yuesong Pan, Yilong Wan. Causal effect of insulin resistance on small vessel stroke and Alzheimer's disease: A Mendelian randomization analysis. European journal of neurology. 2021-12-07. PMID:34797599. |
causal effect of insulin resistance on small vessel stroke and alzheimer's disease: a mendelian randomization analysis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Mengyuan Zhou, Hao Li, Yongjun Wang, Yuesong Pan, Yilong Wan. Causal effect of insulin resistance on small vessel stroke and Alzheimer's disease: A Mendelian randomization analysis. European journal of neurology. 2021-12-07. PMID:34797599. |
the causal effect of insulin resistance on small vessel stroke and alzheimer's disease (ad) was controversial in previous studies. |
2021-12-07 |
2023-08-13 |
Not clear |
| Ting Li, Hong-Xia Cao, Dan K. Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance. Current medical science. 2021-12-07. PMID:34874485. |
type 2 diabetes mellitus easily develops into alzheimer's disease via hyperglycemia and insulin resistance. |
2021-12-07 |
2023-08-13 |
Not clear |
| Maria L Price, Cameron D Ley, Caroline M Gorvi. The emerging role of heterodimerisation and interacting proteins in ghrelin receptor function. The Journal of endocrinology. vol 252. issue 1. 2021-12-03. PMID:34663757. |
herein, we summarise the evidence published to date describing interactions between ghsr1a and transmembrane proteins, discuss the experimental strengths and limitations of these studies, describe the physiological evidence for each interaction, and address their potential as novel drug targets for appetite regulation, alzheimer's disease, insulin secretion, and inflammation. |
2021-12-03 |
2023-08-13 |
Not clear |
| Rachel R Corrigan, Helen Piontkivska, Gemma Casadesu. Amylin Pharmacology in Alzheimer's Disease Pathogenesis and Treatment. Current neuropharmacology. 2021-12-02. PMID:34852745. |
the metabolic peptide hormone amylin, in concert with other metabolic peptides like insulin and leptin, has an important role in metabolic homeostasis and has been intimately linked to alzheimer's disease (ad). |
2021-12-02 |
2023-08-13 |
Not clear |
| William A Banks, Elizabeth M Rhe. The Blood-Brain Barrier, Oxidative Stress, and Insulin Resistance. Antioxidants (Basel, Switzerland). vol 10. issue 11. 2021-11-29. PMID:34829566. |
in this review, we cover the interactions of oxidative stress at the bbb, how insulin signaling is related to oxidative stress, and the impact of the bbb in two diseases greatly affected by oxidative stress and insulin resistance: diabetes mellitus and alzheimer's disease. |
2021-11-29 |
2023-08-13 |
Not clear |
| Marine Tournissac, Manon Leclerc, Josue Valentin-Escalera, Milène Vandal, Cristina R Bosoi, Emmanuel Planel, Frédéric Calo. Metabolic determinants of Alzheimer's disease: A focus on thermoregulation. Ageing research reviews. vol 72. 2021-11-25. PMID:34534683. |
alzheimer's disease (ad) is a complex age-related neurodegenerative disease, associated with central and peripheral metabolic anomalies, such as impaired glucose utilization and insulin resistance. |
2021-11-25 |
2023-08-13 |
Not clear |
| Anit Tyagi, Subbiah Pugazhenth. Targeting Insulin Resistance to Treat Cognitive Dysfunction. Molecular neurobiology. vol 58. issue 6. 2021-11-24. PMID:33483903. |
recent studies are now beginning to recognize type 2 diabetes mellitus, characterized by chronic hyperglycemia and insulin resistance, as a risk factor for alzheimer's disease and other cognitive disorders. |
2021-11-24 |
2023-08-13 |
Not clear |
| Eugenio Barone, Fabio Di Domenico, Marzia Perluigi, D Allan Butterfiel. The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease. Free radical biology & medicine. vol 176. 2021-11-23. PMID:34530075. |
the interplay among oxidative stress, brain insulin resistance and ampk dysfunction contribute to neurodegeneration in type 2 diabetes and alzheimer disease. |
2021-11-23 |
2023-08-13 |
Not clear |
| Manfred Hallschmi. Intranasal Insulin for Alzheimer's Disease. CNS drugs. vol 35. issue 1. 2021-11-22. PMID:33515428. |
intranasal insulin for alzheimer's disease. |
2021-11-22 |
2023-08-13 |
Not clear |
| Manfred Hallschmi. Intranasal Insulin for Alzheimer's Disease. CNS drugs. vol 35. issue 1. 2021-11-22. PMID:33515428. |
brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including alzheimer's disease. |
2021-11-22 |
2023-08-13 |
Not clear |